Literature for peptidase C76.001: viral tegument protein deubiquitinylating peptidase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, P Specificity, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Antinone,S.E., Miller,J.S., Huffmaster,N.J., Pickard,G.E. and Smith,G.A.
    Tethered release of the pseudorabies virus deubiquitinase from the capsid promotes enzymatic activity
    J Virole0151724-e0151724. PubMed  Europe PubMed DOI
  2. Wu,H., Han,B.W., Liu,T., Zhang,M., Wu,Y. and Nie,J.
    Epstein-Barr virus deubiquitinating enzyme BPLF1 is involved in EBV carcinogenesis by affecting cellular genomic stability
    Neoplasia55, 101012-101012. PubMed  Europe PubMed DOI
  3. 2022
  4. Mohnke,J., Stark,I., Fischer,M., Fischer,P.M., Schlosser,A., Grothey,A., O'Hare,P., Sodeik,B., Erhard,F., Dolken,L. and Hennig,T.
    pUL36 Deubiquitinase Activity Augments Both the Initiation and the Progression of Lytic Herpes Simplex Virus Infection in IFN-Primed Cells
    J Virol96, e0096322-e0096322. PubMed  Europe PubMed DOI
  5. 2021
  6. Kwon,K.M., Kim,Y.E., Lee,M.K., Chung,W.C., Hyeon,S., Han,M., Lee,D., Gong,S. and Ahn,J.H.
    Human cytomegalovirus UL48 deubiquitinase primarily targets innermost tegument proteins pp150 and itself to regulate their stability and protects virions from inclusion of ubiquitin conjugates
    J VirolJVI0099121-JVI0099121. PubMed  Europe PubMed DOI
  7. Li,J., Nagy,N., Liu,J., Gupta,S., Frisan,T., Hennig,T., Cameron,D.P., Baranello,L. and Masucci,M.G.
    The Epstein-Barr virus deubiquitinating enzyme BPLF1 regulates the activity of topoisomerase II during productive infection
    PLoS Pathog17, e1009954-e1009954. PubMed  Europe PubMed DOI
  8. Yla-Anttila,P. and Masucci,M.G.
    Inhibition of selective autophagy by members of the herpesvirus ubiquitin-deconjugase family
    Biochem J478, 2297-2308. PubMed  Europe PubMed DOI
  9. 2020
  10. Atkins,S.L., Motaib,S., Wiser,L.C., Hopcraft,S.E., Hardy,P.B., Shackelford,J., Foote,P., Wade,A.H., Damania,B., Pagano,J.S., Pearce,K.H. and Whitehurst,C.B.
    Small molecule screening identifies inhibitors of the Epstein-Barr virus deubiquitinating enzyme, BPLF1
    Antiviral Res173, 104649-104649. PubMed  Europe PubMed DOI  I
  11. 2018
  12. Yuan,H., You,J., You,H. and Zheng,C.
    Herpes simplex virus 1 UL36USP antagonizes type I IFN-mediated antiviral innate immunity
    J Virol92, e01161-18-e01161-18. PubMed  Europe PubMed DOI
  13. 2017
  14. Kwon,K.M., Oh,S.E., Kim,Y.E., Han,T.H. and Ahn,J.H.
    Cooperative inhibition of RIP1-mediated NF-kappaB signaling by cytomegalovirus-encoded deubiquitinase and inactive homolog of cellular ribonucleotide reductase large subunit
    PLoS Pathog13, e1006423-e1006423. PubMed  Europe PubMed DOI
  15. 2016
  16. Kim,Y.E., Oh,S.E., Kwon,K.M., Lee,C.H. and Ahn,J.H.
    Involvement of the N-terminal deubiquitinating protease domain of human cytomegalovirus UL48 tegument protein in autoubiquitination, virion stability, and virus entry
    J Virol90, 3229-3242. PubMed  Europe PubMed DOI
  17. Ye,R., Su,C., Xu,H. and Zheng,C.
    Herpes simplex virus type 1 ubiquitin-specific protease UL36 abrogates NF-kappaB activation in DNA sensing signal pathway
    J Virol91, e02417-16-e02417-16. PubMed  Europe PubMed DOI
  18. 2015
  19. Calistri,A., Munegato,D., Toffoletto,M., Celestino,M., Franchin,E., Comin,A., Sartori,E., Salata,C., Parolin,C. and Palu,G.
    Functional interaction between the ESCRT-I component TSG101 and the HSV-1 tegument ubiquitin specific protease
    J Cell Physiol230, 1794-1806. PubMed  Europe PubMed DOI
  20. Scrima,N., Lepault,J., Boulard,Y., Pasdeloup,D., Bressanelli,S. and Roche,S.
    Insights into herpesvirus tegument organization from structural analyses of the 970 central residues of HSV-1 UL36 protein
    J Biol Chem290, 8820-8833. PubMed  Europe PubMed DOI  S
  21. 2014
  22. Hennig,T., Abaitua,F. and O'Hare,P.
    Functional analysis of nuclear localization signals in VP1-2 homologues from all herpesvirus subfamilies
    J Virol88, 5391-5405. PubMed  Europe PubMed DOI
  23. 2013
  24. Gastaldello,S., Chen,X., Callegari,S. and Masucci,M.G.
    Caspase-1 promotes Epstein-Barr virus replication by targeting the large tegument protein deneddylase to the nucleus of productively infected cells
