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Literature for peptidase M12.021: ADAMTS9 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

(Topics flags: M Mutation, P Specificity, I Inhibitor, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Ahmed,M., Fischer,S., Robert,K.L., Lange,K.I., Stuck,M.W., Best,S., Johnson,C.A., Pazour,G.J., Blacque,O.E. and Nandadasa,S.
    Cleavage of the Meckel-Gruber syndrome protein TMEM67 by ADAMTS9 uncouples Wnt signaling and ciliogenesis
    Nat Commun (2025) 16, 4946-4946. PubMed  Europe PubMed DOI  PMC  EPMC
  2. Apte,S.S.
    A serendipitous convergence- insights on extracellular matrix proteoglycans and their proteolysis in ensuring successful mammalian birth
    Dev Biol (2025) 530, 70-76. PubMed  Europe PubMed DOI
  3. Martin,D.R., Sardelli,G., Burkhard,T., Fowkes,M.M., Minns,A.F., Moschini,R., Del Corso,A., de Groot,R., Apte,S.S. and Santamaria,S.
    Characterization of ADAMTS9 proteoglycanase activity: comparison with ADAMTS1, ADAMTS4 and ADAMTS5
    J Biol Chem (2025) , 110301-110301. PubMed  Europe PubMed DOI
    4. 2024
  4. Pietrzak,J., Swiechowski,R., Wosiak,A., Wcislo,S. and Balcerczak,E.
    ADAMTS Gene-Derived circRNA Molecules in Non-Small-Cell Lung Cancer: Expression Profiling, Clinical Correlations and Survival Analysis
    Int J Mol Sci (2024) 25 PubMed  Europe PubMed DOI  PMC  EPMC
  5. Yu,Q., Guo,K., Yang,Y., Liu,H., Huang,Y. and Li,W.
    LncRNA ADAMTS9-AS2 regulates periodontal ligament cell migration under mechanical compression via ADAMTS9/fibronectin
    J Periodontal Res (2024) 59, 174-186. PubMed  Europe PubMed DOI  K
    6. 2022
  6. Tayman,M.A. and Koyuncu,I.
    Differential gene expression of ADAMTS-1, ADAMTS-9 and TIMP-3 in periodontitis
    Biotech Histochem (2022) , 1-6. PubMed  Europe PubMed DOI
    7. 2020
  7. Satz-Jacobowitz,B. and Hubmacher,D.
    The quest for substrates and binding partners: A critical barrier for understanding the role of ADAMTS proteases in musculoskeletal development and disease
    Dev Dyn (2020) 250, 8-26. PubMed  Europe PubMed DOI  V
    8. 2019
  8. Nandadasa,S., Kraft,C.M., Wang,L.W., O'Donnell,A., Patel,R., Gee,H.Y., Grobe,K., Cox,T.C., Hildebrandt,F. and Apte,S.S.
    Secreted metalloproteases ADAMTS9 and ADAMTS20 have a non-canonical role in ciliary vesicle growth during ciliogenesis
    Nat Commun (2019) 10, 953-953. PubMed  Europe PubMed DOI  PMC  EPMC
    9. 2018
  9. Tharmarajah,G., Eckhard,U., Jain,F., Marino,G., Prudova,A., Urtatiz,O., Fuchs,H., de Angelis,M.H., Overall,C.M. and Van Raamsdonk,C.D.
    Melanocyte development in the mouse tail epidermis requires the Adamts9 metalloproteinase
    Pigment Cell Melanoma Res (2018) 31, 693-707. PubMed  Europe PubMed DOI
    10. 2016
  10. Barreto-Luis,A., Pino-Yanes,M., Corrales,A., Campo,P., Callero,A., Acosta-Herrera,M., Cumplido,J., Ma,S.F., Martinez-Tadeo,J., Villar,J., Garcia,J.G., Carrillo,T., Carracedo,A., Blanca,M. and Flores,C.
