Literature for peptidase M41.001: FtsH peptidase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, P Specificity, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2025

Fremlen,H. and Burmann,B.M. Maintaining the Integral Membrane Proteome: Revisiting the Functional Repertoire of Integral Membrane Proteases Chembiochem (2025) , e202500048-e202500048. PubMed Europe PubMed DOI V
Ghanbarpour,A., Telusma,B., Powell,B.M., Zhang,J.J., Bolstad,I., Vargas,C., Keller,S., Baker,T.A., Sauer,R.T. and Davis,J.H. An asymmetric nautilus-like HflK/C assembly controls FtsH proteolysis of membrane proteins EMBO J (2025) PubMed Europe PubMed DOI
Li,Y., Zhu,J., Zhang,Z., Wei,J., Wang,F., Meisl,G., Knowles,T.P.J., Egelman,E.H. and Tezcan,F.A. Transforming an ATP-dependent enzyme into a dissipative, self-assembling system Nat Chem Biol (2025) PubMed Europe PubMed DOI

2024

Akkulak,H., Ince,H.K., Goc,G., Lebrilla,C.B., Kabasakal,B.V. and Ozcan,S. Structural proteomics of a bacterial mega membrane protein complex: FtsH-HflK-HflC Int J Biol Macromol (2024) 269, 131923-131923. PubMed Europe PubMed DOI
Brangulis,K., Drunka,L., Akopjana,I. and Tars,K. Structure of the Borrelia burgdorferi ATP-dependent metalloprotease FtsH in its functionally relevant hexameric form Biochim Biophys Acta Proteins Proteom (2024) 1872, 140969-140969. PubMed Europe PubMed DOI
Ghanbarpour,A., Telusma,B., Powell,B.M., Zhang,J.J., Bolstad,I., Vargas,C., Keller,S., Baker,T., Sauer,R.T. and Davis,J.H. An asymmetric nautilus-like HflK/C assembly controls FtsH proteolysis of membrane proteins bioRxiv (2024) PubMed Europe PubMed DOI PMC EPMC
Mawla,G.D., Kamal,S.M., Cao,L.Y., Purhonen,P., Hebert,H., Sauer,R.T., Baker,T.A. and Romling,U. The membrane-cytoplasmic linker defines activity of FtsH proteases in Pseudomonas aeruginosa clone C J Biol Chem (2024) 300, 105622-105622. PubMed Europe PubMed DOI PMC EPMC

2023

Hari,S.B., Morehouse,J.P., Baker,T.A. and Sauer,R.T. FtsH degrades kinetically stable dimers of cyclopropane fatty acid synthase via an internal degron Mol Microbiol (2023) 119, 101-111. PubMed Europe PubMed DOI PMC EPMC
Osman,I.O., Caputo,A., Pinault,L., Mege,J.L., Levasseur,A. and Devaux,C.A. Identification and Characterization of an HtrA Sheddase Produced by Coxiella burnetii Int J Mol Sci (2023) 24 PubMed Europe PubMed DOI PMC EPMC
Song,H., Choi,E. and Lee,E.J. Membrane-Bound Protease FtsH Protects PhoP from the Proteolysis by Cytoplasmic ClpAP Protease in Salmonella Typhimurium J Microbiol Biotechnol (2023) 33, 1130-1140. PubMed Europe PubMed DOI

2022

Ma,C., Wang,C., Luo,D., Yan,L., Yang,W., Li,N. and Gao,N. Structural insights into the membrane microdomain organization by SPFH family proteins Cell Res (2022) 32, 176-189. PubMed Europe PubMed DOI PMC EPMC
Qiao,Z., Yokoyama,T., Yan,X.F., Beh,I.T., Shi,J., Basak,S., Akiyama,Y. and Gao,Y.G. Cryo-EM structure of the entire FtsH-HflKC AAA protease complex Cell Rep (2022) 39, 110890-110890. PubMed Europe PubMed DOI
Shu,S. and Mi,W. Regulatory mechanisms of lipopolysaccharide synthesis in Escherichia coli Nat Commun (2022) 13, 4576-4576. PubMed Europe PubMed DOI PMC EPMC

2021

Prabudiansyah,I., van der Valk,R. and Aubin-Tam,M.E. Reconstitution and functional characterization of the FtsH protease in lipid nanodiscs Biochim Biophys Acta Biomembr (2021) 1863, 183526-183526. PubMed Europe PubMed DOI

