Substrates for peptidase C19.037: ubiquitin-specific peptidase 33

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
polyubiquitinated beta-arrestin-1	P0CG47/P49407	1-76	peptide-Gly76+Lys-peptide	P	Leu	Arg	Gly	Gly	Lys	Xaa	Xaa	Xaa	Shenoy et al., 2009
polyubiquitinated beta-arrestin-2	P0CG47/P32121	1-76	peptide-Gly76+Lys-peptide	P	Leu	Arg	Gly	Gly	Lys	Xaa	Xaa	Xaa	Shenoy et al., 2009
polyubiquitinated CCP110 (centriolar coiled-coil protein of 110 kDa)	P0CG47/O43303	1-76	peptide-Gly76+Lys-peptide	P	Leu	Arg	Gly	Gly	Lys	Xaa	Xaa	Xaa	Li et al., 2013
polyubiquitinated type II iodothyronine deiodinase	P0CG47/Q92813	1-76	peptide-Gly76+Lys-peptide	P	Leu	Arg	Gly	Gly	Lys	Xaa	Xaa	Xaa	Curcio-Morelli et al., 2003