Substrates for peptidase M12.155: trimerelysin II

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
Abz-Gly-Phe-Arg-Leu-Leu-Dna Abz-Gly-Phe-Arg+Leu-Leu-Dna S Abz Gly Phe Arg Leu Leu EDD - Takeya et al., 1993
Abz-Ser-Pro-Met-Leu-Dna Abz-Ser-Pro+Met-Leu-Dna S - Abz Ser Pro Met Leu EDD - Takeya et al., 1993
Abz-Thr-Glu-Lys-Leu-Val-Dna Abz-Thr-Glu-Lys+Leu-Val-Dna S Abz Thr Glu Lys Leu Val EDD - Takeya et al., 1993
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn+Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N - Phe Val Asn Gln His Leu Cya
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His+Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Cya Gly Ser His Leu Val Glu Ala
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala+Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Leu Val Glu Ala Leu Tyr Leu Val
insulin B-chain (oxidized) P01308 25-54 peptide-Ala38+Leu-peptide N Leu Val Glu Ala Leu Tyr Leu Val Chou et al., 2013
insulin B-chain (oxidized) P01308 25-54 peptide-Tyr40+Leu-peptide N Glu Ala Leu Tyr Leu Val Cys Gly Chou et al., 2013
insulin B-chain (oxidized) P01308 25-54 peptide-His34+Leu-peptide N Cys Gly Ser His Leu Val Glu Ala Chou et al., 2013
insulin B-chain (oxidized) P01308 25-54 peptide-Phe48+Phe-peptide N Glu Arg Gly Phe Phe Tyr Thr Pro Chou et al., 2013
insulin B-chain (oxidized) P01308 25-54 peptide-Gln28+His-peptide N Phe Val Asn Gln His Leu Cys Gly Chou et al., 2013
Z-Gly-Pro-Leu-Gly-Pro Z-Gly-Pro+Leu-Gly-Pro S - Z Gly Pro Leu Gly Pro -