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Literature for peptidase C67.001: CylD peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, T Target, M Mutation, R Splicing, I Inhibitor, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Adam,E., Leitgeb,B., Danis,J., Hajdu,A., Kelemen,E., Pal,M., Belso,N., Nemeth,I.B., Rajan,N., Nagy,N. and Szell,M.
    Truncating CYLD pathogenic variants in CYLD cutaneous syndrome distinctly influence CYLD proteostasis and NF-kappaB signaling
    J Invest Dermatol PubMed  Europe PubMed DOI
  2. Li,H., Li,F., Chen,Z., Wu,E., Dai,X., Li,D., An,H., Zeng,S., Wang,C., Yang,L. and Long,C.
    Glutamatergic CYLD deletion leads to aberrant excitatory activity in the basolateral amygdala: association with enhanced cued fear expression
    Neural Regen Res20, 3259-3272. PubMed  Europe PubMed DOI
  3. Nardi,L., Bicker,F., Maier,J., Waisman,A. and Schmeisser,M.J.
    Role of CYLD in brain physiology and pathology
    J Mol Med (Berl) PubMed  Europe PubMed DOI
  4. Pseftogas,A., Bordini,J., Heltai,S., Bonfiglio,F., Gavriilidis,G., Vasileiou,V., Keisaris,S., Belloni,D., Taccetti,C., Ranghetti,P., Perotta,E., Frenquelli,M., Sarkar,U.A., Albi,E., Martini,F., Sant'Antonio,E., Mavilia,F., Psomopoulos,F., Daibata,M., Martinez Climent,J.A., Mosialos,G., Rossi,D., Campanella,A., Scarfo,L., Stamatopoulos,K., Xanthopoulos,K. and Ghia,P.
    Loss of CYLD promotes splenic marginal zone lymphoma
    Hemasphere9, e70098-e70098. PubMed  Europe PubMed DOI
  5. Schmidt,C., Harit,K., Traidl,S., Naumann,M., Werfel,T., Roesner,L.M., Nishanth,G. and Schluter,D.
    Ablation of the deubiquitinating enzyme cylindromatosis (CYLD) augments STAT1-mediated M1 macrophage polarization and fosters Staphylococcus aureus control
    Front Immunol16, 1507989-1507989. PubMed  Europe PubMed DOI
  6. Wu,Y.C., Su,B.H., Cheng,W.H., Zou,C.T., Yeh,E.T.H. and Yang,F.M.
    CYLD links the TRAF6/sNASP axis to TLR4 signaling in sepsis-induced acute lung injury
    Cell Mol Life Sci82, 124-124. PubMed  Europe PubMed DOI
  7. Wu,Z., Zhang,P., Huang,W., Zhou,Y., Cao,Z. and Wu,C.
    Qufeng epimedium decoction alleviates rheumatoid arthritis through CYLD-antagonized NF-kB activation by deubiquitinating Sirt1
    Immunobiology230, 152875-152875. PubMed  Europe PubMed DOI
  8. Zheng,M., Wang,S., Tang,K., Kong,R., Wang,X., Zhou,J., Chen,Y. and Wang,Y.
    The CYLD-PARP1 feedback loop regulates DNA damage repair and chemosensitivity in breast cancer cells
    Proc Natl Acad Sci U S A122, e2413890121-e2413890121. PubMed  Europe PubMed DOI
    9. 2024
  9. Amaral,P., Soares,I., Correia,P., Correia,C., Vasconcelos,P., Almeida,S. and Filipe,P.
    Novel CYLD pathogenic variant associated with multiple cylindromas of the scalp-A case report
