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Literature for peptidase M12.021: ADAMTS9 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

(Topics flags: M Mutation, P Specificity, I Inhibitor, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Ahmed,M., Fischer,S., Robert,K.L., Lange,K.I., Stuck,M.W., Best,S., Johnson,C.A., Pazour,G.J., Blacque,O.E. and Nandadasa,S.<br>Cleavage of the Meckel-Gruber syndrome protein TMEM67 by ADAMTS9 uncouples Wnt signaling and ciliogenesis<br>Nat Commun (2025) 16, 4946-4946. PubMed  Europe PubMed DOI  PMC  EPMC
  2. Apte,S.S.<br>A serendipitous convergence- insights on extracellular matrix proteoglycans and their proteolysis in ensuring successful mammalian birth<br>Dev Biol (2025) 530, 70-76. PubMed  Europe PubMed DOI
  3. Martin,D.R., Sardelli,G., Burkhard,T., Fowkes,M.M., Minns,A.F., Moschini,R., Del Corso,A., de Groot,R., Apte,S.S. and Santamaria,S.<br>Characterization of ADAMTS9 proteoglycanase activity: comparison with ADAMTS1, ADAMTS4 and ADAMTS5<br>J Biol Chem (2025) , 110301-110301. PubMed  Europe PubMed DOI
    4. 2024
  4. Pietrzak,J., Swiechowski,R., Wosiak,A., Wcislo,S. and Balcerczak,E.<br>ADAMTS Gene-Derived circRNA Molecules in Non-Small-Cell Lung Cancer: Expression Profiling, Clinical Correlations and Survival Analysis<br>Int J Mol Sci (2024) 25 PubMed  Europe PubMed DOI  PMC  EPMC
  5. Yu,Q., Guo,K., Yang,Y., Liu,H., Huang,Y. and Li,W.<br>LncRNA ADAMTS9-AS2 regulates periodontal ligament cell migration under mechanical compression via ADAMTS9/fibronectin<br>J Periodontal Res (2024) 59, 174-186. PubMed  Europe PubMed DOI  K
    6. 2022
  6. Tayman,M.A. and Koyuncu,I.<br>Differential gene expression of ADAMTS-1, ADAMTS-9 and TIMP-3 in periodontitis<br>Biotech Histochem (2022) , 1-6. PubMed  Europe PubMed DOI
    7. 2020
  7. Satz-Jacobowitz,B. and Hubmacher,D.<br>The quest for substrates and binding partners: A critical barrier for understanding the role of ADAMTS proteases in musculoskeletal development and disease<br>Dev Dyn (2020) 250, 8-26. PubMed  Europe PubMed DOI  V
    8. 2019
  8. Nandadasa,S., Kraft,C.M., Wang,L.W., O'Donnell,A., Patel,R., Gee,H.Y., Grobe,K., Cox,T.C., Hildebrandt,F. and Apte,S.S.<br>Secreted metalloproteases ADAMTS9 and ADAMTS20 have a non-canonical role in ciliary vesicle growth during ciliogenesis<br>Nat Commun (2019) 10, 953-953. PubMed  Europe PubMed DOI  PMC  EPMC
    9. 2018
  9. Tharmarajah,G., Eckhard,U., Jain,F., Marino,G., Prudova,A., Urtatiz,O., Fuchs,H., de Angelis,M.H., Overall,C.M. and Van Raamsdonk,C.D.<br>Melanocyte development in the mouse tail epidermis requires the Adamts9 metalloproteinase<br>Pigment Cell Melanoma Res (2018) 31, 693-707. PubMed  Europe PubMed DOI
    10. 2016
  10. Barreto-Luis,A., Pino-Yanes,M., Corrales,A., Campo,P., Callero,A., Acosta-Herrera,M., Cumplido,J., Ma,S.F., Martinez-Tadeo,J., Villar,J., Garcia,J.G., Carrillo,T., Carracedo,A., Blanca,M. and Flores,C.<br>Genome-wide association study in Spanish identifies ADAM metallopeptidase with thrombospondin type 1 motif, 9 (ADAMTS9), as a novel asthma susceptibility gene<br>J Allergy Clin Immunol (2016) 137, 964-966. PubMed  Europe PubMed DOI
    11. 2015
  11. Dubail,J. and Apte,S.S.<br>Insights on ADAMTS proteases and ADAMTS-like proteins from mammalian genetics<br>Matrix Biol (2015) 44-46, 24-37. PubMed  Europe PubMed DOI