2020

Carvalho,V., Prabudiansyah,I., Kovacik,L., Chami,M., Kieffer,R., van der Valk,R., de Lange,N., Engel,A. and Aubin-Tam,M.E. The cytoplasmic domain of the AAA+ protease FtsH is tilted with respect to the membrane to facilitate substrate entry J Biol Chem (2020) PubMed Europe PubMed DOI
Nguyen,D., Kelly,K., Qiu,N. and Misra,R. YejM controls LpxC levels by regulating Protease Activity of the FtsH/YciM Complex of Escherichia coli J Bacteriol (2020) PubMed Europe PubMed DOI
Yeo,W.S., Anokwute,C., Marcadis,P., Levitan,M., Ahmed,M., Bae,Y., Kim,K., Kostrominova,T., Liu,Q. and Bae,T. A membrane-bound transcription factor is proteolytically regulated by the AAA+ protease FtsH in Staphylococcus aureus J Bacteriol (2020) 202, e00019-20-e00019-20. PubMed Europe PubMed DOI
Yeom,J., Shao,Y. and Groisman,E.A. Small proteins regulate Salmonella survival inside macrophages by controlling degradation of a magnesium transporter Proc Natl Acad Sci U S A (2020) 117, 20235-20243. PubMed Europe PubMed DOI

2019

Kamal,S.M., Rybtke,M.L., Nimtz,M., Sperlein,S., Giske,C., Trcek,J., Deschamps,J., Briandet,R., Dini,L., Jansch,L., Tolker-Nielsen,T., Lee,C. and Romling,U. Two FtsH proteases contribute to fitness and adaptation of Pseudomonas aeruginosa Clone C strains Front Microbiol (2019) 10, 1372-1372. PubMed Europe PubMed DOI PMC EPMC
Yang,Y., Gunasekara,M., Muhammednazaar,S., Li,Z. and Hong,H. Proteolysis mediated by the membrane-integrated ATP-dependent protease FtsH has a unique nonlinear dependence on ATP hydrolysis rates Protein Sci (2019) 28, 1262-1275. PubMed Europe PubMed DOI

2018

Baek,J., Choi,E. and Lee,E.J. A rule governing the FtsH-mediated proteolysis of the MgtC virulence protein from Salmonella enterica serovarTyphimurium J Microbiol (2018) 56, 565-570. PubMed Europe PubMed DOI P
Lindemann,C., Thomanek,N., Kuhlmann,K., Meyer,H.E., Marcus,K. and Narberhaus,F. Next-generation trapping of protease substrates by label-free proteomics Methods Mol Biol (2018) 1841, 189-206. PubMed Europe PubMed DOI P
Ruer,M., Krainer,G., Groger,P. and Schlierf,M. ATPase and protease domain movements in the bacterial AAA+ protease FtsH are driven by thermal fluctuations J Mol Biol (2018) 430, 4592-4602. PubMed Europe PubMed DOI
Uthoff,M. and Baumann,U. Conformational flexibility of pore loop-1 gives insights into substrate translocation by the AAA(+) protease FtsH J Struct Biol (2018) 204, 199-206. PubMed Europe PubMed DOI S
Yang,Y., Guo,R., Gaffney,K., Kim,M., Muhammednazaar,S., Tian,W., Wang,B., Liang,J. and Hong,H. Folding-degradation relationship of a membrane protein mediated by the universally conserved ATP-dependent protease FtsH J Am Chem Soc (2018) 140, 4656-4665. PubMed Europe PubMed DOI

2017

Bittner,L.M., Arends,J. and Narberhaus,F. When, how and why? Regulated proteolysis by the essential FtsH protease in Escherichia coli Biol Chem (2017) 398, 625-635. PubMed Europe PubMed DOI

2016

Arends,J., Thomanek,N., Kuhlmann,K., Marcus,K. and Narberhaus,F. In vivo trapping of FtsH substrates by label-free quantitative proteomics Proteomics (2016) 16, 3161-3172. PubMed Europe PubMed DOI P
Hari,S.B. and Sauer,R.T. The AAA+ FtsH protease degrades an ssrA-tagged model protein in the inner membrane of Escherichia coli Biochemistry (2016) 55, 5649-5652. PubMed Europe PubMed DOI

2015

Bittner,L.M., Westphal,K. and Narberhaus,F. Conditional proteolysis of the membrane protein YfgM by the FtsH protease depends on a novel N-terminal degron J Biol Chem (2015) 290, 19367-19378. PubMed Europe PubMed DOI

