Substrates for peptidase M12.021: ADAMTS9 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB	MERNUM
aggrecan core protein	P13608	17-2364	peptide-Glu1790+Ala-peptide	P	AB	Thr	Ala	Gln	Glu	Ala	Gly	Glu	Gly	Somerville et al., 2003	19900
Versican core protein	P81282-2	21-2394	peptide-Glu436+Ala-peptide	P	AB	Glu	Ala	Ala	Glu	Ala	Arg	Arg	Gly	Somerville et al., 2003