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Literature for peptidase C67.001: CylD peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, T Target, M Mutation, R Splicing, I Inhibitor, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Adam,E., Leitgeb,B., Danis,J., Hajdu,A., Kelemen,E., Pal,M., Belso,N., Nemeth,I.B., Rajan,N., Nagy,N. and Szell,M.<br>Truncating CYLD pathogenic variants in CYLD cutaneous syndrome distinctly influence CYLD proteostasis and NF-kappaB signaling<br>J Invest Dermatol (2025) PubMed  Europe PubMed DOI
  2. Fernandes,S.A., Pan,J., Terziyska,D.S., Koyuncu,S., Ding,X., Nemeth,I.B., Wilhelm,S., Nuchel,J., Al-Gburi,S., Gonidas,C., Pasparakis,M., Mosialos,G., Szell,M., Teleman,A.A., Eming,S.A., Vilchez,D. and Demetriades,C.<br>The tumor suppressor CYLD acts as a deubiquitinase for mTOR to constrain its activity<br>bioRxiv (2025) PubMed  Europe PubMed DOI  PMC  EPMC
  3. Jang,J.H., Kim,H.R., Kim,H. and Cho,J.H.<br>CYLD suppresses LPS-induced inflammation through RIP1 deubiquitination in rainbow trout<br>Fish Shellfish Immunol (2025) 165, 110489-110489. PubMed  Europe PubMed DOI
  4. Li,H., Li,F., Chen,Z., Wu,E., Dai,X., Li,D., An,H., Zeng,S., Wang,C., Yang,L. and Long,C.<br>Glutamatergic CYLD deletion leads to aberrant excitatory activity in the basolateral amygdala: association with enhanced cued fear expression<br>Neural Regen Res (2025) 20, 3259-3272. PubMed  Europe PubMed DOI
  5. Nardi,L., Bicker,F., Maier,J., Waisman,A. and Schmeisser,M.J.<br>Role of CYLD in brain physiology and pathology<br>J Mol Med (Berl) (2025) PubMed  Europe PubMed DOI
  6. Pseftogas,A., Bordini,J., Heltai,S., Bonfiglio,F., Gavriilidis,G., Vasileiou,V., Keisaris,S., Belloni,D., Taccetti,C., Ranghetti,P., Perotta,E., Frenquelli,M., Sarkar,U.A., Albi,E., Martini,F., Sant'Antonio,E., Mavilia,F., Psomopoulos,F., Daibata,M., Martinez Climent,J.A., Mosialos,G., Rossi,D., Campanella,A., Scarfo,L., Stamatopoulos,K., Xanthopoulos,K. and Ghia,P.<br>Loss of CYLD promotes splenic marginal zone lymphoma<br>Hemasphere (2025) 9, e70098-e70098. PubMed  Europe PubMed DOI  PMC  EPMC
  7. Schmidt,C., Harit,K., Traidl,S., Naumann,M., Werfel,T., Roesner,L.M., Nishanth,G. and Schluter,D.<br>Ablation of the deubiquitinating enzyme cylindromatosis (CYLD) augments STAT1-mediated M1 macrophage polarization and fosters Staphylococcus aureus control<br>Front Immunol (2025) 16, 1507989-1507989. PubMed  Europe PubMed DOI  PMC  EPMC
  8. Wu,Y.C., Su,B.H., Cheng,W.H., Zou,C.T., Yeh,E.T.H. and Yang,F.M.<br>CYLD links the TRAF6/sNASP axis to TLR4 signaling in sepsis-induced acute lung injury<br>Cell Mol Life Sci (2025) 82, 124-124. PubMed  Europe PubMed DOI  PMC  EPMC
  9. Wu,Z., Zhang,P., Huang,W., Zhou,Y., Cao,Z. and Wu,C.<br>Qufeng epimedium decoction alleviates rheumatoid arthritis through CYLD-antagonized NF-kB activation by deubiquitinating Sirt1<br>Immunobiology (2025) 230, 152875-152875. PubMed  Europe PubMed DOI
