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Literature for peptidase S01.247: epitheliasin

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

(Topics flags: M Mutation, T Target, R Splicing, I Inhibitor, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Akagi,M., Ohta,K., Sakuma,M., Naruse,T., Ishida,Y., Niwata,C., Yamakado,N., Nakagawa,T., Ono,S., Nishi,H., Shigeishi,H. and Aikawa,T.
    TMPRSS2 expression in oral mucosal cells induced by transfected double-stranded RNA and IL-1beta
    J Oral Biosci100619-100619. PubMed  Europe PubMed DOI
  2. Baby,K., Vithalkar,M.P., Dastidar,S.G., Mukhopadhyay,C., Hamdy,R., Soliman,S.S.M. and Nayak,Y.
    Exploring TMPRSS2 Drug Target to Combat Influenza and Coronavirus Infection
    Scientifica (Cairo)2025, 3687892-3687892. PubMed  Europe PubMed DOI  V
  3. Barros de Lima,G., Nencioni,E., Thimoteo,F., Perea,C., Pinto,R.F.A. and Sasaki,S.D.
    TMPRSS2 as a Key Player in Viral Pathogenesis: Influenza and Coronaviruses
    Biomolecules15, PubMed  Europe PubMed DOI  V
  4. Gabaev,I., Rowland,A., Jovanovic,E., Gawden-Bone,C.M., Crozier,T.W.M., Teixeira-Silva,A., Greenwood,E.J.D., Gerber,P.P., Wit,N., Nathan,J.A., Matheson,N.J. and Lehner,P.J.
    CRISPR-Cas9 genetic screens reveal regulation of TMPRSS2 by the Elongin BC-VHL complex
    Sci Rep15, 11907-11907. PubMed  Europe PubMed DOI
  5. Jung,J., Sung,J.S., Kwon,S., Bae,H.E., Kang,M.J., Jose,J., Lee,M. and Pyun,J.C.
    Transmembrane protease serine 2 (TMPRSS2) inhibitors screened from an Fv-antibody library for preventing SARS-CoV-2 infection
    RSC Med Chem PubMed  Europe PubMed DOI
  6. Lusvarghi,S., Vassell,R., Williams,B., Baha,H., Neerukonda,S.N. and Weiss,C.D.
    Capture of fusion-intermediate conformations of SARS-CoV-2 spike requires receptor binding and cleavage at either the S1/S2 or S2' site
    PLoS Pathog21, e1012808-e1012808. PubMed  Europe PubMed DOI
  7. Tang,X., Lu,L., Li,X. and Huang,P.
    Bridging Cancer and COVID-19: The Complex Interplay of ACE2 and TMPRSS2
    Cancer Med14, e70829-e70829. PubMed  Europe PubMed DOI  V
  8. Verhulst,E., de Bruyn,M., Berckmans,P., Sim,Y., Augustyns,K., Pintelon,I., Berg,M., Van Wielendaele,P., Lambeir,A.M., Sterckx,Y.G., Nelissen,I. and De Meester,I.
    Human Transmembrane Serine Protease 2 (TMPRSS2) on Human Seminal Fluid Extracellular Vesicles Is Proteolytically Active
    J Extracell Vesicles14, e70061-e70061. PubMed  Europe PubMed DOI
    9. 2024
  9. Al-Saigh,N.N., Harb,A.A. and Abdalla,S.
    Receptors Involved in COVID-19-Related Anosmia: An Update on the Pathophysiology and the Mechanistic Aspects
    Int J Mol Sci25, PubMed  Europe PubMed DOI  V
  10. Bach,M.L., Laftih,S., Andresen,J.K., Pedersen,R.M., Andersen,T.E., Madsen,L.W., Madsen,K., Hinrichs,G.R., Zachar,R., Svenningsen,P., Lund,L., Johansen,I.S., Hansen,L.F., Palarasah,Y. and Jensen,B.L.
