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Literature for peptidase S08.003: subtilisin lentus

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Yang,Y., Zhang,B. and Zhang,J.<br>Dynamic catalytic domain plasticity governs substrate specificity in industrial serine proteases: Structural and functional implications<br>Int J Biol Macromol (2025) 331, 148374-148374. PubMed  Europe PubMed DOI
    2. 2023
  2. Miao,H., Xiang,X., Han,N., Wu,Q. and Huang,Z.<br>Improving the Thermostability of Serine Protease PB92 from Bacillus alcalophilus via Site-Directed Mutagenesis Based on Semi-Rational Design<br>Foods (2023) 12 PubMed  Europe PubMed DOI  PMC  EPMC
    3. 2014
  3. Frankaer,C.G., Moroz,O.V., Turkenburg,J.P., Aspmo,S.I., Thymark,M., Friis,E.P., Stahl,K., Nielsen,J.E., Wilson,K.S. and Harris,P.<br>Analysis of an industrial production suspension of Bacillus lentus subtilisin crystals by powder diffraction: a powerful quality-control tool<br>Acta Crystallogr D Biol Crystallogr (2014) 70, 1115-1123. PubMed  Europe PubMed DOI  S
    4. 2013
  4. Jakob,F., Martinez,R., Mandawe,J., Hellmuth,H., Siegert,P., Maurer,K.H. and Schwaneberg,U.<br>Surface charge engineering of a Bacillus gibsonii subtilisin protease<br>Appl Microbiol Biotechnol (2013) 97, 6793-6802. PubMed  Europe PubMed DOI
  5. Joshi,S. and Satyanarayana,T.<br>Characteristics and applications of a recombinant alkaline serine protease from a novel bacterium Bacillus lehensis<br>Bioresour Technol (2013) 131, 76-85. PubMed  Europe PubMed DOI
  6. Lipinska-Ojrzanowska,A., Swierczynska-Machura,D., Tymoszuk,D., Nowakowska-Swirta,E. and Walusiak-Skorupa,J.<br>Occupational asthma in female factory worker resulting from exposure to savinase in dishwashing tablets - a case study<br>J Occup Health (2013) 55, 318-321. PubMed  Europe PubMed
  7. Liu,B., Zhang,J., Li,B., Liao,X., Du,G. and Chen,J.<br>Expression and characterization of extreme alkaline, oxidation-resistant keratinase from Bacillus licheniformis in recombinant Bacillus subtilis WB600 expression system and its application in wool fiber processing<br>World J Microbiol Biotechnol (2013) 29, 825-832. PubMed  Europe PubMed DOI  E
  8. Martinez,R., Jakob,F., Tu,R., Siegert,P., Maurer,K.H. and Schwaneberg,U.<br>Increasing activity and thermal resistance of Bacillus gibsonii alkaline protease (BgAP) by directed evolution<br>Biotechnol Bioeng (2013) 110, 711-720. PubMed  Europe PubMed DOI
    9. 2012
  9. Graycar,T.P., Bott,R.R., Power,S.D. and Estell,D.A.<br>Subtilisins<br>[ISSN:978-0-12-407742-3] (2012) 3, 3148-3155. DOI
    10. 2011
  10. Deng,A., Wu,J., Zhang,G. and Wen,T.<br>Molecular and structural characterization of a surfactant-stable high-alkaline protease AprB with a novel structural feature unique to subtilisin family<br>Biochimie (2011) 93, 783-791. PubMed  Europe PubMed DOI
    11. 2010
  11. Deng,A., Wu,J., Zhang,Y., Zhang,G. and Wen,T.<br>Purification and characterization of a surfactant-stable high-alkaline protease from Bacillus sp. B001<br>Bioresour Technol (2010) 101, 7111-7117. PubMed  Europe PubMed DOI
  12. Montazer,M. and Ramin,A.<br>Influences of proteases and trans-glutaminases on wool<br>Fibres Text East Eur (2010) 79, 98-102.
