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Literature for peptidase M01.005: alanyl aminopeptidase (bacterial-type)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, P Specificity, I Inhibitor, E Expression. To select only the references relevant to a single topic, click the link above. See explanation.)

    2019
  1. Mendez,Y., De Armas,G., Perez,I., Rojas,T., Valdes-Tresanco,M.E., Izquierdo,M., Alonso Del Rivero,M., Alvarez-Ginarte,Y.M., Valiente,P.A., Soto,C., de Leon,L., Vasco,A.V., Scott,W.L., Westermann,B., Gonzalez-Bacerio,J. and Rivera,D.G.
    Discovery of potent and selective inhibitors of the Escherichia coli M1-aminopeptidase via multicomponent solid-phase synthesis of tetrazole-peptidomimetics
    Eur J Med Chem163, 481-499. PubMed  Europe PubMed DOI  I
  2. Sharma,N., Aggarwal,S., Kumar,S., Sharma,R., Choudhury,K., Singh,N., Jayaswal,P., Goel,R., Wajid,S., Yadav,A.K. and Atmakuri,K.
    Comparative analysis of homologous aminopeptidase PepN from pathogenic and non-pathogenic mycobacteria reveals divergent traits
    PLoS ONE14, e0215123-e0215123. PubMed  Europe PubMed DOI
    3. 2018
  3. Salomon,E., Schmitt,M., Marapaka,A.K., Stamogiannos,A., Revelant,G., Schmitt,C., Alavi,S., Florent,I., Addlagatta,A., Stratikos,E., Tarnus,C. and Albrecht,S.
    Aminobenzosuberone scaffold as a modular chemical tool for the inhibition of therapeutically relevant M1 aminopeptidases
    Molecules23, PubMed  Europe PubMed DOI  I
    4. 2016
  4. Das,M., Bhosale,M., Wadhwa,N., Ahmed,S.M., Bhaskarla,C., Kumar,A., Srinivasan,N. and Nandi,D.
    Importance of amino acids, Gln-119 and Tyr-376, in the S1 pocket of Escherichia coli peptidase N in determining substrate specificity
    Protein Pept Lett23, 548-561. PubMed  Europe PubMed
  5. Stressler,T., Pfahler,N., Merz,M., Hubschneider,L., Lutz-Wahl,S., Claassen,W. and Fischer,L.
    A fusion protein consisting of the exopeptidases PepN and PepX-production, characterization, and application
    Appl Microbiol Biotechnol100, 7499-7515. PubMed  Europe PubMed DOI
    6. 2015
  6. Ganji,R.J., Reddi,R., Gumpena,R., Marapaka,A.K., Arya,T., Sankoju,P., Bhukya,S. and Addlagatta,A.
    Structural basis for the inhibition of M1 family aminopeptidases by the natural product actinonin: crystal structure in complex with E. coli aminopeptidase N
    Protein Sci24, 823-831. PubMed  Europe PubMed DOI  S  I
  7. Yu,G., Li,L., Liu,X., Liu,G., Deng,Z., Zabriskie,M.T., Jiang,M. and He,X.
    The standalone aminopeptidase PepN catalyzes the maturation of blasticidin S from leucylblasticidin S
    Sci Rep5, 17641-17641. PubMed  Europe PubMed DOI
    8. 2014
  8. Gras,S., Byzia,A., Gilbert,F.B., McGowan,S., Drag,M., Silvestre,A., Niepceron,A., Lecaille,F., Lalmanach,G. and Brossier,F.
    Aminopeptidase N1 (EtAPN1), an M1 metalloprotease of the apicomplexan parasite Eimeria tenella, participates in parasite development
    Eukaryot Cell13, 884-895. PubMed  Europe PubMed DOI
  9. Vassiliou,S., Weglarz-Tomczak,E., Berlicki,L., Pawelczak,M., Nocek,B., Mulligan,R., Joachimiak,A. and Mucha,A.
    Structure-guided, single-point modifications in the phosphinic dipeptide structure yield highly potent and selective inhibitors of neutral aminopeptidases
    J Med Chem57, 8140-8151. PubMed  Europe PubMed DOI  I
    10. 2013
  10. Bhosale,M., Kumar,A., Das,M., Bhaskarla,C., Agarwal,V. and Nandi,D.
    Catalytic activity of peptidase N is required for adaptation of Escherichia coli to nutritional downshift and high temperature stress
