Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase M01.005: alanyl aminopeptidase (bacterial-type)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, P Specificity, I Inhibitor, E Expression. To select only the references relevant to a single topic, click the link above. See explanation.)

    2019
  1. Mendez,Y., De Armas,G., Perez,I., Rojas,T., Valdes-Tresanco,M.E., Izquierdo,M., Alonso Del Rivero,M., Alvarez-Ginarte,Y.M., Valiente,P.A., Soto,C., de Leon,L., Vasco,A.V., Scott,W.L., Westermann,B., Gonzalez-Bacerio,J. and Rivera,D.G.<br>Discovery of potent and selective inhibitors of the Escherichia coli M1-aminopeptidase via multicomponent solid-phase synthesis of tetrazole-peptidomimetics<br>Eur J Med Chem (2019) 163, 481-499. PubMed  Europe PubMed DOI  I
  2. Sharma,N., Aggarwal,S., Kumar,S., Sharma,R., Choudhury,K., Singh,N., Jayaswal,P., Goel,R., Wajid,S., Yadav,A.K. and Atmakuri,K.<br>Comparative analysis of homologous aminopeptidase PepN from pathogenic and non-pathogenic mycobacteria reveals divergent traits<br>PLoS ONE (2019) 14, e0215123-e0215123. PubMed  Europe PubMed DOI
    3. 2018
  3. Salomon,E., Schmitt,M., Marapaka,A.K., Stamogiannos,A., Revelant,G., Schmitt,C., Alavi,S., Florent,I., Addlagatta,A., Stratikos,E., Tarnus,C. and Albrecht,S.<br>Aminobenzosuberone scaffold as a modular chemical tool for the inhibition of therapeutically relevant M1 aminopeptidases<br>Molecules (2018) 23 PubMed  Europe PubMed DOI  I
    4. 2016
  4. Das,M., Bhosale,M., Wadhwa,N., Ahmed,S.M., Bhaskarla,C., Kumar,A., Srinivasan,N. and Nandi,D.<br>Importance of amino acids, Gln-119 and Tyr-376, in the S1 pocket of Escherichia coli peptidase N in determining substrate specificity<br>Protein Pept Lett (2016) 23, 548-561. PubMed  Europe PubMed
  5. Stressler,T., Pfahler,N., Merz,M., Hubschneider,L., Lutz-Wahl,S., Claassen,W. and Fischer,L.<br>A fusion protein consisting of the exopeptidases PepN and PepX-production, characterization, and application<br>Appl Microbiol Biotechnol (2016) 100, 7499-7515. PubMed  Europe PubMed DOI
    6. 2015
  6. Ganji,R.J., Reddi,R., Gumpena,R., Marapaka,A.K., Arya,T., Sankoju,P., Bhukya,S. and Addlagatta,A.<br>Structural basis for the inhibition of M1 family aminopeptidases by the natural product actinonin: crystal structure in complex with E. coli aminopeptidase N<br>Protein Sci (2015) 24, 823-831. PubMed  Europe PubMed DOI  S  I
  7. Yu,G., Li,L., Liu,X., Liu,G., Deng,Z., Zabriskie,M.T., Jiang,M. and He,X.<br>The standalone aminopeptidase PepN catalyzes the maturation of blasticidin S from leucylblasticidin S<br>Sci Rep (2015) 5, 17641-17641. PubMed  Europe PubMed DOI  PMC  EPMC
    8. 2014
  8. Gras,S., Byzia,A., Gilbert,F.B., McGowan,S., Drag,M., Silvestre,A., Niepceron,A., Lecaille,F., Lalmanach,G. and Brossier,F.<br>Aminopeptidase N1 (EtAPN1), an M1 metalloprotease of the apicomplexan parasite Eimeria tenella, participates in parasite development<br>Eukaryot Cell (2014) 13, 884-895. PubMed  Europe PubMed DOI