  10. Yoshida,Y., Shinomiya,A., Hanaki,K.I. and Watanabe,Y.<br>Fibroblast growth factor 21 affects the colocalization of post-synaptic density 95 and Kalirin7 through CYLD-expression regulation<br>Biochem Biophys Res Commun (2025) 789, 152874-152874. PubMed  Europe PubMed DOI
  11. Yu,H., He,L., Wu,X., Zhang,M., Chen,Z., Sun,J. and Xu,X.<br>Porcine epidemic diarrhea coronavirus infection activates caspase-8 to enhance innate immunity by blocking CYLD-mediated deubiquitination of RIG-I<br>Virology (2025) 604, 110443-110443. PubMed  Europe PubMed DOI
  12. Zeng,Q., Huang,M., Zha,B., Huang,Y., Fu,Q., Chen,Z., Wu,X., Li,X., Chen,H., Chen,Z. and Wu,H.<br>CYLD suppresses infectious Bursal disease virus replication by deubiquitinating VP1<br>Vet Microbiol (2025) 309, 110690-110690. PubMed  Europe PubMed DOI  K
  13. Zheng,M., Wang,S., Tang,K., Kong,R., Wang,X., Zhou,J., Chen,Y. and Wang,Y.<br>The CYLD-PARP1 feedback loop regulates DNA damage repair and chemosensitivity in breast cancer cells<br>Proc Natl Acad Sci U S A (2025) 122, e2413890121-e2413890121. PubMed  Europe PubMed DOI
  14. Zhou,J., Xie,R., Wang,T., Xu,Y. and Zhang,B.<br>CYLD inhibits ubiquitin-mediated degradation of IRE1 to promote inflammatory injury in ulcerative colitis<br>Int Immunopharmacol (2025) 167, 115698-115698. PubMed  Europe PubMed DOI  K
    15. 2024
  15. Amaral,P., Soares,I., Correia,P., Correia,C., Vasconcelos,P., Almeida,S. and Filipe,P.<br>Novel CYLD pathogenic variant associated with multiple cylindromas of the scalp-A case report<br>Skin Health Dis (2024) 4, e436-e436. PubMed  Europe PubMed DOI  PMC  EPMC
  16. Bhardwaj,A., Panepinto,M.C., Ueberheide,B. and Neel,B.G.<br>A mechanism for hypoxia-induced inflammatory cell death in cancer<br>Nature (2024) PubMed  Europe PubMed DOI
  17. Cui,Z., Kang,H., Li,H., Lee,E.D., Lee,Y.S., Peterson,C.N., Long,S.R., Grandis,J.R. and Johnson,D.E.<br>CYLD Alterations Are Associated With Metastasis and Poor Prognosis in Human Papilloma Virus-Positive Head and Neck Cancer<br>Head Neck (2024) 47, 606-614. PubMed  Europe PubMed DOI
  18. Gu,Y., Wu,S., Fan,J., Meng,Z., Gao,G., Liu,T., Wang,Q., Xia,H., Wang,X. and Wu,K.<br>CYLD regulates cell ferroptosis through Hippo/YAP signaling in prostate cancer progression<br>Cell Death Dis (2024) 15, 79-79. PubMed  Europe PubMed DOI  PMC  EPMC
  19. Jiang,G., Cai,Y., Cheng,D., Wang,H., Deng,G. and Xiang,D.<br>CYLD alleviates NLRP3 inflammasome-mediated pyroptosis in osteoporosis by deubiquitinating WNK1<br>J Orthop Surg Res (2024) 19, 212-212. PubMed  Europe PubMed DOI  PMC  EPMC
  20. Rinotas,V., Iliaki,K., Pavlidi,L., Meletakos,T., Mosialos,G. and Armaka,M.<br>Cyld restrains the hyperactivation of synovial fibroblasts in inflammatory arthritis by regulating the TAK1/IKK2 signaling axis<br>Cell Death Dis (2024) 15, 584-584. PubMed  Europe PubMed DOI  PMC  EPMC
  21. Roy,A.S., Feroz,T., Islam,M.K., Munim,M.A., Supti,D.A., Antora,N.J., Al Reza,H., Gosh,S., Bahadur,N.M., Alam,M.R. and Hossain,M.S.<br>A computational approach for structural and functional analyses of disease-associated mutations in the human CYLD gene<br>Genomics Inform (2024) 22, 4-4. PubMed  Europe PubMed DOI
