Substrates for family C30 unassigned peptidases

Summary Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
nF-kappa-B essential modulator	Q9Y6K9	1-419	peptide-Gln231+Val-peptide	P	NT	Ala	Gln	Leu	Gln	Val	Ala	Tyr	His	Koudelka et al., 2020
signal transducer and activator of transcription 2	O02799	1-864	peptide-Gln685+Glu-peptide	P	NT	Ala	Asn	Leu	Gln	Glu	Arg	Lys	Lys	Koudelka et al., 2020
signal transducer and activator of transcription 2	O02799	1-864	peptide-Gln758+Ser-peptide	P	NT	Pro	Met	Leu	Gln	Ser	Thr	Leu	Glu	Koudelka et al., 2020