  9. Vassiliou,S., Weglarz-Tomczak,E., Berlicki,L., Pawelczak,M., Nocek,B., Mulligan,R., Joachimiak,A. and Mucha,A.<br>Structure-guided, single-point modifications in the phosphinic dipeptide structure yield highly potent and selective inhibitors of neutral aminopeptidases<br>J Med Chem (2014) 57, 8140-8151. PubMed  Europe PubMed DOI  PMC  EPMC  I
    10. 2013
  10. Bhosale,M., Kumar,A., Das,M., Bhaskarla,C., Agarwal,V. and Nandi,D.<br>Catalytic activity of peptidase N is required for adaptation of Escherichia coli to nutritional downshift and high temperature stress<br>Microbiol Res (2013) 168, 56-64. PubMed  Europe PubMed DOI
  11. Weglarz-Tomczak,E., Poreba,M., Byzia,A., Berlicki,L., Nocek,B., Mulligan,R., Joachimiak,A., Drag,M. and Mucha,A.<br>An integrated approach to the ligand binding specificity of Neisseria meningitidis M1 alanine aminopeptidase by fluorogenic substrate profiling, inhibitory studies and molecular modeling<br>Biochimie (2013) 95, 419-428. PubMed  Europe PubMed DOI  P
    12. 2012
  12. Bhosale,M., Kadthur,J.C. and Nandi,D.<br>Roles of Salmonella enterica serovar typhimurium encoded peptidase N during systemic infection of ifngamma-/- mice<br>Immunobiology (2012) 217, 354-362. PubMed  Europe PubMed DOI
  13. Bhosale,M., Bhaskarla,C. and Nandi,D.<br>Alanyl aminopeptidase (bacterial-type)<br>[ISSN:978-0-12-407744-7] (2012) 3, 456-462. DOI
  14. Fidopiastis,P.M., Rader,B.A., Gerling,D.G., Gutierrez,N.A., Watkins,K.H., Frey,M.W., Nyholm,S.V. and Whistler,C.A.<br>Characterization of a Vibrio fischeri aminopeptidase and evidence for its influence on an early stage of squid colonization<br>J Bacteriol (2012) 194, 3995-4002. PubMed  Europe PubMed DOI
  15. Gumpena,R., Kishor,C., Ganji,R.J., Jain,N. and Addlagatta,A.<br>Glu121-Lys319 salt bridge between catalytic and N-terminal domains is pivotal for the activity and stability of Escherichia coli aminopeptidase N<br>Protein Sci (2012) 21, 727-736. PubMed  Europe PubMed DOI  S
  16. Lee,O.R. and Cho,H.T.<br>Cytoplasm localization of aminopeptidase M1 and its functional activity in root hair cells and BY-2 cells<br>Mol Biol Rep (2012) 39, 10211-10218. PubMed  Europe PubMed DOI
    17. 2011
  17. Su,J., Wang,Q., Feng,J., Zhang,C., Zhu,D., Wei,T., Xu,W. and Gu,L.<br>Engineered Thermoplasma acidophilum factor F3 mimics human aminopeptidase N (APN) as a target for anticancer drug development<br>Bioorg Med Chem (2011) 19, 2991-2996. PubMed  Europe PubMed DOI  I
    18. 2009
  18. Fournie-Zaluski,M.C., Poras,H., Roques,B.P., Nakajima,Y., Ito,K. and Yoshimoto,T.<br>Structure of aminopeptidase N from Escherichia coli complexed with the transition-state analogue aminophosphinic inhibitor PL250<br>Acta Crystallogr D Biol Crystallogr (2009) 65, 814-822. PubMed  Europe PubMed DOI  S  I
  19. Kumar,A., Reddy,S., Srinivasan,N. and Nandi,D.<br>Interaction between two residues in the inter-domain interface of Escherichia coli peptidase N modulates catalytic activity<br>Protein Pept Lett (2009) 16, 415-422. PubMed  Europe PubMed DOI
  20. Kumar,A., Bhosale,M., Reddy,S., Srinivasan,N. and Nandi,D.<br>Importance of non-conserved distal carboxyl terminal amino acids in two peptidases belonging to the M1 family: Thermoplasma acidophilum Tricorn interacting factor F2 and Escherichia coli peptidase N<br>Biochimie (2009) 91, 1145-1155. PubMed  Europe PubMed DOI