    Skin Health Dis4, e436-e436. PubMed  Europe PubMed DOI
  10. Bhardwaj,A., Panepinto,M.C., Ueberheide,B. and Neel,B.G.
    A mechanism for hypoxia-induced inflammatory cell death in cancer
    Nature PubMed  Europe PubMed DOI
  11. Cui,Z., Kang,H., Li,H., Lee,E.D., Lee,Y.S., Peterson,C.N., Long,S.R., Grandis,J.R. and Johnson,D.E.
    CYLD Alterations Are Associated With Metastasis and Poor Prognosis in Human Papilloma Virus-Positive Head and Neck Cancer
    Head Neck47, 606-614. PubMed  Europe PubMed DOI
  12. Gu,Y., Wu,S., Fan,J., Meng,Z., Gao,G., Liu,T., Wang,Q., Xia,H., Wang,X. and Wu,K.
    CYLD regulates cell ferroptosis through Hippo/YAP signaling in prostate cancer progression
    Cell Death Dis15, 79-79. PubMed  Europe PubMed DOI
  13. Jiang,G., Cai,Y., Cheng,D., Wang,H., Deng,G. and Xiang,D.
    CYLD alleviates NLRP3 inflammasome-mediated pyroptosis in osteoporosis by deubiquitinating WNK1
    J Orthop Surg Res19, 212-212. PubMed  Europe PubMed DOI
  14. Rinotas,V., Iliaki,K., Pavlidi,L., Meletakos,T., Mosialos,G. and Armaka,M.
    Cyld restrains the hyperactivation of synovial fibroblasts in inflammatory arthritis by regulating the TAK1/IKK2 signaling axis
    Cell Death Dis15, 584-584. PubMed  Europe PubMed DOI
  15. Roy,A.S., Feroz,T., Islam,M.K., Munim,M.A., Supti,D.A., Antora,N.J., Al Reza,H., Gosh,S., Bahadur,N.M., Alam,M.R. and Hossain,M.S.
    A computational approach for structural and functional analyses of disease-associated mutations in the human CYLD gene
    Genomics Inform22, 4-4. PubMed  Europe PubMed DOI
  16. Xue,Y., Xue,C. and Song,W.
    Emerging roles of deubiquitinating enzymes in actin cytoskeleton and tumor metastasis
    Cell Oncol (Dordr) PubMed  Europe PubMed DOI  V
  17. Yang,S., Yu,F., Yang,M., Ni,H., Bu,W., Yin,H., Yang,J., Wang,W., Zhai,D., Wu,X., Ma,N., Li,T., Hao,H., Ran,J., Song,T., Li,D., Yoshida,S., Lu,Q., Yang,Y., Zhou,J. and Liu,M.
    CYLD Maintains Retinal Homeostasis by Deubiquitinating ENKD1 and Promoting the Phagocytosis of Photoreceptor Outer Segments
    Adv Sci (Weinh)e2404067-e2404067. PubMed  Europe PubMed DOI
    18. 2023
  18. Bekas,N., Samiotaki,M., Papathanasiou,M., Mokos,P., Pseftogas,A., Xanthopoulos,K., Thanos,D., Mosialos,G. and Dafou,D.
    Inactivation of Tumor Suppressor CYLD Inhibits Fibroblast Reprogramming to Pluripotency
    Cancers (Basel)15, PubMed  Europe PubMed DOI
  19. Bhardwaj,A., Antonelli,M., Ueberheide,B. and Neel,B.G.
    Identification of a Novel Hypoxia-induced Inflammatory Cell Death Pathway
    bioRxiv PubMed  Europe PubMed DOI
  20. Cao,Y., Zhang,X., Hu,M., Yang,S., Li,X., Han,R., Zhou,J., Li,D. and Liu,D.
    CYLD inhibits osteoclastogenesis to ameliorate alveolar bone loss in mice with periodontitis
    J Cell Physiol238, 1036-1045. PubMed  Europe PubMed DOI
  21. Chen,S.Y., Liu,K.F., Tan,S.Y., Chen,X.S., Li,H.D., Li,J.J., Zhou,J.W., Yang,L. and Long,C.
    Deubiquitinase CYLD regulates excitatory synaptic transmission and short-term plasticity in the hippocampus
    Brain Res1806, 148313-148313. PubMed  Europe PubMed DOI
  22. Cheng,N. and Trejo,J.
    An siRNA library screen identifies CYLD and USP34 as deubiquitinases that regulate GPCR-p38 MAPK signaling and distinct inflammatory responses
    J Biol Chem299, 105370-105370. PubMed  Europe PubMed DOI  K
  23. Compagnoni,C., Capelli,R., Zelli,V., Corrente,A., Vecchiotti,D., Flati,I., Di Vito Nolfi,M., Angelucci,A., Alesse,E., Zazzeroni,F. and Tessitore,A.
