Substrates for peptidase C30.004: porcine transmissible gastroenteritis virus-type main peptidase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
replicase polyprotein 1ab P0C6Y5 2871-2885 Val-Ser-Val-Asn-Ser-Thr-Leu-Gln+Ser-Gly-Leu-Arg-Lys-Met-Ala P NT Ser Thr Leu Gln Ser Gly Leu Arg Hegyi & Ziebuhr, 2002
replicase polyprotein 1ab P0C6Y5 3173-3187 Gln-Met-Tyr-Gly-Val-Asn-Leu-Gln+Ala-Gly-Lys-Val-Lys-Ser-Phe P NT Val Asn Leu Gln Ala Gly Lys Val Hegyi & Ziebuhr, 2002
replicase polyprotein 1ab P0C6Y5 3745-3759 Cys-Glu-Arg-Thr-Thr-Lys-Leu-Gln+Asn-Asn-Glu-Ile-Met-Pro-Gly P NT Thr Lys Leu Gln Asn Asn Glu Ile Hegyi & Ziebuhr, 2002
replicase polyprotein 1ab P0C6Y5 3856-3870 Ile-Gly-Ala-Thr-Val-Arg-Leu-Gln+Ala-Gly-Lys-Pro-Thr-Glu-His P NT Val Arg Leu Gln Ala Gly Lys Pro Hegyi & Ziebuhr, 2002