Substrates for peptidase S01.247: epitheliasin

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
amiloride-sensitive sodium channel subunit gamma	P51170	1-649	peptide-Arg135+Lys-peptide	P	MU	Pro	Glu	Ser	Arg	Lys	Arg	Arg	Glu	Sure et al., 2022
amiloride-sensitive sodium channel subunit gamma	P51170	1-649	peptide-Lys136+Arg-peptide	P	MU	Glu	Ser	Arg	Lys	Arg	Arg	Glu	Ala	Sure et al., 2022
amiloride-sensitive sodium channel subunit gamma	P51170	1-649	peptide-Arg137+Arg-peptide	P	MU	Ser	Arg	Lys	Arg	Arg	Glu	Ala	Glu	Sure et al., 2022
amiloride-sensitive sodium channel subunit gamma	P51170	1-649	peptide-Arg138+Glu-peptide	P	MU	Arg	Lys	Arg	Arg	Glu	Ala	Glu	Ser	Sure et al., 2022
amiloride-sensitive sodium channel subunit gamma	P51170	1-649	peptide-Arg153+Phe-peptide	P	MU	Lys	Gln	Pro	Arg	Phe	Ser	His	Arg	Sure et al., 2022
amiloride-sensitive sodium channel subunit gamma	P51170	1-649	peptide-Lys168+Gly-peptide	P	MU	Gln	Asp	Glu	Lys	Gly	Lys	Ala	Arg	Sure et al., 2022
amiloride-sensitive sodium channel subunit gamma	P51170	1-649	peptide-Lys170+Ala-peptide	P	MU	Glu	Lys	Gly	Lys	Ala	Arg	Asp	Phe	Sure et al., 2022
amiloride-sensitive sodium channel subunit gamma	P51170	1-649	peptide-Arg172+Asp-peptide	P	MU	Gly	Lys	Ala	Arg	Asp	Phe	Phe	Thr	Sure et al., 2022
amiloride-sensitive sodium channel subunit gamma	P51170	1-649	peptide-Arg178+Lys-peptide	P	MU	Phe	Thr	Gly	Arg	Lys	Arg	Lys	Val	Sure et al., 2022
amiloride-sensitive sodium channel subunit gamma	P51170	1-649	peptide-Lys179+Arg-peptide	P	MU	Thr	Gly	Arg	Lys	Arg	Lys	Val	Gly	Sure et al., 2022
amiloride-sensitive sodium channel subunit gamma	P51170	1-649	peptide-Arg180+Lys-peptide	P	MU	Gly	Arg	Lys	Arg	Lys	Val	Gly	Gly	Sure et al., 2022
amiloride-sensitive sodium channel subunit gamma	P51170	1-649	peptide-Lys181+Val-peptide	P	MU	Arg	Lys	Arg	Lys	Val	Gly	Gly	Ser	Sure et al., 2022
amiloride-sensitive sodium channel subunit gamma	P51170	1-649	peptide-Lys189+Ala-peptide	P	MU	Ile	Ile	His	Lys	Ala	Ser	Asn	Val	Sure et al., 2022
epitheliasin precursor	Q96T73	1-492	peptide-Arg255+Ile-peptide	P		Arg	Gln	Ser	Arg	Ile	Val	Gly	Gly	Afar et al., 2001	17439
hemagglutinin {ECO:0000313\|EMBL:ABM46228.1}	A3R530	1-518	peptide-Arg320+Gly-peptide	N	NT	Arg	Ser	Ser	Arg	Gly	Leu	Phe	Gly	Baron et al., 2013
hemagglutinin {ECO:0000313\|EMBL:ABM46232.1}	A3R534	1-536	peptide-Arg338+Gly-peptide	N	NT	Arg	Ser	Arg	Arg	Gly	Leu	Phe	Gly	Baron et al., 2013
hemagglutinin {ECO:0000313\|EMBL:AEA04408.1}	F2P1E0	1-560	peptide-Arg338+Gly-peptide	N	NT	Val	Ser	Ser	Arg	Gly	Leu	Phe	Gly	Baron et al., 2013
spike glycoprotein	K9N5Q8	18-1353	peptide-Arg887+Ser-peptide	P	NT	Arg	Ser	Ala	Arg	Ser	Ala	Ile	Glu	Bestle et al., 2020
spike glycoprotein	P0DTC2	18-1353	peptide-Arg815+Ser-peptide	P	NT	Pro	Ser	Lys	Arg	Ser	Phe	Ile	Glu	Bestle et al., 2020
spike glycoprotein	P59594	18-1353	peptide-Arg797+Ser-peptide	P	NT	Pro	Thr	Lys	Arg	Ser	Phe	Ile	Glu	Bestle et al., 2020
transmembrane protease serine 2	O15393	1-492	peptide-Arg255+Ile-peptide	P	NT	Arg	Gln	Ser	Arg	Ile	Val	Gly	Gly	Reid et al., 2017