Substrates for peptidase C30.002: avian infectious bronchitis coronavirus 3C-like peptidase

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
replicase polyprotein 1ab	P0C6Y1	1-6629	peptide-Gln2779+Ser-peptide	P	MU	Ser	Arg	Leu	Gln	Ser	Gly	Phe	Lys
replicase polyprotein 1ab	P0C6Y1	1-6629	peptide-Gln3086+Ser-peptide	P	MU	Val	Arg	Leu	Gln	Ser	Ser	Phe	Val	Ng & Liu, 2000
replicase polyprotein 1ab	P0C6Y1	1-6629	peptide-Gln3379+Ala-peptide	P	MU	Ala	Thr	Val	Gln	Ala	Lys	Leu	Ser	Ng & Liu, 2000
replicase polyprotein 1ab	P0C6Y1	1-6629	peptide-Gln3462+Ser-peptide	P	MU	Thr	Val	Leu	Gln	Ser	Val	Thr	Gln	Ng & Liu, 1998
replicase polyprotein 1ab	P0C6Y1	1-6629	peptide-Gln3672+Asn-peptide	P	MU	Val	Val	Leu	Gln	Asn	Asn	Glu	Leu	Ng & Liu, 1998
replicase polyprotein 1ab	P0C6Y1	1-6629	peptide-Gln3783+Ser-peptide	P	MU	Val	Val	Leu	Gln	Ser	Lys	Gly	His	Ng & Liu, 1998
replicase polyprotein 1ab	P0C6Y1	1-6629	peptide-Gln3928+Ser-peptide	P	MU	Ser	Ser	Val	Gln	Ser	Val	Ala	Gly	Liu & Brown, 1995
replicase polyprotein 1ab	P0C6Y1	1-6629	peptide-Gln4868+Ser-peptide	P	MU	Thr	Thr	Leu	Gln	Ser	Cys	Gly	Val	Liu & Brown, 1995
replicase polyprotein 1ab	P0C6Y1	1-6629	peptide-Gln5468+Gly-peptide	P	MU	Thr	Ser	Leu	Gln	Gly	Thr	Gly	Leu	Liu et al., 1998
replicase polyprotein 1ab	P0C6Y1	1-6629	peptide-Gln5989+Ser-peptide	P	MU	Ser	Ala	Leu	Gln	Ser	Ile	Asp	Asn	Liu et al., 1998
replicase polyprotein 1ab	P0C6Y1	1-6629	peptide-Gln6327+Ser-peptide	P	MU	Pro	Gln	Leu	Gln	Ser	Ala	Trp	Thr	Liu et al., 1998
replicase polyprotein 1ab (Gln2779Asn mutant)		1-6629	peptide-Asn2779+Ser-peptide	N		Ser	Arg	Leu	Asn	Ser	Gly	Phe	Lys	Fang et al., 2010
replicase polyprotein 1ab (Gln3086Asn mutant)		1-6629	peptide-Asn2779+Ser-peptide	N		Val	Arg	Leu	Asn	Ser	Ser	Phe	Val	Fang et al., 2010
replicase polyprotein 1ab (Gln3462Asn mutant)		1-6629	peptide-Asn2779+Ser-peptide	N		Thr	Val	Leu	Asn	Ser	Val	Thr	Gln	Fang et al., 2010
replicase polyprotein 1ab (Gln3672Asn mutant)		1-6629	peptide-Asn2779+Ser-peptide	N		Val	Val	Leu	Asn	Asn	Asn	Glu	Leu	Fang et al., 2010
replicase polyprotein 1ab (Gln3783Asn mutant)		1-6629	peptide-Asn2779+Ser-peptide	N		Val	Val	Leu	Asn	Ser	Lys	Gly	His	Fang et al., 2010
replicase polyprotein 1ab (Glu3672Asn mutant)		1-6629	peptide-Asn2779+Ser-peptide	N		Val	Val	Leu	Glu	Asn	Asn	Glu	Leu	Fang et al., 2010
replicase polyprotein 1ab (His6327Asn mutant)		1-6629	peptide-Asn2779+Ser-peptide	N		Pro	Gln	Leu	His	Ser	Ala	Trp	Thr	Fang et al., 2010