Substrates for peptidase C53.001: pestivirus Npro peptidase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
Genome polyprotein	P19711	1-3988	peptide-Cys168+Ser-peptide	P	CS	Val	Thr	Thr	Cys	Ser	Asp	Thr	Lys	Gottipati et al., 2014
Hog cholera virus (Npro-GFP fusion)	Q68871	1-3898	Peptide-Cys168+Ser-peptide	P	NT	Val	Thr	Ser	Cys	Ser	Asp	Asp	Gly	Gottipati et al., 2014
polyprotein		1-3898	peptide-Cys168+Ser-peptide	P		Val	Thr	Ser	Cys	Ser	Asp	Asp	Gly	Rumenapf & Thiel, 2004	16378
Polyprotein	Q9PYB2	1-3989	peptide-Cys168+Ser-peptide	P	CS	Leu	Thr	Ser	Cys	Ser	Asp	Glu	Gly	Gottipati et al., 2014