  22. Xue,Y., Xue,C. and Song,W.<br>Emerging roles of deubiquitinating enzymes in actin cytoskeleton and tumor metastasis<br>Cell Oncol (Dordr) (2024) PubMed  Europe PubMed DOI  V
  23. Yang,S., Yu,F., Yang,M., Ni,H., Bu,W., Yin,H., Yang,J., Wang,W., Zhai,D., Wu,X., Ma,N., Li,T., Hao,H., Ran,J., Song,T., Li,D., Yoshida,S., Lu,Q., Yang,Y., Zhou,J. and Liu,M.<br>CYLD Maintains Retinal Homeostasis by Deubiquitinating ENKD1 and Promoting the Phagocytosis of Photoreceptor Outer Segments<br>Adv Sci (Weinh) (2024) , e2404067-e2404067. PubMed  Europe PubMed DOI
    24. 2023
  24. Bekas,N., Samiotaki,M., Papathanasiou,M., Mokos,P., Pseftogas,A., Xanthopoulos,K., Thanos,D., Mosialos,G. and Dafou,D.<br>Inactivation of Tumor Suppressor CYLD Inhibits Fibroblast Reprogramming to Pluripotency<br>Cancers (Basel) (2023) 15 PubMed  Europe PubMed DOI  PMC  EPMC
  25. Bhardwaj,A., Antonelli,M., Ueberheide,B. and Neel,B.G.<br>Identification of a Novel Hypoxia-induced Inflammatory Cell Death Pathway<br>bioRxiv (2023) PubMed  Europe PubMed DOI  PMC  EPMC
  26. Cao,Y., Zhang,X., Hu,M., Yang,S., Li,X., Han,R., Zhou,J., Li,D. and Liu,D.<br>CYLD inhibits osteoclastogenesis to ameliorate alveolar bone loss in mice with periodontitis<br>J Cell Physiol (2023) 238, 1036-1045. PubMed  Europe PubMed DOI
  27. Chen,S.Y., Liu,K.F., Tan,S.Y., Chen,X.S., Li,H.D., Li,J.J., Zhou,J.W., Yang,L. and Long,C.<br>Deubiquitinase CYLD regulates excitatory synaptic transmission and short-term plasticity in the hippocampus<br>Brain Res (2023) 1806, 148313-148313. PubMed  Europe PubMed DOI
  28. Cheng,N. and Trejo,J.<br>An siRNA library screen identifies CYLD and USP34 as deubiquitinases that regulate GPCR-p38 MAPK signaling and distinct inflammatory responses<br>J Biol Chem (2023) 299, 105370-105370. PubMed  Europe PubMed DOI  PMC  EPMC  K
  29. Compagnoni,C., Capelli,R., Zelli,V., Corrente,A., Vecchiotti,D., Flati,I., Di Vito Nolfi,M., Angelucci,A., Alesse,E., Zazzeroni,F. and Tessitore,A.<br>MiR-182-5p Is Upregulated in Hepatic Tissues from a Diet-Induced NAFLD/NASH/HCC C57BL/6J Mouse Model and Modulates Cyld and Foxo1 Expression<br>Int J Mol Sci (2023) 24 PubMed  Europe PubMed DOI  PMC  EPMC
  30. Giang,N.H., Lien,N.T.K., Trang,D.T., Huong,P.T., Hoang,N.H. and Xuan,N.T.<br>Associations of A20, CYLD, Cezanne and JAK2 Genes and Immunophenotype with Psoriasis Susceptibility<br>Medicina (Kaunas) (2023) 59 PubMed  Europe PubMed DOI  PMC  EPMC  M
  31. Huang,Y., Zhang,W., Yu,Z., Su,H., Zeng,B., Piao,J., Wang,J. and Wu,J.<br>A Tumor Suppressive Role of CYLD as a Novel Potential DUB of Aurora B in Cervical Cancer<br>Clin Med Insights Oncol (2023) 17, 11795549231180832-11795549231180832. PubMed  Europe PubMed DOI  PMC  EPMC
  32. Huang,Z. and Tan,Y.<br>The Potential of Cylindromatosis (CYLD) as a Therapeutic Target in Oxidative Stress-Associated Pathologies: A Comprehensive Evaluation<br>Int J Mol Sci (2023) 24 PubMed  Europe PubMed DOI  PMC  EPMC  V
