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Literature for peptidase M67.002: Csn5 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, M Mutation, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Ding,S., Clapperton,J.A., Maeots,M.E., Kunzelmann,S., Shaaban,M. and Enchev,R.I.<br>Structural basis of CSN-mediated SCF deneddylation<br>Nat Commun (2026) 17, 951-951. PubMed  Europe PubMed DOI  PMC  EPMC
    2. 2025
  2. Hwang,S.H., Kim,J.W., Park,H., Aguirre,A.J., Kim,K.J., Choi,S., Park,W., Seo,J., Chae,H., Kang,M., Jung,E.H., Suh,K.J., Kim,S.H., Kim,J.W., Kim,Y.J., Kim,J.H. and Lee,K.W.<br>COPS5 inhibition synergizes with the antitumor effect of trastuzumab by PTEN upregulation in HER2-amplified gastric cancer<br>Gastric Cancer (2025) PubMed  Europe PubMed DOI
    3. 2022
  3. Lv,T., Jin,Y., Miao,Y., Xu,T., Jia,F., Feng,H. and Zhang,X.<br>LncRNA PVT1 promotes tumorigenesis of glioblastoma by recruiting COPS5 to deubiquitinate and stabilize TRIM24<br>Mol Ther Nucleic Acids (2022) 27, 109-121. PubMed  Europe PubMed DOI  PMC  EPMC
  4. Pan,X., Wu,S., Wei,W., Chen,Z., Wu,Y. and Gong,K.<br>Structural and Functional Basis of JAMM Deubiquitinating Enzymes in Disease<br>Biomolecules (2022) 12 PubMed  Europe PubMed DOI  PMC  EPMC  V
    5. 2021
  5. Mou,Y.N., Ren,K., Tong,S.M., Ying,S.H. and Feng,M.G.<br>Essential Role of COP9 Signalosome Subunit 5 (Csn5) in Insect Pathogenicity and Asexual Development of Beauveria bassiana<br>J Fungi (Basel) (2021) 7, 642-642. PubMed  Europe PubMed DOI  PMC  EPMC
    6. 2020
  6. Dubiel,W., Chaithongyot,S., Dubiel,D. and Naumann,M.<br>The COP9 Signalosome: A Multi-DUB Complex<br>Biomolecules (2020) 10, 1082-1082. PubMed  Europe PubMed DOI
    7. 2019
  7. Bramasole,L., Sinha,A., Harshuk,D., Cirigliano,A., Gurevich,S., Yu,Z., Carmeli,R.L., Glickman,M.H., Rinaldi,T. and Pick,E.<br>The proteasome lid triggers COP9 signalosome activity during the transition of Sachharomyces cerevisiae cells into quiescence<br>Biomolecules (2019) 9, 449-449. PubMed  Europe PubMed DOI  M
    8. 2018
  8. Kumar,V., Naumann,M. and Stein,M.<br>Computational Studies on the Inhibitor Selectivity of Human JAMM Deubiquitinylases Rpn11 and CSN5<br>Front Chem (2018) 6, 480-480. PubMed  Europe PubMed DOI  PMC  EPMC  I
  9. Li,J., Zhang,Y., Da Silva Sil Dos Santos,B., Wang,F., Ma,Y., Perez,C., Yang,Y., Peng,J., Cohen,S.M., Chou,T.F., Hilton,S.T. and Deshaies,R.J.<br>Epidithiodiketopiperazines inhibit protein degradation by targeting proteasome deubiquitinase Rpn11<br>Cell Chem Biol (2018) 25, 1350-1358. PubMed  Europe PubMed DOI  I
  10. Liu,Q., Wu,Y., Qin,Y., Hu,J., Xie,W., Qin,F.X. and Cui,J.<br>Broad and diverse mechanisms used by deubiquitinase family members in regulating the type I interferon signaling pathway during antiviral responses<br>Sci Adv (2018) 4, eaar2824-eaar2824. PubMed  Europe PubMed DOI  PMC  EPMC
  11. Watanabe,K., Yokoyama,S., Kaneto,N., Hori,T., Iwakami,Y., Kato,S., Hayakawa,Y., Sakurai,H., Fukuoka,J. and Saiki,I.<br>COP9 signalosome subunit 5 regulates cancer metastasis by deubiquitinating SNAIL<br>Oncotarget (2018) 9, 20670-20680. PubMed  Europe PubMed DOI  PMC  EPMC
    12. 2017
  12. Altmann,E., Erbel,P., Renatus,M., Schaefer,M., Schlierf,A., Druet,A., Kieffer,L., Sorge,M., Pfister,K., Hassiepen,U., Jones,M., Ruedisser,S., Ostermeier,D., Martoglio,B., Jefferson,A.B. and Quancard,J.<br>Azaindoles as zinc-binding small-molecule inhibitors of the JAMM protease CSN5<br>Angew Chem Int Ed Engl (2017) 56, 1294-1297. DOI  I
  13. Lauinger,L., Li,J., Shostak,A., Cemel,I.A., Ha,N., Zhang,Y., Merkl,P.E., Obermeyer,S., Stankovic-Valentin,N., Schafmeier,T., Wever,W.J., Bowers,A.A., Carter,K.P., Palmer,A.E., Tschochner,H., Melchior,F., Deshaies,R.J., Brunner,M. and Diernfellner,A.<br>Thiolutin is a zinc chelator that inhibits the Rpn11 and other JAMM metalloproteases<br>Nat Chem Biol (2017) 13, 709-714. PubMed  Europe PubMed DOI  I
    14. 2016
