Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase C19.037: ubiquitin-specific peptidase 33

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: I Inhibitor, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Chen,D., Zhao,Y., Zhang,X., Shi,X., Liu,Y. and Lou,G.
    USP33-mediated stabilization of c-Myc drives glycolytic reprogramming and promotes ovarian cancer progression
    Biochim Biophys Acta Gen Subj (2025) 1869, 130830-130830. PubMed  Europe PubMed DOI  K
  2. Sinko,R., Salas-Lucia,F., Mohacsik,P., Halmos,E., Wittmann,G., Egri,P., Bocco,B.M.L.C., Batistuzzo,A., Fonseca,T.L., Fekete,C., Bianco,A.C. and Gereben,B.
    Variable transduction of thyroid hormone signaling in structures of the mouse brain
    Proc Natl Acad Sci U S A (2025) 122, e2415970122-e2415970122. PubMed  Europe PubMed DOI
  3. Xu,Y., Tan,Y., Zhang,Z., Chen,D., Zhou,C., Sun,L., Xia,S., Bao,X., Yang,H. and Xu,Y.
    13-Docosenamide Enhances Oligodendrocyte Precursor Cell Differentiation via USP33-Mediated Deubiquitination of CNR1 in Chronic Cerebral Hypoperfusion
    Neurosci Bull (2025) PubMed  Europe PubMed DOI
    4. 2024
  4. Chen,J., Shan,W., Jia,Q., Chen,Y., Jiang,W., Tian,Y., Huang,X., Li,X., Wang,Z. and Xia,B.
    USP33 facilitates the ovarian cancer progression via deubiquitinating and stabilizing CBX2
    Oncogene (2024) 43, 3170-3183. PubMed  Europe PubMed DOI
  5. Guo,J., Qu,H., Cui,P. and Xue,Y.
    USP33 promotes caerulein-induced apoptotic, oxidative and inflammatory injuries in acute pancreatitis by deubiquitinating TRAF3
    Shock (2024) PubMed  Europe PubMed DOI  K
  6. Hang,Q., Zuo,S., Yang,Y., Wang,Y., Li,C., Li,W., Guo,J., Hou,S. and Huang,H.
    USP33 is an integrin alpha6 deubiquitinase and promotes esophageal squamous cell carcinoma cell migration and metastasis
    J Cancer Res Clin Oncol (2024) 150, 511-511. PubMed  Europe PubMed DOI  PMC  EPMC  K
  7. Liang,J., Chen,J. and Xu,P.
    USP33 promotes pulmonary microvascular endothelial cell pyroptosis by stabilizing TRAF2 through deubiquitination
    Histol Histopathol (2024) , 18835-18835. PubMed  Europe PubMed DOI
  8. Tang,Y., Wang,T., Gu,L., Xu,Y., Yang,Z., Zhu,W., Zhang,Q., Luo,J., Cao,J. and Jiao,Y.
    USP11 Exacerbates Radiation-Induced Pneumonitis by Activating Endothelial Cell Inflammatory Response via OTUD5-STING Signaling
    Int J Radiat Oncol Biol Phys (2024) 119, 1261-1274. PubMed  Europe PubMed DOI  I
  9. Xue,Y., Xue,C. and Song,W.
    Emerging roles of deubiquitinating enzymes in actin cytoskeleton and tumor metastasis
    Cell Oncol (Dordr) (2024) PubMed  Europe PubMed DOI  V
  10. Zhu,Y., Chen,Z., Niu,K., Li,M., Deng,Y., Zhang,J., Wei,D., Wang,J. and Zhao,Y.
    USP33 Regulates DNA Damage Response and Carcinogenesis Through Deubiquitylating and Stabilising p53
    Cell Prolif (2024) , e13793-e13793. PubMed  Europe PubMed DOI
    11. 2023
  11. Dong,W., Chen,J., Wang,Y., Weng,J., Du,X., Fang,X., Liu,W., Long,T., You,J., Wang,W. and Peng,X.
    miR-206 alleviates LPS-induced inflammatory injury in cardiomyocytes via directly targeting USP33 to inhibit the JAK2/STAT3 signaling pathway
    Mol Cell Biochem (2023) , 1-12. PubMed  Europe PubMed DOI  PMC  EPMC
  12. Ke,X., Hu,H., Peng,Q., Ying,H. and Chu,X.
    USP33 promotes nonalcoholic fatty acid disease-associated fibrosis in gerbils via the c-myc signaling