    13. 2009
  13. Dickinson,J., Murdoch,H., Dennis,M.J., Hall,G.A., Bott,R., Crabb,W.D., Penet,C., Sutton,J.M. and Raven,N.D.<br>Decontamination of prion protein (BSE301V) using a genetically engineered protease<br>J Hosp Infect (2009) 72, 65-70. PubMed  Europe PubMed DOI
  14. Hangler,M., Burmolle,M., Schneider,I., Allermann,K. and Jensen,B.<br>The serine protease Esperase HPF inhibits the formation of multispecies biofilm<br>Biofouling (2009) 25, 667-674. PubMed  Europe PubMed DOI
  15. Siddiqui,K.S., Parkin,D.M., Curmi,P.M., De Francisci,D., Poljak,A., Barrow,K., Noble,M.H., Trewhella,J. and Cavicchioli,R.<br>A novel approach for enhancing the catalytic efficiency of a protease at low temperature: reduction in substrate inhibition by chemical modification<br>Biotechnol Bioeng (2009) 103, 676-686. PubMed  Europe PubMed DOI
    16. 2008
  16. Micheelsen,P.O., Vevodova,J., De Maria,L., Ostergaard,P.R., Friis,E.P., Wilson,K. and Skjot,M.<br>Structural and mutational analyses of the interaction between the barley alpha-amylase/subtilisin inhibitor and the subtilisin savinase reveal a novel mode of inhibition<br>J Mol Biol (2008) 380, 681-690. PubMed  Europe PubMed DOI  S
    17. 2004
  17. Graycar,T.P., Ballinger,M.D. and Wells,J.A.<br>Subtilisins<br>[ISSN:0-12-079610-4] (2004) 2, 1786-1792.  V
    18. 2003
  18. [YEAR:16-9-2003]Bott,R.R., Chan,G., Domingo,B., Ganshaw,G., Hsia,C.Y., Knapp,M. and Murray,C.J.<br>Do enzymes change the nature of transition states? Mapping the transition state for general acid-base catalysis of a serine protease<br>Biochemistry (16-9-2003) 42, 10545-10553. PubMed  Europe PubMed DOI
    19. 2001
  19. Georgieva,D.N., Stoeva,S., Voelter,W., Genov,N. and Betzel,C.<br>Substrate specificity of the highly alkalophilic bacterial proteinase Esperase: relation to the X-ray structure<br>Curr Microbiol (2001) 42, 368-371. PubMed  Europe PubMed DOI  S
  20. [YEAR:15-3-2001]Georgieva,D.N., Stoeva,S., Voelter,W., Genov,N. and Betzel,C.<br>Differences in the specificities of the highly alkalophilic proteinases Savinase and Esperase imposed by changes in the rigidity and geometry of the substrate binding sites<br>Arch Biochem Biophys (15-3-2001) 387, 197-201. PubMed  Europe PubMed DOI
    21. 2000
  21. Jorgensen,P.L., Tangney,M., Pedersen,P.E., Hastrup,S., Diderichsen,B. and Jorgensen,S.T.<br>Cloning and sequencing of an alkaline protease gene from Bacillus lentus and amplification of the gene on the B. lentus chromosome by an improved technique<br>Appl Environ Microbiol (2000) 66, 825-827. PubMed  Europe PubMed DOI  PMC  EPMC
    22. 1999
  22. Davis,B.G., Khumtaveeporn,K., Bott,R.R. and Jones,J.B.<br>Altering the specificity of subtilisin Bacillus lentus through the introduction of positive charge at single amino acid sites<br>Bioorg Med Chem (1999) 7, 2303-2311. PubMed  Europe PubMed DOI
  23. Davis,B.G., Shang,X., DeSantis,G., Bott,R.R. and Jones,J.B.<br>The controlled introduction of multiple negative charge at single amino acid sites in subtilisin Bacillus lentus<br>Bioorg Med Chem (1999) 7, 2293-2301. PubMed  Europe PubMed DOI
