Substrates for peptidase C60.001: sortase A (Staphylococcus-type)

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
5-nucleotidase family protein	Q5HJX2	1-772	peptide-Thr742+Gly-peptide	P	CS	Leu	Pro	Lys	Thr	Gly	Thr	Asn	Gln	Mazmanian et al., 2002
cell surface protein, gram positive anchor	Q6HRJ7	1-2025	peptide-Thr1994+Gly-peptide	P	CS	Leu	Pro	Lys	Thr	Gly	Ala	Ala	Ser
cell wall surface anchor family protein	Q5HJN4	1-241	peptide-Ala208+Gly-peptide	P	CS	Leu	Pro	Ala	Ala	Gly	Glu	Ser	Met	Mazmanian et al., 2002
clumping factor A	Q53653	40-933	peptide-Thr899+Gly-peptide	P	CS	Leu	Pro	Asp	Thr	Gly	Ser	Glu	Asp	Mazmanian et al., 2002
clumping factor B	O86476	45-913	peptide-Thr877+Gly-peptide	P	CS	Leu	Pro	Glu	Thr	Gly	Asp	Lys	Ser	Mazmanian et al., 2002
collagen adhesin	Q53654	30-1183	peptide-Thr1154+Gly-peptide	P	CS	Leu	Pro	Lys	Thr	Gly	Met	Lys	Ile	Mazmanian et al., 2002
fibronectin binding protein B	Q5HD53	1-940	peptide-Thr907+Gly-peptide	P	CS	Leu	Pro	Glu	Thr	Gly	Gly	Glu	Glu	Mazmanian et al., 2002
fibronectin-binding protein A	P14738	37-1018	peptide-Thr985+Gly-peptide	N	CS	Leu	Pro	Glu	Thr	Gly	Gly	Glu	Glu	Mazmanian et al., 2002
IgA protease precursor	Q9AES2	1-1234	peptide-Thr1199+Gly-peptide	P		Ser	Pro	Gln	Thr	Gly	Asp	Asn	Ser	Potempa & Poulsen, 2004	16389
immunoglobulin G-binding protein A	P38507	37-508	peptide-Thr477+Gly-peptide	P	CS	Leu	Pro	Glu	Thr	Gly	Glu	Glu	Asn	Mazmanian et al., 2002
iron-regulated surface determinant protein A	Q2FZE9	47-350	peptide-Thr316+Gly-peptide	P	CS	Leu	Pro	Lys	Thr	Gly	Leu	Thr	Ser	Mazmanian et al., 2002
iron-regulated surface determinant protein B	Q2FZF0	41-645	peptide-Thr613+Gly-peptide	P	CS	Leu	Pro	Gln	Thr	Gly	Glu	Glu	Ser	Mazmanian et al., 2002
iron-regulated surface determinant protein H	Q8NW39	41-895	peptide-Thr864+Gly-peptide	P	CS	Leu	Pro	Lys	Thr	Gly	Glu	Thr	Thr	Mazmanian et al., 2002
LPXTG cell wall surface anchor family protein	Q5HCQ1	1-635	peptide-Ala600+Gly-peptide	P	CS	Leu	Pro	Lys	Ala	Gly	Glu	Thr	Ile	Mazmanian et al., 2002
sasB protein	Q5HE44	1-2478	peptide-Thr2443+Gly-peptide	P	CS	Leu	Pro	Asp	Thr	Gly	Met	Ser	His	Mazmanian et al., 2002
serine-aspartate repeat-containing protein C	O86487	51-947	peptide-Thr913+Gly-peptide	P	CS	Leu	Pro	Glu	Thr	Gly	Ser	Glu	Asn	Mazmanian et al., 2002
serine-aspartate repeat-containing protein D	O86488	36-1315	peptide-Thr1281+Gly-peptide	P	CS	Leu	Pro	Glu	Thr	Gly	Asn	Glu	Asn	Mazmanian et al., 2002
serine-aspartate repeat-containing protein E	O86489	53-1166	peptide-Thr1132+Gly-peptide	P	CS	Leu	Pro	Glu	Thr	Gly	Ser	Glu	Asn	Mazmanian et al., 2002
serine-rich adhesin for platelets	Q6GDE9	1-1351	peptide-Thr1312+Gly-peptide	P	CS	Leu	Pro	Asp	Thr	Gly	Asp	Ser	Ile	Mazmanian et al., 2002
surface protein	P80544	49-1637	peptide-Thr1601+Gly-peptide	P	CS	Leu	Pro	Asp	Thr	Gly	Asn	Asp	Ala	Mazmanian et al., 2002
surface protein G	Q2G2B2	1-1627	peptide-Thr1598+Gly-peptide	P	CS	Leu	Pro	Lys	Thr	Gly	Leu	Glu	Ser	Mazmanian et al., 2002