2013

Emiola,A., Falcarin,P., Tocher,J. and George,J. A model for the proteolytic regulation of LpxC in the lipopolysaccharide pathway of Escherichia coli Comput Biol Chem (2013) 47, 1-7. PubMed Europe PubMed DOI
Li,W., Rao,D.K. and Kaur,P. Dual role of the metalloprotease FtsH in biogenesis of the DrrAB drug transporter J Biol Chem (2013) 288, 11854-11864. PubMed Europe PubMed DOI
Okuno,T. and Ogura,T. FtsH protease-mediated regulation of various cellular functions Subcell Biochem (2013) 66, 53-69. PubMed Europe PubMed DOI
Schakermann,M., Langklotz,S. and Narberhaus,F. FtsH-mediated coordination of lipopolysaccharide biosynthesis in Escherichia coli correlates with the growth rate and the alarmone (p)ppGpp J Bacteriol (2013) 195, 1912-1919. PubMed Europe PubMed DOI

2012

Langklotz,S., Baumann,U. and Narberhaus,F. Structure and function of the bacterial AAA protease FtsH Biochim Biophys Acta (2012) 1823, 40-48. PubMed Europe PubMed DOI V
Ogura,T., Okuno,T., Suno,R. and Akiyama,Y. FtsH protease [ISSN:978-0-12-407744-7] (2012) 3, 685-692. DOI
Suno,R., Shimoyama,M., Abe,A., Shimamura,T., Shimodate,N., Watanabe,Y., Akiyama,Y. and Yoshida,M. Conformational transition of the lid helix covering the protease active site is essential for the ATP-dependent protease activity of FtsH FEBS Lett (2012) 586, 3117-3121. PubMed Europe PubMed DOI
Westphal,K., Langklotz,S., Thomanek,N. and Narberhaus,F. A trapping approach reveals novel substrates and physiological functions of the essential protease FtsH in Escherichia coli J Biol Chem (2012) 287, 42962-42971. PubMed Europe PubMed DOI

2011

Bandyopadhyay,K., Parua,P.K., Datta,A.B. and Parrack,P. Studies on Escherichia coli HflKC suggest the presence of an unidentified lambda factor that influences the lysis-lysogeny switch BMC Microbiol (2011) 11, 34-34. PubMed Europe PubMed DOI
Chauleau,M., Mora,L., Serba,J. and de Zamaroczy,M. FtsH-dependent processing of RNase colicins D and E3 means that only the cytotoxic domains are imported into the cytoplasm J Biol Chem (2011) 286, 29397-29407. PubMed Europe PubMed DOI
Sauer,R.T. and Baker,T.A. AAA+ Proteases: ATP-fueled machines of protein destruction Annu Rev Biochem (2011) 80, 587-612. PubMed Europe PubMed DOI
Singh,S. and Darwin,A.J. FtsH-dependent degradation of phage shock protein C in Yersinia enterocolitica and Escherichia coli J Bacteriol (2011) 193, 6436-6442. PubMed Europe PubMed DOI

2010

Ayuso-Tejedor,S., Nishikori,S., Okuno,T., Ogura,T. and Sancho,J. FtsH cleavage of non-native conformations of proteins J Struct Biol (2010) 171, 117-124. PubMed Europe PubMed DOI

2009

Akiyama,Y. Quality control of cytoplasmic membrane proteins in Escherichia coli J Biochem (2009) 146, 449-454. PubMed Europe PubMed DOI
Ingmer,H. and Brondsted,L. Proteases in bacterial pathogenesis Res Microbiol (2009) 160, 704-710. PubMed Europe PubMed DOI V
Inwood,W.B., Hall,J.A., Kim,K.S., Demirkhanyan,L., Wemmer,D., Zgurskaya,H. and Kustu,S. Epistatic effects of the protease/chaperone HflB on some damaged forms of the Escherichia coli ammonium channel AmtB Genetics (2009) 183, 1327-1340. PubMed Europe PubMed DOI PMC EPMC
Koodathingal,P., Jaffe,N.E., Kraut,D.A., Prakash,S., Fishbain,S., Herman,C. and Matouschek,A. ATP-dependent proteases differ substantially in their ability to unfold globular proteins J Biol Chem (2009) 284, 18674-18684. PubMed Europe PubMed DOI PMC EPMC
Narberhaus,F., Obrist,M., Fuhrer,F. and Langklotz,S. Degradation of cytoplasmic substrates by FtsH, a membrane-anchored protease with many talents Res Microbiol (2009) 160, 652-659. PubMed Europe PubMed DOI V

