$VAR1 = undef;

Summary for peptidase C30.002: avian infectious bronchitis coronavirus 3C-like peptidase

Names
MEROPS Name	avian infectious bronchitis coronavirus 3C-like peptidase
Other names	IBV picornain 3C-like endopeptidase, 3CLpro

Domain architecture

MEROPS Classification
Classification	Clan PA >> Subclan PA(C) >> Family C30 >> Subfamily (none) >> C30.002
Holotype	avian infectious bronchitis coronavirus 3C-like peptidase (avian infectious bronchitis virus), Uniprot accession P0C6Y3 (peptidase unit: 2782-3088), MERNUM MER0002027
History	Identifier created: MEROPS 3.02 (25 June 1998)

Activity
Catalytic type	Cysteine
NC-IUBMB	Not yet included in IUBMB recommendations.
Physiology	Viral polyprotein processing in replication.
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	vstp/vr/L/QnS/-/fg/- (based on 18 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	0	0	0	0	1	2	4	1
Pro	2	0	0	0	0	0	0	0
Ala	1	1	0	0	1	2	1	0
Val	7	7	2	0	0	3	0	3
Leu	0	0	16	0	0	0	1	4
Ile	0	0	0	0	0	1	0	0
Met	0	0	0	0	0	0	0	0
Phe	0	0	0	0	0	0	4	0
Tyr	0	0	0	0	0	0	0	0
Trp	0	0	0	0	0	0	2	0
Ser	4	2	0	0	13	2	0	1
Thr	4	2	0	0	0	1	2	2
Cys	0	0	0	0	0	1	0	0
Asn	0	0	0	5	3	3	0	1
Gln	0	2	0	11	0	0	0	2
Asp	0	0	0	0	0	0	1	0
Glu	0	0	0	1	0	0	3	0
Lys	0	0	0	0	0	3	0	2
Arg	0	4	0	0	0	0	0	0
His	0	0	0	1	0	0	0	2