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Literature for peptidase S08.003: subtilisin lentus

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Yang,Y., Zhang,B. and Zhang,J.
    Dynamic catalytic domain plasticity governs substrate specificity in industrial serine proteases: Structural and functional implications
    Int J Biol Macromol (2025) 331, 148374-148374. PubMed  Europe PubMed DOI
    2. 2023
  2. Miao,H., Xiang,X., Han,N., Wu,Q. and Huang,Z.
    Improving the Thermostability of Serine Protease PB92 from Bacillus alcalophilus via Site-Directed Mutagenesis Based on Semi-Rational Design
    Foods (2023) 12 PubMed  Europe PubMed DOI  PMC  EPMC
    3. 2014
  3. Frankaer,C.G., Moroz,O.V., Turkenburg,J.P., Aspmo,S.I., Thymark,M., Friis,E.P., Stahl,K., Nielsen,J.E., Wilson,K.S. and Harris,P.
    Analysis of an industrial production suspension of Bacillus lentus subtilisin crystals by powder diffraction: a powerful quality-control tool
    Acta Crystallogr D Biol Crystallogr (2014) 70, 1115-1123. PubMed  Europe PubMed DOI  S
    4. 2013
  4. Jakob,F., Martinez,R., Mandawe,J., Hellmuth,H., Siegert,P., Maurer,K.H. and Schwaneberg,U.
    Surface charge engineering of a Bacillus gibsonii subtilisin protease
    Appl Microbiol Biotechnol (2013) 97, 6793-6802. PubMed  Europe PubMed DOI
  5. Joshi,S. and Satyanarayana,T.
    Characteristics and applications of a recombinant alkaline serine protease from a novel bacterium Bacillus lehensis
    Bioresour Technol (2013) 131, 76-85. PubMed  Europe PubMed DOI
  6. Lipinska-Ojrzanowska,A., Swierczynska-Machura,D., Tymoszuk,D., Nowakowska-Swirta,E. and Walusiak-Skorupa,J.
    Occupational asthma in female factory worker resulting from exposure to savinase in dishwashing tablets - a case study
    J Occup Health (2013) 55, 318-321. PubMed  Europe PubMed
  7. Liu,B., Zhang,J., Li,B., Liao,X., Du,G. and Chen,J.
    Expression and characterization of extreme alkaline, oxidation-resistant keratinase from Bacillus licheniformis in recombinant Bacillus subtilis WB600 expression system and its application in wool fiber processing
    World J Microbiol Biotechnol (2013) 29, 825-832. PubMed  Europe PubMed DOI  E
  8. Martinez,R., Jakob,F., Tu,R., Siegert,P., Maurer,K.H. and Schwaneberg,U.
    Increasing activity and thermal resistance of Bacillus gibsonii alkaline protease (BgAP) by directed evolution
    Biotechnol Bioeng (2013) 110, 711-720. PubMed  Europe PubMed DOI
    9. 2012
  9. Graycar,T.P., Bott,R.R., Power,S.D. and Estell,D.A.
    Subtilisins
    [ISSN:978-0-12-407742-3] (2012) 3, 3148-3155. DOI
    10. 2011
  10. Deng,A., Wu,J., Zhang,G. and Wen,T.
    Molecular and structural characterization of a surfactant-stable high-alkaline protease AprB with a novel structural feature unique to subtilisin family
    Biochimie (2011) 93, 783-791. PubMed  Europe PubMed DOI
    11. 2010
  11. Deng,A., Wu,J., Zhang,Y., Zhang,G. and Wen,T.
    Purification and characterization of a surfactant-stable high-alkaline protease from Bacillus sp. B001
    Bioresour Technol (2010) 101, 7111-7117. PubMed  Europe PubMed DOI
  12. Montazer,M. and Ramin,A.
    Influences of proteases and trans-glutaminases on wool
    Fibres Text East Eur (2010) 79, 98-102.