2008

Inobe,T. and Matouschek,A. Protein targeting to ATP-dependent proteases Curr Opin Struct Biol (2008) 18, 43-51. PubMed Europe PubMed DOI PMC EPMC V
Katz,C. and Ron,E.Z. Dual role of FtsH in regulating lipopolysaccharide biosynthesis in Escherichia coli J Bacteriol (2008) 190, 7117-7122. PubMed Europe PubMed DOI PMC EPMC
Licht,S. and Lee,I. Resolving individual steps in the operation of ATP-dependent proteolytic molecular machines: from conformational changes to substrate translocation and processivity Biochemistry (2008) 47, 3595-3605. PubMed Europe PubMed DOI
Srinivasan,R., Rajeswari,H. and Ajitkumar,P. Analysis of degradation of bacterial cell division protein FtsZ by the ATP-dependent zinc-metalloprotease FtsH in vitro Microbiol Res (2008) 163, 21-30. PubMed Europe PubMed DOI
van Bloois,E., Dekker,H.L., Froderberg,L., Houben,E.N., Urbanus,M.L., de Koster,C.G., de Gier,J.W. and Luirink,J. Detection of cross-links between FtsH, YidC, HflK/C suggests a linked role for these proteins in quality control upon insertion of bacterial inner membrane proteins FEBS Lett (2008) 582, 1419-1424. PubMed Europe PubMed DOI

2007

Fuhrer,F., Muller,A., Baumann,H., Langklotz,S., Kutscher,B. and Narberhaus,F. Sequence and length recognition of the C-terminal turnover element of LpxC, a soluble substrate of the membrane-bound FtsH protease J Mol Biol (2007) 372, 485-496. PubMed Europe PubMed DOI
Halder,S., Datta,A.B. and Parrack,P. Probing the antiprotease activity of lambdaCIII, an inhibitor of the Escherichia coli metalloprotease HflB (FtsH) J Bacteriol (2007) 189, 8130-8138. PubMed Europe PubMed DOI PMC EPMC
Kobiler,O., Rokney,A. and Oppenheim,A.B. Phage lambda CIII: a protease inhibitor regulating the lysis-lysogeny decision PLoS ONE (2007) 2, e363-e363. PubMed Europe PubMed DOI PMC EPMC

2006

Chiba,S., Ito,K. and Akiyama,Y. The Escherichia coli plasma membrane contains two PHB (prohibitin homology) domain protein complexes of opposite orientations Mol Microbiol (2006) 60, 448-457. PubMed Europe PubMed DOI
Fuhrer,F., Langklotz,S. and Narberhaus,F. The C-terminal end of LpxC is required for degradation by the FtsH protease Mol Microbiol (2006) 59, 1025-1036. PubMed Europe PubMed DOI
Okuno,T., Yamanaka,K. and Ogura,T. An AAA protease FtsH can initiate proteolysis from internal sites of a model substrate, apo-flavodoxin Genes Cells (2006) 11, 261-268. PubMed Europe PubMed DOI
[YEAR:3-3-2006]Okuno,T., Yamanaka,K. and Ogura,T. Flavodoxin, a new fluorescent substrate for monitoring proteolytic activity of FtsH lacking a robust unfolding activity J Struct Biol (3-3-2006) 156, 115-119. PubMed Europe PubMed DOI
[YEAR:6-3-2006]Okuno,T., Yamanaka,K. and Ogura,T. Characterization of mutants of the Escherichia coli AAA protease, FtsH, carrying a mutation in the central pore region J Struct Biol (6-3-2006) 156, 109-114. PubMed Europe PubMed DOI

2005

[YEAR:16-3-2005]Ito,K. and Akiyama,Y. Cellular functions, mechanism of action, and regulation of FtsH protease Annu Rev Microbiol (16-3-2005) 59, 211-231. PubMed Europe PubMed DOI V

2004

Akiyama,Y., Ito,K. and Ogura,T. FtsH protease [ISSN:0-12-079610-4] (2004) 2, 794-798. V
Lithgow,J.K., Ingham,E. and Foster,S.J. Role of the hprT-ftsH locus in Staphylococcus aureus Microbiology (Reading, Engl.) (2004) 150, 373-381. PubMed Europe PubMed
Okuno,T., Yamada-Inagawa,T., Karata,K., Yamanaka,K. and Ogura,T. Spectrometric analysis of degradation of a physiological substrate sigma32 by Escherichia coli AAA protease FtsH J Struct Biol (2004) 146, 148-154. PubMed Europe PubMed DOI
Saikawa,N., Akiyama,Y. and Ito,K. FtsH exists as an exceptionally large complex containing HflKC in the plasma membrane of Escherichia coli J Struct Biol (2004) 146, 123-129. PubMed Europe PubMed DOI

