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Literature for peptidase C19.037: ubiquitin-specific peptidase 33

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: I Inhibitor, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Chen,D., Zhao,Y., Zhang,X., Shi,X., Liu,Y. and Lou,G.<br>USP33-mediated stabilization of c-Myc drives glycolytic reprogramming and promotes ovarian cancer progression<br>Biochim Biophys Acta Gen Subj (2025) 1869, 130830-130830. PubMed  Europe PubMed DOI  K
  2. Sinko,R., Salas-Lucia,F., Mohacsik,P., Halmos,E., Wittmann,G., Egri,P., Bocco,B.M.L.C., Batistuzzo,A., Fonseca,T.L., Fekete,C., Bianco,A.C. and Gereben,B.<br>Variable transduction of thyroid hormone signaling in structures of the mouse brain<br>Proc Natl Acad Sci U S A (2025) 122, e2415970122-e2415970122. PubMed  Europe PubMed DOI
  3. Xu,Y., Tan,Y., Zhang,Z., Chen,D., Zhou,C., Sun,L., Xia,S., Bao,X., Yang,H. and Xu,Y.<br>13-Docosenamide Enhances Oligodendrocyte Precursor Cell Differentiation via USP33-Mediated Deubiquitination of CNR1 in Chronic Cerebral Hypoperfusion<br>Neurosci Bull (2025) PubMed  Europe PubMed DOI
    4. 2024
  4. Chen,J., Shan,W., Jia,Q., Chen,Y., Jiang,W., Tian,Y., Huang,X., Li,X., Wang,Z. and Xia,B.<br>USP33 facilitates the ovarian cancer progression via deubiquitinating and stabilizing CBX2<br>Oncogene (2024) 43, 3170-3183. PubMed  Europe PubMed DOI
  5. Guo,J., Qu,H., Cui,P. and Xue,Y.<br>USP33 promotes caerulein-induced apoptotic, oxidative and inflammatory injuries in acute pancreatitis by deubiquitinating TRAF3<br>Shock (2024) PubMed  Europe PubMed DOI  K
  6. Hang,Q., Zuo,S., Yang,Y., Wang,Y., Li,C., Li,W., Guo,J., Hou,S. and Huang,H.<br>USP33 is an integrin alpha6 deubiquitinase and promotes esophageal squamous cell carcinoma cell migration and metastasis<br>J Cancer Res Clin Oncol (2024) 150, 511-511. PubMed  Europe PubMed DOI  PMC  EPMC  K
  7. Liang,J., Chen,J. and Xu,P.<br>USP33 promotes pulmonary microvascular endothelial cell pyroptosis by stabilizing TRAF2 through deubiquitination<br>Histol Histopathol (2024) , 18835-18835. PubMed  Europe PubMed DOI
  8. Tang,Y., Wang,T., Gu,L., Xu,Y., Yang,Z., Zhu,W., Zhang,Q., Luo,J., Cao,J. and Jiao,Y.<br>USP11 Exacerbates Radiation-Induced Pneumonitis by Activating Endothelial Cell Inflammatory Response via OTUD5-STING Signaling<br>Int J Radiat Oncol Biol Phys (2024) 119, 1261-1274. PubMed  Europe PubMed DOI  I
  9. Xue,Y., Xue,C. and Song,W.<br>Emerging roles of deubiquitinating enzymes in actin cytoskeleton and tumor metastasis<br>Cell Oncol (Dordr) (2024) PubMed  Europe PubMed DOI  V
  10. Zhu,Y., Chen,Z., Niu,K., Li,M., Deng,Y., Zhang,J., Wei,D., Wang,J. and Zhao,Y.<br>USP33 Regulates DNA Damage Response and Carcinogenesis Through Deubiquitylating and Stabilising p53<br>Cell Prolif (2024) , e13793-e13793. PubMed  Europe PubMed DOI
    11. 2023
  11. Dong,W., Chen,J., Wang,Y., Weng,J., Du,X., Fang,X., Liu,W., Long,T., You,J., Wang,W. and Peng,X.<br>miR-206 alleviates LPS-induced inflammatory injury in cardiomyocytes via directly targeting USP33 to inhibit the JAK2/STAT3 signaling pathway<br>Mol Cell Biochem (2023) , 1-12. PubMed  Europe PubMed DOI  PMC  EPMC
  12. Ke,X., Hu,H., Peng,Q., Ying,H. and Chu,X.<br>USP33 promotes nonalcoholic fatty acid disease-associated fibrosis in gerbils via the c-myc signaling<br>Biochem Biophys Res Commun (2023) 669, 68-76. PubMed  Europe PubMed DOI  K
  13. Liu,N., Lin,M.M. and Wang,Y.<br>The Emerging Roles of E3 Ligases and DUBs in Neurodegenerative Diseases<br>Mol Neurobiol (2023) 60, 247-263. PubMed  Europe PubMed DOI  PMC  EPMC  V