    Microbiol Res168, 56-64. PubMed  Europe PubMed DOI
  11. Weglarz-Tomczak,E., Poreba,M., Byzia,A., Berlicki,L., Nocek,B., Mulligan,R., Joachimiak,A., Drag,M. and Mucha,A.
    An integrated approach to the ligand binding specificity of Neisseria meningitidis M1 alanine aminopeptidase by fluorogenic substrate profiling, inhibitory studies and molecular modeling
    Biochimie95, 419-428. PubMed  Europe PubMed DOI  P
    12. 2012
  12. Bhosale,M., Bhaskarla,C. and Nandi,D.
    Alanyl aminopeptidase (bacterial-type)
    [ISSN:978-0-12-407744-7]3, 456-462. DOI
  13. Bhosale,M., Kadthur,J.C. and Nandi,D.
    Roles of Salmonella enterica serovar typhimurium encoded peptidase N during systemic infection of ifngamma-/- mice
    Immunobiology217, 354-362. PubMed  Europe PubMed DOI
  14. Fidopiastis,P.M., Rader,B.A., Gerling,D.G., Gutierrez,N.A., Watkins,K.H., Frey,M.W., Nyholm,S.V. and Whistler,C.A.
    Characterization of a Vibrio fischeri aminopeptidase and evidence for its influence on an early stage of squid colonization
    J Bacteriol194, 3995-4002. PubMed  Europe PubMed DOI
  15. Gumpena,R., Kishor,C., Ganji,R.J., Jain,N. and Addlagatta,A.
    Glu121-Lys319 salt bridge between catalytic and N-terminal domains is pivotal for the activity and stability of Escherichia coli aminopeptidase N
    Protein Sci21, 727-736. PubMed  Europe PubMed DOI  S
  16. Lee,O.R. and Cho,H.T.
    Cytoplasm localization of aminopeptidase M1 and its functional activity in root hair cells and BY-2 cells
    Mol Biol Rep39, 10211-10218. PubMed  Europe PubMed DOI
    17. 2011
  17. Su,J., Wang,Q., Feng,J., Zhang,C., Zhu,D., Wei,T., Xu,W. and Gu,L.
    Engineered Thermoplasma acidophilum factor F3 mimics human aminopeptidase N (APN) as a target for anticancer drug development
    Bioorg Med Chem19, 2991-2996. PubMed  Europe PubMed DOI  I
    18. 2009
  18. Fournie-Zaluski,M.C., Poras,H., Roques,B.P., Nakajima,Y., Ito,K. and Yoshimoto,T.
    Structure of aminopeptidase N from Escherichia coli complexed with the transition-state analogue aminophosphinic inhibitor PL250
    Acta Crystallogr D Biol Crystallogr65, 814-822. PubMed  Europe PubMed DOI  S  I
  19. Kumar,A., Bhosale,M., Reddy,S., Srinivasan,N. and Nandi,D.
    Importance of non-conserved distal carboxyl terminal amino acids in two peptidases belonging to the M1 family: Thermoplasma acidophilum Tricorn interacting factor F2 and Escherichia coli peptidase N
    Biochimie91, 1145-1155. PubMed  Europe PubMed DOI
  20. Kumar,A., Reddy,S., Srinivasan,N. and Nandi,D.
    Interaction between two residues in the inter-domain interface of Escherichia coli peptidase N modulates catalytic activity
    Protein Pept Lett16, 415-422. PubMed  Europe PubMed DOI
  21. Peer,W.A., Hosein,F.N., Bandyopadhyay,A., Makam,S.N., Otegui,M.S., Lee,G.J., Blakeslee,J.J., Cheng,Y., Titapiwatanakun,B., Yakubov,B., Bangari,B. and Murphy,A.S.
    Mutation of the membrane-associated M1 protease APM1 results in distinct embryonic and seedling developmental defects in Arabidopsis
    Plant Cell21, 1693-1721. PubMed  Europe PubMed DOI
    22. 2008
  22. Addlagatta,A., Gay,L. and Matthews,B.W.
    Structural basis for the unusual specificity of Escherichia coli aminopeptidase N
    Biochemistry47, 5303-5311. PubMed  Europe PubMed DOI  P  S
  23. Kazakov,T., Vondenhoff,G.H., Datsenko,K.A., Novikova,M., Metlitskaya,A., Wanner,B.L. and Severinov,K.
    Escherichia coli peptidase A, B, or N can process translation inhibitor microcin C
    J Bacteriol190, 2607-2610. PubMed  Europe PubMed DOI
  24. Nocek,B., Mulligan,R., Bargassa,M., Collart,F. and Joachimiak,A.
    Crystal structure of aminopeptidase N from human pathogen Neisseria meningitidis
    Proteins70, 273-279. PubMed  Europe PubMed DOI  S
    25. 2007
  25. [YEAR:16-2-2007]Kumar,A. and Nandi,D.
