Substrates for peptidase M12.026: ADAMTS16 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
fibronectin	P11276	33-2477	peptide-Ser285+Phe-peptide	P	MS	Gly	Ser	Gly	Ser	Phe	Thr	Asp	Val	Schnellmann et al., 2018
fibronectin	P11276	33-2477	peptide-Asp556+Pro-peptide	P	MS	Trp	Lys	Cys	Asp	Pro	Ile	Asp	Gln	Schnellmann et al., 2018
gelsolin	P13020	26-780	peptide-Tyr463+Gly-peptide	P	MS	Pro	Ala	Thr	Tyr	Gly	Gln	Phe	Tyr	Schnellmann et al., 2018
latent-transforming growth factor beta-binding protein 1	Q8CG19	24-1712	peptide-Tyr1579+Gly-peptide	P	MS	Arg	Arg	Pro	Tyr	Gly	Arg	Asp	Ala	Schnellmann et al., 2018
periostin	Q62009	24-838	peptide-Thr603+Leu-peptide	P	MS	Val	Asn	Glu	Thr	Leu	Leu	Val	Asn	Schnellmann et al., 2018