  14. Liu,X., Xu,J., Shen,B., Xu,J. and Jiang,J.<br>USP33 promotes pancreatic cancer malignant phenotype through the regulation of TGFBR2/TGFbeta signaling pathway<br>Cell Death Dis (2023) 14, 362-362. PubMed  Europe PubMed DOI  PMC  EPMC
  15. Zhong,B., Zhu,Q., Wang,L., Wang,F., Zheng,Y., Lin,S. and Cheng,X.<br>USP33 enhances cell survival and stemness by deubiquitinating CTNNB1 in BXPC-3 and SW1990 cells<br>Cell Biol Int (2023) 47, 1368-1380. PubMed  Europe PubMed DOI
  16. Zhou,B., Wang,N., Chen,Q., Ren,J., Fu,X. and Cheng,X.<br>Deubiquitinase USP33 promotes the glycolysis and growth of osteosarcoma by modifying PFKFB3 ubiquitination and degradation<br>Am J Cancer Res (2023) 13, 922-935. PubMed  Europe PubMed  PMC  EPMC
    17. 2022
  17. Niu,Y., Jiang,H., Yin,H., Wang,F., Hu,R., Hu,X., Peng,B., Shu,Y., Li,Z., Chen,S. and Guo,F.<br>Hepatokine ERAP1 Disturbs Skeletal Muscle Insulin Sensitivity Via Inhibiting USP33-Mediated ADRB2 Deubiquitination<br>Diabetes (2022) 71, 921-933. PubMed  Europe PubMed DOI  K
  18. Zhang,A., Huang,Z., Tao,W., Zhai,K., Wu,Q., Rich,J.N., Zhou,W. and Bao,S.<br>USP33 deubiquitinates and stabilizes HIF-2alpha to promote hypoxia response in glioma stem cells<br>EMBO J (2022) 41, e109187-e109187. PubMed  Europe PubMed DOI  PMC  EPMC
    19. 2021
  19. Ding,T., Zhu,Y., Jin,H., Zhang,P., Guo,J. and Zheng,J.<br>Circular RNA circ_0057558 Controls Prostate Cancer Cell Proliferation Through Regulating miR-206/USP33/c-Myc Axis<br>Front Cell Dev Biol (2021) 9, 644397-644397. PubMed  Europe PubMed DOI  PMC  EPMC  K
  20. Mishra,R. and Banerjea,A.C.<br>SARS-CoV-2 Spike Targets USP33-IRF9 Axis via Exosomal miR-148a to Activate Human Microglia<br>Front Immunol (2021) 12, 656700-656700. PubMed  Europe PubMed DOI  PMC  EPMC
  21. Wang,H., Liu,Z., Sun,Z., Zhou,D., Mao,H. and Deng,G.<br>Ubiquitin specific peptidase 33 promotes cell proliferation and reduces apoptosis through regulation of the SP1/PI3K/AKT pathway in retinoblastoma<br>Cell Cycle (2021) , 1-11. PubMed  Europe PubMed DOI
    22. 2020
  22. Gan,Q., Shao,J., Cao,Y., Lei,J., Xie,P., Ge,J. and Hu,G.<br>USP33 regulates c-Met expression by deubiquitinating SP1 to facilitate metastasis in hepatocellular carcinoma<br>Life Sci (2020) 261, 118316-118316. PubMed  Europe PubMed DOI  K
  23. Guo,F., Zhang,C., Wang,F., Zhang,W., Shi,X., Zhu,Y., Fang,Z., Yang,B. and Sun,Y.<br>Deubiquitinating enzyme USP33 restrains docetaxel-induced apoptosis via stabilising the phosphatase DUSP1 in prostate cancer<br>Cell Death Differ (2020) 27, 1938-1951. PubMed  Europe PubMed DOI
  24. Kaur,S., Chen,Y. and Shenoy,S.K.<br>Agonist-activated glucagon receptors are deubiquitinated at early endosomes by two distinct deubiquitinases to facilitate Rab4a-dependent recycling<br>J Biol Chem (2020) PubMed  Europe PubMed DOI
  25. Mishra,R., Lahon,A. and Banerjea,A.C.<br>Dengue Virus Degrades USP33-ATF3 Axis via Extracellular Vesicles to Activate Human Microglial Cells<br>J Immunol (2020) 205, 1787-1798. PubMed  Europe PubMed DOI  K
  26. Niu,K., Fang,H., Chen,Z., Zhu,Y., Tan,Q., Wei,D., Li,Y., Balajee,A.S. and Zhao,Y.<br>USP33 deubiquitinates PRKN/parkin and antagonizes its role in mitophagy<br>Autophagy (2020) 16, 724-734. PubMed  Europe PubMed DOI
    27. 2017
  27. Cheng,Q., Yuan,Y., Li,L., Guo,T., Miao,Y., Ren,Y., Liu,J., Feng,Q., Wang,X., Zhao,P., Zuo,Y., Qian,L., Zhang,L. and Zheng,H.<br>Deubiquitinase USP33 is negatively regulated by beta-TrCP through ubiquitin-dependent proteolysis<br>Exp Cell Res (2017) 356, 1-7. PubMed  Europe PubMed DOI