2003

[YEAR:16-5-2003]Akiyama,Y. and Ito,K. Reconstitution of membrane proteolysis by FtsH J Biol Chem (16-5-2003) 278, 18146-18153. PubMed Europe PubMed DOI
[YEAR:16-9-2003]Bruckner,R.C., Gunyuzlu,P.L. and Stein,R.L. Coupled kinetics of ATP and peptide hydrolysis by Escherichia coli FtsH protease Biochemistry (16-9-2003) 42, 10843-10852. PubMed Europe PubMed DOI
Herman,C., Prakash,S., Lu,C.Z., Matouschek,A. and Gross,C.A. Lack of a robust unfoldase activity confers a unique level of substrate specificity to the universal AAA protease FtsH Mol Cell (2003) 11, 659-669. PubMed Europe PubMed DOI
[YEAR:12-12-2003]Yamada-Inagawa,T., Okuno,T., Karata,K., Yamanaka,K. and Ogura,T. Conserved pore residues in the AAA protease FtsH are important for proteolysis and its coupling to ATP hydrolysis J Biol Chem (12-12-2003) 278, 50182-50187. PubMed Europe PubMed DOI

2002

[YEAR:11-6-2002]Akiyama,Y. Proton-motive force stimulates the proteolytic activity of FtsH, a membrane-bound ATP- dependent protease in Escherichiacoli Proc Natl Acad Sci U S A (11-6-2002) 99, 8066-8071. PubMed Europe PubMed DOI PMC EPMC
Chiba,S., Akiyama,Y. and Ito,K. Membrane protein degradation by FtsH can be initiated from either end J Bacteriol (2002) 184, 4775-4782. PubMed Europe PubMed DOI PMC EPMC
Fischer,B., Rummel,G., Aldridge,P. and Jenal,U. The FtsH protease is involved in development, stress response and heat shock control in Caulobacter crescentus Mol Microbiol (2002) 44, 461-478. PubMed Europe PubMed DOI
Krzywda,S., Brzozowski,A.M., Verma,C., Karata,K., Ogura,T. and Wilkinson,A.J. The crystal structure of the AAA domain of the ATP-dependent protease FtsH of Escherichia coli at 1.5 A resolution Structure (2002) 10, 1073-1083. PubMed Europe PubMed DOI S
[YEAR:12-2-2002]Saikawa,N., Ito,K. and Akiyama,Y. Identification of glutamic acid 479 as the gluzincin coordinator of zinc in FtsH (HflB) Biochemistry (12-2-2002) 41, 1861-1868. PubMed Europe PubMed DOI

2001

[YEAR:26-6-2001]Akiyama,Y. and Ito,K. Roles of homooligomerization and membrane association in ATPase and proteolytic activities of FtsH in vitro Biochemistry (26-6-2001) 40, 7687-7693. PubMed Europe PubMed
Anilkumar,G., Srinivasan,R., Anand,S.P. and Ajitkumar,P. Bacterial cell division protein FtsZ is a specific substrate for the AAA family protease FtsH Microbiology (Reading, Engl.) (2001) 147, 516-517. PubMed Europe PubMed
[YEAR:23-3-2001]Bertani,D., Oppenheim,A.B. and Narberhaus,F. An internal region of the RpoH heat shock transcription factor is critical for rapid degradation by the FtsH protease FEBS Lett (23-3-2001) 493, 17-20. PubMed Europe PubMed DOI
Cooper,K.W. and Baneyx,F. Escherichia coli FtsH (HflB) degrades a membrane-associated TolAI-II-beta-lactamase fusion protein under highly denaturing conditions Protein Expr Purif (2001) 21, 323-332. PubMed Europe PubMed DOI
Inagawa,T., Kato,J., Niki,H., Karata,K. and Ogura,T. Defective plasmid partition in ftsH mutants of Escherichia coli Mol Gen Genet (2001) 265, 755-762. DOI
Karata,K., Verma,C.S., Wilkinson,A.J. and Ogura,T. Probing the mechanism of ATP hydrolysis and substrate translocation in the AAA protease FtsH by modelling and mutagenesis Mol Microbiol (2001) 39, 890-903. PubMed Europe PubMed DOI
Tomoyasu,T., Arsene,F., Ogura,T. and Bukau,B. The C terminus of sigma(32) is not essential for degradation by FtsH J Bacteriol (2001) 183, 5911-5917. PubMed Europe PubMed DOI PMC EPMC