  21. Peer,W.A., Hosein,F.N., Bandyopadhyay,A., Makam,S.N., Otegui,M.S., Lee,G.J., Blakeslee,J.J., Cheng,Y., Titapiwatanakun,B., Yakubov,B., Bangari,B. and Murphy,A.S.<br>Mutation of the membrane-associated M1 protease APM1 results in distinct embryonic and seedling developmental defects in Arabidopsis<br>Plant Cell (2009) 21, 1693-1721. PubMed  Europe PubMed DOI  PMC  EPMC
    22. 2008
  22. Addlagatta,A., Gay,L. and Matthews,B.W.<br>Structural basis for the unusual specificity of Escherichia coli aminopeptidase N<br>Biochemistry (2008) 47, 5303-5311. PubMed  Europe PubMed DOI  P  S
  23. Kazakov,T., Vondenhoff,G.H., Datsenko,K.A., Novikova,M., Metlitskaya,A., Wanner,B.L. and Severinov,K.<br>Escherichia coli peptidase A, B, or N can process translation inhibitor microcin C<br>J Bacteriol (2008) 190, 2607-2610. PubMed  Europe PubMed DOI  PMC  EPMC
  24. Nocek,B., Mulligan,R., Bargassa,M., Collart,F. and Joachimiak,A.<br>Crystal structure of aminopeptidase N from human pathogen Neisseria meningitidis<br>Proteins (2008) 70, 273-279. PubMed  Europe PubMed DOI  S
    25. 2007
  25. [YEAR:16-2-2007]Kumar,A. and Nandi,D.<br>Characterization and role of peptidase N from Salmonella enterica serovar Typhimurium<br>Biochem Biophys Res Commun (16-2-2007) 353, 706-712. PubMed  Europe PubMed DOI  P
  26. Patil,V., Kumar,A., Kuruppath,S. and Nandi,D.<br>Peptidase N encoded by Salmonella enterica serovar Typhimurium modulates systemic infection in mice<br>FEMS Immunol Med Microbiol (2007) 51, 431-442. PubMed  Europe PubMed DOI
    27. 2006
  27. Addlagatta,A., Gay,L. and Matthews,B.W.<br>Structure of aminopeptidase N from Escherichia coli suggests a compartmentalized, gated active site<br>Proc Natl Acad Sci U S A (2006) 103, 13339-13344. PubMed  Europe PubMed DOI  PMC  EPMC  S  I
  28. Contreras-Rodriguez,A., Seleem,M.N., Schurig,G.G., Sriranganathan,N., Boyle,S.M. and Lopez-Merino,A.<br>Cloning, expression and characterization of immunogenic aminopeptidase N from Brucella melitensis<br>FEMS Immunol Med Microbiol (2006) 48, 252-256. PubMed  Europe PubMed DOI
  29. Golich,F.C., Han,M. and Crowder,M.W.<br>Over-expression, purification, and characterization of aminopeptidase N from Escherichia coli<br>Protein Expr Purif (2006) 47, 634-639. PubMed  Europe PubMed DOI
  30. Ito,K., Nakajima,Y., Onohara,Y., Takeo,M., Nakashima,K., Matsubara,F., Ito,T. and Yoshimoto,T.<br>Crystal structure of aminopeptidase N (proteobacteria alanyl aminopeptidase) from Escherichia coli and conformational change of methionine 260 involved in substrate recognition<br>J Biol Chem (2006) 281, 33664-33676. PubMed  Europe PubMed DOI  S
    31. 2005
  31. Fetterer,R.H., Miska,K.B. and Barfield,R.C.<br>Partial purification and characterization of an aminopeptidase from Eimeria tenella<br>J Parasitol (2005) 91, 1280-1286. PubMed  Europe PubMed DOI
    32. 2004
  32. [YEAR:1-5-2004]Garcia Gonzalez,O., Garcia,R.M., de la Garza,M., Vaca,S., Paniagua,G.L., Mejia,R., Tenorio,V.R. and Negrete-Abascal,E.<br>Actinobacillus pleuropneumoniae metalloprotease: cloning and in vivo expression<br>FEMS Microbiol Lett (1-5-2004) 234, 81-86. PubMed  Europe PubMed DOI