  33. Marin-Rubio,J.L., Raote,I., Inns,J., Dobson-Stone,C. and Rajan,N.<br>CYLD in health and disease<br>Dis Model Mech (2023) 16 PubMed  Europe PubMed DOI  PMC  EPMC  V
  34. Minderman,M., Lantermans,H.C., Gruneberg,L.J., Cillessen,S.A.G.M., Bende,R.J., van Noesel,C.J.M., Kersten,M.J., Pals,S.T. and Spaargaren,M.<br>MALT1-dependent cleavage of CYLD promotes NF-kappaB signaling and growth of aggressive B-cell receptor-dependent lymphomas<br>Blood Cancer J (2023) 13, 37-37. PubMed  Europe PubMed DOI  PMC  EPMC
  35. Zamani,F., Khalighfard,S., Kalhori,M.R., Poorkhani,A., Amiriani,T., Hosseinzadeh,P., Esmati,E., Alemrajabi,M., Nikoofar,A., Safarnezhad Tameshkel,F. and Alizadeh,A.M.<br>Expanding CYLD protein in NF-kappabeta/TNF-alpha signaling pathway in response to Lactobacillus acidophilus in non-metastatic rectal cancer patients<br>Med Oncol (2023) 40, 302-302. PubMed  Europe PubMed DOI
  36. Zhang,Z., Yu,Y., Zhang,Z., Li,D., Liang,Z., Wang,L., Chen,Y., Liang,Y. and Niu,H.<br>Cancer-associated fibroblasts-derived CXCL12 enhances immune escape of bladder cancer through inhibiting P62-mediated autophagic degradation of PDL1<br>J Exp Clin Cancer Res (2023) 42, 316-316. PubMed  Europe PubMed DOI  PMC  EPMC
    37. 2022
  37. Erol,A.<br>Genotoxicity-Stimulated and CYLD-Driven Malignant Transformation<br>Cancer Manag Res (2022) 14, 2339-2356. PubMed  Europe PubMed DOI  PMC  EPMC
  38. Haq,S., Sarodaya,N., Karapurkar,J.K., Suresh,B., Jo,J.K., Singh,V., Bae,Y.S., Kim,K.S. and Ramakrishna,S.<br>CYLD destabilizes NoxO1 protein by promoting ubiquitination and regulates prostate cancer progression<br>Cancer Lett (2022) 525, 146-157. PubMed  Europe PubMed DOI
  39. Khoury,E., Godfrey,M. and Yeoh,C.C.<br>Gynaecological cylindroma in association with CYLD gene mutation<br>Oxf Med Case Reports (2022) 2022, omab139-omab139. PubMed  Europe PubMed DOI  PMC  EPMC
  40. Pirooznia,S.K., Wang,H., Panicker,N., Kumar,M., Neifert,S., Dar,M.A., Lau,E., Kang,B.G., Redding-Ochoa,J., Troncoso,J.C., Dawson,V.L. and Dawson,T.M.<br>Deubiquitinase CYLD acts as a negative regulator of dopamine neuron survival in Parkinson's disease<br>Sci Adv (2022) 8, eabh1824-eabh1824. PubMed  Europe PubMed DOI
  41. Schott,M., Kappelmann-Fenzl,M., Fischer,S., Fernandez-Barrena,M.G., Pineda-Lucena,A., Avila,M.A., Kuphal,S. and Bosserhoff,A.K.<br>Impact of CYLD on chromatin structure and histone methylation in malignant melanoma<br>Int J Mol Med (2022) 49 PubMed  Europe PubMed DOI  PMC  EPMC
  42. Trang,D.T., Giang,N.H., Trang,B.K., Ngoc,N.T., Giang,N.V., Canh,N.X., Vuong,N.B. and Xuan,N.T.<br>Prevalence of CYLD mutations in Vietnamese patients with polycythemia vera<br>Adv Clin Exp Med (2022) PubMed  Europe PubMed DOI
  43. Xie,W., Gao,S., Yang,Y., Li,H., Zhou,J., Chen,M., Yang,S., Zhang,Y., Zhang,L., Meng,X., Xie,S., Liu,M., Li,D., Chen,Y. and Zhou,J.<br>CYLD deubiquitinates plakoglobin to promote Cx43 membrane targeting and gap junction assembly in the heart<br>Cell Rep (2022) 41, 111864-111864. PubMed  Europe PubMed DOI
    44. 2021
