Literature for peptidase M67.002: Csn5 peptidase

(Topics flags: S Structure, M Mutation, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2026
1. Ding,S., Clapperton,J.A., Maeots,M.E., Kunzelmann,S., Shaaban,M. and Enchev,R.I.
   Structural basis of CSN-mediated SCF deneddylation
   Nat Commun (2026) 17, 951-951. PubMed  Europe PubMed DOI  PMC  EPMC
2025
2. Hwang,S.H., Kim,J.W., Park,H., Aguirre,A.J., Kim,K.J., Choi,S., Park,W., Seo,J., Chae,H., Kang,M., Jung,E.H., Suh,K.J., Kim,S.H., Kim,J.W., Kim,Y.J., Kim,J.H. and Lee,K.W.
   COPS5 inhibition synergizes with the antitumor effect of trastuzumab by PTEN upregulation in HER2-amplified gastric cancer
   Gastric Cancer (2025) PubMed  Europe PubMed DOI
2022
3. Lv,T., Jin,Y., Miao,Y., Xu,T., Jia,F., Feng,H. and Zhang,X.
   LncRNA PVT1 promotes tumorigenesis of glioblastoma by recruiting COPS5 to deubiquitinate and stabilize TRIM24
   Mol Ther Nucleic Acids (2022) 27, 109-121. PubMed  Europe PubMed DOI  PMC  EPMC
4. Pan,X., Wu,S., Wei,W., Chen,Z., Wu,Y. and Gong,K.
   Structural and Functional Basis of JAMM Deubiquitinating Enzymes in Disease
   Biomolecules (2022) 12 PubMed  Europe PubMed DOI  PMC  EPMC  V
2021
5. Mou,Y.N., Ren,K., Tong,S.M., Ying,S.H. and Feng,M.G.
   Essential Role of COP9 Signalosome Subunit 5 (Csn5) in Insect Pathogenicity and Asexual Development of Beauveria bassiana
   J Fungi (Basel) (2021) 7, 642-642. PubMed  Europe PubMed DOI  PMC  EPMC
2020
6. Dubiel,W., Chaithongyot,S., Dubiel,D. and Naumann,M.
   The COP9 Signalosome: A Multi-DUB Complex
   Biomolecules (2020) 10, 1082-1082. PubMed  Europe PubMed DOI
2019
7. Bramasole,L., Sinha,A., Harshuk,D., Cirigliano,A., Gurevich,S., Yu,Z., Carmeli,R.L., Glickman,M.H., Rinaldi,T. and Pick,E.
   The proteasome lid triggers COP9 signalosome activity during the transition of Sachharomyces cerevisiae cells into quiescence
   Biomolecules (2019) 9, 449-449. PubMed  Europe PubMed DOI  M
2018
8. Kumar,V., Naumann,M. and Stein,M.
   Computational Studies on the Inhibitor Selectivity of Human JAMM Deubiquitinylases Rpn11 and CSN5
   Front Chem (2018) 6, 480-480. PubMed  Europe PubMed DOI  PMC  EPMC  I
9. Li,J., Zhang,Y., Da Silva Sil Dos Santos,B., Wang,F., Ma,Y., Perez,C., Yang,Y., Peng,J., Cohen,S.M., Chou,T.F., Hilton,S.T. and Deshaies,R.J.
   Epidithiodiketopiperazines inhibit protein degradation by targeting proteasome deubiquitinase Rpn11
   Cell Chem Biol (2018) 25, 1350-1358. PubMed  Europe PubMed DOI  I
10. Liu,Q., Wu,Y., Qin,Y., Hu,J., Xie,W., Qin,F.X. and Cui,J.
    Broad and diverse mechanisms used by deubiquitinase family members in regulating the type I interferon signaling pathway during antiviral responses
    Sci Adv (2018) 4, eaar2824-eaar2824. PubMed  Europe PubMed DOI  PMC  EPMC
11. Watanabe,K., Yokoyama,S., Kaneto,N., Hori,T., Iwakami,Y., Kato,S., Hayakawa,Y., Sakurai,H., Fukuoka,J. and Saiki,I.
    COP9 signalosome subunit 5 regulates cancer metastasis by deubiquitinating SNAIL
    Oncotarget (2018) 9, 20670-20680. PubMed  Europe PubMed DOI  PMC  EPMC
2017
12. Altmann,E., Erbel,P., Renatus,M., Schaefer,M., Schlierf,A., Druet,A., Kieffer,L., Sorge,M., Pfister,K., Hassiepen,U., Jones,M., Ruedisser,S., Ostermeier,D., Martoglio,B., Jefferson,A.B. and Quancard,J.
    Azaindoles as zinc-binding small-molecule inhibitors of the JAMM protease CSN5
    Angew Chem Int Ed Engl (2017) 56, 1294-1297. DOI  I
13. Lauinger,L., Li,J., Shostak,A., Cemel,I.A., Ha,N., Zhang,Y., Merkl,P.E., Obermeyer,S., Stankovic-Valentin,N., Schafmeier,T., Wever,W.J., Bowers,A.A., Carter,K.P., Palmer,A.E., Tschochner,H., Melchior,F., Deshaies,R.J., Brunner,M. and Diernfellner,A.