  33. Sanchez-Moran,E., Jones,G.H., Franklin,F.C. and Santos,J.L.<br>A puromycin-sensitive aminopeptidase is essential for meiosis in Arabidopsis thaliana<br>Plant Cell (2004) 16, 2895-2909. PubMed  Europe PubMed DOI  PMC  EPMC  I
    34. 2003
  34. Chandu,D. and Nandi,D.<br>PepN is the major aminopeptidase in Escherichia coli: insights on substrate specificity and role during sodium-salicylate-induced stress<br>Microbiology (Reading, Engl.) (2003) 149, 3437-3447. PubMed  Europe PubMed
  35. [YEAR:21-2-2003]Chandu,D., Kumar,A. and Nandi,D.<br>PepN, the major Suc-LLVY-AMC-hydrolyzing enzyme in Escherichia coli, displays functional similarity with downstream processing enzymes in Archaea and eukarya. Implications in cytosolic protein degradation<br>J Biol Chem (21-2-2003) 278, 5548-5556. PubMed  Europe PubMed DOI
  36. Contreras-Rodriguez,A., Ramirez-Zavala,B., Contreras,A., Schurig,G.G., Sriranganathan,N. and Lopez-Merino,A.<br>Purification and characterization of an immunogenic aminopeptidase of Brucella melitensis<br>Infect Immun (2003) 71, 5238-5244. PubMed  Europe PubMed DOI  PMC  EPMC
    37. 2002
  37. Murphy,A.S., Hoogner,K.R., Peer,W.A. and Taiz,L.<br>Identification, purification, and molecular cloning of N-1-naphthylphthalmic acid-binding plasma membrane-associated aminopeptidases from Arabidopsis<br>Plant Physiol (2002) 128, 935-950. PubMed  Europe PubMed DOI  PMC  EPMC
    38. 2001
  38. Luoma,S., Peltoniemi,K., Joutsjoki,V., Rantanen,T., Tamminen,M., Heikkinen,I. and Palva,A.<br>Expression of six peptidases from Lactobacillus helveticus in Lactococcus lactis<br>Appl Environ Microbiol (2001) 67, 1232-1238. PubMed  Europe PubMed DOI  PMC  EPMC  E
  39. Suzuki,H., Kamatani,S., Kim,E.S. and Kumagai,H.<br>Aminopeptidases A, B, and N and dipeptidase D are the four cysteinylglycinases of Escherichia coli K-12<br>J Bacteriol (2001) 183, 1489-1490. PubMed  Europe PubMed DOI
  40. Yamauchi,Y., Ejiri,Y. and Tanaka,K.<br>Purification of an aminopeptidase preferentially releasing N-terminal alanine from cucumber leaves and its identification as a plant aminopeptidase N<br>Biosci Biotechnol Biochem (2001) 65, 2802-2805. PubMed  Europe PubMed DOI
    41. 1997
  41. Jensch,T. and Fricke,B.<br>Localization of alanyl aminopeptidase and leucyl aminopeptidase in cells of Pseudomonas aeruginosa by application of different methods for periplasm release<br>J Basic Microbiol (1997) 37, 115-128. PubMed  Europe PubMed
  42. Leopold,I. and Fricke,B.<br>Inhibition, reactivation, and determination of metal ions in membrane metalloproteases of bacterial origin using high-performance liquid chromatography coupled on-line with inductively coupled plasma mass spectrometry<br>Anal Biochem (1997) 252, 277-285. PubMed  Europe PubMed DOI
    43. 1988
  43. Yoshimoto,T., Tamesa,Y., Gushi,K., Murayama,N. and Tsuru,D.<br>An aminopeptidase N from Escherichia coli HB101: purification and demonstration that the enzyme possesses arylamidase and peptidase activities<br>Agric Biol Chem (1988) 52, 217-225. DOI
    44. 1987