2000

[YEAR:1-8-2000]Akiyama,Y. and Ito,K. Roles of multimerization and membrane association in the proteolytic functions of FtsH (HflB) EMBO J (1-8-2000) 19, 3888-3895. PubMed Europe PubMed DOI PMC EPMC
Chiba,S., Akiyama,Y., Mori,H., Matsuo,E. and Ito,K. Length recognition at the N-terminal tail for the initiation of FtsH-mediated proteolysis EMBO Rep (2000) 1, 47-52. PubMed Europe PubMed DOI PMC EPMC
[YEAR:1-8-2000]Jayasekera,M.M.K., Foltin,S.K., Olson,E.R. and Holler,T.P. Escherichia coli requires the protease activity of FtsH for growth Arch Biochem Biophys (1-8-2000) 380, 103-107. PubMed Europe PubMed DOI
[YEAR:16-6-2000]Shotland,Y., Teff,D., Koby,S., Kobiler,O. and Oppenheim,A.B. Characterization of a conserved alpha-helical, coiled-coil motif at the C-terminal domain of the ATP-dependent FtsH (HflB) protease of Escherichia coli J Mol Biol (16-6-2000) 299, 953-964. PubMed Europe PubMed DOI
Shotland,Y., Shifrin,A., Ziv,T., Teff,D., Koby,S., Kobiler,O. and Oppenheim,A.B. Proteolysis of bacteriophage lambda CII by Escherichia coli FtsH (HflB) J Bacteriol (2000) 182, 3111-3116. PubMed Europe PubMed DOI PMC EPMC
[YEAR:1-2-2000]Teff,D., Koby,S., Shotland,Y., Ogura,T. and Oppenheim,A.B. A colicin-tolerant Escherichia coli mutant that confers Hfl phenotype carries two mutations in the region coding for the C-terminal domain of FtsH (HflB) FEMS Microbiol Lett (1-2-2000) 183, 115-117. PubMed Europe PubMed DOI
Urech,C., Koby,S., Oppenheim,A.B., Munchbach,M., Hennecke,H. and Narberhaus,F. Differential degradation of Escherichia coli sigma32 and Bradyrhizobium japonicum RpoH factors by the FtsH protease Eur J Biochem (2000) 267, 4831-4839. PubMed Europe PubMed DOI

1999

[YEAR:7-9-1999]Akiyama,Y. Self-processing of FtsH and its implication for the cleavage specificity of this protease Biochemistry (7-9-1999) 38, 11693-11699. PubMed Europe PubMed DOI
Blaszczak,A., Georgopoulos,C. and Liberek,K. On the mechanism of FtsH-dependent degradation of the sigma32 transcriptional regulator of Escherichia coli and the role of the DnaK chaperone machine Mol Microbiol (1999) 31, 157-166. PubMed Europe PubMed DOI
Carmona,M. and de Lorenzo,V. Involvement of the FtsH (HflB) protease in the activity of sigma54 promoters Mol Microbiol (1999) 31, 261-270. PubMed Europe PubMed DOI
[YEAR:10-9-1999]Karata,K., Inagawa,T., Wilkinson,A.J., Tatsuta,T. and Ogura,T. Dissecting the role of a conserved motif (the second region of homology) in the AAA family of ATPases. Site-directed mutagenesis of the ATP-dependent protease FtsH J Biol Chem (10-9-1999) 274, 26225-26232. PubMed Europe PubMed DOI
[YEAR:1-6-1999]Kihara,A., Akiyama,Y. and Ito,K. Dislocation of membrane proteins in FtsH-mediated proteolysis EMBO J (1-6-1999) 18, 2970-2981. PubMed Europe PubMed DOI PMC EPMC
[YEAR:5-11-1999]Makino,S., Makino,T., Abe,K., Hashimoto,J., Tatsuta,T., Kitagawa,M., Mori,H., Ogura,T., Fujii,T., Fushinobu,S., Wakagi,T., Matsuzawa,H. and Makinoa,T. Second transmembrane segment of FtsH plays a role in its proteolytic activity and homo-oligomerization FEBS Lett (5-11-1999) 460, 554-558. PubMed Europe PubMed DOI
Narberhaus,F., Urech,C. and Hennecke,H. Characterization of the Bradyrhizobium japonicum ftsH gene and its product J Bacteriol (1999) 181, 7394-7397. PubMed Europe PubMed PMC EPMC
Ogura,T., Inoue,K., Tatsuta,T., Suzaki,T., Karata,K., Young,K., Su,L.H., Fierke,C.A., Jackman,J.E., Raetz,C.R., Coleman,J., Tomoyasu,T. and Matsuzawa,H. Balanced biosynthesis of major membrane components through regulated degradation of the committed enzyme of lipid A biosynthesis by the AAA protease FtsH (HflB) in Escherichia coli Mol Microbiol (1999) 31, 833-844. PubMed Europe PubMed DOI
Schumann,W. FtsH - a single-chain charonin? FEMS Microbiol Rev (1999) 23, 1-11. PubMed Europe PubMed DOI V

