Substrates for peptidase M41.001: FtsH peptidase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
beta-casein	P02666	16-224	peptide-Gln138+Ser-peptide	N	Thr	Glu	Ser	Gln	Ser	Leu	Thr	Leu	Shotland et al., 2000
beta-casein	P02666	16-224	peptide-Glu136+Ser-peptide	N	Pro	Phe	Thr	Glu	Ser	Gln	Ser	Leu	Shotland et al., 2000
beta-casein	P02666	16-224	peptide-Trp158+Met-peptide	N	Leu	Gln	Ser	Trp	Met	His	Gln	Pro	Shotland et al., 2000
beta-casein	P02666	16-224	peptide-Leu178+Ser-peptide	N	Gln	Ser	Val	Leu	Ser	Leu	Ser	Gln	Shotland et al., 2000
beta-casein	P02666	16-224	peptide-Ser183+Lys-peptide	N	Leu	Ser	Gln	Ser	Lys	Val	Leu	Pro	Shotland et al., 2000
beta-casein	P02666	16-224	peptide-Lys191+Ala-peptide	N	Val	Pro	Gln	Lys	Ala	Val	Pro	Tyr	Shotland et al., 2000
beta-casein	P02666	16-224	peptide-Ala204+Phe-peptide	N	Pro	Ile	Gln	Ala	Phe	Leu	Leu	Tyr	Shotland et al., 2000
beta-casein	P02666	16-224	peptide-Phe205+Leu-peptide	N	Ile	Gln	Ala	Phe	Leu	Leu	Tyr	Gln	Shotland et al., 2000
beta-casein	P02666	16-224	peptide-Leu206+Leu-peptide	N	Gln	Ala	Phe	Leu	Leu	Tyr	Gln	Glu	Shotland et al., 2000
beta-casein	P02666	16-224	peptide-Leu207+Tyr-peptide	N	Ala	Phe	Leu	Leu	Tyr	Gln	Glu	Pro	Shotland et al., 2000
beta-casein	P02666	16-224	peptide-Tyr208+Gln-peptide	N	Phe	Leu	Leu	Tyr	Gln	Glu	Pro	Val	Shotland et al., 2000
cell division protein ftsH	P0AAI3	1-644	peptide-Met637+Ser-peptide	P	Gly	Asn	Thr	Met	Ser	Glu	Gln	Leu	Akiyama, 1999
regulatory protein CII	P03042	1-97	peptide-Leu11+Arg-peptide	N	Asn	Glu	Ala	Leu	Arg	Ile	Glu	Ser	Shotland et al., 2000
regulatory protein CII	P03042	1-97	peptide-Leu18+Asn-peptide	N	Ser	Ala	Leu	Leu	Asn	Lys	Ile	Ala	Shotland et al., 2000
regulatory protein CII	P03042	1-97	peptide-Glu27+Lys-peptide	N	Leu	Gly	Thr	Glu	Lys	Thr	Ala	Glu	Shotland et al., 2000
regulatory protein CII	P03042	1-97	peptide-Ile48+Pro-peptide	N	Arg	Asp	Trp	Ile	Pro	Lys	Phe	Ser	Shotland et al., 2000
regulatory protein CII	P03042	1-97	peptide-Lys50+Phe-peptide	N	Trp	Ile	Pro	Lys	Phe	Ser	Met	Leu	Shotland et al., 2000
regulatory protein CII	P03042	1-97	peptide-Leu54+Leu-peptide	N	Phe	Ser	Met	Leu	Leu	Ala	Val	Leu	Shotland et al., 2000
regulatory protein CII	P03042	1-97	peptide-Leu55+Ala-peptide	N	Ser	Met	Leu	Leu	Ala	Val	Leu	Glu	Shotland et al., 2000
regulatory protein CII	P03042	1-97	peptide-Ala56+Val-peptide	N	Met	Leu	Leu	Ala	Val	Leu	Glu	Trp	Shotland et al., 2000
regulatory protein CII	P03042	1-97	peptide-Val57+Leu-peptide	N	Leu	Leu	Ala	Val	Leu	Glu	Trp	Gly	Shotland et al., 2000
regulatory protein CII	P03042	1-97	peptide-Leu58+Glu-peptide	N	Leu	Ala	Val	Leu	Glu	Trp	Gly	Val	Shotland et al., 2000
regulatory protein CII	P03042	1-97	peptide-Glu59+Trp-peptide	N	Ala	Val	Leu	Glu	Trp	Gly	Val	Val	Shotland et al., 2000
regulatory protein CII	P03042	1-97	peptide-Arg89+Ser-peptide	N	Ala	Thr	Glu	Arg	Ser	Glu	Gln	Ile	Shotland et al., 2000