    12. 2014
  12. Dubail,J., Aramaki-Hattori,N., Bader,H.L., Nelson,C.M., Katebi,N., Matuska,B., Olsen,B.R. and Apte,S.S.<br>A new Adamts9 conditional mouse allele identifies its non-redundant role in interdigital web regression<br>Genesis (2014) 52, 702-712. PubMed  Europe PubMed DOI  K
    13. 2012
  13. Apte,S.S.<br>ADAMTS9<br>[ISSN:978-0-12-407744-7] (2012) 3, 1186-1191. DOI
  14. Yoshina,S., Sakaki,K., Yonezumi-Hayashi,A., Gengyo-Ando,K., Inoue,H., Iino,Y. and Mitani,S.<br>Identification of a novel ADAMTS9/GON-1 function for protein transport from the ER to the Golgi<br>Mol Biol Cell (2012) 23, 1728-1741. PubMed  Europe PubMed DOI
    15. 2010
  15. Enomoto,H., Nelson,C.M., Somerville,R.P., Mielke,K., Dixon,L.J., Powell,K. and Apte,S.S.<br>Cooperation of two ADAMTS metalloproteases in closure of the mouse palate identifies a requirement for versican proteolysis in regulating palatal mesenchyme proliferation<br>Development (2010) 137, 4029-4038. PubMed  Europe PubMed DOI  PMC  EPMC
  16. Kern,C.B., Wessels,A., McGarity,J., Dixon,L.J., Alston,E., Argraves,W.S., Geeting,D., Nelson,C.M., Menick,D.R. and Apte,S.S.<br>Reduced versican cleavage due to Adamts9 haploinsufficiency is associated with cardiac and aortic anomalies<br>Matrix Biol (2010) 29, 304-316. PubMed  Europe PubMed DOI
  17. Koo,B.H. and Apte,S.S.<br>Cell-surface processing of the metalloprotease pro-ADAMTS9 is influenced by the chaperone GRP94/GP96<br>J Biol Chem (2010) 285, 197-205. PubMed  Europe PubMed DOI
  18. Koo,B.H., Coe,D.M., Dixon,L.J., Somerville,R.P., Nelson,C.M., Wang,L.W., Young,M.E., Lindner,D.J. and Apte,S.S.<br>ADAMTS9 is a cell-autonomously acting, anti-angiogenic metalloprotease expressed by microvascular endothelial cells<br>Am J Pathol (2010) 176, 1494-1504. PubMed  Europe PubMed DOI
  19. Lo,P.H., Lung,H.L., Cheung,A.K., Apte,S.S., Chan,K.W., Kwong,F.M., Ko,J.M., Cheng,Y., Law,S., Srivastava,G., Zabarovsky,E.R., Tsao,S.W., Tang,J.C., Stanbridge,E.J. and Lung,M.L.<br>Extracellular protease ADAMTS9 suppresses esophageal and nasopharyngeal carcinoma tumor formation by inhibiting angiogenesis<br>Cancer Res (2010) 70, 5567-5576. PubMed  Europe PubMed DOI
    20. 2008
  20. Silver,D.L., Hou,L., Somerville,R., Young,M.E., Apte,S.S. and Pavan,W.J.<br>The secreted metalloprotease ADAMTS20 is required for melanoblast survival<br>PLoS Genet (2008) 4, e1000003-e1000003. PubMed  Europe PubMed DOI  PMC  EPMC
    21. 2007
  21. Koo,B.H., Longpre,J.M., Somerville,R.P., Alexander,J.P., Leduc,R. and Apte,S.S.<br>Regulation of ADAMTS9 secretion and enzymatic activity by its propeptide<br>J Biol Chem (2007) 282, 16146-16154. PubMed  Europe PubMed DOI  I
    22. 2003
  22. Rao,C., Foernzler,D., Loftus,S.K., Liu,S., McPherson,J.D., Jungers,K.A., Apte,S.S., Pavan,W.J. and Beier,D.R.<br>A defect in a novel ADAMTS family member is the cause of the belted white-spotting mutation<br>Development (2003) 130, 4665-4672. PubMed  Europe PubMed DOI  M
  23. [YEAR:14-3-2003]Somerville,R.P., Longpre,J.M., Jungers,K.A., Engle,J.M., Ross,M., Evanko,S., Wight,T.N., Leduc,R. and Apte,S.S.<br>Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1<br>J Biol Chem (14-3-2003) 278, 9503-9513. PubMed  Europe PubMed DOI  P

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