Substrates for peptidase C76.001: viral tegument protein deubiquitinylating peptidase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
neddylated cullin-1	Q15843/Q13616	1-76	peptide-Gly76+Lys720-peptide	P	Leu	Arg	Gly	Gly	Lys	Met	Arg	Lys	Gastaldello et al., 2010
polyubiquitin	P0CG47	1-76	peptide-Gly76+Lys48-peptide	P	Leu	Arg	Gly	Gly	Lys	Gln	Leu	Glu	Kattenhorn et al., 2005
ubiquitin dimer	P0CG47	1-76	peptide-Gly76+Lys63-peptide	S	Leu	Arg	Gly	Gly	Lys	Glu	Ser	Thr	Kim et al., 2009
ubiquitin-NHMec	P0CG47	1-76	peptide-Gly76+NHMec	S	Leu	Arg	Gly	Gly	AMC	-	-	-	Kattenhorn et al., 2005