    28. 2015
  28. Huang,Z., Wen,P., Kong,R., Cheng,H., Zhang,B., Quan,C., Bian,Z., Chen,M., Zhang,Z., Chen,X., Du,X., Liu,J., Zhu,L., Fushimi,K., Hua,D. and Wu,J.Y.<br>USP33 mediates Slit-Robo signaling in inhibiting colorectal cancer cell migration<br>Int J Cancer (2015) 136, 1792-1802. PubMed  Europe PubMed DOI
    29. 2014
  29. Chan,N.C., den Besten,W., Sweredoski,M.J., Hess,S., Deshaies,R.J. and Chan,D.C.<br>Degradation of the deubiquitinating enzyme USP33 is mediated by p97 and the ubiquitin ligase HERC2<br>J Biol Chem (2014) 289, 19789-19798. PubMed  Europe PubMed DOI
  30. Wen,P., Kong,R., Liu,J., Zhu,L., Chen,X., Li,X., Nie,Y., Wu,K. and Wu,J.Y.<br>USP33, a new player in lung cancer, mediates Slit-Robo signaling<br>Protein Cell (2014) 5, 704-713. PubMed  Europe PubMed DOI
    31. 2013
  31. Barenz,F. and Hoffmann,I.<br>Cell biology: DUBing CP110 controls centrosome numbers<br>Curr Biol (2013) 23, R459-R460. PubMed  Europe PubMed DOI
  32. Li,J., D'Angiolella,V., Seeley,E.S., Kim,S., Kobayashi,T., Fu,W., Campos,E.I., Pagano,M. and Dynlacht,B.D.<br>USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110<br>Nature (2013) 495, 255-259. PubMed  Europe PubMed DOI
  33. Simicek,M., Lievens,S., Laga,M., Guzenko,D., Aushev,V.N., Kalev,P., Baietti,M.F., Strelkov,S.V., Gevaert,K., Tavernier,J. and Sablina,A.A.<br>The deubiquitylase USP33 discriminates between RALB functions in autophagy and innate immune response<br>Nat Cell Biol (2013) 15, 1220-1230. PubMed  Europe PubMed DOI
    34. 2011
  34. Thorne,C., Eccles,R.L., Coulson,J.M., Urbe,S. and Clague,M.J.<br>Isoform-specific localization of the deubiquitinase USP33 to the Golgi Apparatus<br>Traffic (2011) 12, 1563-1574. PubMed  Europe PubMed DOI
    35. 2009
  35. Berthouze,M., Venkataramanan,V., Li,Y. and Shenoy,S.K.<br>The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization<br>EMBO J (2009) 28, 1684-1696. PubMed  Europe PubMed DOI  PMC  EPMC
  36. Shenoy,S.K., Modi,A.S., Shukla,A.K., Xiao,K., Berthouze,M., Ahn,S., Wilkinson,K.D., Miller,W.E. and Lefkowitz,R.J.<br>Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2<br>Proc Natl Acad Sci U S A (2009) 106, 6650-6655. PubMed  Europe PubMed DOI  PMC  EPMC
  37. Yuasa-Kawada,J., Kinoshita-Kawada,M., Rao,Y. and Wu,J.Y.<br>Deubiquitinating enzyme USP33/VDU1 is required for Slit signaling in inhibiting breast cancer cell migration<br>Proc Natl Acad Sci U S A (2009) 106, 14530-14535. PubMed  Europe PubMed DOI  PMC  EPMC
    38. 2003
  38. Curcio-Morelli,C., Zavacki,A.M., Christofollete,M., Gereben,B., de Freitas,B.C., Harney,J.W., Li,Z., Wu,G. and Bianco,A.C.<br>Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation<br>J Clin Invest (2003) 112, 189-196. PubMed  Europe PubMed DOI  PMC  EPMC
  39. Puente,X.S., Sanchez,L.M., Overall,C.M. and Lopez-Otin,C.<br>Human and mouse proteases: a comparative genomic approach<br>Nat Rev Genet (2003) 4, 544-558. PubMed  Europe PubMed DOI
    40. 2002
  40. [YEAR:14-6-2002]Li,Z., Wang,D., Na,X., Schoen,S.R., Messing,E.M. and Wu,G.<br>Identification of a deubiquitinating enzyme subfamily as substrates of the von Hippel-Lindau tumor suppressor<br>Biochem Biophys Res Commun (14-6-2002) 294, 700-709. PubMed  Europe PubMed DOI
  41. [YEAR:15-2-2002]Li,Z., Na,X., Wang,D., Schoen,S.R., Messing,E.M. and Wu,G.<br>Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein<br>J Biol Chem (15-2-2002) 277, 4656-4662. PubMed  Europe PubMed DOI

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