Substrates for peptidase M10.066: karilysin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
CLIPS library peptide			peptide-Ala+Leu-peptide	S	Lys	Pro	Met	Ala	Leu	Arg	Gly	Gly	Karim et al., 2010
CLIPS library peptide			peptide-Ala+Leu-peptide	S	Ala	Pro	Gly	Ala	Leu	Leu	Gly	Gly	Karim et al., 2010
CLIPS library peptide			peptide-Ala+Leu-peptide	S	Ser	Pro	Phe	Ala	Leu	Arg	Gly	Gly	Karim et al., 2010
CLIPS library peptide			peptide-Leu+Leu-peptide	S	Leu	Pro	Leu	Leu	Leu	Ser	Gly	Gly	Karim et al., 2010
CLIPS library peptide			peptide-Val+Leu-peptide	S	Pro	Pro	Asn	Val	Leu	Met	Leu	Thr	Karim et al., 2010
CLIPS library peptide			peptide-Ala+Leu-peptide	S	Ala	Pro	Pro	Ala	Leu	Val	Ala	Gly	Karim et al., 2010
CLIPS library peptide			peptide-Ser+Leu-peptide	S	Pro	Pro	Gly	Ser	Leu	Ile	Val	Gly	Karim et al., 2010
CLIPS library peptide			peptide-Ser+Ile-peptide	S	Ser	Pro	Leu	Ser	Ile	Thr	Gly	Gly	Karim et al., 2010
CLIPS library peptide			peptide-Ala+Leu-peptide	S	Thr	Pro	Met	Ala	Leu	Leu	Gly	Gly	Karim et al., 2010
CLIPS library peptide			peptide-Ser+Leu-peptide	S	Gly	Pro	Ala	Ser	Leu	Thr	Met	Gly	Karim et al., 2010
CLIPS library peptide			peptide-Trp+Leu-peptide	S	Pro	Pro	Ser	Trp	Leu	Trp	Leu	Gly	Karim et al., 2010
CLIPS library peptide			peptide-Phe+Leu-peptide	S	Ala	Pro	Gly	Phe	Leu	Val	Ser	Gly	Karim et al., 2010
CLIPS library peptide			peptide-Leu+Leu-peptide	S	Pro	Pro	Gly	Leu	Leu	Leu	Val	Pro	Karim et al., 2010
CLIPS library peptide			peptide-Ser+Leu-peptide	S	Ile	Pro	Gln	Ser	Leu	Thr	Leu	Gly	Karim et al., 2010
CLIPS library peptide			peptide-Ser+Leu-peptide	S	Ala	Ala	Ser	Ser	Leu	Gly	Met	Tyr	Karim et al., 2010
CLIPS library peptide			peptide-Pro+Leu-peptide	S	Leu	Ala	Gly	Pro	Leu	Leu	Met	Ala	Karim et al., 2010
CLIPS library peptide			peptide-Gly+Leu-peptide	S	Leu	Ala	Tyr	Gly	Leu	Leu	Leu	Asp	Karim et al., 2010
CLIPS library peptide			peptide-Pro+Leu-peptide	S	Ala	Ala	Ala	Pro	Leu	Leu	Gln	Phe	Karim et al., 2010
CLIPS library peptide			peptide-Thr+Tyr-peptide	S	Ser	Pro	Met	Thr	Tyr	Pro	Phe	Gly	Karim et al., 2010
CLIPS library peptide			peptide-Ala+Tyr-peptide	S	Gly	Pro	Ala	Ala	Tyr	Thr	Ser	Trp	Karim et al., 2010
CLIPS library peptide			peptide-Met+Tyr-peptide	S	Pro	Pro	Ala	Met	Tyr	Thr	Leu	Leu	Karim et al., 2010
CLIPS library peptide			peptide-Leu+Tyr-peptide	S	Ala	Pro	Ala	Leu	Tyr	Ala	Asn	Tyr	Karim et al., 2010
CLIPS library peptide			peptide-Asn+Tyr-peptide	S	Leu	Gly	Ser	Asn	Tyr	Ser	Val	Tyr	Karim et al., 2010
CLIPS library peptide			peptide-Leu+Tyr-peptide	S	Gly	Pro	Leu	Leu	Tyr	Arg	Ile	Ser	Karim et al., 2010
CLIPS library peptide			peptide-Ser+Tyr-peptide	S	Gly	Pro	Pro	Ser	Tyr	Thr	Leu	Pro	Karim et al., 2010
CLIPS library peptide			peptide-Ser+Met-peptide	S	Ile	Pro	Gly	Ser	Met	Val	Phe	Arg	Karim et al., 2010
CLIPS library peptide			peptide-Asn+Met-peptide	S	Leu	Ala	Val	Asn	Met	Thr	Thr	Gly	Karim et al., 2010
CLIPS library peptide			peptide-Val+Met-peptide	S	Gly	Pro	Ser	Val	Met	Val	Leu	Ala	Karim et al., 2010
CLIPS library peptide			peptide-Gly+Met-peptide	S	Ser	Ala	Met	Gly	Met	Val	Gly	Gly	Karim et al., 2010
CLIPS library peptide			peptide-Ala+Phe-peptide	S	Gly	Pro	Pro	Ala	Phe	Ser	Thr	Phe	Karim et al., 2010
CLIPS library peptide			peptide-Asn+Phe-peptide	S	Gly	Pro	Ala	Asn	Phe	Ser	Val	Gly	Karim et al., 2010
CLIPS library peptide			peptide-Thr+Leu-peptide	S	Met	Asn	Ser	Thr	Leu	Val	Leu	Pro	Karim et al., 2010
CLIPS library peptide			peptide-Ala+Val-peptide	S	Arg	Pro	Ala	Ala	Val	Gln	Tyr	Gly	Karim et al., 2010
Karilysin precursor	D0EM77	21-472	peptide-Asn34+Tyr-peptide	P	Gly	Asp	Asn	Asn	Tyr	Val	Leu	Gln	Karim et al., 2010
Karilysin precursor	D0EM77	21-472	peptide-His131+Leu-peptide	P	Tyr	Ala	Gly	His	Leu	His	Phe	Asp	Karim et al., 2010
Karilysin precursor	D0EM77	21-472	peptide-Leu195+Tyr-peptide	P	Val	Trp	Asp	Leu	Tyr	Gly	Tyr	Pro	Karim et al., 2010
Karilysin precursor	D0EM77	21-472	peptide-Lys269+Ile-peptide	P	Thr	Pro	Leu	Lys	Ile	Cys	Leu	Gly	Karim et al., 2010
Karilysin precursor	D0EM77	21-472	peptide-Asp279+Ile-peptide	P	Ile	Ser	Gln	Asp	Ile	Thr	Leu	Thr	Karim et al., 2010