Literature for peptidase M67.002: Csn5 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, M Mutation, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2022
  1. Lv,T., Jin,Y., Miao,Y., Xu,T., Jia,F., Feng,H. and Zhang,X.
    LncRNA PVT1 promotes tumorigenesis of glioblastoma by recruiting COPS5 to deubiquitinate and stabilize TRIM24
    Mol Ther Nucleic Acids27, 109-121. PubMed  Europe PubMed DOI
  2. Pan,X., Wu,S., Wei,W., Chen,Z., Wu,Y. and Gong,K.
    Structural and Functional Basis of JAMM Deubiquitinating Enzymes in Disease
    Biomolecules12, PubMed  Europe PubMed DOI  V
  3. 2021
  4. Mou,Y.N., Ren,K., Tong,S.M., Ying,S.H. and Feng,M.G.
    Essential Role of COP9 Signalosome Subunit 5 (Csn5) in Insect Pathogenicity and Asexual Development of Beauveria bassiana
    J Fungi (Basel)7, 642-642. PubMed  Europe PubMed DOI
  5. 2020
  6. Dubiel,W., Chaithongyot,S., Dubiel,D. and Naumann,M.
    The COP9 Signalosome: A Multi-DUB Complex
    Biomolecules10, 1082-1082. PubMed  Europe PubMed DOI
  7. 2019
  8. Bramasole,L., Sinha,A., Harshuk,D., Cirigliano,A., Gurevich,S., Yu,Z., Carmeli,R.L., Glickman,M.H., Rinaldi,T. and Pick,E.
    The proteasome lid triggers COP9 signalosome activity during the transition of Sachharomyces cerevisiae cells into quiescence
    Biomolecules9, 449-449. PubMed  Europe PubMed DOI  M
  9. 2018
  10. Kumar,V., Naumann,M. and Stein,M.
    Computational Studies on the Inhibitor Selectivity of Human JAMM Deubiquitinylases Rpn11 and CSN5
    Front Chem6, 480-480. PubMed  Europe PubMed DOI  I
  11. Li,J., Zhang,Y., Da Silva Sil Dos Santos,B., Wang,F., Ma,Y., Perez,C., Yang,Y., Peng,J., Cohen,S.M., Chou,T.F., Hilton,S.T. and Deshaies,R.J.
    Epidithiodiketopiperazines inhibit protein degradation by targeting proteasome deubiquitinase Rpn11
    Cell Chem Biol25, 1350-1358. PubMed  Europe PubMed DOI  I
  12. Liu,Q., Wu,Y., Qin,Y., Hu,J., Xie,W., Qin,F.X. and Cui,J.
    Broad and diverse mechanisms used by deubiquitinase family members in regulating the type I interferon signaling pathway during antiviral responses
    Sci Adv4, eaar2824-eaar2824. PubMed  Europe PubMed DOI
  13. Watanabe,K., Yokoyama,S., Kaneto,N., Hori,T., Iwakami,Y., Kato,S., Hayakawa,Y., Sakurai,H., Fukuoka,J. and Saiki,I.
    COP9 signalosome subunit 5 regulates cancer metastasis by deubiquitinating SNAIL
    Oncotarget9, 20670-20680. PubMed  Europe PubMed DOI
  14. 2017
  15. Altmann,E., Erbel,P., Renatus,M., Schaefer,M., Schlierf,A., Druet,A., Kieffer,L., Sorge,M., Pfister,K., Hassiepen,U., Jones,M., Ruedisser,S., Ostermeier,D., Martoglio,B., Jefferson,A.B. and Quancard,J.
    Azaindoles as zinc-binding small-molecule inhibitors of the JAMM protease CSN5
    Angew Chem Int Ed Engl56, 1294-1297. DOI  I
  16. Lauinger,L., Li,J., Shostak,A., Cemel,I.A., Ha,N., Zhang,Y., Merkl,P.E., Obermeyer,S., Stankovic-Valentin,N., Schafmeier,T., Wever,W.J., Bowers,A.A., Carter,K.P., Palmer,A.E., Tschochner,H., Melchior,F., Deshaies,R.J., Brunner,M. and Diernfellner,A.
    Thiolutin is a zinc chelator that inhibits the Rpn11 and other JAMM metalloproteases
    Nat Chem Biol13, 709-714. PubMed  Europe PubMed DOI  I
  17. 2016
  18. Ronau,J.A., Beckmann,J.F. and Hochstrasser,M.
    Substrate specificity of the ubiquitin and Ubl proteases
    Cell Res26, 441-456. PubMed  Europe PubMed DOI
  19. Schlierf,A., Altmann,E., Quancard,J., Jefferson,A.B., Assenberg,R., Renatus,M., Jones,M., Hassiepen,U., Schaefer,M., Kiffe,M., Weiss,A., Wiesmann,C., Sedrani,R., Eder,J. and Martoglio,B.
