Substrates for peptidase C67.001: CylD peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
polyubiquitin	P0CG47	1-76	peptide-Gly76+Lys63-peptide	N	Leu	Arg	Gly	Gly	Lys	Glu	Ser	Thr	Kovalenko et al., 2003
polyubiquitin-ATP-dependent RNA helicase DDX58	P0CG47	1-76	peptide-Gly76+Lys63-peptide	P	Leu	Arg	Gly	Gly	Lys	Glu	Ser	Thr	Friedman et al., 2008
polyubiquitin-TNF receptor-associated factor 2 conjugate	P0CG47	1-76	peptide-Gly76+Lys63-peptide	P	Leu	Arg	Gly	Gly	Lys	Glu	Ser	Thr	Li et al., 2009
polyubiquitinated B-cell lymphoma 3 protein	P0CG47/P20749	1-76	peptide-Gly76+Lys63-peptide	N	Leu	Arg	Gly	Gly	Lys	Glu	Ser	Thr
polyubiquitinated DVL3 (segment polarity protein dishevelled homolog DVL-3)	P0CG47/Q92997	1-76	peptide-Gly76+Lys63-peptide	P	Leu	Arg	Gly	Gly	Lys	Glu	Ser	Thr	Tauriello et al., 2010
polyubiquitinated mitogen-activated protein kinase kinase kinase 7	P0CG47/O43318	1-76	peptide-Gly76+Lys63-peptide	P	Leu	Arg	Gly	Gly	Lys	Glu	Ser	Thr	Reiley et al., 2007
polyubiquitinated TNF receptor-associated factor 2	P0CG47/Q12933	1-76	peptide-Gly76+Lys63-peptide	P	Leu	Arg	Gly	Gly	Lys	Glu	Ser	Thr	Trompouki et al., 2003