    MiR-182-5p Is Upregulated in Hepatic Tissues from a Diet-Induced NAFLD/NASH/HCC C57BL/6J Mouse Model and Modulates Cyld and Foxo1 Expression
    Int J Mol Sci24, PubMed  Europe PubMed DOI
  24. Giang,N.H., Lien,N.T.K., Trang,D.T., Huong,P.T., Hoang,N.H. and Xuan,N.T.
    Associations of A20, CYLD, Cezanne and JAK2 Genes and Immunophenotype with Psoriasis Susceptibility
    Medicina (Kaunas)59, PubMed  Europe PubMed DOI  M
  25. Huang,Y., Zhang,W., Yu,Z., Su,H., Zeng,B., Piao,J., Wang,J. and Wu,J.
    A Tumor Suppressive Role of CYLD as a Novel Potential DUB of Aurora B in Cervical Cancer
    Clin Med Insights Oncol17, 11795549231180832-11795549231180832. PubMed  Europe PubMed DOI
  26. Huang,Z. and Tan,Y.
    The Potential of Cylindromatosis (CYLD) as a Therapeutic Target in Oxidative Stress-Associated Pathologies: A Comprehensive Evaluation
    Int J Mol Sci24, PubMed  Europe PubMed DOI  V
  27. Marin-Rubio,J.L., Raote,I., Inns,J., Dobson-Stone,C. and Rajan,N.
    CYLD in health and disease
    Dis Model Mech16, PubMed  Europe PubMed DOI  V
  28. Minderman,M., Lantermans,H.C., Gruneberg,L.J., Cillessen,S.A.G.M., Bende,R.J., van Noesel,C.J.M., Kersten,M.J., Pals,S.T. and Spaargaren,M.
    MALT1-dependent cleavage of CYLD promotes NF-kappaB signaling and growth of aggressive B-cell receptor-dependent lymphomas
    Blood Cancer J13, 37-37. PubMed  Europe PubMed DOI
  29. Zamani,F., Khalighfard,S., Kalhori,M.R., Poorkhani,A., Amiriani,T., Hosseinzadeh,P., Esmati,E., Alemrajabi,M., Nikoofar,A., Safarnezhad Tameshkel,F. and Alizadeh,A.M.
    Expanding CYLD protein in NF-kappabeta/TNF-alpha signaling pathway in response to Lactobacillus acidophilus in non-metastatic rectal cancer patients
    Med Oncol40, 302-302. PubMed  Europe PubMed DOI
  30. Zhang,Z., Yu,Y., Zhang,Z., Li,D., Liang,Z., Wang,L., Chen,Y., Liang,Y. and Niu,H.
    Cancer-associated fibroblasts-derived CXCL12 enhances immune escape of bladder cancer through inhibiting P62-mediated autophagic degradation of PDL1
    J Exp Clin Cancer Res42, 316-316. PubMed  Europe PubMed DOI
    31. 2022
  31. Erol,A.
    Genotoxicity-Stimulated and CYLD-Driven Malignant Transformation
    Cancer Manag Res14, 2339-2356. PubMed  Europe PubMed DOI
  32. Haq,S., Sarodaya,N., Karapurkar,J.K., Suresh,B., Jo,J.K., Singh,V., Bae,Y.S., Kim,K.S. and Ramakrishna,S.
    CYLD destabilizes NoxO1 protein by promoting ubiquitination and regulates prostate cancer progression
    Cancer Lett525, 146-157. PubMed  Europe PubMed DOI
  33. Khoury,E., Godfrey,M. and Yeoh,C.C.
    Gynaecological cylindroma in association with CYLD gene mutation
    Oxf Med Case Reports2022, omab139-omab139. PubMed  Europe PubMed DOI
  34. Pirooznia,S.K., Wang,H., Panicker,N., Kumar,M., Neifert,S., Dar,M.A., Lau,E., Kang,B.G., Redding-Ochoa,J., Troncoso,J.C., Dawson,V.L. and Dawson,T.M.
    Deubiquitinase CYLD acts as a negative regulator of dopamine neuron survival in Parkinson's disease
    Sci Adv8, eabh1824-eabh1824. PubMed  Europe PubMed DOI
  35. Schott,M., Kappelmann-Fenzl,M., Fischer,S., Fernandez-Barrena,M.G., Pineda-Lucena,A., Avila,M.A., Kuphal,S. and Bosserhoff,A.K.
