$VAR1 = undef;

Summary for peptidase M10.066: karilysin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

 

Names
MEROPS Namekarilysin
Other namesKLIKK protease
Domain architecture
MEROPS Classification
Classification Clan MA >> Subclan MA(M) >> Family M10 >> Subfamily A >> M10.066
Holotypekarilysin (Tannerella forsythia), Uniprot accession D0EM77 (peptidase unit: 35-218), MERNUM MER0157380
History Identifier created: MEROPS 9.1 (28 January 2010)
Activity
Catalytic typeMetallo
NC-IUBMBNot yet included in IUBMB recommendations.
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patterng/Pa/-/-Scissile bondLymi/-/lg/g (based on 38 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 8 1 7 2 0 2 7 18
Pro 5 26 3 2 0 1 0 4
Ala 6 7 7 8 0 1 1 2
Val 1 0 1 2 1 7 4 0
Leu 5 0 4 5 19 6 11 1
Ile 3 0 0 0 3 1 1 0
Met 1 0 4 1 4 1 3 0
Phe 0 0 1 1 2 0 3 2
Tyr 1 0 1 0 9 0 2 3
Trp 0 1 0 1 0 1 0 1
Ser 4 1 5 7 0 4 2 1
Thr 2 0 0 2 0 8 2 2
Cys 0 0 0 0 0 1 0 0
Asn 0 1 2 4 0 0 1 0
Gln 0 0 2 0 0 1 1 1
Asp 0 1 1 1 0 0 0 2
Glu 0 0 0 0 0 0 0 0
Lys 1 0 0 1 0 0 0 0
Arg 1 0 0 0 0 3 0 1
His 0 0 0 1 0 1 0 0