Substrates for peptidase M67.002: Csn5 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
neddylated cullin homolog 1	Q9VJ33/Q24311	1-76	peptide-Gly76+Lys718-peptide	P	Leu	Arg	Gly	Gly	Lys	Met	Arg	Lys	Cope et al., 2002
neddylated cullin-1	Q15843/Q13616	1-76	peptide-Gly76+Lys720-peptide	P	Leu	Arg	Gly	Gly	Lys	Met	Arg	Lys
neddylated cullin-1	Q9SHE7/Q94AH6	77-152	peptide-Gly152+Lys682-peptide	P	Leu	Arg	Gly	Gly	Lys	Ser	Arg	Lys	Wang et al., 2002
neddylated cullin-3	Q93725/Q17391	1-76	peptide-Gly76+Lys721-peptide	P	Leu	Arg	Gly	Gly	Lys	Ala	Arg	Lys	Pintard et al., 2003