    ACE2 and TMPRSS2 in human kidney tissue and urine extracellular vesicles with age, sex, and COVID-19
    Pflugers Arch PubMed  Europe PubMed DOI
  11. Bashar,N.A.S., Gohar,N.M.A., Tantawy,A.A. and Kamel,M.H.M.
    Evaluation of relationship between TMPRSS2 p.(Val197Met) variant and COVID-19 susceptibility and severity
    BMC Infect Dis24, 112-112. PubMed  Europe PubMed DOI
  12. Bestle,D., Bittel,L., Werner,A.D., Kamper,L., Dolnik,O., Krahling,V., Steinmetzer,T. and Bottcher-Friebertshauser,E.
    Novel proteolytic activation of Ebolavirus glycoprotein GP by TMPRSS2 and cathepsin L at an uncharted position can compensate for furin cleavage
    Virus Res347, 199430-199430. PubMed  Europe PubMed DOI  K
  13. Calcagnile,M., Damiano,F., Lobreglio,G., Siculella,L., Bozzetti,M.P., Forgez,P., Malgoyre,A., Libert,N., Bucci,C., Alifano,M. and Alifano,P.
    In silico evidence that substitution of glycine for valine (p.G8V) in a common variant of TMPRSS2 isoform 1 increases accessibility to an endocytic signal: Implication for SARS-cov-2 entry into host cells and susceptibility to COVID-19
    Biochimie225, 89-98. PubMed  Europe PubMed DOI
  14. Chen,Y., Ou,X., Li,P., Zan,F., Tan,L. and Qian,Z.
    Identification of the critical residues of TMPRSS2 for entry and host range of human coronavirus HKU1
    J Virole0158724-e0158724. PubMed  Europe PubMed DOI
  15. Costa,T.F.R., Catta-Preta,C.M.C., Goundry,A., Carvalho,D.B., Rodrigues,N.S., Vivarini,A.C., de Abreu,M.F., Reis,F.C.G. and Lima,A.P.C.A.
    The ecotin-like peptidase inhibitor of Trypanosoma cruzi prevents TMPRSS2-PAR2-TLR4 crosstalk downmodulating infection and inflammation
    FASEB J38, e23566-e23566. PubMed  Europe PubMed DOI  K
  16. D'Anna,L., Froux,A., Rainot,A., Spinello,A., Perricone,U., Barbault,F., Grandemange,S., Barone,G., Terenzi,A. and Monari,A.
    Resolving the Structure of a Guanine Quadruplex in TMPRSS2 Messenger RNA by Circular Dichroism and Molecular Modeling
    Chemistrye202403572-e202403572. PubMed  Europe PubMed DOI
  17. De Magis,A., Schult,P., Schonleber,A., Linke,R., Ludwig,K.U., Kummerer,B.M. and Paeschke,K.
    TMPRSS2 isoform 1 downregulation by G-quadruplex stabilization induces SARS-CoV-2 replication arrest
    BMC Biol22, 5-5. PubMed  Europe PubMed DOI
  18. de Oliveira-Simoes,F.A., Victorino da Silva Amatto,I., Langer Marciano,C., Rosa-Garzon,N.G.D., Noma Okamoto,D., Juliano,M.A., Juliano,L. and Cabral,H.
    Biochemical characterization, stability, and kinetics of three substrates of the recombinant TMPRSS2 serine protease domain
    Prep Biochem Biotechnol1-9. PubMed  Europe PubMed DOI
  19. Farooqi,A.A., Turgambayeva,A., Almabayeva,A., Zhanaliyeva,M., Orakbay,L., Shabanbayeva,Z., Narmanova,O. and Syzdykbayev,M.K.
    Mechanistic Insights and Molecular Diagnostics of TMPRSS2-ERG: Overview of the Journey from Regulation of Signaling Landscape in Fusion Positive Prostate Cancer to Appraisal as a Diagnostic Marker
    Front Biosci (Landmark Ed)29, 343-343. PubMed  Europe PubMed DOI
  20. Fernandez,I., Saunders,N., Duquerroy,S., Bolland,W.H., Arbabian,A., Baquero,E., Blanc,C., Lafaye,P., Haouz,A., Buchrieser,J., Schwartz,O. and Rey,F.A.