  44. Foglino,M. and Lazdunski,A.<br>Deletion analysis of the promoter region of the Escherichia coli pepn gene, a gene subject in vivo to multiple global controls<br>Mol Gen Genet (1987) 210, 523-527. PubMed  Europe PubMed DOI
    45. 1986
  45. Bally,M., Foglino,M., Bruschi,M., Murgier,M. and Lazdunski,A.<br>Nucleotide sequence of the promoter and amino-terminal encoding region of the Escherichia coli pepN gene<br>Eur J Biochem (1986) 155, 565-569. PubMed  Europe PubMed
  46. Foglino,M., Gharbi,S. and Lazdunski,A.<br>Nucleotide sequence of the pepN gene encoding aminopeptidase N of Escherichia coli<br>Gene (1986) 49, 303-309. PubMed  Europe PubMed
  47. Gharbi,S., Bally,M., Lazdunski,A. and Murgier,M.<br>Mutation that affects pepn translation initiation in Escherichia coli<br>Biochimie (1986) 68, 1159-1163. PubMed  Europe PubMed
  48. McCaman,M.T. and Gabe,J.D.<br>The nucleotide sequence of the pepN gene and its over-expression in Escherichia coli<br>Gene (1986) 48, 145-153. PubMed  Europe PubMed
    49. 1985
  49. Gharbi,S., Belaich,A., Murgier,M. and Lazdunski,A.<br>Multiple controls exerted on in vivo expression of the pepN gene in Escherichia coli: studies with pepN-lacZ operon and protein fusion strains<br>J Bacteriol (1985) 163, 1191-1195. PubMed  Europe PubMed  PMC  EPMC
    50. 1977
  50. Chappelet-Tordo,D., Lazdunski,C., Murgier,M. and Lazdunski,A.<br>Aminopeptidase N from Escherichia coli: ionizable active-center groups and substrate specificity<br>Eur J Biochem (1977) 81, 293-305. PubMed  Europe PubMed  P
  51. Murgier,M., Pelissier,C. and Lazdunski,A.<br>Aminopeptidase N from Escherichia coli. Unusual interactions with the cell surface<br>Eur J Biochem (1977) 74, 425-433. PubMed  Europe PubMed
    52. 1976
  52. Latil,M., Murgier,M., Lazdunski,A. and Lazdunski,C.<br>Isolation and genetic mapping of Escherichia coli aminopeptidase mutants<br>Mol Gen Genet (1976) 148, 43-47. PubMed  Europe PubMed
  53. Murgier,M., Pelissier,C., Lazdunski,A. and Lazdunski,C.<br>Existence, localization and regulation of the biosynthesis of aminoendopeptidase in gram-negative bacteria<br>Eur J Biochem (1976) 65, 517-520. PubMed  Europe PubMed
  54. Yang,L.M. and Somerville,R.L.<br>Purification and properties of a new aminopeptidase from Escherichia coli K12<br>Biochim Biophys Acta (1976) 445, 406-419. PubMed  Europe PubMed
    55. 1975
  55. Lazdunski,A., Murgier,M. and Lazdunski,C.<br>Evidence for an aminoendopeptidase localized near the cell surface of Escherichia coli. Regulation of synthesis by inorganic phosphate<br>Eur J Biochem (1975) 60, 349-355. PubMed  Europe PubMed
  56. Lazdunski,C., Busuttil,J. and Lazdunski,A.<br>Purification and properties of a periplasmic aminoendopeptidase from Escherichia coli<br>Eur J Biochem (1975) 60, 363-369. PubMed  Europe PubMed
    57. 1971
  57. Matsumura,Y., Minamiura,N., Fukumoto,J. and Yamamoto,T.<br>Intracellular peptidase of Bacillus subtilis Part III. Effects of metal ions on activity and specificity of aminopeptidase of Bacillus subtilis<br>Agric Biol Chem (1971) 35, 975-982. DOI

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2025 EBI
Terms of use