    Biochem Biophys Res Commun (2023) 669, 68-76. PubMed  Europe PubMed DOI  K
  13. Liu,N., Lin,M.M. and Wang,Y.
    The Emerging Roles of E3 Ligases and DUBs in Neurodegenerative Diseases
    Mol Neurobiol (2023) 60, 247-263. PubMed  Europe PubMed DOI  PMC  EPMC  V
  14. Liu,X., Xu,J., Shen,B., Xu,J. and Jiang,J.
    USP33 promotes pancreatic cancer malignant phenotype through the regulation of TGFBR2/TGFbeta signaling pathway
    Cell Death Dis (2023) 14, 362-362. PubMed  Europe PubMed DOI  PMC  EPMC
  15. Zhong,B., Zhu,Q., Wang,L., Wang,F., Zheng,Y., Lin,S. and Cheng,X.
    USP33 enhances cell survival and stemness by deubiquitinating CTNNB1 in BXPC-3 and SW1990 cells
    Cell Biol Int (2023) 47, 1368-1380. PubMed  Europe PubMed DOI
  16. Zhou,B., Wang,N., Chen,Q., Ren,J., Fu,X. and Cheng,X.
    Deubiquitinase USP33 promotes the glycolysis and growth of osteosarcoma by modifying PFKFB3 ubiquitination and degradation
    Am J Cancer Res (2023) 13, 922-935. PubMed  Europe PubMed  PMC  EPMC
    17. 2022
  17. Niu,Y., Jiang,H., Yin,H., Wang,F., Hu,R., Hu,X., Peng,B., Shu,Y., Li,Z., Chen,S. and Guo,F.
    Hepatokine ERAP1 Disturbs Skeletal Muscle Insulin Sensitivity Via Inhibiting USP33-Mediated ADRB2 Deubiquitination
    Diabetes (2022) 71, 921-933. PubMed  Europe PubMed DOI  K
  18. Zhang,A., Huang,Z., Tao,W., Zhai,K., Wu,Q., Rich,J.N., Zhou,W. and Bao,S.
    USP33 deubiquitinates and stabilizes HIF-2alpha to promote hypoxia response in glioma stem cells
    EMBO J (2022) 41, e109187-e109187. PubMed  Europe PubMed DOI  PMC  EPMC
    19. 2021
  19. Ding,T., Zhu,Y., Jin,H., Zhang,P., Guo,J. and Zheng,J.
    Circular RNA circ_0057558 Controls Prostate Cancer Cell Proliferation Through Regulating miR-206/USP33/c-Myc Axis
    Front Cell Dev Biol (2021) 9, 644397-644397. PubMed  Europe PubMed DOI  PMC  EPMC  K
  20. Mishra,R. and Banerjea,A.C.
    SARS-CoV-2 Spike Targets USP33-IRF9 Axis via Exosomal miR-148a to Activate Human Microglia
    Front Immunol (2021) 12, 656700-656700. PubMed  Europe PubMed DOI  PMC  EPMC
  21. Wang,H., Liu,Z., Sun,Z., Zhou,D., Mao,H. and Deng,G.
    Ubiquitin specific peptidase 33 promotes cell proliferation and reduces apoptosis through regulation of the SP1/PI3K/AKT pathway in retinoblastoma
    Cell Cycle (2021) , 1-11. PubMed  Europe PubMed DOI
    22. 2020
  22. Gan,Q., Shao,J., Cao,Y., Lei,J., Xie,P., Ge,J. and Hu,G.
    USP33 regulates c-Met expression by deubiquitinating SP1 to facilitate metastasis in hepatocellular carcinoma
    Life Sci (2020) 261, 118316-118316. PubMed  Europe PubMed DOI  K
  23. Guo,F., Zhang,C., Wang,F., Zhang,W., Shi,X., Zhu,Y., Fang,Z., Yang,B. and Sun,Y.
    Deubiquitinating enzyme USP33 restrains docetaxel-induced apoptosis via stabilising the phosphatase DUSP1 in prostate cancer
    Cell Death Differ (2020) 27, 1938-1951. PubMed  Europe PubMed DOI
  24. Kaur,S., Chen,Y. and Shenoy,S.K.
    Agonist-activated glucagon receptors are deubiquitinated at early endosomes by two distinct deubiquitinases to facilitate Rab4a-dependent recycling
    J Biol Chem (2020) PubMed  Europe PubMed DOI
  25. Mishra,R., Lahon,A. and Banerjea,A.C.
    Dengue Virus Degrades USP33-ATF3 Axis via Extracellular Vesicles to Activate Human Microglial Cells
    J Immunol (2020) 205, 1787-1798. PubMed  Europe PubMed DOI  K
  26. Niu,K., Fang,H., Chen,Z., Zhu,Y., Tan,Q., Wei,D., Li,Y., Balajee,A.S. and Zhao,Y.
    USP33 deubiquitinates PRKN/parkin and antagonizes its role in mitophagy
    Autophagy (2020) 16, 724-734. PubMed  Europe PubMed DOI
    27. 2017
  27. Cheng,Q., Yuan,Y., Li,L., Guo,T., Miao,Y., Ren,Y., Liu,J., Feng,Q., Wang,X., Zhao,P., Zuo,Y., Qian,L., Zhang,L. and Zheng,H.