    Structural basis of TMPRSS2 zymogen activation and recognition by the HKU1 seasonal coronavirus
    Cell187, 4246-4260. PubMed  Europe PubMed DOI
  21. Heindl,M.R., Rupp,A.L., Schwerdtner,M., Bestle,D., Harbig,A., De Rocher,A., Schmacke,L.C., Staker,B., Steinmetzer,T., Stein,D.A., Moulton,H.M. and Bottcher-Friebertshauser,E.
    ACE2 acts as a novel regulator of TMPRSS2-catalyzed proteolytic activation of influenza A virus in airway cells
    J Virol98, e0010224-e0010224. PubMed  Europe PubMed DOI  K
  22. Jin,Z., Zhang,Y., Chen,W., Li,H., Shi,L., Wang,D., Zhu,R. and Zhang,C.
    Intracellular autoactivation and surface location of hepsin, TMPRSS2, and TMPRSS13
    Life Sci123299-123299. PubMed  Europe PubMed DOI
  23. Kakizaki,M., Hashimoto,R., Nagata,N., Yamamoto,T., Okura,T., Katoh,H., Kitai,Y., Akahori,Y., Shirato,K., Ryo,A., Takayama,K. and Takeda,M.
    The respective roles of TMPRSS2 and cathepsins for SARS-CoV-2 infection in human respiratory organoids
    J Virole0185324-e0185324. PubMed  Europe PubMed DOI
  24. Kundrapu,D.B., Chaitanya,A.K., Manaswi,K., Kumari,S. and Malla,R.
    Quercetin and taxifolin inhibits TMPRSS2 activity and its interaction with EGFR in paclitaxel-resistant breast cancer cells: An in silico and in vitro study
    Chem Biol Drug Des104, e14600-e14600. PubMed  Europe PubMed DOI  I
  25. Kwon,T., Artiaga,B.L., McDowell,C.D., Whitworth,K.M., Wells,K.D., Prather,R.S., Delhon,G., Cigan,M., White,S.N., Retallick,J., Gaudreault,N.N., Morozov,I. and Richt,J.A.
    Gene editing of pigs to control influenza A virus infections
    Emerg Microbes Infect2387449-2387449. PubMed  Europe PubMed DOI
  26. McCallum,M., Park,Y.J., Stewart,C., Sprouse,K.R., Addetia,A., Brown,J., Tortorici,M.A., Gibson,C., Wong,E., Ieven,M., Telenti,A. and Veesler,D.
    Human coronavirus HKU1 recognition of the TMPRSS2 host receptor
    Cell187, 4231-4245. PubMed  Europe PubMed DOI
  27. McCallum,M., Park,Y.J., Stewart,C., Sprouse,K.R., Brown,J., Tortorici,M.A., Gibson,C., Wong,E., Ieven,M., Telenti,A. and Veesler,D.
    Human coronavirus HKU1 recognition of the TMPRSS2 host receptor
    bioRxiv PubMed  Europe PubMed DOI
  28. Meng,R., Zhong,X., Gong,Y., Shi,Y., Li,J., Wu,Z., Duan,Q., Zhang,X., Mei,Y., Zhu,J., Peng,Z., Li,Y. and Song,D.
    Discovery and development of novel 10,12-disubstituted aloperine derivatives against HCoV-OC43 by targeting allosteric site of host TMPRSS2
    Bioorg Chem147, 107317-107317. PubMed  Europe PubMed DOI
  29. Mohan,E.C., Savarraj,J.P.J., Colpo,G.D., Morales,D., Finger,C.E., McAlister,A., Ahnstedt,H., Choi,H., McCullough,L.D. and Manwani,B.