  14. Ronau,J.A., Beckmann,J.F. and Hochstrasser,M.<br>Substrate specificity of the ubiquitin and Ubl proteases<br>Cell Res (2016) 26, 441-456. PubMed  Europe PubMed DOI
  15. Schlierf,A., Altmann,E., Quancard,J., Jefferson,A.B., Assenberg,R., Renatus,M., Jones,M., Hassiepen,U., Schaefer,M., Kiffe,M., Weiss,A., Wiesmann,C., Sedrani,R., Eder,J. and Martoglio,B.<br>Targeted inhibition of the COP9 signalosome for treatment of cancer<br>Nat Commun (2016) 7, 13166-13166. PubMed  Europe PubMed DOI  PMC  EPMC  I
    16. 2014
  16. Birol,M., Enchev,R.I., Padilla,A., Stengel,F., Aebersold,R., Betzi,S., Yang,Y., Hoh,F., Peter,M., Dumas,C. and Echalier,A.<br>Structural and biochemical characterization of the Cop9 signalosome CSN5/CSN6 heterodimer<br>PLoS ONE (2014) 9, e105688-e105688. PubMed  Europe PubMed DOI  PMC  EPMC
  17. Birol,M. and Echalier,A.<br>Structure and function of MPN (Mpr1/Pad1 N-terminal) domain-containing proteins<br>Curr Protein Pept Sci (2014) 15, 504-517. PubMed  Europe PubMed DOI
  18. Lingaraju,G.M., Bunker,R.D., Cavadini,S., Hess,D., Hassiepen,U., Renatus,M., Fischer,E.S. and Thoma,N.H.<br>Crystal structure of the human COP9 signalosome<br>Nature (2014) 512, 161-165. PubMed  Europe PubMed DOI  S
  19. Pick,E. and Bramasole,L.<br>Moonlighting and pleiotropy within two regulators of the degradation machinery: the proteasome lid and the CSN<br>Biochem Soc Trans (2014) 42, 1786-1791. PubMed  Europe PubMed DOI
    20. 2013
  20. Echalier,A., Pan,Y., Birol,M., Tavernier,N., Pintard,L., Hoh,F., Ebel,C., Galophe,N., Claret,F.X. and Dumas,C.<br>Insights into the regulation of the human COP9 signalosome catalytic subunit, CSN5/Jab1<br>Proc Natl Acad Sci U S A (2013) 110, 1273-1278. PubMed  Europe PubMed DOI  S
  21. Serino,G. and Pick,E.<br>Duplication and familial promiscuity within the proteasome lid and COP9 signalosome kin complexes<br>Plant Sci (2013) 203-204, 89-97. PubMed  Europe PubMed DOI
    22. 2012
  22. Zhou,J., Wan,B., Li,R., Gu,X., Zhong,Z., Wang,Y. and Yu,L.<br>Jab1 interacts with brain-specific kinase 2 (BRSK2) and promotes its degradation in the ubiquitin-proteasome pathway<br>Biochem Biophys Res Commun (2012) 422, 647-652. PubMed  Europe PubMed DOI
    23. 2008
  23. Wei,N., Serino,G. and Deng,X.W.<br>The COP9 signalosome: more than a protease<br>Trends Biochem Sci (2008) 33, 592-600. PubMed  Europe PubMed DOI  V
    24. 2003
  24. Pintard,L., Kurz,T., Glaser,S., Willis,J.H., Peter,M. and Bowerman,B.<br>Neddylation and deneddylation of CUL-3 is required to target MEI-1/Katanin for degradation at the meiosis-to-mitosis transition in C. elegans<br>Curr Biol (2003) 13, 911-921. PubMed  Europe PubMed DOI
  25. Wei,N. and Deng,X.W.<br>The COP9 signalosome<br>Annu Rev Cell Dev Biol (2003) 19, 261-286. PubMed  Europe PubMed DOI
    26. 2002
  26. [YEAR:18-10-2002]Cope,G.A., Suh,G.S., Aravind,L., Schwarz,S.E., Zipursky,S.L., Koonin,E.V. and Deshaies,R.J.<br>Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1<br>Science (18-10-2002) 298, 608-611. PubMed  Europe PubMed DOI
  27. Wang,X., Kang,D., Feng,S., Serino,G., Schwechheimer,C. and Wei,N.<br>CSN1 N-terminal-dependent activity is required for Arabidopsis development but not for Rub1/Nedd8 deconjugation of cullins: a structure-function study of CSN1 subunit of COP9 signalosome<br>Mol Biol Cell (2002) 13, 646-655. PubMed  Europe PubMed DOI  PMC  EPMC
    28. 1998
  28. [YEAR:1-4-1998]Seeger,M., Kraft,R., Ferrell,K., Bech-Otschir,D., Dumdey,R., Schade,R., Gordon,C., Naumann,M. and Dubiel,W.<br>A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits<br>FASEB J. (1-4-1998) 12, 469-478. PubMed  Europe PubMed
    29. 1996
  29. Claret,F.X., Hibi,M., Dhut,S., Toda,T. and Karin,M.<br>A new group of conserved coactivators that increase the specificity of AP-1 transcription factors<br>Nature (1996) 383, 453-457. PubMed  Europe PubMed DOI

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