  44. Elliott,P.R., Leske,D., Wagstaff,J., Schlicher,L., Berridge,G., Maslen,S., Timmermann,F., Ma,B., Fischer,R., Freund,S.M.V., Komander,D. and Gyrd-Hansen,M.<br>Regulation of CYLD activity and specificity by phosphorylation and ubiquitin-binding CAP-Gly domains<br>Cell Rep (2021) 37, 109777-109777. PubMed  Europe PubMed DOI  PMC  EPMC
  45. Li,H.D., Li,D.N., Yang,L. and Long,C.<br>Deficiency of the CYLD Impairs Fear Memory of Mice and Disrupts Neuronal Activity and Synaptic Transmission in the Basolateral Amygdala<br>Front Cell Neurosci (2021) 15, 740165-740165. PubMed  Europe PubMed DOI  PMC  EPMC
  46. Snyder,N.A. and Silva,G.M.<br>Deubiquitinating enzymes (DUBs): Regulation, homeostasis, and oxidative stress response<br>J Biol Chem (2021) 297, 101077-101077. PubMed  Europe PubMed DOI  V
  47. Williams,E.A., Montesion,M., Alexander,B.M., Ramkissoon,S.H., Elvin,J.A., Ross,J.S., Williams,K.J., Glomski,K., Bledsoe,J.R., Tse,J.Y. and Mochel,M.C.<br>CYLD mutation characterizes a subset of HPV-positive head and neck squamous cell carcinomas with distinctive genomics and frequent cylindroma-like histologic features<br>Mod Pathol (2021) 34, 358-370. PubMed  Europe PubMed DOI
  48. Yamanaka,S., Sato,Y., Oikawa,D., Goto,E., Fukai,S., Tokunaga,F., Takahashi,H. and Sawasaki,T.<br>Corrigendum to "Subquinocin, a small molecule inhibitor of CYLD and USP-family deubiquitinating enzymes, promotes NF-kappaB signaling" [Biochem. Biophys. Res. Commun. 524 (1) (2020) 1-7]<br>Biochem Biophys Res Commun (2021) 536, 115-115. PubMed  Europe PubMed DOI
  49. Zhu,G., Herlyn,M. and Yang,X.<br>TRIM15 and CYLD regulate ERK activation via lysine-63-linked polyubiquitination<br>Nat Cell Biol (2021) 23, 978-991. PubMed  Europe PubMed DOI  PMC  EPMC
    50. 2020
  50. Cui,Z., Kang,H., Grandis,J.R. and Johnson,D.E.<br>CYLD Alterations in the Tumorigenesis and Progression of Human Papillomavirus-Associated Head and Neck Cancers<br>Mol Cancer Res (2020) PubMed  Europe PubMed DOI  V
  51. Dai,H., Liu,C., Liu,Y., Zhang,Z., Peng,C., Wang,Z., Zheng,J., Li,C., Yu,W. and Cheng,F.<br>Research on mechanism of miR-130a in regulating autophagy of bladder cancer cells through CYLD<br>J BUON (2020) 25, 1636-1642. PubMed  Europe PubMed  K
  52. Deng,M., Dai,W., Yu,V.Z., Tao,L. and Lung,M.L.<br>Cylindromatosis Lysine 63 Deubiquitinase (CYLD) Regulates NF-kB Signaling Pathway and Modulates Fibroblast and Endothelial Cells Recruitment in Nasopharyngeal Carcinoma<br>Cancers (Basel) (2020) 12 PubMed  Europe PubMed DOI
  53. Dobson-Stone,C., Hallupp,M., Shahheydari,H., Ragagnin,A.M.G., Chatterton,Z., Carew-Jones,F., Shepherd,C.E., Stefen,H., Paric,E., Fath,T., Thompson,E.M., Blumbergs,P., Short,C.L., Field,C.D., Panegyres,P.K., Hecker,J., Nicholson,G., Shaw,A.D., Fullerton,J.M., Luty,A.A., Schofield,P.R., Brooks,W.S., Rajan,N., Bennett,M.F., Bahlo,M., Landers,J.E., Piguet,O., Hodges,J.R., Halliday,G.M., Topp,S.D., Smith,B.N., Shaw,C.E., McCann,E., Fifita,J.A., Williams,K.L., Atkin,J.D., Blair,I.P. and Kwok,J.B.<br>CYLD is a causative gene for frontotemporal dementia - amyotrophic lateral sclerosis<br>Brain (2020) 143, 783-799. PubMed  Europe PubMed DOI  M