    Characterization and role of peptidase N from Salmonella enterica serovar Typhimurium
    Biochem Biophys Res Commun353, 706-712. PubMed  Europe PubMed DOI  P
  26. Patil,V., Kumar,A., Kuruppath,S. and Nandi,D.
    Peptidase N encoded by Salmonella enterica serovar Typhimurium modulates systemic infection in mice
    FEMS Immunol Med Microbiol51, 431-442. PubMed  Europe PubMed DOI
    27. 2006
  27. Addlagatta,A., Gay,L. and Matthews,B.W.
    Structure of aminopeptidase N from Escherichia coli suggests a compartmentalized, gated active site
    Proc Natl Acad Sci U S A103, 13339-13344. PubMed  Europe PubMed DOI  S  I
  28. Contreras-Rodriguez,A., Seleem,M.N., Schurig,G.G., Sriranganathan,N., Boyle,S.M. and Lopez-Merino,A.
    Cloning, expression and characterization of immunogenic aminopeptidase N from Brucella melitensis
    FEMS Immunol Med Microbiol48, 252-256. PubMed  Europe PubMed DOI
  29. Golich,F.C., Han,M. and Crowder,M.W.
    Over-expression, purification, and characterization of aminopeptidase N from Escherichia coli
    Protein Expr Purif47, 634-639. PubMed  Europe PubMed DOI
  30. Ito,K., Nakajima,Y., Onohara,Y., Takeo,M., Nakashima,K., Matsubara,F., Ito,T. and Yoshimoto,T.
    Crystal structure of aminopeptidase N (proteobacteria alanyl aminopeptidase) from Escherichia coli and conformational change of methionine 260 involved in substrate recognition
    J Biol Chem281, 33664-33676. PubMed  Europe PubMed DOI  S
    31. 2005
  31. Fetterer,R.H., Miska,K.B. and Barfield,R.C.
    Partial purification and characterization of an aminopeptidase from Eimeria tenella
    J Parasitol91, 1280-1286. PubMed  Europe PubMed DOI
    32. 2004
  32. [YEAR:1-5-2004]Garcia Gonzalez,O., Garcia,R.M., de la Garza,M., Vaca,S., Paniagua,G.L., Mejia,R., Tenorio,V.R. and Negrete-Abascal,E.
    Actinobacillus pleuropneumoniae metalloprotease: cloning and in vivo expression
    FEMS Microbiol Lett234, 81-86. PubMed  Europe PubMed DOI
  33. Sanchez-Moran,E., Jones,G.H., Franklin,F.C. and Santos,J.L.
    A puromycin-sensitive aminopeptidase is essential for meiosis in Arabidopsis thaliana
    Plant Cell16, 2895-2909. PubMed  Europe PubMed DOI  I
    34. 2003
  34. [YEAR:21-2-2003]Chandu,D., Kumar,A. and Nandi,D.
    PepN, the major Suc-LLVY-AMC-hydrolyzing enzyme in Escherichia coli, displays functional similarity with downstream processing enzymes in Archaea and eukarya. Implications in cytosolic protein degradation
    J Biol Chem278, 5548-5556. PubMed  Europe PubMed DOI
  35. Chandu,D. and Nandi,D.
    PepN is the major aminopeptidase in Escherichia coli: insights on substrate specificity and role during sodium-salicylate-induced stress
    Microbiology (Reading, Engl )149, 3437-3447. PubMed  Europe PubMed
  36. Contreras-Rodriguez,A., Ramirez-Zavala,B., Contreras,A., Schurig,G.G., Sriranganathan,N. and Lopez-Merino,A.
    Purification and characterization of an immunogenic aminopeptidase of Brucella melitensis
    Infect Immun71, 5238-5244. PubMed  Europe PubMed DOI
    37. 2002
  37. Murphy,A.S., Hoogner,K.R., Peer,W.A. and Taiz,L.
    Identification, purification, and molecular cloning of N-1-naphthylphthalmic acid-binding plasma membrane-associated aminopeptidases from Arabidopsis
    Plant Physiol128, 935-950. PubMed  Europe PubMed DOI
    38. 2001
  38. Luoma,S., Peltoniemi,K., Joutsjoki,V., Rantanen,T., Tamminen,M., Heikkinen,I. and Palva,A.
    Expression of six peptidases from Lactobacillus helveticus in Lactococcus lactis
    Appl Environ Microbiol67, 1232-1238. PubMed  Europe PubMed DOI  E
  39. Suzuki,H., Kamatani,S., Kim,E.S. and Kumagai,H.
    Aminopeptidases A, B, and N and dipeptidase D are the four cysteinylglycinases of Escherichia coli K-12