    Impact of CYLD on chromatin structure and histone methylation in malignant melanoma
    Int J Mol Med49, PubMed  Europe PubMed DOI
  36. Trang,D.T., Giang,N.H., Trang,B.K., Ngoc,N.T., Giang,N.V., Canh,N.X., Vuong,N.B. and Xuan,N.T.
    Prevalence of CYLD mutations in Vietnamese patients with polycythemia vera
    Adv Clin Exp Med PubMed  Europe PubMed DOI
  37. Xie,W., Gao,S., Yang,Y., Li,H., Zhou,J., Chen,M., Yang,S., Zhang,Y., Zhang,L., Meng,X., Xie,S., Liu,M., Li,D., Chen,Y. and Zhou,J.
    CYLD deubiquitinates plakoglobin to promote Cx43 membrane targeting and gap junction assembly in the heart
    Cell Rep41, 111864-111864. PubMed  Europe PubMed DOI
    38. 2021
  38. Elliott,P.R., Leske,D., Wagstaff,J., Schlicher,L., Berridge,G., Maslen,S., Timmermann,F., Ma,B., Fischer,R., Freund,S.M.V., Komander,D. and Gyrd-Hansen,M.
    Regulation of CYLD activity and specificity by phosphorylation and ubiquitin-binding CAP-Gly domains
    Cell Rep37, 109777-109777. PubMed  Europe PubMed DOI
  39. Li,H.D., Li,D.N., Yang,L. and Long,C.
    Deficiency of the CYLD Impairs Fear Memory of Mice and Disrupts Neuronal Activity and Synaptic Transmission in the Basolateral Amygdala
    Front Cell Neurosci15, 740165-740165. PubMed  Europe PubMed DOI
  40. Snyder,N.A. and Silva,G.M.
    Deubiquitinating enzymes (DUBs): Regulation, homeostasis, and oxidative stress response
    J Biol Chem297, 101077-101077. PubMed  Europe PubMed DOI  V
  41. Williams,E.A., Montesion,M., Alexander,B.M., Ramkissoon,S.H., Elvin,J.A., Ross,J.S., Williams,K.J., Glomski,K., Bledsoe,J.R., Tse,J.Y. and Mochel,M.C.
    CYLD mutation characterizes a subset of HPV-positive head and neck squamous cell carcinomas with distinctive genomics and frequent cylindroma-like histologic features
    Mod Pathol34, 358-370. PubMed  Europe PubMed DOI
  42. Yamanaka,S., Sato,Y., Oikawa,D., Goto,E., Fukai,S., Tokunaga,F., Takahashi,H. and Sawasaki,T.
    Corrigendum to "Subquinocin, a small molecule inhibitor of CYLD and USP-family deubiquitinating enzymes, promotes NF-kappaB signaling" [Biochem. Biophys. Res. Commun. 524 (1) (2020) 1-7]
    Biochem Biophys Res Commun536, 115-115. PubMed  Europe PubMed DOI
  43. Zhu,G., Herlyn,M. and Yang,X.
    TRIM15 and CYLD regulate ERK activation via lysine-63-linked polyubiquitination
    Nat Cell Biol23, 978-991. PubMed  Europe PubMed DOI
    44. 2020
  44. Cui,Z., Kang,H., Grandis,J.R. and Johnson,D.E.
    CYLD Alterations in the Tumorigenesis and Progression of Human Papillomavirus-Associated Head and Neck Cancers
    Mol Cancer Res PubMed  Europe PubMed DOI  V
  45. Dai,H., Liu,C., Liu,Y., Zhang,Z., Peng,C., Wang,Z., Zheng,J., Li,C., Yu,W. and Cheng,F.
    Research on mechanism of miR-130a in regulating autophagy of bladder cancer cells through CYLD