  54. Douglas,T. and Saleh,M.<br>The plot thickens: OTULIN regulation in cell death<br>Mol Cell Oncol (2020) 7, 1740541-1740541. PubMed  Europe PubMed DOI  PMC  EPMC
  55. Jang,J.H., Lee,H.M., Kim,H. and Cho,J.H.<br>Molecular cloning and functional analysis of deubiquitinase CYLD in rainbow trout, Oncorhynchus mykiss<br>Fish Shellfish Immunol (2020) 101, 135-142. PubMed  Europe PubMed DOI
  56. La,T., Jin,L., Liu,X.Y., Song,Z.H., Farrelly,M., Feng,Y.C., Yan,X.G., Zhang,Y.Y., Thorne,R.F., Zhang,X.D. and Teng,L.<br>Cylindromatosis is required for survival of a subset of melanoma cells<br>Oncol Res (2020) PubMed  Europe PubMed DOI
  57. Lee,J.H., Zou,L., Yang,R., Han,J., Wan,Q., Zhang,X., El Baghdady,S., Roman,A., Elly,C., Jin,H.S., Park,Y., Croft,M. and Liu,Y.C.<br>The deubiquitinase CYLD controls protective immunity against helminth infection by regulation of Treg plasticity<br>J Allergy Clin Immunol (2020) PubMed  Europe PubMed DOI  K
  58. Mukherjee,S., Kumar,R., Tsakem Lenou,E., Basrur,V., Kontoyiannis,D.L., Ioakeimidis,F., Mosialos,G., Theiss,A.L., Flavell,R.A. and Venuprasad,K.<br>Deubiquitination of NLRP6 inflammasome by Cyld critically regulates intestinal inflammation<br>Nat Immunol (2020) 21, 626-635. PubMed  Europe PubMed DOI
  59. Oshiumi,H.<br>Recent Advances and Contradictions in the Study of the Individual Roles of Ubiquitin Ligases That Regulate RIG-I-Like Receptor-Mediated Antiviral Innate Immune Responses<br>Front Immunol (2020) 11, 1296-1296. PubMed  Europe PubMed DOI  PMC  EPMC
  60. Qi,L., Zang,H., Wu,W., Nagarkatti,P., Nagarkatti,M., Liu,Q., Robbins,J., Wang,X. and Cui,T.<br>CYLD exaggerates pressure overload-induced cardiomyopathy via suppressing autolysosome efflux in cardiomyocytes<br>J Mol Cell Cardiol (2020) 145, 59-73. PubMed  Europe PubMed DOI
  61. Qiu,C., Liu,K., Zhang,S., Gao,S., Chen,W., Li,D. and Huang,Y.<br>Bisdemethoxycurcumin inhibits hepatocellular carcinoma proliferation through Akt inactivation via CYLD-mediated deubiquitination<br>Drug Des Devel Ther (2020) 14, 993-1001. PubMed  Europe PubMed DOI  PMC  EPMC  I
  62. Rasaei,R., Sarodaya,N., Kim,K.S., Ramakrishna,S. and Hong,S.H.<br>Importance of Deubiquitination in Macrophage-Mediated Viral Response and Inflammation<br>Int J Mol Sci (2020) 21 PubMed  Europe PubMed DOI  PMC  EPMC  V
  63. Sarikaya Solak,S., Yalcintepe,S., Atahan,C., Nagy,N. and Can,N.<br>A novel nonsense mutation of the CYLD gene in a Turkish family with multiple familial trichoepithelioma<br>Clin Exp Dermatol (2020) 45, 508-511. PubMed  Europe PubMed DOI  M
  64. Xiao,Y., Huang,Q., Wu,Z. and Chen,W.<br>Roles of protein ubiquitination in inflammatory bowel disease<br>Immunobiology (2020) 225, 152026-152026. PubMed  Europe PubMed DOI  V
  65. Yamanaka,S., Sato,Y., Oikawa,D., Goto,E., Fukai,S., Tokunaga,F., Takahashi,H. and Sawasaki,T.<br>Subquinocin, a small molecule inhibitor of CYLD and USP-family deubiquitinating enzymes, promotes NF-kappaB signaling<br>Biochem Biophys Res Commun (2020) 524, 1-7. PubMed  Europe PubMed DOI  I
