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Substrates for peptidase M01.005: alanyl aminopeptidase (bacterial-type)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
2-Nal-ACC 2-Nal+ACC S - - - Nal ACC - - - Weglarz-Tomczak et al., 2013
3-OH-Pro-ACC 3-OH-Pro+ACC S - - - OPr ACC - - - Weglarz-Tomczak et al., 2013
4-Br-Phe-ACC 4-Br-Phe+ACC S - - - Bph ACC - - - Weglarz-Tomczak et al., 2013
4-Cl-Phe-ACC 4-Cl-Phe+ACC S - - - Cph ACC - - - Weglarz-Tomczak et al., 2013
6-Obzl-Nle-ACC 6-Obzl-Nle+ACC S - - - ONl ACC - - - Weglarz-Tomczak et al., 2013
Abu(Bth)-ACC Abu(Bth)+ACC S - - - ABB ACC - - - Weglarz-Tomczak et al., 2013
Abu-ACC Abu+ACC S - - - Abu ACC - - - Weglarz-Tomczak et al., 2013
Ala-ACC Ala+ACC S - - - Ala ACC - - - Gras et al., 2014
Ala-ACC Ala+ACC S - - - Ala ACC - - - Weglarz-Tomczak et al., 2013
Ala-AFC Ala+AFC S - - - Ala AFC - - - Murphy et al., 2002
Ala-Ala-Phe-NHMec Ala-Ala-Phe+NHMec S - Ala Ala Phe AMC - - - Chandu et al., 2003
Ala-NHMec Ala+NHMec S - - - Ala AMC - - - Gras et al., 2014
Ala-NHNap Ala+NHNap S - - - Ala NAP - - - Miller & Mackinnon, 1974
Ala-NHPhNO2 Ala+NHPhNO2 S - - - Ala NAN - - - Kumar & Nandi, 2006
allylGly-ACC allylGly+ACC S - - - AGl ACC - - - Weglarz-Tomczak et al., 2013
Arg(NO2)-Acc Arg(NO2)+Acc S - - - Arn ACC - - - Weglarz-Tomczak et al., 2013
Arg-ACC Arg+ACC S - - - Arg ACC - - - Weglarz-Tomczak et al., 2013
Arg-NHMec Arg+NHMec S - - - Arg AMC - - - Kumar & Nandi, 2006
Arg-NHMec Arg+NHMec S - - - Arg AMC - - - Fidopiastis et al., 2012
Arg-NHPhNO2 Arg+NHPhNO2 S - - - Arg NAN - - - Fidopiastis et al., 2012
Asp(Bzl)-ACC Asp(Bzl)+ACC S - - - AsB ACC - - - Weglarz-Tomczak et al., 2013
Boc-Leu-Arg-Arg-NHMec Boc-Leu-Arg-Arg+NHMec S Boc Leu Arg Arg AMC - - - Chandu et al., 2003
Cha-ACC Cha+ACC S - - - Cha ACC - - - Weglarz-Tomczak et al., 2013
Cys-Gly Cys+Gly P - - - Cys Gly - - - Suzuki et al., 2001
Gln-ACC Gln+ACC S - - - Gln ACC - - - Weglarz-Tomczak et al., 2013
Glu(Bzl)-ACC Glu(Bzl)+ACC S - - - GlB ACC - - - Weglarz-Tomczak et al., 2013
Gly-ACC Gly+ACC S - - - Gly ACC - - - Weglarz-Tomczak et al., 2013
hArg-ACC hArg+ACC S - - - Har ACC - - - Gras et al., 2014
hArg-ACC hArg+ACC S - - - HAr ACC - - - Weglarz-Tomczak et al., 2013
hCha-ACC hCha+ACC S - - - HCh ACC - - - Gras et al., 2014
hCha-ACC hCha+ACC S - - - HCh ACC - - - Weglarz-Tomczak et al., 2013
hLeu-ACC hLeu+ACC S - - - HLe ACC - - - Weglarz-Tomczak et al., 2013