    Aromatase, testosterone, TMPRSS2: determinants of COVID-19 severity
    Biol Sex Differ15, 84-84. PubMed  Europe PubMed DOI
  30. Parsons,R.J. and Acharya,P.
    Prying the lid open: Atomic-level insights on sialoglycan-TMPRSS2 coordination in HKU1 entry
    Cell187, 4147-4149. PubMed  Europe PubMed DOI
  31. Qu,B., Miskey,C., Gomer,A., Kleinert,R.D.V., Ibanez,S.C., Eberle,R., Ebenig,A., Postmus,D., Nocke,M.K., Herrmann,M., Itotia,T.K., Herrmann,S.T., Heinen,N., Hock,S., Hastert,F.D., von Rhein,C., Schurmann,C., Li,X., van Zandbergen,G., Widera,M., Ciesek,S., Schnierle,B.S., Tarr,A.W., Steinmann,E., Goffinet,C., Pfaender,S., Locker,J.K., Muhlebach,M.D., Todt,D. and Brown,R.J.P.
    TMPRSS2-mediated SARS-CoV-2 uptake boosts innate immune activation, enhances cytopathology, and drives convergent virus evolution
    Proc Natl Acad Sci U S A121, e2407437121-e2407437121. PubMed  Europe PubMed DOI
  32. Saunders,N. and Schwartz,O.
    [TMPRSS2 is the receptor of seasonal coronavirus HKU1]
    Med Sci (Paris)40, 335-337. PubMed  Europe PubMed DOI
  33. Schwerdtner,M., Schmacke,L.C., Nave,J., Limburg,H., Steinmetzer,T., Stein,D.A., Moulton,H.M. and Bottcher-Friebertshauser,E.
    Unveiling the Role of TMPRSS2 in the Proteolytic Activation of Pandemic and Zoonotic Influenza Viruses and Coronaviruses in Human Airway Cells
    Viruses16, PubMed  Europe PubMed DOI  K
  34. Tanriverdi,O., Alkan,A., Karaoglu,T., Kitapli,S. and Yildiz,A.
    COVID-19 and Carcinogenesis: Exploring the Hidden Links
    Cureus16, e68303-e68303. PubMed  Europe PubMed DOI  V
  35. Yang,H., Zhou,J.N., Zhang,X.M., Ling,D.D., Sun,Y.B., Li,C.Y., Zhou,Q.Q., Shi,G.N., Wang,S.H., Lin,X.S., Fan,T., Wang,H.Y., Zeng,Q., Jia,Y.L., Xi,J.F., Jin,Y.G., Pei,X.T. and Yue,W.
    Nanoengineered Red Blood Cells Loaded with TMPRSS2 and Cathepsin L Inhibitors Block SARS-CoV-2 Pseudovirus Entry into Lung ACE2(+) Cells
    Adv Matere2310306-e2310306. PubMed  Europe PubMed DOI
  36. Yang,H., Xu,H., Lin,X., Cai,Z., Xia,Y., Wang,Y., Chen,Z., Zhang,K., Wu,Y., Wang,J., Awadasseid,A. and Zhang,W.
    Design, synthesis and biological evaluation of novel TMPRSS2-PROTACs with florosubstituted 4-guanidino-N-phenylbenzamide derivative ligands
    Bioorg Med Chem116, 117982-117982. PubMed  Europe PubMed DOI
    37. 2023
  37. Dos Santos Nascimento,I.J. and de Moura,R.O.
    Would the Development of a Multitarget Inhibitor of 3CLpro and TMPRSS2 be Promising in the Fight Against SARS-CoV-2?
    Med Chem19, 405-412. PubMed  Europe PubMed DOI  V
  38. Drazdauskiene,U., Kapustina,Z., Medziune,J., Dubovskaja,V., Sabaliauskaite,R., Jarmalaite,S. and Lubys,A.
    Fusion sequencing via terminator-assisted synthesis (FTAS-seq) identifies TMPRSS2 fusion partners in prostate cancer
    Mol Oncol17, 993-1006. PubMed  Europe PubMed DOI
  39. Farkas,B., Minneci,M., Misevicius,M. and Rozas,I.
    A Tale of Two Proteases: M(Pro) and TMPRSS2 as Targets for COVID-19 Therapies
    Pharmaceuticals (Basel)16, PubMed  Europe PubMed DOI  V
  40. Gioukaki,C., Georgiou,A., Gkaralea,L.E., Kroupis,C., Lazaris,A.C., Alamanis,C. and Thomopoulou,G.E.
    Unravelling the Role of P300 and TMPRSS2 in Prostate Cancer: A Literature Review
    Int J Mol Sci24, PubMed  Europe PubMed DOI  V
  41. Koistinen,H., Kovanen,R.M., Hollenberg,M.D., Dufour,A., Radisky,E.S., Stenman,U.H., Batra,J., Clements,J., Hooper,J.D., Diamandis,E., Schilling,O., Rannikko,A. and Mirtti,T.