  66. Zhu,R., Xu,J., Shen,J., Li,W., Tan,F., Li,C., Wei,Z., Liu,Y. and Bai,Y.<br>A novel large deletion of the CYLD gene causes CYLD cutaneous syndrome in a Chinese family<br>Mol Genet Genomic Med (2020) , e1441-e1441. PubMed  Europe PubMed DOI  M
    67. 2019
  67. Alameda,J.P., Ramirez,A., Garcia-Fernandez,R.A., Navarro,M., Page,A., Segovia,J.C., Sanchez,R., Suarez-Cabrera,C., Paramio,J.M., Bravo,A., Fernandez-Acenero,M.J. and Casanova,M.L.<br>Premature aging and cancer development in transgenic mice lacking functional CYLD<br>Aging (Albany NY) (2019) 11, 127-159. PubMed  Europe PubMed DOI  M
  68. Tang,Y., Reissig,S., Glasmacher,E., Regen,T., Wanke,F., Nikolaev,A., Gerlach,K., Popp,V., Karram,K., Fantini,M.C., Schattenberg,J.M., Galle,P.R., Neurath,M.F., Weigmann,B., Kurschus,F.C., Hovelmeyer,N. and Waisman,A.<br>Alternative splice forms of CYLD mediate ubiquitination of SMAD7 to prevent TGFB signaling and promote colitis<br>Gastroenterology (2019) 156, 692-707. PubMed  Europe PubMed DOI  M
  69. Uematsu,A., Kido,K., Takahashi,H., Takahashi,C., Yanagihara,Y., Saeki,N., Yoshida,S., Maekawa,M., Honda,M., Kai,T., Shimizu,K., Higashiyama,S., Imai,Y., Tokunaga,F. and Sawasaki,T.<br>The E3 ubiquitin ligase MIB2 enhances inflammation by degrading the deubiquitinating enzyme CYLD<br>J Biol Chem (2019) 294, 14135-14148. PubMed  Europe PubMed DOI
    70. 2018
  70. Johari,T. and Maiti,T.K.<br>Catalytic domain mutation in CYLD inactivates its enzyme function by structural perturbation and induces cell migration and proliferation<br>Biochim Biophys Acta (2018) 1862, 2081-2089. PubMed  Europe PubMed DOI  M
  71. Legarda,D. and Ting,A.T.<br>Analysis of CYLD proteolysis by caspase 8 in bone marrow-derived macrophages<br>Methods Mol Biol (2018) 1857, 181-188. PubMed  Europe PubMed DOI
  72. Lu,Y., Zhou,Q., Han,Q., Wu,P., Zhang,L., Zhu,L., Weaver,D.T., Xu,C. and Zhang,B.<br>Inactivation of deubiquitinase CYLD enhances therapeutic antibody production in Chinese hamster ovary cells<br>Appl Microbiol Biotechnol (2018) 102, 6081-6093. PubMed  Europe PubMed DOI  K
  73. Sanchez-Quiles,V., Osinalde,N., Akimov,V., Kratchmarova,I. and Blagoev,B.<br>Data on mass spectrometry-based proteomics for studying the involvement of CYLD in the ubiquitination events downstream of EGFR activation<br>Data Brief (2018) 18, 1856-1863. PubMed  Europe PubMed DOI  PMC  EPMC
  74. Zhang,L., Wei,N., Cui,Y., Hong,Z., Liu,X., Wang,Q., Li,S., Liu,H., Yu,H., Cai,Y., Wang,Q., Zhu,J., Meng,W., Chen,Z. and Wang,C.<br>The deubiquitinase CYLD is a specific checkpoint of the STING antiviral signaling pathway<br>PLoS Pathog (2018) 14, e1007435-e1007435. PubMed  Europe PubMed DOI
    75. 2017
  75. Dubois,A., Hodgson,K. and Rajan,N.<br>Understanding inherited cylindromas: clinical implications of gene discovery<br>Dermatol Clin (2017) 35, 61-71. PubMed  Europe PubMed DOI  M
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