    J Bacteriol183, 1489-1490. PubMed  Europe PubMed DOI
  40. Yamauchi,Y., Ejiri,Y. and Tanaka,K.
    Purification of an aminopeptidase preferentially releasing N-terminal alanine from cucumber leaves and its identification as a plant aminopeptidase N
    Biosci Biotechnol Biochem65, 2802-2805. PubMed  Europe PubMed DOI
    41. 1997
  41. Jensch,T. and Fricke,B.
    Localization of alanyl aminopeptidase and leucyl aminopeptidase in cells of Pseudomonas aeruginosa by application of different methods for periplasm release
    J Basic Microbiol37, 115-128. PubMed  Europe PubMed
  42. Leopold,I. and Fricke,B.
    Inhibition, reactivation, and determination of metal ions in membrane metalloproteases of bacterial origin using high-performance liquid chromatography coupled on-line with inductively coupled plasma mass spectrometry
    Anal Biochem252, 277-285. PubMed  Europe PubMed DOI
    43. 1988
  43. Yoshimoto,T., Tamesa,Y., Gushi,K., Murayama,N. and Tsuru,D.
    An aminopeptidase N from Escherichia coli HB101: purification and demonstration that the enzyme possesses arylamidase and peptidase activities
    Agric Biol Chem52, 217-225. DOI
    44. 1987
  44. Foglino,M. and Lazdunski,A.
    Deletion analysis of the promoter region of the Escherichia coli pepn gene, a gene subject in vivo to multiple global controls
    Mol Gen Genet210, 523-527. PubMed  Europe PubMed DOI
    45. 1986
  45. Bally,M., Foglino,M., Bruschi,M., Murgier,M. and Lazdunski,A.
    Nucleotide sequence of the promoter and amino-terminal encoding region of the Escherichia coli pepN gene
    Eur J Biochem155, 565-569. PubMed  Europe PubMed
  46. Foglino,M., Gharbi,S. and Lazdunski,A.
    Nucleotide sequence of the pepN gene encoding aminopeptidase N of Escherichia coli
    Gene49, 303-309. PubMed  Europe PubMed
  47. Gharbi,S., Bally,M., Lazdunski,A. and Murgier,M.
    Mutation that affects pepn translation initiation in Escherichia coli
    Biochimie68, 1159-1163. PubMed  Europe PubMed
  48. McCaman,M.T. and Gabe,J.D.
    The nucleotide sequence of the pepN gene and its over-expression in Escherichia coli
    Gene48, 145-153. PubMed  Europe PubMed
    49. 1985
  49. Gharbi,S., Belaich,A., Murgier,M. and Lazdunski,A.
    Multiple controls exerted on in vivo expression of the pepN gene in Escherichia coli: studies with pepN-lacZ operon and protein fusion strains
    J Bacteriol163, 1191-1195. PubMed  Europe PubMed
    50. 1977
  50. Chappelet-Tordo,D., Lazdunski,C., Murgier,M. and Lazdunski,A.
    Aminopeptidase N from Escherichia coli: ionizable active-center groups and substrate specificity
    Eur J Biochem81, 293-305. PubMed  Europe PubMed  P
  51. Murgier,M., Pelissier,C. and Lazdunski,A.
    Aminopeptidase N from Escherichia coli. Unusual interactions with the cell surface
    Eur J Biochem74, 425-433. PubMed  Europe PubMed
    52. 1976
  52. Latil,M., Murgier,M., Lazdunski,A. and Lazdunski,C.
    Isolation and genetic mapping of Escherichia coli aminopeptidase mutants
    Mol Gen Genet148, 43-47. PubMed  Europe PubMed
  53. Murgier,M., Pelissier,C., Lazdunski,A. and Lazdunski,C.
    Existence, localization and regulation of the biosynthesis of aminoendopeptidase in gram-negative bacteria
    Eur J Biochem65, 517-520. PubMed  Europe PubMed
  54. Yang,L.M. and Somerville,R.L.
    Purification and properties of a new aminopeptidase from Escherichia coli K12
    Biochim Biophys Acta445, 406-419. PubMed  Europe PubMed
    55. 1975
  55. Lazdunski,A., Murgier,M. and Lazdunski,C.
    Evidence for an aminoendopeptidase localized near the cell surface of Escherichia coli. Regulation of synthesis by inorganic phosphate
    Eur J Biochem60, 349-355. PubMed  Europe PubMed
  56. Lazdunski,C., Busuttil,J. and Lazdunski,A.
    Purification and properties of a periplasmic aminoendopeptidase from Escherichia coli
    Eur J Biochem60, 363-369. PubMed  Europe PubMed
    57. 1971
  57. Matsumura,Y., Minamiura,N., Fukumoto,J. and Yamamoto,T.
    Intracellular peptidase of Bacillus subtilis Part III. Effects of metal ions on activity and specificity of aminopeptidase of Bacillus subtilis
    Agric Biol Chem35, 975-982. DOI

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