    The roles of proteases in prostate cancer
    IUBMB Life75, 493-513. PubMed  Europe PubMed DOI  V
  42. Li,Y., Wang,K., Sun,H., Wu,S., Wang,H., Shi,Y., Li,X., Yan,H., Yang,G., Wu,M., Li,Y., Ding,X., Si,S., Jiang,J., Du,Y., Li,Y. and Hong,B.
    Omicsynin B4 potently blocks coronavirus infection by inhibiting host proteases cathepsin L and TMPRSS2
    Antiviral Res214, 105606-105606. PubMed  Europe PubMed DOI  I
  43. Lie,L.K., Synowiec,A., Mazur,J., Rabalski,L. and Pyrc,K.
    An engineered A549 cell line expressing CD13 and TMPRSS2 is permissive to clinical isolate of human coronavirus 229E
    Virology588, 109889-109889. PubMed  Europe PubMed DOI
  44. Saunders,N., Fernandez,I., Planchais,C., Michel,V., Rajah,M.M., Baquero Salazar,E., Postal,J., Porrot,F., Guivel-Benhassine,F., Blanc,C., Chauveau-Le Friec,G., Martin,A., Grzelak,L., Oktavia,R.M., Meola,A., Ahouzi,O., Hoover-Watson,H., Prot,M., Delaune,D., Cornelissen,M., Deijs,M., Meriaux,V., Mouquet,H., Simon-Loriere,E., van der Hoek,L., Lafaye,P., Rey,F., Buchrieser,J. and Schwartz,O.
    TMPRSS2 is a functional receptor for human coronavirus HKU1
    Nature624, 207-214. PubMed  Europe PubMed DOI
  45. Yang,H., Lin,X., Yu,Q., Awadasseid,A. and Zhang,W.
    Repurposing and discovery of transmembrane serine protease 2 (TMPRSS2) inhibitors as prophylactic therapies for new coronavirus disease 2019 (COVID-19)
    Pharmazie78, 217-224. PubMed  Europe PubMed DOI  V
  46. Zhang,W., Golynker,I., Brosh,R., Fajardo,A., Zhu,Y., Wudzinska,A.M., Ordonez,R., Ribeiro-Dos-Santos,A.M., Carrau,L., Damani-Yokota,P., Yeung,S.T., Khairallah,C., Vela Gartner,A., Chalhoub,N., Huang,E., Ashe,H.J., Khanna,K.M., Maurano,M.T., Kim,S.Y., tenOever,B.R. and Boeke,J.D.
    Mouse genome rewriting and tailoring of three important disease loci
    Nature623, 423-431. PubMed  Europe PubMed DOI
    47. 2022
  47. Chen,Y., Yang,W.H., Chen,H.F., Huang,L.M., Gao,J.Y., Lin,C.W., Wang,Y.C., Yang,C.S., Liu,Y.L., Hou,M.H., Tsai,C.L., Chou,Y.Z., Huang,B.Y., Hung,C.F., Hung,Y.L., Wang,W.J., Su,W.C., Kumar,V., Wu,Y.C., Chao,S.W., Chang,C.S., Chen,J.S., Chiang,Y.P., Cho,D.Y., Jeng,L.B., Tsai,C.H. and Hung,M.C.
    Tafenoquine and its derivatives as inhibitors for the severe acute respiratory syndrome coronavirus 2
    J Biol Chem298, 101658-101658. PubMed  Europe PubMed DOI  I
  48. David,A., Parkinson,N., Peacock,T.P., Pairo-Castineira,E., Khanna,T., Cobat,A., Tenesa,A., Sancho-Shimizu,V., Casanova,J.L., Abel,L., Barclay,W.S., Baillie,J.K. and Sternberg,M.J.