    PLoS Pathog9, e1003664-e1003664. PubMed  Europe PubMed DOI
  25. Veiga,I.B., Jarosinski,K.W., Kaufer,B.B. and Osterrieder,N.
    Marek's disease virus (MDV) ubiquitin-specific protease (USP) performs critical functions beyond its enzymatic activity during virus replication
    Virology437, 110-117. PubMed  Europe PubMed DOI
  26. Wang,S., Wang,K., Li,J. and Zheng,C.
    Herpes simplex virus 1 ubiquitin-specific protease UL36 inhibits beta interferon production by deubiquitinating TRAF3
    J Virol87, 11851-11860. PubMed  Europe PubMed DOI
  27. 2012
  28. Ploegh,H.
    UL36 deubiquitinylating peptidase
    [ISSN:978-0-12-407743-0]3, 2131-2134. DOI
  29. Sanyal,S., Claessen,J.H. and Ploegh,H.L.
    A viral deubiquitylating enzyme restores dislocation of substrates from the endoplasmic reticulum (ER) in semi-intact cells
    J Biol Chem287, 23594-23603. PubMed  Europe PubMed DOI
  30. Whitehurst,C.B., Vaziri,C., Shackelford,J. and Pagano,J.S.
    Epstein-Barr Virus BPLF1 deubiquitinates PCNA and attenuates polymerase eta recruitment to DNA damage sites
    J Virol86, 8097-8106. PubMed  Europe PubMed DOI
  31. 2011
  32. Bolstad,M., Abaitua,F., Crump,C.M. and O'Hare,P.
    Autocatalytic activity of the ubiquitin-specific protease domain of herpes simplex virus 1 VP1-2
    J Virol85, 8738-8751. PubMed  Europe PubMed DOI
  33. Ernst,R., Claessen,J.H., Mueller,B., Sanyal,S., Spooner,E., van der Veen,A.G., Kirak,O., Schlieker,C.D., Weihofen,W.A. and Ploegh,H.L.
    Enzymatic blockade of the ubiquitin-proteasome pathway
    PLoS Biol8, e1000605-e1000605. PubMed  Europe PubMed DOI
  34. 2010
  35. Gastaldello,S., Hildebrand,S., Faridani,O., Callegari,S., Palmkvist,M., Di Guglielmo,C. and Masucci,M.G.
    A deneddylase encoded by Epstein-Barr virus promotes viral DNA replication by regulating the activity of cullin-RING ligases
    Nat Cell Biol12, 351-361. PubMed  Europe PubMed DOI
  36. 2009
  37. Gredmark-Russ,S., Isaacson,M.K., Kattenhorn,L., Cheung,E.J., Watson,N. and Ploegh,H.L.
    A gammaherpesvirus ubiquitin-specific protease is involved in the establishment of murine gammaherpesvirus 68 infection
    J Virol83, 10644-10652. PubMed  Europe PubMed DOI
  38. Kim,E.T., Oh,S.E., Lee,Y.O., Gibson,W. and Ahn,J.H.
    Cleavage specificity of the UL48 deubiquitinating protease activity of human cytomegalovirus and the growth of an active-site mutant virus in cultured cells
    J Virol83, 12046-12056. PubMed  Europe PubMed DOI  P
  39. Whitehurst,C.B., Ning,S., Bentz,G.L., Dufour,F., Gershburg,E., Shackelford,J., Langelier,Y. and Pagano,J.S.
    The Epstein-Barr virus (EBV) deubiquitinating enzyme BPLF1 reduces EBV ribonucleotide reductase activity
    J Virol83, 4345-4353. PubMed  Europe PubMed DOI
  40. 2008
  41. Bottcher,S., Maresch,C., Granzow,H., Klupp,B.G., Teifke,J.P. and Mettenleiter,T.C.
    Mutagenesis of the active-site cysteine in the ubiquitin-specific protease contained in large tegument protein pUL36 of Pseudorabies virus impairs viral replication in vitro and neuroinvasion in vivo
    J Virol82, 6009-6016. PubMed  Europe PubMed DOI
  42. 2007
  43. Gredmark,S., Schlieker,C., Quesada,V., Spooner,E. and Ploegh,H.L.
    A functional ubiquitin-specific protease embedded in the large tegument protein (ORF64) of murine gammaherpesvirus 68 is active during the course of infection
    J Virol81, 10300-10309. PubMed  Europe PubMed DOI
  44. Jarosinski,K., Kattenhorn,L., Kaufer,B., Ploegh,H. and Osterrieder,N.
    A herpesvirus ubiquitin-specific protease is critical for efficient T cell lymphoma formation
    Proc Natl Acad Sci U S A104, 20025-20030. PubMed  Europe PubMed DOI
  45. Schlieker,C., Weihofen,W.A., Frijns,E., Kattenhorn,L.M., Gaudet,R. and Ploegh,H.L.
    Structure of a herpesvirus-encoded cysteine protease reveals a unique class of deubiquitinating enzymes
    Mol Cell25, 677-687. PubMed  Europe PubMed DOI  S
  46. 2005
  47. [YEAR:19-8-2005]Kattenhorn,L.M., Korbel,G.A., Kessler,B.M., Spooner,E. and Ploegh,H.L.
    A deubiquitinating enzyme encoded by HSV-1 belongs to a family of cysteine proteases that is conserved across the family Herpesviridae
    Mol Cell19, 547-557. PubMed  Europe PubMed DOI
  48. Schlieker,C., Korbel,G.A., Kattenhorn,L.M. and Ploegh,H.L.
    A deubiquitinating activity is conserved in the large tegument protein of the herpesviridae
    J Virol79, 15582-15585. PubMed  Europe PubMed DOI