Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P13020

,

Click here to display alignment and conservation of cleavage sites of this sequence with close homologues. This will take a few moments.

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
25	unknown peptidase	1-780	P		NT	<%Agarwal et al., 2012[]%>
312	cathepsin D	26-780	P		MS	Impens et al., 2010
312	cathepsin E	26-780	P		MS	Impens et al., 2010
323	matrix metallopeptidase-2	26-780	N		MS	Kleifeld et al., 2010
401	caspase-3	26-780	P			Kothakota et al., 1997
433	matrix metallopeptidase-2	26-780	N		MS	Kleifeld et al., 2010
507	cathepsin D	26-780	P		MS	Impens et al., 2010
508	cathepsin D	26-780	P		MS	Impens et al., 2010
511	cathepsin E	26-780	P		MS	Impens et al., 2010
536	cathepsin D	26-780	P		MS	Impens et al., 2010