    13. 2009
  13. Dickinson,J., Murdoch,H., Dennis,M.J., Hall,G.A., Bott,R., Crabb,W.D., Penet,C., Sutton,J.M. and Raven,N.D.
    Decontamination of prion protein (BSE301V) using a genetically engineered protease
    J Hosp Infect (2009) 72, 65-70. PubMed  Europe PubMed DOI
  14. Hangler,M., Burmolle,M., Schneider,I., Allermann,K. and Jensen,B.
    The serine protease Esperase HPF inhibits the formation of multispecies biofilm
    Biofouling (2009) 25, 667-674. PubMed  Europe PubMed DOI
  15. Siddiqui,K.S., Parkin,D.M., Curmi,P.M., De Francisci,D., Poljak,A., Barrow,K., Noble,M.H., Trewhella,J. and Cavicchioli,R.
    A novel approach for enhancing the catalytic efficiency of a protease at low temperature: reduction in substrate inhibition by chemical modification
    Biotechnol Bioeng (2009) 103, 676-686. PubMed  Europe PubMed DOI
    16. 2008
  16. Micheelsen,P.O., Vevodova,J., De Maria,L., Ostergaard,P.R., Friis,E.P., Wilson,K. and Skjot,M.
    Structural and mutational analyses of the interaction between the barley alpha-amylase/subtilisin inhibitor and the subtilisin savinase reveal a novel mode of inhibition
    J Mol Biol (2008) 380, 681-690. PubMed  Europe PubMed DOI  S
    17. 2004
  17. Graycar,T.P., Ballinger,M.D. and Wells,J.A.
    Subtilisins
    [ISSN:0-12-079610-4] (2004) 2, 1786-1792.  V
    18. 2003
  18. [YEAR:16-9-2003]Bott,R.R., Chan,G., Domingo,B., Ganshaw,G., Hsia,C.Y., Knapp,M. and Murray,C.J.
    Do enzymes change the nature of transition states? Mapping the transition state for general acid-base catalysis of a serine protease
    Biochemistry (16-9-2003) 42, 10545-10553. PubMed  Europe PubMed DOI
    19. 2001
  19. Georgieva,D.N., Stoeva,S., Voelter,W., Genov,N. and Betzel,C.
    Substrate specificity of the highly alkalophilic bacterial proteinase Esperase: relation to the X-ray structure
    Curr Microbiol (2001) 42, 368-371. PubMed  Europe PubMed DOI  S
  20. [YEAR:15-3-2001]Georgieva,D.N., Stoeva,S., Voelter,W., Genov,N. and Betzel,C.
    Differences in the specificities of the highly alkalophilic proteinases Savinase and Esperase imposed by changes in the rigidity and geometry of the substrate binding sites
    Arch Biochem Biophys (15-3-2001) 387, 197-201. PubMed  Europe PubMed DOI
    21. 2000
  21. Jorgensen,P.L., Tangney,M., Pedersen,P.E., Hastrup,S., Diderichsen,B. and Jorgensen,S.T.
    Cloning and sequencing of an alkaline protease gene from Bacillus lentus and amplification of the gene on the B. lentus chromosome by an improved technique
    Appl Environ Microbiol (2000) 66, 825-827. PubMed  Europe PubMed DOI  PMC  EPMC
    22. 1999
  22. Davis,B.G., Khumtaveeporn,K., Bott,R.R. and Jones,J.B.
    Altering the specificity of subtilisin Bacillus lentus through the introduction of positive charge at single amino acid sites
    Bioorg Med Chem (1999) 7, 2303-2311. PubMed  Europe PubMed DOI
  23. Davis,B.G., Shang,X., DeSantis,G., Bott,R.R. and Jones,J.B.
    The controlled introduction of multiple negative charge at single amino acid sites in subtilisin Bacillus lentus
    Bioorg Med Chem (1999) 7, 2293-2301. PubMed  Europe PubMed DOI
  24. [YEAR:10-9-1999]Graycar,T., Knapp,M., Ganshaw,G., Dauberman,J. and Bott,R.
