Substrates for peptidase C46.002: Sonic hedgehog protein

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
Sonic hedgehog protein	Q63673	25-437	peptide-Gly198+Cys-peptide	P	CS	Lys	Ser	Asp	Gly	Cys	Phe	Pro	Gly	Kumar et al., 1996
Sonic hedgehog protein	Q92000	25-444	peptide-Gly198+Cys-peptide	P	CS	Lys	Ser	Gly	Gly	Cys	Phe	Pro	Ala	Kumar et al., 1996
sonic hedgehog protein	Q15465	24-462	peptide-Gly197+Cys-peptide	N		Lys	Ser	Gly	Gly	Cys	Phe	Pro	Gly
sonic hedgehog protein precursor	Q91035	27-425	peptide-Gly200+Cys-peptide	P		Lys	Ser	Gly	Gly	Cys	Phe	Pro	Gly	Lopez-Martinez et al., 1995