    J BUON25, 1636-1642. PubMed  Europe PubMed  K
  46. Deng,M., Dai,W., Yu,V.Z., Tao,L. and Lung,M.L.
    Cylindromatosis Lysine 63 Deubiquitinase (CYLD) Regulates NF-kB Signaling Pathway and Modulates Fibroblast and Endothelial Cells Recruitment in Nasopharyngeal Carcinoma
    Cancers (Basel)12, PubMed  Europe PubMed DOI
  47. Dobson-Stone,C., Hallupp,M., Shahheydari,H., Ragagnin,A.M.G., Chatterton,Z., Carew-Jones,F., Shepherd,C.E., Stefen,H., Paric,E., Fath,T., Thompson,E.M., Blumbergs,P., Short,C.L., Field,C.D., Panegyres,P.K., Hecker,J., Nicholson,G., Shaw,A.D., Fullerton,J.M., Luty,A.A., Schofield,P.R., Brooks,W.S., Rajan,N., Bennett,M.F., Bahlo,M., Landers,J.E., Piguet,O., Hodges,J.R., Halliday,G.M., Topp,S.D., Smith,B.N., Shaw,C.E., McCann,E., Fifita,J.A., Williams,K.L., Atkin,J.D., Blair,I.P. and Kwok,J.B.
    CYLD is a causative gene for frontotemporal dementia - amyotrophic lateral sclerosis
    Brain143, 783-799. PubMed  Europe PubMed DOI  M
  48. Douglas,T. and Saleh,M.
    The plot thickens: OTULIN regulation in cell death
    Mol Cell Oncol7, 1740541-1740541. PubMed  Europe PubMed DOI
  49. Jang,J.H., Lee,H.M., Kim,H. and Cho,J.H.
    Molecular cloning and functional analysis of deubiquitinase CYLD in rainbow trout, Oncorhynchus mykiss
    Fish Shellfish Immunol101, 135-142. PubMed  Europe PubMed DOI
  50. La,T., Jin,L., Liu,X.Y., Song,Z.H., Farrelly,M., Feng,Y.C., Yan,X.G., Zhang,Y.Y., Thorne,R.F., Zhang,X.D. and Teng,L.
    Cylindromatosis is required for survival of a subset of melanoma cells
    Oncol Res PubMed  Europe PubMed DOI
  51. Mukherjee,S., Kumar,R., Tsakem Lenou,E., Basrur,V., Kontoyiannis,D.L., Ioakeimidis,F., Mosialos,G., Theiss,A.L., Flavell,R.A. and Venuprasad,K.
    Deubiquitination of NLRP6 inflammasome by Cyld critically regulates intestinal inflammation
    Nat Immunol21, 626-635. PubMed  Europe PubMed DOI
  52. Oshiumi,H.
    Recent Advances and Contradictions in the Study of the Individual Roles of Ubiquitin Ligases That Regulate RIG-I-Like Receptor-Mediated Antiviral Innate Immune Responses
    Front Immunol11, 1296-1296. PubMed  Europe PubMed DOI
  53. Qi,L., Zang,H., Wu,W., Nagarkatti,P., Nagarkatti,M., Liu,Q., Robbins,J., Wang,X. and Cui,T.
    CYLD exaggerates pressure overload-induced cardiomyopathy via suppressing autolysosome efflux in cardiomyocytes
    J Mol Cell Cardiol145, 59-73. PubMed  Europe PubMed DOI
  54. Qiu,C., Liu,K., Zhang,S., Gao,S., Chen,W., Li,D. and Huang,Y.
    Bisdemethoxycurcumin inhibits hepatocellular carcinoma proliferation through Akt inactivation via CYLD-mediated deubiquitination
    Drug Des Devel Ther14, 993-1001. PubMed  Europe PubMed DOI  I
  55. Rasaei,R., Sarodaya,N., Kim,K.S., Ramakrishna,S. and Hong,S.H.
    Importance of Deubiquitination in Macrophage-Mediated Viral Response and Inflammation
    Int J Mol Sci21, PubMed  Europe PubMed DOI  V
  56. Sarikaya Solak,S., Yalcintepe,S., Atahan,C., Nagy,N. and Can,N.
    A novel nonsense mutation of the CYLD gene in a Turkish family with multiple familial trichoepithelioma