    Deubiquitinase USP33 is negatively regulated by beta-TrCP through ubiquitin-dependent proteolysis
    Exp Cell Res (2017) 356, 1-7. PubMed  Europe PubMed DOI
    28. 2015
  28. Huang,Z., Wen,P., Kong,R., Cheng,H., Zhang,B., Quan,C., Bian,Z., Chen,M., Zhang,Z., Chen,X., Du,X., Liu,J., Zhu,L., Fushimi,K., Hua,D. and Wu,J.Y.
    USP33 mediates Slit-Robo signaling in inhibiting colorectal cancer cell migration
    Int J Cancer (2015) 136, 1792-1802. PubMed  Europe PubMed DOI
    29. 2014
  29. Chan,N.C., den Besten,W., Sweredoski,M.J., Hess,S., Deshaies,R.J. and Chan,D.C.
    Degradation of the deubiquitinating enzyme USP33 is mediated by p97 and the ubiquitin ligase HERC2
    J Biol Chem (2014) 289, 19789-19798. PubMed  Europe PubMed DOI
  30. Wen,P., Kong,R., Liu,J., Zhu,L., Chen,X., Li,X., Nie,Y., Wu,K. and Wu,J.Y.
    USP33, a new player in lung cancer, mediates Slit-Robo signaling
    Protein Cell (2014) 5, 704-713. PubMed  Europe PubMed DOI
    31. 2013
  31. Barenz,F. and Hoffmann,I.
    Cell biology: DUBing CP110 controls centrosome numbers
    Curr Biol (2013) 23, R459-R460. PubMed  Europe PubMed DOI
  32. Li,J., D'Angiolella,V., Seeley,E.S., Kim,S., Kobayashi,T., Fu,W., Campos,E.I., Pagano,M. and Dynlacht,B.D.
    USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110
    Nature (2013) 495, 255-259. PubMed  Europe PubMed DOI
  33. Simicek,M., Lievens,S., Laga,M., Guzenko,D., Aushev,V.N., Kalev,P., Baietti,M.F., Strelkov,S.V., Gevaert,K., Tavernier,J. and Sablina,A.A.
    The deubiquitylase USP33 discriminates between RALB functions in autophagy and innate immune response
    Nat Cell Biol (2013) 15, 1220-1230. PubMed  Europe PubMed DOI
    34. 2011
  34. Thorne,C., Eccles,R.L., Coulson,J.M., Urbe,S. and Clague,M.J.
    Isoform-specific localization of the deubiquitinase USP33 to the Golgi Apparatus
    Traffic (2011) 12, 1563-1574. PubMed  Europe PubMed DOI
    35. 2009
  35. Berthouze,M., Venkataramanan,V., Li,Y. and Shenoy,S.K.
    The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization
    EMBO J (2009) 28, 1684-1696. PubMed  Europe PubMed DOI  PMC  EPMC
  36. Shenoy,S.K., Modi,A.S., Shukla,A.K., Xiao,K., Berthouze,M., Ahn,S., Wilkinson,K.D., Miller,W.E. and Lefkowitz,R.J.
    Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2
    Proc Natl Acad Sci U S A (2009) 106, 6650-6655. PubMed  Europe PubMed DOI  PMC  EPMC
  37. Yuasa-Kawada,J., Kinoshita-Kawada,M., Rao,Y. and Wu,J.Y.
    Deubiquitinating enzyme USP33/VDU1 is required for Slit signaling in inhibiting breast cancer cell migration
    Proc Natl Acad Sci U S A (2009) 106, 14530-14535. PubMed  Europe PubMed DOI  PMC  EPMC
    38. 2003
  38. Curcio-Morelli,C., Zavacki,A.M., Christofollete,M., Gereben,B., de Freitas,B.C., Harney,J.W., Li,Z., Wu,G. and Bianco,A.C.
    Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation
    J Clin Invest (2003) 112, 189-196. PubMed  Europe PubMed DOI  PMC  EPMC
  39. Puente,X.S., Sanchez,L.M., Overall,C.M. and Lopez-Otin,C.
    Human and mouse proteases: a comparative genomic approach
    Nat Rev Genet (2003) 4, 544-558. PubMed  Europe PubMed DOI
    40. 2002
  40. [YEAR:14-6-2002]Li,Z., Wang,D., Na,X., Schoen,S.R., Messing,E.M. and Wu,G.
    Identification of a deubiquitinating enzyme subfamily as substrates of the von Hippel-Lindau tumor suppressor
    Biochem Biophys Res Commun (14-6-2002) 294, 700-709. PubMed  Europe PubMed DOI
  41. [YEAR:15-2-2002]Li,Z., Na,X., Wang,D., Schoen,S.R., Messing,E.M. and Wu,G.
    Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein
    J Biol Chem (15-2-2002) 277, 4656-4662. PubMed  Europe PubMed DOI

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2026 EBI
Terms of use