1998

[YEAR:28-8-1998]Akiyama,Y., Kihara,A., Mori,H., Ogura,T. and Ito,K. Roles of the periplasmic domain of Escherichia coli FtsH (HflB) in protein interactions and activity modulation J Biol Chem (28-8-1998) 273, 22326-22333. PubMed Europe PubMed DOI
Akiyama,Y., Ehrmann,M., Kihara,A. and Ito,K. Polypeptide binding of Escherichia coli FtsH (HflB) Mol Microbiol (1998) 28, 803-812. PubMed Europe PubMed DOI
[YEAR:1-5-1998]Herman,C., Thevenet,D., Bouloc,P., Walker,G.C. and D'Ari,R. Degradation of carboxy-terminal-tagged cytoplasmic proteins by the Escherichia coli protease HflB (FtsH) Genes Dev (1-5-1998) 12, 1348-1355. PubMed Europe PubMed PMC EPMC
[YEAR:29-5-1998]Kihara,A., Akiyama,Y. and Ito,K. Different pathways for protein degradation by the FtsH/HflKC membrane-embedded protease complex: An implication from the interference by a mutant form of a new substrate protein, YccA J Mol Biol (29-5-1998) 279, 175-188. PubMed Europe PubMed DOI
Melchers,K., Wiegert,T., Buhmann,A., Postius,S., Schafer,K.P. and Schumann,W. The Helicobacter felis ftsH gene encoding an ATP-dependent metalloprotease can replace the Escherichia coli homologue for growth and phage lambda lysogenization Arch Microbiol (1998) 169, 393-396. PubMed Europe PubMed DOI
Wang,R.F., O'Hara,E.B., Aldea,M., Bargmann,C.I., Gromley,H. and Kushner,S.R. Escherichia coli mrsC is an allele of hflB, encoding a membrane-associated ATPase and protease that is required for mRNA decay J Bacteriol (1998) 180, 1929-1938. PubMed Europe PubMed PMC EPMC

1997

Herman,C., Thevenet,D., D'Ari,R. and Bouloc,P. The HflB protease of Escherichia coli degrades its inhibitor lambda CIII J Bacteriol (1997) 179, 358-363. PubMed Europe PubMed PMC EPMC
Kihara,A., Akiyama,Y. and Ito,K. Host regulation of lysogenic decision in bacteriophage lambda: transmembrane modulation of FtsH (HflB), the cII degrading protease, by HflKC (HflA) Proc Natl Acad Sci U S A (1997) 94, 5544-5549. PubMed Europe PubMed DOI PMC EPMC
Lupas,A., Flanagan,J.M., Tamura,T. and Baumeister,W. Self-compartmentalizing proteases Trends Biochem Sci (1997) 22, 399-404. PubMed Europe PubMed DOI
Makino,S., Qu,J.N., Uemori,K., Ichikawa,H., Ogura,T. and Matsuzawa,H. A silent mutation in the ftsh gene of Escherichia coli that affects ftsH protein production and colicin tolerance Mol Gen Genet (1997) 254, 578-583. PubMed Europe PubMed DOI
Shotland,Y., Koby,S., Teff,D., Mansur,N., Oren,D.A., Tatematsu,K., Tomoyasu,T., Kessel,M., Bukau,B., Ogura,T. and Oppenheim,A.B. Proteolysis of the phage lambda CII regulatory protein by FtsH (HflB) of Escherichia coli Mol Microbiol (1997) 24, 1303-1310. PubMed Europe PubMed
Suzuki,C.K., Rep,M., van Dijl,J.M., Suda,K., Grivell,L.A. and Schatz,G. ATP-dependent proteases that also chaperone protein biogenesis Trends Biochem Sci (1997) 22, 118-123. PubMed Europe PubMed DOI V

1996

Akiyama,Y., Kihara,A., Tokuda,H. and Ito,K. FtsH (HflB) is an ATP-dependent protease selectively acting on SecY and some other membrane proteins J Biol Chem (1996) 271, 31196-31201. PubMed Europe PubMed DOI
Akiyama,Y., Kihara,A. and Ito,K. Subunit a of proton ATPase F0 sector is a substrate of the FtsH protease in Escherichia coli FEBS Lett (1996) 399, 26-28. PubMed Europe PubMed DOI
Gottesman,S. Proteases and their targets in Escherichia coli Annu Rev Genet (1996) 30, 465-506. PubMed Europe PubMed DOI V
Kihara,A., Akiyama,Y. and Ito,K. A protease complex in the Escherichia coli plasma membrane: HflKC (HflA) forms a complex with FtsH (HflB), regulating its proteolytic activity against SecY EMBO J (1996) 15, 6122-6131. PubMed Europe PubMed PMC EPMC
Qu,J.N., Makino,S.I., Adachi,H., Koyama,Y., Akiyama,Y., Ito,K., Tomoyasu,T., Ogura,T. and Matsuzawa,H. The tolZ gene of Escherichia coli is identified as the ftsH gene J Bacteriol (1996) 178, 3457-3461. PubMed Europe PubMed PMC EPMC
Tsui,H.C., Feng,G. and Winkler,M.E. Transcription of the mutL repair, miaA tRNA modification, hfq pleiotropic regulator, and hflA region protease genes of Escherichia coli K-12 from clustered Esigma32-specific promoters during heat shock J Bacteriol (1996) 178, 5719-5731. PubMed Europe PubMed PMC EPMC