    Targeted inhibition of the COP9 signalosome for treatment of cancer
    Nat Commun7, 13166-13166. PubMed  Europe PubMed DOI  I
  20. 2014
  21. Birol,M. and Echalier,A.
    Structure and function of MPN (Mpr1/Pad1 N-terminal) domain-containing proteins
    Curr Protein Pept Sci15, 504-517. PubMed  Europe PubMed DOI
  22. Birol,M., Enchev,R.I., Padilla,A., Stengel,F., Aebersold,R., Betzi,S., Yang,Y., Hoh,F., Peter,M., Dumas,C. and Echalier,A.
    Structural and biochemical characterization of the Cop9 signalosome CSN5/CSN6 heterodimer
    PLoS ONE9, e105688-e105688. PubMed  Europe PubMed DOI
  23. Lingaraju,G.M., Bunker,R.D., Cavadini,S., Hess,D., Hassiepen,U., Renatus,M., Fischer,E.S. and Thoma,N.H.
    Crystal structure of the human COP9 signalosome
    Nature512, 161-165. PubMed  Europe PubMed DOI  S
  24. Pick,E. and Bramasole,L.
    Moonlighting and pleiotropy within two regulators of the degradation machinery: the proteasome lid and the CSN
    Biochem Soc Trans42, 1786-1791. PubMed  Europe PubMed DOI
  25. 2013
  26. Echalier,A., Pan,Y., Birol,M., Tavernier,N., Pintard,L., Hoh,F., Ebel,C., Galophe,N., Claret,F.X. and Dumas,C.
    Insights into the regulation of the human COP9 signalosome catalytic subunit, CSN5/Jab1
    Proc Natl Acad Sci U S A110, 1273-1278. PubMed  Europe PubMed DOI  S
  27. Serino,G. and Pick,E.
    Duplication and familial promiscuity within the proteasome lid and COP9 signalosome kin complexes
    Plant Sci203-204, 89-97. PubMed  Europe PubMed DOI
  28. 2012
  29. Zhou,J., Wan,B., Li,R., Gu,X., Zhong,Z., Wang,Y. and Yu,L.
    Jab1 interacts with brain-specific kinase 2 (BRSK2) and promotes its degradation in the ubiquitin-proteasome pathway
    Biochem Biophys Res Commun422, 647-652. PubMed  Europe PubMed DOI
  30. 2008
  31. Wei,N., Serino,G. and Deng,X.W.
    The COP9 signalosome: more than a protease
    Trends Biochem Sci33, 592-600. PubMed  Europe PubMed DOI  V
  32. 2003
  33. Pintard,L., Kurz,T., Glaser,S., Willis,J.H., Peter,M. and Bowerman,B.
    Neddylation and deneddylation of CUL-3 is required to target MEI-1/Katanin for degradation at the meiosis-to-mitosis transition in C. elegans
    Curr Biol13, 911-921. PubMed  Europe PubMed DOI
  34. Wei,N. and Deng,X.W.
    The COP9 signalosome
    Annu Rev Cell Dev Biol19, 261-286. PubMed  Europe PubMed DOI
  35. 2002
  36. [YEAR:18-10-2002]Cope,G.A., Suh,G.S., Aravind,L., Schwarz,S.E., Zipursky,S.L., Koonin,E.V. and Deshaies,R.J.
    Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1
    Science298, 608-611. PubMed  Europe PubMed DOI
  37. Wang,X., Kang,D., Feng,S., Serino,G., Schwechheimer,C. and Wei,N.
    CSN1 N-terminal-dependent activity is required for Arabidopsis development but not for Rub1/Nedd8 deconjugation of cullins: a structure-function study of CSN1 subunit of COP9 signalosome
    Mol Biol Cell13, 646-655. PubMed  Europe PubMed DOI
  38. 1998
  39. [YEAR:1-4-1998]Seeger,M., Kraft,R., Ferrell,K., Bech-Otschir,D., Dumdey,R., Schade,R., Gordon,C., Naumann,M. and Dubiel,W.
    A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits
    FASEB J12, 469-478. PubMed  Europe PubMed
  40. 1996
  41. Claret,F.X., Hibi,M., Dhut,S., Toda,T. and Karin,M.
    A new group of conserved coactivators that increase the specificity of AP-1 transcription factors
    Nature383, 453-457. PubMed  Europe PubMed DOI