    Clin Exp Dermatol45, 508-511. PubMed  Europe PubMed DOI  M
  57. Xiao,Y., Huang,Q., Wu,Z. and Chen,W.
    Roles of protein ubiquitination in inflammatory bowel disease
    Immunobiology225, 152026-152026. PubMed  Europe PubMed DOI  V
  58. Yamanaka,S., Sato,Y., Oikawa,D., Goto,E., Fukai,S., Tokunaga,F., Takahashi,H. and Sawasaki,T.
    Subquinocin, a small molecule inhibitor of CYLD and USP-family deubiquitinating enzymes, promotes NF-kappaB signaling
    Biochem Biophys Res Commun524, 1-7. PubMed  Europe PubMed DOI  I
  59. Zhu,R., Xu,J., Shen,J., Li,W., Tan,F., Li,C., Wei,Z., Liu,Y. and Bai,Y.
    A novel large deletion of the CYLD gene causes CYLD cutaneous syndrome in a Chinese family
    Mol Genet Genomic Mede1441-e1441. PubMed  Europe PubMed DOI  M
    60. 2019
  60. Alameda,J.P., Ramirez,A., Garcia-Fernandez,R.A., Navarro,M., Page,A., Segovia,J.C., Sanchez,R., Suarez-Cabrera,C., Paramio,J.M., Bravo,A., Fernandez-Acenero,M.J. and Casanova,M.L.
    Premature aging and cancer development in transgenic mice lacking functional CYLD
    Aging (Albany NY)11, 127-159. PubMed  Europe PubMed DOI  M
  61. Tang,Y., Reissig,S., Glasmacher,E., Regen,T., Wanke,F., Nikolaev,A., Gerlach,K., Popp,V., Karram,K., Fantini,M.C., Schattenberg,J.M., Galle,P.R., Neurath,M.F., Weigmann,B., Kurschus,F.C., Hovelmeyer,N. and Waisman,A.
    Alternative splice forms of CYLD mediate ubiquitination of SMAD7 to prevent TGFB signaling and promote colitis
    Gastroenterology156, 692-707. PubMed  Europe PubMed DOI  M
  62. Uematsu,A., Kido,K., Takahashi,H., Takahashi,C., Yanagihara,Y., Saeki,N., Yoshida,S., Maekawa,M., Honda,M., Kai,T., Shimizu,K., Higashiyama,S., Imai,Y., Tokunaga,F. and Sawasaki,T.
    The E3 ubiquitin ligase MIB2 enhances inflammation by degrading the deubiquitinating enzyme CYLD
    J Biol Chem294, 14135-14148. PubMed  Europe PubMed DOI
    63. 2018
  63. Johari,T. and Maiti,T.K.
    Catalytic domain mutation in CYLD inactivates its enzyme function by structural perturbation and induces cell migration and proliferation
    Biochim Biophys Acta1862, 2081-2089. PubMed  Europe PubMed DOI  M
  64. Legarda,D. and Ting,A.T.
    Analysis of CYLD proteolysis by caspase 8 in bone marrow-derived macrophages
    Methods Mol Biol1857, 181-188. PubMed  Europe PubMed DOI
  65. Lu,Y., Zhou,Q., Han,Q., Wu,P., Zhang,L., Zhu,L., Weaver,D.T., Xu,C. and Zhang,B.
    Inactivation of deubiquitinase CYLD enhances therapeutic antibody production in Chinese hamster ovary cells
    Appl Microbiol Biotechnol102, 6081-6093. PubMed  Europe PubMed DOI  K
  66. Sanchez-Quiles,V., Osinalde,N., Akimov,V., Kratchmarova,I. and Blagoev,B.
    Data on mass spectrometry-based proteomics for studying the involvement of CYLD in the ubiquitination events downstream of EGFR activation
    Data Brief18, 1856-1863. PubMed  Europe PubMed DOI
  67. Zhang,L., Wei,N., Cui,Y., Hong,Z., Liu,X., Wang,Q., Li,S., Liu,H., Yu,H., Cai,Y., Wang,Q., Zhu,J., Meng,W., Chen,Z. and Wang,C.