  24. [YEAR:10-9-1999]Graycar,T., Knapp,M., Ganshaw,G., Dauberman,J. and Bott,R.<br>Engineered Bacillus lentus subtilisins having altered flexibility<br>J Mol Biol (10-9-1999) 292, 97-109. PubMed  Europe PubMed DOI
  25. [YEAR:10-9-1999]Mulder,F.A., Schipper,D., Bott,R. and Boelens,R.<br>Altered flexibility in the substrate-binding site of related native and engineered high-alkaline Bacillus subtilisins<br>J Mol Biol (10-9-1999) 292, 111-123. PubMed  Europe PubMed DOI
    26. 1998
  26. [YEAR:2-9-1998]DeSantis,G. and Jones,J.B.<br>Chemical modifications at a single site can induce significant shifts in the pH profiles of a serine protease<br>J Am Chem Soc (2-9-1998) 120, 8582-8586. DOI
  27. Georgieva,D.N., Nikolov,P. and Betzel,C.<br>Steady-state and time-resolved fluorescence of Esperase: comparison with the X-ray structure in the region of the two tryptophans<br>Spectrochim Acta A Mol Biomol Spectrosc (1998) 54A, 1109-1116. PubMed  Europe PubMed
  28. [YEAR:29-9-1998]Kuhn,P., Knapp,M., Soltis,S.M., Ganshaw,G., Thoene,M. and Bott,R.<br>The 0.78 A structure of a serine protease: Bacillus lentus subtilisin<br>Biochemistry (29-9-1998) 37, 13446-13452. PubMed  Europe PubMed DOI  S
    29. 1997
  29. Martin,J.R., Mulder,F.A., Karimi-Nejad,Y., van der Zwan,J., Mariani,M., Schipper,D. and Boelens,R.<br>The solution structure of serine protease PB92 from Bacillus alcalophilus presents a rigid fold with a flexible substrate- binding site<br>Structure (1997) 5, 521-532. PubMed  Europe PubMed  S
    30. 1996
  30. Betzel,C., Klupsch,S., Branner,S. and Wilson,K.S.<br>Crystal structures of the alkaline proteases Savinase and Esperase from Bacillus lentus<br>Adv Exp Med Biol (1996) 379, 49-61. PubMed  Europe PubMed  S  I
  31. Bott,R., Dauberman,J., Wilson,L., Ganshaw,G., Sagar,H., Graycar,T. and Estell,D.<br>Structural changes leading to increased enzymatic activity in an engineered variant of Bacillus lentus subtilisin<br>Adv Exp Med Biol (1996) 379, 277-283. PubMed  Europe PubMed
  32. Gron,H., Bech,L.M., Sorensen,S.B., Meldal,M. and Breddam,K.<br>Studies of binding sites in the subtilisin from Bacillus lentus by means of site directed mutagenesis and kinetic investigations<br>Adv Exp Med Biol (1996) 379, 105-112. PubMed  Europe PubMed
  33. Maurer,K.H., Markgraf,M. and Goddette,D.<br>Substrate specificity of natural variants and genetically engineered intermediates of Bacillus lentus alkaline proteases<br>Adv Exp Med Biol (1996) 379, 243-256. PubMed  Europe PubMed
  34. Pfeffer-Hennig,S., Dauter,Z., Hennig,M., Hohne,W., Wilson,K. and Betzel,C.<br>Three dimensional structure of the antibiotic bacitracin A complexed to two different subtilisin proteases: novel mode of enzyme inhibition<br>Adv Exp Med Biol (1996) 379, 29-41. PubMed  Europe PubMed  S  I
    35. 1995
  35. Genov,N., Filippi,B., Dolashka,P., Wilson,K.S. and Betzel,C.<br>Stability of subtilisins and related proteinases (subtilases)<br>Int J Pept Protein Res (1995) 45, 391-400. PubMed  Europe PubMed
    36. 1994