    Engineered Bacillus lentus subtilisins having altered flexibility
    J Mol Biol (10-9-1999) 292, 97-109. PubMed  Europe PubMed DOI
  25. [YEAR:10-9-1999]Mulder,F.A., Schipper,D., Bott,R. and Boelens,R.
    Altered flexibility in the substrate-binding site of related native and engineered high-alkaline Bacillus subtilisins
    J Mol Biol (10-9-1999) 292, 111-123. PubMed  Europe PubMed DOI
    26. 1998
  26. [YEAR:2-9-1998]DeSantis,G. and Jones,J.B.
    Chemical modifications at a single site can induce significant shifts in the pH profiles of a serine protease
    J Am Chem Soc (2-9-1998) 120, 8582-8586. DOI
  27. Georgieva,D.N., Nikolov,P. and Betzel,C.
    Steady-state and time-resolved fluorescence of Esperase: comparison with the X-ray structure in the region of the two tryptophans
    Spectrochim Acta A Mol Biomol Spectrosc (1998) 54A, 1109-1116. PubMed  Europe PubMed
  28. [YEAR:29-9-1998]Kuhn,P., Knapp,M., Soltis,S.M., Ganshaw,G., Thoene,M. and Bott,R.
    The 0.78 A structure of a serine protease: Bacillus lentus subtilisin
    Biochemistry (29-9-1998) 37, 13446-13452. PubMed  Europe PubMed DOI  S
    29. 1997
  29. Martin,J.R., Mulder,F.A., Karimi-Nejad,Y., van der Zwan,J., Mariani,M., Schipper,D. and Boelens,R.
    The solution structure of serine protease PB92 from Bacillus alcalophilus presents a rigid fold with a flexible substrate- binding site
    Structure (1997) 5, 521-532. PubMed  Europe PubMed  S
    30. 1996
  30. Betzel,C., Klupsch,S., Branner,S. and Wilson,K.S.
    Crystal structures of the alkaline proteases Savinase and Esperase from Bacillus lentus
    Adv Exp Med Biol (1996) 379, 49-61. PubMed  Europe PubMed  S  I
  31. Bott,R., Dauberman,J., Wilson,L., Ganshaw,G., Sagar,H., Graycar,T. and Estell,D.
    Structural changes leading to increased enzymatic activity in an engineered variant of Bacillus lentus subtilisin
    Adv Exp Med Biol (1996) 379, 277-283. PubMed  Europe PubMed
  32. Gron,H., Bech,L.M., Sorensen,S.B., Meldal,M. and Breddam,K.
    Studies of binding sites in the subtilisin from Bacillus lentus by means of site directed mutagenesis and kinetic investigations
    Adv Exp Med Biol (1996) 379, 105-112. PubMed  Europe PubMed
  33. Maurer,K.H., Markgraf,M. and Goddette,D.
    Substrate specificity of natural variants and genetically engineered intermediates of Bacillus lentus alkaline proteases
    Adv Exp Med Biol (1996) 379, 243-256. PubMed  Europe PubMed
  34. Pfeffer-Hennig,S., Dauter,Z., Hennig,M., Hohne,W., Wilson,K. and Betzel,C.
    Three dimensional structure of the antibiotic bacitracin A complexed to two different subtilisin proteases: novel mode of enzyme inhibition
    Adv Exp Med Biol (1996) 379, 29-41. PubMed  Europe PubMed  S  I
    35. 1995
  35. Genov,N., Filippi,B., Dolashka,P., Wilson,K.S. and Betzel,C.
    Stability of subtilisins and related proteinases (subtilases)
