Literature for family C30 unassigned peptidases

Summary Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, P Specificity, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

2025

Li,C., Shi,Y., Xie,C., Duan,K., Ding,T., Xu,X., Fang,L., Zhou,Y. and Xiao,S. GSDMD and GSDME exhibit distinct roles in enteric coronavirus PDCoV-induced pyroptosis and inflammatory responses J Virol (2025) , e0187624-e0187624. PubMed Europe PubMed DOI
Martianez-Vendrell,X., van Kasteren,P.B., Myeni,S.K. and Kikkert,M. HCoV-229E Mpro Suppresses RLR-Mediated Innate Immune Signalling Through Cleavage of NEMO and Through Other Mechanisms Int J Mol Sci (2025) 26 PubMed Europe PubMed DOI PMC EPMC

2024

Huang,H., Lei,X., Zhao,C., Qin,Y., Li,Y., Zhang,X., Li,C., Lan,T., Zhao,B., Sun,W., Lu,H. and Jin,N. Porcine deltacoronavirus nsp5 antagonizes type I interferon signaling by cleaving IFIT3 J Virol (2024) 98, e0168223-e0168223. PubMed Europe PubMed DOI PMC EPMC
Li,Z., Xiao,W., Yang,Z., Guo,J., Zhou,J., Xiao,S., Fang,P. and Fang,L. Cleavage of HDAC6 to dampen its antiviral activity by nsp5 is a common strategy of swine enteric coronaviruses J Virol (2024) 98, e0181423-e0181423. PubMed Europe PubMed DOI PMC EPMC

2023

Zvornicanin,S.N., Shaqra,A.M., Huang,Q.J., Ornelas,E., Moghe,M., Knapp,M., Moquin,S., Dovala,D., Schiffer,C.A. and Kurt Yilmaz,N. Crystal Structures of Inhibitor-Bound Main Protease from Delta- and Gamma-Coronaviruses Viruses (2023) 15 PubMed Europe PubMed DOI PMC EPMC I

2022

Wang,F., Chen,C., Wang,Z., Han,X., Shi,P., Zhou,K., Liu,X., Xiao,Y., Cai,Y., Huang,J., Zhang,L. and Yang,H. The Structure of the Porcine Deltacoronavirus Main Protease Reveals a Conserved Target for the Design of Antivirals Viruses (2022) 14 PubMed Europe PubMed DOI PMC EPMC

2020

Zhu,X., Chen,J., Tian,L., Zhou,Y., Xu,S., Long,S., Wang,D., Fang,L. and Xiao,S. Porcine deltacoronavirus nsp5 cleaves DCP1A to decrease its antiviral ability J Virol (2020) 94, e02162-19-e02162-19. PubMed Europe PubMed DOI

2017

Zhu,X., Wang,D., Zhou,J., Pan,T., Chen,J., Yang,Y., Lv,M., Ye,X., Peng,G., Fang,L. and Xiao,S. Porcine deltacoronavirus Nsp5 antagonizes type I interferon signaling by cleaving STAT2 J Virol (2017) 91, e00003-17-e00003-17. PubMed Europe PubMed DOI

2015

St John,S.E., Tomar,S., Stauffer,S.R. and Mesecar,A.D. Targeting zoonotic viruses: structure-based inhibition of the 3C-like protease from bat coronavirus HKU4-the likely reservoir host to the human coronavirus that causes Middle East Respiratory Syndrome (MERS) Bioorg Med Chem (2015) 23, 6036-6048. PubMed Europe PubMed DOI S I

2013

Ren,Z., Yan,L., Zhang,N., Guo,Y., Yang,C., Lou,Z. and Rao,Z. The newly emerged SARS-like coronavirus HCoV-EMC also has an "Achilles' heel": current effective inhibitor targeting a 3C-like protease Protein Cell (2013) 4, 248-250. PubMed Europe PubMed DOI S I

2011

Chuck,C.P., Chow,H.F., Wan,D.C. and Wong,K.B. Profiling of substrate specificities of 3C-like proteases from group 1, 2a, 2b, and 3 coronaviruses PLoS ONE (2011) 6, e27228-e27228. PubMed Europe PubMed DOI PMC EPMC P

2005

Woo,P.C., Huang,Y., Lau,S.K., Tsoi,H.W. and Yuen,K.Y. In silico analysis of ORF1ab in coronavirus HKU1 genome reveals a unique putative cleavage site of coronavirus HKU1 3C-like protease Microbiol Immunol (2005) 49, 899-908. PubMed Europe PubMed