Substrates for peptidase S01.019: corin

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
atrial natriuretic peptide-converting enzyme	Q9Y5Q5	1-1042	peptide-Arg164+Asn-peptide	P	NT	Ser	Val	Val	Arg	Asn	Met	Glu	Met	Jiang et al., 2011
atrial natriuretic peptide-converting enzyme	Q9Y5Q5	1-1042	peptide-Arg427+Cys-peptide	P	NT	Gly	Asp	Gln	Arg	Cys	Leu	Tyr	Asn	Jiang et al., 2011
pro-atrial natriuretic peptide	P01160	26-151	peptide-Arg98+Ser-peptide	P		Thr	Ala	Pro	Arg	Ser	Leu	Arg	Arg	Wu et al., 2002	4038