hPhe-ACC hPhe+ACC S - - - HPh ACC - - - Gras et al., 2014
hPhe-ACC hPhe+ACC S - - - HPh ACC - - - Weglarz-Tomczak et al., 2013
hSer(Bzl)-ACC hSer(Bzl)+ACC S - - - SeB ACC - - - Weglarz-Tomczak et al., 2013
hSer-ACC hSer+ACC S - - - HSe ACC - - - Weglarz-Tomczak et al., 2013
hTyr-ACC hTyr+ACC S - - - HTy ACC - - - Weglarz-Tomczak et al., 2013
Igl-ACC Igl+ACC S - - - Igl ACC - - - Weglarz-Tomczak et al., 2013
Leu-ACC Leu+ACC S - - - Leu ACC - - - Weglarz-Tomczak et al., 2013
Leu-NHMec Leu+NHMec S - - - Leu AMC - - - Fidopiastis et al., 2012
Leu-NHPhNO2 Leu+NHPhNO2 S - - - Leu NAN - - - Chandu et al., 2003
Leu-NHPhNO2 Leu+NHPhNO2 S - - - Leu NAN - - - Fidopiastis et al., 2012
Lys-ACC Lys+ACC S - - - Lys ACC - - - Weglarz-Tomczak et al., 2013
Lys-NHPhNO2 Lys+NHPhNO2 S - - - Lys NAN - - - Fidopiastis et al., 2012
Met-ACC Met+ACC S - - - Met ACC - - - Gras et al., 2014
Met-ACC Met+ACC S - - - Met ACC - - - Weglarz-Tomczak et al., 2013
Met-NHMec Met+NHMec S - - - Met AMC - - - Fidopiastis et al., 2012
microcin C7 Q47505 6-7 Ala+Asn P NT Thr Gly Asn Ala Asn - - - Kazakov et al., 2008
neopentylGly-AC neopentylGly+AC S - - - NPG ACC - - - Weglarz-Tomczak et al., 2013
Nle-ACC Nle+ACC S - - '-' Nle ACC - - - Gras et al., 2014
Nle-ACC Nle+ACC S - - - Nle ACC - - - Weglarz-Tomczak et al., 2013
Nva-ACC Nva+ACC S - - - Nva ACC - - - Gras et al., 2014
Nva-ACC Nva+ACC S - - - Nva ACC - - - Weglarz-Tomczak et al., 2013
Phe-ACC Phe+ACC S - - - Phe ACC - - - Weglarz-Tomczak et al., 2013
Phe-NHMec Phe+NHMec S - - - Phe AMC - - - Fidopiastis et al., 2012
Phe-NHPhNO2 Leu+NHPhNO2 S - - - Leu NAN - - - Chandu et al., 2003
Pro-AFC Pro+AFC S - - - Pro AFC - - - Murphy et al., 2002
propargylGly-ACC propargylGly+ACC S - - - PAG ACC - - - Weglarz-Tomczak et al., 2013
Styryl-Ala-ACC Styryl-Ala+ACC S - - - Sal ACC - - - Gras et al., 2014
Suc-Ala-Ala-Phe-NHMec Suc-Ala-Ala-Phe+NHMec S Suc Ala Ala Phe AMC - - - Chandu et al., 2003
Suc-Leu-Leu-Val-Tyr-NHMec Suc-Leu-Leu-Val-Tyr+NHMec S Leu Leu Val Tyr AMC - - - Chandu et al., 2003
Thr-NHMec Thr+NHMec S - - - Thr AMC - - - Kumar & Nandi, 2006
Tyr-ACC Tyr+ACC S - - - Tyr ACC - - - Weglarz-Tomczak et al., 2013
Tyr-AFC Tyr+AFC S - - - Tyr AFC - - - Murphy et al., 2002
Tyr-NHMec Tyr+NHMec S - - - Tyr AMC - - - Chandu et al., 2003
Z-Gly-Gly-Arg-NHMec Z-Gly-Gly-Arg+NHMec S Z Gly Gly Arg AMC - - - Chandu et al., 2003

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