Substrates for peptidase C19.011: ubiquitin-specific peptidase 8

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
polyubiquitin-E3 ubiquitin-protein ligase parkin conjugate	P0CG47	1-76	peptide-Gly76+Lys6-peptide	P	Leu	Arg	Gly	Gly	Lys	Thr	Leu	Thr	Durcan et al., 2014
polyubiquitinated baculoviral IAP repeat-containing protein 6	P0CG47/Q9NR09	1-76	peptide-Gly76+peptide	P	Leu	Arg	Gly	Gly	Lys	Xaa	Xaa	Xaa	Pohl & Jentsch, 2008
polyubiquitinated E3 ubiquitin-protein ligase NRDP1	P0CG47/Q9H4P4	1-76	peptide-Gly76+Lys-peptide	P	Leu	Arg	Gly	Gly	Lys	Xaa	Xaa	Xaa	Wu et al., 2004
polyubiquitinated kinesin-like protein KIF23	P0CG47/Q02241	1-76	peptide-Gly76+peptide	P	Leu	Arg	Gly	Gly	Lys	Xaa	Xaa	Xaa	Pohl & Jentsch, 2008
tetra-ubiquitin	P0CG47	1-76	peptide-Gly76+Lys48-peptide	N	Leu	Arg	Gly	Gly	Lys	Gln	Leu	Glu	McCulloch et al., 2004
tetra-ubiquitin	P0CG47	1-76	peptide-Gly76+Lys63-peptide	N	Leu	Arg	Gly	Gly	Lys	Glu	Ser	Thr	McCulloch et al., 2004