    Genome-wide association study in Spanish identifies ADAM metallopeptidase with thrombospondin type 1 motif, 9 (ADAMTS9), as a novel asthma susceptibility gene
    J Allergy Clin Immunol (2016) 137, 964-966. PubMed  Europe PubMed DOI
    11. 2015
  11. Dubail,J. and Apte,S.S.
    Insights on ADAMTS proteases and ADAMTS-like proteins from mammalian genetics
    Matrix Biol (2015) 44-46, 24-37. PubMed  Europe PubMed DOI
    12. 2014
  12. Dubail,J., Aramaki-Hattori,N., Bader,H.L., Nelson,C.M., Katebi,N., Matuska,B., Olsen,B.R. and Apte,S.S.
    A new Adamts9 conditional mouse allele identifies its non-redundant role in interdigital web regression
    Genesis (2014) 52, 702-712. PubMed  Europe PubMed DOI  K
    13. 2012
  13. Apte,S.S.
    ADAMTS9
    [ISSN:978-0-12-407744-7] (2012) 3, 1186-1191. DOI
  14. Yoshina,S., Sakaki,K., Yonezumi-Hayashi,A., Gengyo-Ando,K., Inoue,H., Iino,Y. and Mitani,S.
    Identification of a novel ADAMTS9/GON-1 function for protein transport from the ER to the Golgi
    Mol Biol Cell (2012) 23, 1728-1741. PubMed  Europe PubMed DOI
    15. 2010
  15. Enomoto,H., Nelson,C.M., Somerville,R.P., Mielke,K., Dixon,L.J., Powell,K. and Apte,S.S.
    Cooperation of two ADAMTS metalloproteases in closure of the mouse palate identifies a requirement for versican proteolysis in regulating palatal mesenchyme proliferation
    Development (2010) 137, 4029-4038. PubMed  Europe PubMed DOI  PMC  EPMC
  16. Kern,C.B., Wessels,A., McGarity,J., Dixon,L.J., Alston,E., Argraves,W.S., Geeting,D., Nelson,C.M., Menick,D.R. and Apte,S.S.
    Reduced versican cleavage due to Adamts9 haploinsufficiency is associated with cardiac and aortic anomalies
    Matrix Biol (2010) 29, 304-316. PubMed  Europe PubMed DOI
  17. Koo,B.H. and Apte,S.S.
    Cell-surface processing of the metalloprotease pro-ADAMTS9 is influenced by the chaperone GRP94/GP96
    J Biol Chem (2010) 285, 197-205. PubMed  Europe PubMed DOI
  18. Koo,B.H., Coe,D.M., Dixon,L.J., Somerville,R.P., Nelson,C.M., Wang,L.W., Young,M.E., Lindner,D.J. and Apte,S.S.
    ADAMTS9 is a cell-autonomously acting, anti-angiogenic metalloprotease expressed by microvascular endothelial cells
    Am J Pathol (2010) 176, 1494-1504. PubMed  Europe PubMed DOI
  19. Lo,P.H., Lung,H.L., Cheung,A.K., Apte,S.S., Chan,K.W., Kwong,F.M., Ko,J.M., Cheng,Y., Law,S., Srivastava,G., Zabarovsky,E.R., Tsao,S.W., Tang,J.C., Stanbridge,E.J. and Lung,M.L.
    Extracellular protease ADAMTS9 suppresses esophageal and nasopharyngeal carcinoma tumor formation by inhibiting angiogenesis
    Cancer Res (2010) 70, 5567-5576. PubMed  Europe PubMed DOI
    20. 2008
  20. Silver,D.L., Hou,L., Somerville,R., Young,M.E., Apte,S.S. and Pavan,W.J.
    The secreted metalloprotease ADAMTS20 is required for melanoblast survival
    PLoS Genet (2008) 4, e1000003-e1000003. PubMed  Europe PubMed DOI  PMC  EPMC
    21. 2007
  21. Koo,B.H., Longpre,J.M., Somerville,R.P., Alexander,J.P., Leduc,R. and Apte,S.S.
    Regulation of ADAMTS9 secretion and enzymatic activity by its propeptide
    J Biol Chem (2007) 282, 16146-16154. PubMed  Europe PubMed DOI  I
    22. 2003
  22. Rao,C., Foernzler,D., Loftus,S.K., Liu,S., McPherson,J.D., Jungers,K.A., Apte,S.S., Pavan,W.J. and Beier,D.R.
    A defect in a novel ADAMTS family member is the cause of the belted white-spotting mutation
    Development (2003) 130, 4665-4672. PubMed  Europe PubMed DOI  M
  23. [YEAR:14-3-2003]Somerville,R.P., Longpre,J.M., Jungers,K.A., Engle,J.M., Ross,M., Evanko,S., Wight,T.N., Leduc,R. and Apte,S.S.
    Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1
    J Biol Chem (14-3-2003) 278, 9503-9513. PubMed  Europe PubMed DOI  P

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