    Int J Pept Protein Res (1995) 45, 391-400. PubMed  Europe PubMed
    36. 1994
  36. Fogh,R.H., Schipper,D., Boelens,R. and Kaptein,R.
    (1)H, (13)C and (15)N NMR backbone assignments of the 269-residue serine protease PB92 from Bacillus alcalophilus
    J Biomol NMR (1994) 4, 123-128. PubMed  Europe PubMed DOI
  37. Lange,G., Betzel,C., Branner,S. and Wilson,K.S.
    Crystallographic studies of Savinase, a subtilisin-like proteinase, at pH 10.5
    Eur J Biochem (1994) 224, 507-518. PubMed  Europe PubMed  S
    38. 1993
  38. Hjortkjaer,R.K., Stavnsbjerg,M., Pedersen,P.B., Heath,J., Wilson,J.A., Marshall,R.R. and Clements,J.
    Safety evaluation of Esperase
    Food Chem Toxicol (1993) 31, 999-1011. PubMed  Europe PubMed DOI
    39. 1992
  39. Bech,L.M., Branner,S., Hastrup,S. and Breddam,K.
    Introduction of a free cysteinyl residue at position 68 in the subtilisin Savinase, based on homology with proteinase K
    FEBS Lett (1992) 297, 164-166. PubMed  Europe PubMed DOI
  40. Betzel,C., Klupsch,S., Papendorf,G., Hastrup,S., Branner,S. and Wilson,K.S.
    Crystal structure of the alkaline proteinase Savinase from Bacillus lentus at 1.4 A resolution
    J Mol Biol (1992) 223, 427-445. PubMed  Europe PubMed  S
  41. Goddette,D.W., Paech,C., Yang,S.S., Mielenz,J.R., Bystroff,C., Wilke,M.E. and Fletterick,R.J.
    The crystal structure of the Bacillus lentus alkaline protease, subtilisin BL, at 1.4 A resolution
    J Mol Biol (1992) 228, 580-595. PubMed  Europe PubMed DOI  S
  42. Gron,H. and Breddam,K.
    Interdependency of the binding subsites in subtilisin
    Biochemistry (1992) 31, 8967-8971. PubMed  Europe PubMed
  43. Gron,H., Meldal,M. and Breddam,K.
    Extensive comparison of the substrate preferences of two subtilisins as determined with peptide substrates which are based on the principle of intramolecular quenching
    Biochemistry (1992) 31, 6011-6018. PubMed  Europe PubMed DOI
  44. [YEAR:5-11-1992]Sobek,H., Hecht,H.J., Aehle,W. and Schomburg,D.
    X-ray structure determination and comparison of two crystal forms of a variant (Asn115Arg) of the alkaline protease from Bacillus alcalophilus refined at 1.85 A resolution
    J Mol Biol (5-11-1992) 228, 108-117. PubMed  Europe PubMed DOI  S
  45. Teplyakov,A.V., van der Laan,J.M., Lammers,A.A., Kelders,H., Kalk,K.H., Misset,O., Mulleners,L.J. and Dijkstra,B.W.
    Protein engineering of the high-alkaline serine protease PB92 from Bacillus alcalophilus: functional and structural consequences of mutation at the S4 substrate binding pocket
    Protein Eng (1992) 5, 413-420. PubMed  Europe PubMed
    46. 1990
  46. Sobek,H., Hecht,H.J., Hofmann,B., Aehle,W. and Schomburg,D.
    Crystal structure of an alkaline protease from Bacillus alcalophilus at 2.4 A resolution
    FEBS Lett (1990) 274, 57-60. PubMed  Europe PubMed DOI  S
    47. 1986
  47. Agarwal,M.K., Ingram,J.W., Dunnette,S. and Gleich,G.J.
    Immunochemical quantitation of an airborne proteolytic enzyme, Esperase, in a consumer products factory
    Am Ind Hyg Assoc J (1986) 47, 138-143. PubMed  Europe PubMed DOI
    48. 1977
  48. Priest,F.G.
    Extracellular enzyme synthesis in the genus Bacillus
    Bacteriol Rev (1977) 41, 711-753. PubMed  Europe PubMed  PMC  EPMC

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