    A common TMPRSS2 variant has a protective effect against severe COVID-19
    Curr Res Transl Med70, 103333-103333. PubMed  Europe PubMed DOI
  49. de Andrade,C.C., Silva,A.T.P., Vasconcelos,L.R.S., Oliveira,P.R.S., de Souza,C.D.F., da Costa Armstrong,A. and do Carmo,R.F.
    A Polymorphism in the TMPRSS2 Gene Increases the Risk of Death in Older Patients Hospitalized with COVID-19
    Viruses14, PubMed  Europe PubMed DOI
  50. Dieter,C., de Almeida Brondani,L., Lemos,N.E., Schaeffer,A.F., Zanotto,C., Ramos,D.T., Girardi,E., Pellenz,F.M., Camargo,J.L., Moresco,K.S., da Silva,L.L., Aubin,M.R., de Oliveira,M.S., Rech,T.H., Canani,L.H., Gerchman,F., Leitao,C.B. and Crispim,D.
    Polymorphisms in ACE1, TMPRSS2, IFIH1, IFNAR2, and TYK2 Genes Are Associated with Worse Clinical Outcomes in COVID-19
    Genes (Basel)14, PubMed  Europe PubMed DOI
  51. Fraser,B.J., Beldar,S., Seitova,A., Hutchinson,A., Mannar,D., Li,Y., Kwon,D., Tan,R., Wilson,R.P., Leopold,K., Subramaniam,S., Halabelian,L., Arrowsmith,C.H. and Benard,F.
    Structure and activity of human TMPRSS2 protease implicated in SARS-CoV-2 activation
    Nat Chem Biol18, 963-971. PubMed  Europe PubMed DOI
  52. Govender,N., Khaliq,O., Moodley,J. and Naicker,T.
    Unravelling the Mechanistic Role of ACE2 and TMPRSS2 in Hypertension: A Risk Factor for COVID-19
    Curr Hypertens Rev18, 130-137. PubMed  Europe PubMed DOI  V
  53. Karimian,A., Behjati,M. and Karimian,M.
    Molecular mechanisms involved in anosmia induced by SARS-CoV-2, with a focus on the transmembrane serine protease TMPRSS2
    Arch Virol167, 1931-1946. PubMed  Europe PubMed DOI  V
  54. Mantzourani,C., Vasilakaki,S., Gerogianni,V.E. and Kokotos,G.
    The discovery and development of transmembrane serine protease 2 (TMPRSS2) inhibitors as candidate drugs for the treatment of COVID-19
    Expert Opin Drug Discov17, 231-246. PubMed  Europe PubMed DOI  V  I
  55. Meng,B., Abdullahi,A., Ferreira,I.A.T.M., Goonawardane,N., Saito,A., Kimura,I., Yamasoba,D., Gerber,P.P., Fatihi,S., Rathore,S., Zepeda,S.K., Papa,G., Kemp,S.A., Ikeda,T., Toyoda,M., Tan,T.S., Kuramochi,J., Mitsunaga,S., Ueno,T., Shirakawa,K., Takaori-Kondo,A., Brevini,T., Mallery,D.L., Charles,O.J., Bowen,J.E., Joshi,A., Walls,A.C., Jackson,L., Martin,D., Smith,K.G.C., Bradley,J., Briggs,J.A.G., Choi,J., Madissoon,E., Meyer,K.B., Mlcochova,P., Ceron-Gutierrez,L., Doffinger,R., Teichmann,S.A., Fisher,A.J., Pizzuto,M.S., de Marco,A., Corti,D., Hosmillo,M., Lee,J.H., James,L.C., Thukral,L., Veesler,D., Sigal,A., Sampaziotis,F., Goodfellow,I.G., Matheson,N.J., Sato,K. and Gupta,R.K.
    Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity
    Nature603, 706-714. PubMed  Europe PubMed DOI
  56. Shapira,T., Monreal,I.A., Dion,S.P., Buchholz,D.W., Imbiakha,B., Olmstead,A.D., Jager,M., Desilets,A., Gao,G., Martins,M., Vandal,T., Thompson,C.A.H., Chin,A., Rees,W.D., Steiner,T., Nabi,I.R., Marsault,E., Sahler,J., Diel,D.G., Van de Walle,G.R., August,A., Whittaker,G.R., Boudreault,P.L., Leduc,R., Aguilar,H.C. and Jean,F.
    A TMPRSS2 inhibitor acts as a pan-SARS-CoV-2 prophylactic and therapeutic
    Nature605, 340-348. PubMed  Europe PubMed DOI
  57. Shrimp,J.H., Janiszewski,J., Chen,C.Z., Xu,M., Wilson,K.M., Kales,S.C., Sanderson,P.E., Shinn,P., Schneider,R., Itkin,Z., Guo,H., Shen,M., Klumpp-Thomas,C., Michael,S.G., Zheng,W., Simeonov,A. and Hall,M.D.
    Suite of TMPRSS2 Assays for Screening Drug Repurposing Candidates as Potential Treatments of COVID-19
    ACS Infect Dis8, 1191-1203. PubMed  Europe PubMed DOI
  58. Singh,S., O'Reilly,S., Gewaid,H., Bowie,A.G., Gautier,V. and Worrall,D.M.
    Reactive Centre Loop Mutagenesis of SerpinB3 to Target TMPRSS2 and Furin: Inhibition of SARS-CoV-2 Cell Entry and Replication
    Int J Mol Sci23, PubMed  Europe PubMed DOI
  59. Sure,F., Bertog,M., Afonso,S., Diakov,A., Rinke,R., Madej,M.G., Wittmann,S., Gramberg,T., Korbmacher,C. and Ilyaskin,A.V.
    Transmembrane serine protease 2 (TMPRSS2) proteolytically activates the epithelial sodium channel (ENaC) by cleaving the channel's gamma-subunit
    J Biol Chem298, 102004-102004. PubMed  Europe PubMed DOI  K
  60. Vankadari,N., Ketavarapu,V., Mitnala,S., Vishnubotla,R., Reddy,D.N. and Ghosal,D.
    Structure of Human TMPRSS2 in Complex with SARS-CoV-2 Spike Glycoprotein and Implications for Potential Therapeutics
    J Phys Chem Lett5324-5333. PubMed  Europe PubMed DOI
  61. Zhang,Y., Sun,S., Du,C., Hu,K., Zhang,C., Liu,M., Wu,Q. and Dong,N.
    Transmembrane serine protease TMPRSS2 implicated in SARS-CoV-2 infection is autoactivated intracellularly and requires N-glycosylation for regulation
    J Biol Chem298, 102643-102643. PubMed  Europe PubMed DOI
    62. 2021
  62. Al-Mulla,F., Mohammad,A., Al Madhoun,A., Haddad,D., Ali,H., Eaaswarkhanth,M., John,S.E., Nizam,R., Channanath,A., Abu-Farha,M., Ahmad,R., Abubaker,J. and Thanaraj,T.A.
    ACE2 and FURIN variants are potential predictors of SARS-CoV-2 outcome: A time to implement precision medicine against COVID-19
    Heliyon7, e06133-e06133. PubMed  Europe PubMed DOI
  63. Andrews,P.L.R., Cai,W., Rudd,J.A. and Sanger,G.J.
    COVID-19, nausea, and vomiting
    J Gastroenterol Hepatol36, 646-656. PubMed  Europe PubMed DOI
  64. Ayipo,Y.O., Yahaya,S.N., Alananzeh,W.A., Babamale,H.F. and Mordi,M.N.
    Pathomechanisms, therapeutic targets and potent inhibitors of some beta-coronaviruses from bench-to-bedside
    Infect Genet Evol93, 104944-104944. PubMed  Europe PubMed DOI  V  I
  65. Azouz,N.P., Klingler,A.M., Callahan,V., Akhrymuk,I.V., Elez,K., Raich,L., Henry,B.M., Benoit,J.L., Benoit,S.W., Noe,F., Kehn-Hall,K. and Rothenberg,M.E.
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