1995

Akiyama,Y., Yoshihisa,T. and Ito,K. FtsH, a membrane-bound ATPase, forms a complex in the cytoplasmic membrane of Escherichia coli J Biol Chem (1995) 270, 23485-23490. PubMed Europe PubMed DOI
Havarstein,L.S., Diep,D.B. and Nes,I.F. A family of bacteriocin ABC transporters carry out proteolytic processing of their substrates concomitant with export Mol Microbiol (1995) 16, 229-240. PubMed Europe PubMed DOI
Herman,C., Thevenet,D., D'Ari,R. and Bouloc,P. Degradation of sigma 32, the heat shock regulator in Escherichia coli, is governed by HflB Proc Natl Acad Sci U S A (1995) 92, 3516-3520. PubMed Europe PubMed PMC EPMC
Kihara,A., Akiyama,Y. and Ito,K. FtsH is required for proteolytic elimination of uncomplexed forms of SecY, an essential protein translocase subunit Proc Natl Acad Sci U S A (1995) 92, 4532-4536. PubMed Europe PubMed PMC EPMC
Tomoyasu,T., Gamer,J., Bukau,B., Kanemori,M., Mori,H., Rutman,A.J., Oppenheim,A.B., Yura,T., Yamanaka,K., Niki,H., Hiraga,S. and Ogura,T. Escherichia coli FtsH is a membrane-bound, ATP-dependent protease which degrades the heat-shock transcription factor sigma32 EMBO J (1995) 14, 2551-2560. PubMed Europe PubMed PMC EPMC

1994

Akiyama,Y., Shirai,Y. and Ito,K. Involvement of FtsH in protein assembly into and through the membrane. II. Dominant mutations affecting FtsH functions J Biol Chem (1994) 269, 5225-5229. PubMed Europe PubMed
Akiyama,Y., Ogura,T. and Ito,K. Involvement of FtsH in protein assembly into and through the membrane. I. Mutations that reduce retention efficiency of a cytoplasmic reporter J Biol Chem (1994) 269, 5218-5224. PubMed Europe PubMed

1993

Herman,C., Ogura,T., Tomoyasu,T., Hiraga,S., Akiyama,Y., Ito,K., Thomas,R., D'Ari,R. and Bouloc,P. Cell growth and lambda phage development controlled by the same essential Escherichia coli gene, ftsH/hflB Proc Natl Acad Sci U S A (1993) 90, 10861-10865. PubMed Europe PubMed DOI PMC EPMC
Noble,J.A., Innis,M.A., Koonin,E.V., Rudd,K.E., Banuett,F. and Herskowitz,I. The Escherichia coli hflA locus encodes a putative GTP-binding protein and two membrane proteins, one of which contains a protease-like domain Proc Natl Acad Sci U S A (1993) 90, 10866-10870. PubMed Europe PubMed DOI PMC EPMC
Tomoyasu,T., Yamanaka,K., Murata,K., Suzaki,T., Bouloc,P., Kato,A., Niki,H., Hiraga,S. and Ogura,T. Topology and subcellular localization of FtsH protein in Escherichia coli J Bacteriol (1993) 175, 1352-1357. PubMed Europe PubMed PMC EPMC
Tomoyasu,T., Yuki,T., Morimura,S., Mori,H., Yamanaka,K., Niki,H., Hiraga,S. and Ogura,T. The Escherichia coli FtsH protein is a prokaryotic member of a protein family of putative ATPases involved in membrane functions, cell cycle control, and gene expression J Bacteriol (1993) 175, 1344-1351. PubMed Europe PubMed PMC EPMC

1992

Begg,K.J., Tomoyasu,T., Donachie,W.D., Khattar,M., Niki,H., Yamanaka,K., Hiraga,S. and Ogura,T. Escherichia coli mutant Y16 is a double mutant carrying thermosensitive ftsH and ftsI mutations J Bacteriol (1992) 174, 2416-2417. PubMed Europe PubMed PMC EPMC

1988

Cheng,H.H., Muhlrad,P.J., Hoyt,M.A. and Echols,H. Cleavage of the cII protein of phage lambda by purified HflA protease: control of the switch between lysis and lysogeny Proc Natl Acad Sci U S A (1988) 85, 7882-7886. PubMed Europe PubMed PMC EPMC