Substrates for peptidase S08.003: subtilisin lentus

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
Abz-Gly-Phe-Gly-Pro-Phe-Tyr(NO2)-Asp			Abz-Gly-Phe-Gly-Pro-Phe+Tyr(NO2)-Asp	S	Phe	Gly	Pro	Phe	TyN	Asp	-	-	Grøn et al., 1992
insulin A chain (oxidized)	P01317	85-105	peptide-Glu88+Gln-peptide	N	Gly	Ile	Val	Glu	Gln	Cys	Cys	Ala	Mei et al., 2003
insulin A chain (oxidized)	P01317	85-105	peptide-Cys90+Cys-peptide	N	Val	Glu	Gln	Cys	Cys	Ala	Ser	Val	Mei et al., 2003
insulin A chain (oxidized)	P01317	85-105	peptide-Ala92+Ser-peptide	N	Gln	Cys	Cys	Ala	Ser	Val	Cys	Ser	Mei et al., 2003
insulin A chain (oxidized)	P01317	85-105	peptide-Cys95+Ser-peptide	N	Ala	Ser	Val	Cys	Ser	Leu	Tyr	Gln	Mei et al., 2003
insulin A chain (oxidized)	P01317	85-105	peptide-Leu97+Tyr-peptide	N	Val	Cys	Ser	Leu	Tyr	Gln	Leu	Glu	Mei et al., 2003
insulin A chain (oxidized)	P01317	85-105	peptide-Glu101+Asn-peptide	N	Tyr	Gln	Leu	Glu	Asn	Tyr	Cys	Asn	Mei et al., 2003
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln+His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala	N	Phe	Val	Asn	Gln	His	Leu	Cya	Gly	Mei et al., 2003
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu+Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala	N	Asn	Gln	His	Leu	Cya	Gly	Ser	His	Mei et al., 2003
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser+His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala	N	Leu	Cya	Gly	Ser	His	Leu	Val	Glu	Mei et al., 2003
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu+Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala	N	Gly	Ser	His	Leu	Val	Glu	Ala	Leu	Mei et al., 2003
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu+Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala	N	His	Leu	Val	Glu	Ala	Leu	Tyr	Leu	Mei et al., 2003
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu+Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala	N	Val	Glu	Ala	Leu	Tyr	Leu	Val	Cya	Mei et al., 2003
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya+Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala	N	Tyr	Leu	Val	Cya	Gly	Glu	Arg	Gly	Mei et al., 2003
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe+Phe-Tyr-Thr-Pro-Lys-Ala	N	Glu	Arg	Gly	Phe	Phe	Tyr	Thr	Pro	Mei et al., 2003
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys+Ala	N	Tyr	Thr	Pro	Lys	Ala	-	-	-	Mei et al., 2003