  36. Fogh,R.H., Schipper,D., Boelens,R. and Kaptein,R.<br>(1)H, (13)C and (15)N NMR backbone assignments of the 269-residue serine protease PB92 from Bacillus alcalophilus<br>J Biomol NMR (1994) 4, 123-128. PubMed  Europe PubMed DOI
  37. Lange,G., Betzel,C., Branner,S. and Wilson,K.S.<br>Crystallographic studies of Savinase, a subtilisin-like proteinase, at pH 10.5<br>Eur J Biochem (1994) 224, 507-518. PubMed  Europe PubMed  S
    38. 1993
  38. Hjortkjaer,R.K., Stavnsbjerg,M., Pedersen,P.B., Heath,J., Wilson,J.A., Marshall,R.R. and Clements,J.<br>Safety evaluation of Esperase<br>Food Chem Toxicol (1993) 31, 999-1011. PubMed  Europe PubMed DOI
    39. 1992
  39. Bech,L.M., Branner,S., Hastrup,S. and Breddam,K.<br>Introduction of a free cysteinyl residue at position 68 in the subtilisin Savinase, based on homology with proteinase K<br>FEBS Lett (1992) 297, 164-166. PubMed  Europe PubMed DOI
  40. Betzel,C., Klupsch,S., Papendorf,G., Hastrup,S., Branner,S. and Wilson,K.S.<br>Crystal structure of the alkaline proteinase Savinase from Bacillus lentus at 1.4 A resolution<br>J Mol Biol (1992) 223, 427-445. PubMed  Europe PubMed  S
  41. Goddette,D.W., Paech,C., Yang,S.S., Mielenz,J.R., Bystroff,C., Wilke,M.E. and Fletterick,R.J.<br>The crystal structure of the Bacillus lentus alkaline protease, subtilisin BL, at 1.4 A resolution<br>J Mol Biol (1992) 228, 580-595. PubMed  Europe PubMed DOI  S
  42. Gron,H. and Breddam,K.<br>Interdependency of the binding subsites in subtilisin<br>Biochemistry (1992) 31, 8967-8971. PubMed  Europe PubMed
  43. Gron,H., Meldal,M. and Breddam,K.<br>Extensive comparison of the substrate preferences of two subtilisins as determined with peptide substrates which are based on the principle of intramolecular quenching<br>Biochemistry (1992) 31, 6011-6018. PubMed  Europe PubMed DOI
  44. [YEAR:5-11-1992]Sobek,H., Hecht,H.J., Aehle,W. and Schomburg,D.<br>X-ray structure determination and comparison of two crystal forms of a variant (Asn115Arg) of the alkaline protease from Bacillus alcalophilus refined at 1.85 A resolution<br>J Mol Biol (5-11-1992) 228, 108-117. PubMed  Europe PubMed DOI  S
  45. Teplyakov,A.V., van der Laan,J.M., Lammers,A.A., Kelders,H., Kalk,K.H., Misset,O., Mulleners,L.J. and Dijkstra,B.W.<br>Protein engineering of the high-alkaline serine protease PB92 from Bacillus alcalophilus: functional and structural consequences of mutation at the S4 substrate binding pocket<br>Protein Eng (1992) 5, 413-420. PubMed  Europe PubMed
    46. 1990
  46. Sobek,H., Hecht,H.J., Hofmann,B., Aehle,W. and Schomburg,D.<br>Crystal structure of an alkaline protease from Bacillus alcalophilus at 2.4 A resolution<br>FEBS Lett (1990) 274, 57-60. PubMed  Europe PubMed DOI  S
    47. 1986
  47. Agarwal,M.K., Ingram,J.W., Dunnette,S. and Gleich,G.J.<br>Immunochemical quantitation of an airborne proteolytic enzyme, Esperase, in a consumer products factory<br>Am Ind Hyg Assoc J (1986) 47, 138-143. PubMed  Europe PubMed DOI
    48. 1977
  48. Priest,F.G.<br>Extracellular enzyme synthesis in the genus Bacillus<br>Bacteriol Rev (1977) 41, 711-753. PubMed  Europe PubMed  PMC  EPMC

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