    Thiolutin is a zinc chelator that inhibits the Rpn11 and other JAMM metalloproteases
    Nat Chem Biol (2017) 13, 709-714. PubMed  Europe PubMed DOI  I
2016
14. Ronau,J.A., Beckmann,J.F. and Hochstrasser,M.
    Substrate specificity of the ubiquitin and Ubl proteases
    Cell Res (2016) 26, 441-456. PubMed  Europe PubMed DOI
15. Schlierf,A., Altmann,E., Quancard,J., Jefferson,A.B., Assenberg,R., Renatus,M., Jones,M., Hassiepen,U., Schaefer,M., Kiffe,M., Weiss,A., Wiesmann,C., Sedrani,R., Eder,J. and Martoglio,B.
    Targeted inhibition of the COP9 signalosome for treatment of cancer
    Nat Commun (2016) 7, 13166-13166. PubMed  Europe PubMed DOI  PMC  EPMC  I
2014
16. Birol,M., Enchev,R.I., Padilla,A., Stengel,F., Aebersold,R., Betzi,S., Yang,Y., Hoh,F., Peter,M., Dumas,C. and Echalier,A.
    Structural and biochemical characterization of the Cop9 signalosome CSN5/CSN6 heterodimer
    PLoS ONE (2014) 9, e105688-e105688. PubMed  Europe PubMed DOI  PMC  EPMC
17. Birol,M. and Echalier,A.
    Structure and function of MPN (Mpr1/Pad1 N-terminal) domain-containing proteins
    Curr Protein Pept Sci (2014) 15, 504-517. PubMed  Europe PubMed DOI
18. Lingaraju,G.M., Bunker,R.D., Cavadini,S., Hess,D., Hassiepen,U., Renatus,M., Fischer,E.S. and Thoma,N.H.
    Crystal structure of the human COP9 signalosome
    Nature (2014) 512, 161-165. PubMed  Europe PubMed DOI  S
19. Pick,E. and Bramasole,L.
    Moonlighting and pleiotropy within two regulators of the degradation machinery: the proteasome lid and the CSN
    Biochem Soc Trans (2014) 42, 1786-1791. PubMed  Europe PubMed DOI
2013
20. Echalier,A., Pan,Y., Birol,M., Tavernier,N., Pintard,L., Hoh,F., Ebel,C., Galophe,N., Claret,F.X. and Dumas,C.
    Insights into the regulation of the human COP9 signalosome catalytic subunit, CSN5/Jab1
    Proc Natl Acad Sci U S A (2013) 110, 1273-1278. PubMed  Europe PubMed DOI  S
21. Serino,G. and Pick,E.
    Duplication and familial promiscuity within the proteasome lid and COP9 signalosome kin complexes
    Plant Sci (2013) 203-204, 89-97. PubMed  Europe PubMed DOI
2012
22. Zhou,J., Wan,B., Li,R., Gu,X., Zhong,Z., Wang,Y. and Yu,L.
    Jab1 interacts with brain-specific kinase 2 (BRSK2) and promotes its degradation in the ubiquitin-proteasome pathway
    Biochem Biophys Res Commun (2012) 422, 647-652. PubMed  Europe PubMed DOI
2008
23. Wei,N., Serino,G. and Deng,X.W.
    The COP9 signalosome: more than a protease
    Trends Biochem Sci (2008) 33, 592-600. PubMed  Europe PubMed DOI  V
2003
24. Pintard,L., Kurz,T., Glaser,S., Willis,J.H., Peter,M. and Bowerman,B.
    Neddylation and deneddylation of CUL-3 is required to target MEI-1/Katanin for degradation at the meiosis-to-mitosis transition in C. elegans
    Curr Biol (2003) 13, 911-921. PubMed  Europe PubMed DOI
25. Wei,N. and Deng,X.W.
    The COP9 signalosome
    Annu Rev Cell Dev Biol (2003) 19, 261-286. PubMed  Europe PubMed DOI
2002
26. [YEAR:18-10-2002]Cope,G.A., Suh,G.S., Aravind,L., Schwarz,S.E., Zipursky,S.L., Koonin,E.V. and Deshaies,R.J.
    Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1
    Science (18-10-2002) 298, 608-611. PubMed  Europe PubMed DOI
27. Wang,X., Kang,D., Feng,S., Serino,G., Schwechheimer,C. and Wei,N.
    CSN1 N-terminal-dependent activity is required for Arabidopsis development but not for Rub1/Nedd8 deconjugation of cullins: a structure-function study of CSN1 subunit of COP9 signalosome
    Mol Biol Cell (2002) 13, 646-655. PubMed  Europe PubMed DOI  PMC  EPMC
1998
28. [YEAR:1-4-1998]Seeger,M., Kraft,R., Ferrell,K., Bech-Otschir,D., Dumdey,R., Schade,R., Gordon,C., Naumann,M. and Dubiel,W.
    A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits
    FASEB J. (1-4-1998) 12, 469-478. PubMed  Europe PubMed
1996
29. Claret,F.X., Hibi,M., Dhut,S., Toda,T. and Karin,M.
    A new group of conserved coactivators that increase the specificity of AP-1 transcription factors
    Nature (1996) 383, 453-457. PubMed  Europe PubMed DOI