    The deubiquitinase CYLD is a specific checkpoint of the STING antiviral signaling pathway
    PLoS Pathog14, e1007435-e1007435. PubMed  Europe PubMed DOI
    68. 2017
  68. Dubois,A., Hodgson,K. and Rajan,N.
    Understanding inherited cylindromas: clinical implications of gene discovery
    Dermatol Clin35, 61-71. PubMed  Europe PubMed DOI  M
  69. Fujii,A., Matsuyama,K., Mizutani,Y., Kanoh,H., Nakano,H. and Seishima,M.
    Multiple familial trichoepithelioma with a novel mutation of the CYLD gene
    J Dermatol44, e228-e228. PubMed  Europe PubMed DOI  M
  70. Lork,M., Verhelst,K. and Beyaert,R.
    CYLD, A20 and OTULIN deubiquitinases in NF-kappaB signaling and cell death: so similar, yet so different
    Cell Death Differ24, 1172-1183. PubMed  Europe PubMed DOI
  71. Sanchez-Quiles,V., Akimov,V., Osinalde,N., Francavilla,C., Puglia,M., Barrio-Hernandez,I., Kratchmarova,I., Olsen,J.V. and Blagoev,B.
    Cylindromatosis tumor suppressor protein (CYLD) deubiquitinase is necessary for proper ubiquitination and degradation of the epidermal growth factor receptor
    Mol Cell Proteomics16, 1433-1446. PubMed  Europe PubMed DOI
  72. Schlicher,L., Brauns-Schubert,P., Schubert,F. and Maurer,U.
    SPATA2: more than a missing link
    Cell Death Differ24, 1142-1147. PubMed  Europe PubMed DOI
  73. Xie,S., Chen,M., Gao,S., Zhong,T., Zhou,P., Li,D., Zhou,J., Gao,J. and Liu,M.
    The B-box module of CYLD is responsible for its intermolecular interaction and cytoplasmic localization
    Oncotarget8, 50889-50895. PubMed  Europe PubMed DOI
  74. Yu,B., Liu,Z., Fu,Y., Wang,Y., Zhang,L., Cai,Z., Yu,F., Wang,X., Zhou,J. and Kong,W.
    CYLD Deubiquitinates nicotinamide adenine dinucleotide phosphate oxidase 4 contributing to adventitial remodeling
    Arterioscler Thromb Vasc Biol37, 1698-1709. PubMed  Europe PubMed DOI
    75. 2016
  75. Elliott,P.R., Leske,D., Hrdinka,M., Bagola,K., Fiil,B.K., McLaughlin,S.H., Wagstaff,J., Volkmar,N., Christianson,J.C., Kessler,B.M., Freund,S.M., Komander,D. and Gyrd-Hansen,M.
    SPATA2 links CYLD to LUBAC, activates CYLD, and controls LUBAC signaling
    Mol Cell63, 990-1005. PubMed  Europe PubMed DOI
  76. Farkas,K., Deak,B.K., Sanchez,L.C., Martinez,A.M., Corell,J.J., Botella,A.M., Benito,G.M., Lopez,R.R., Vanecek,T., Kazakov,D.V., Kromosoeto,J.N., van den Ouweland,A.M., Varga,J., Szell,M. and Nagy,N.
    The CYLD p.R758X worldwide recurrent nonsense mutation detected in patients with multiple familial trichoepithelioma type 1, Brooke-Spiegler syndrome and familial cylindromatosis represents a mutational hotspot in the gene
    BMC Genet17, 36-36. PubMed  Europe PubMed DOI  M
  77. Hellerbrand,C. and Massoumi,R.
    Cylindromatosis-A Protective Molecule against Liver Diseases
    Med Res Rev36, 342-359. PubMed  Europe PubMed DOI  V
  78. Klei,L.R., Hu,D., Panek,R., Alfano,D.N., Bridwell,R.E., Bailey,K.M., Oravecz-Wilson,K.I., Concel,V.J., Hess,E.M., Van Beek,M., Delekta,P.C., Gu,S., Watkins,S.C., Ting,A.T., Gough,P.J., Foley,K.P., Bertin,J., McAllister-Lucas,L.M. and Lucas,P.C.
    MALT1 protease activation triggers acute disruption of endothelial barrier integrity via CYLD cleavage
    Cell Rep17, 221-232. PubMed  Europe PubMed DOI
  79. Lee,B.C., Miyata,M., Lim,J.H. and Li,J.D.
    Deubiquitinase CYLD acts as a negative regulator for bacterium NTHi-induced inflammation by suppressing K63-linked ubiquitination of MyD88
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