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Literature for peptidase C19.011: ubiquitin-specific peptidase 8

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, M Mutation, I Inhibitor, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Zhou,H., Ge,X., Feng,G. and Liu,L.
    Ubiquitin specific peptidase 8 mediates angiotensin-II-induced smooth muscle cell phenotypic transformation during hypertension via regulating LRRC8A
    Am J Hypertens (2026) PubMed  Europe PubMed DOI
    2. 2025
  2. Chandra,P. and Philips,J.A.
    USP8 PROMOTES INTRACELLULAR INFECTION by ENHANCING ESCRT-MEDIATED MEMBRANE REPAIR, LIMITING XENOPHAGY, and REDUCING OXIDATIVE STRESS
    Autophagy (2025) 21, 298-314. PubMed  Europe PubMed DOI
  3. Damiano,A., Sabina,B., Laura,H.J., Jennifer,B., Nicholas,W., Roberto,C., Michelle,R., Andrew,B., Alessandra,S., Lennart,A., Marco,J., Willemijn,D., Maria,M.G., Sara,P., Catherine,K., Ivy,J., Neyaz,A., Robert,D., John,S., Uta,F., Evelina,M. and Rita,A.
    USP8-Rearranged Mesenchymal Tumors With Myofibroblastic Phenotype: A Comprehensive Clinicopathological, Genetic, and Epigenetic Characterization
    Mod Pathol (2025) , 100947-100947. PubMed  Europe PubMed DOI
  4. Hu,B., Liu,Y., Zhao,Z., Yang,S., Ling,J., Sun,Z., Chu,P. and Duan,X.
    Isoginkgetin as a novel USP8 inhibitor discovered by structure-based virtual screening exerts anticancer effects in ovarian cancer
    Biochem Biophys Res Commun (2025) 791, 152924-152924. PubMed  Europe PubMed DOI
  5. Mohan,C.G. and Pavithran,K.
    USP8-EIF2S1 signaling enhances CML cell survival under TKI-induced stress
    FEBS J (2025) PubMed  Europe PubMed DOI
  6. Qian,W., Zhang,X., Yuan,D., Wu,Y., Li,H., Wei,L., Li,Z., Dai,Z., Song,P., Sun,Q., Zhou,Z., Xia,Q. and Cheng,D.
    USP8 and Hsp70 regulate endoreplication by synergistically promoting Fzr deubiquitination and stabilization
    Sci Adv (2025) 11, eadq9111-eadq9111. PubMed  Europe PubMed DOI  PMC  EPMC
  7. Saito,R., Fukushima,M., Sasaki,M., Okamoto,A. and Ogiwara,H.
    Targeting USP8 causes synthetic lethality through degradation of FGFR2 in ARID1A-deficient ovarian clear cell carcinoma
    NPJ Precis Oncol (2025) 9, 69-69. PubMed  Europe PubMed DOI  PMC  EPMC
  8. Yang,H., Sun,T., Sun,Z., Wang,H., Liu,D., Wu,D., Qin,T. and Zhou,M.
    Unravelling the role of ubiquitin-specific proteases in breast carcinoma: insights into tumour progression and immune microenvironment modulation
    World J Surg Oncol (2025) 23, 60-60. PubMed  Europe PubMed DOI  PMC  EPMC  V
  9. Zhang,S., Lai,H., Bao,W., Liao,C. and Li,J.
    The deubiquitinating enzyme USP8 promotes tyrosine kinase inhibitors resistance in chronic myeloid leukemia by stabilizing EIF2S1 protein
    FEBS J (2025) PubMed  Europe PubMed DOI  K
  10. Zhu,Y., Zhang,H., Lan,L., Chen,X., Wei,L. and Zhang,A.
    USP8 modulates primary ovarian insufficiency through regulation of Beclin1-dependent autophagy-induced ferroptosis
    Sci Rep (2025) 15, 35910-35910. PubMed  Europe PubMed DOI  PMC  EPMC  K
    11. 2024
  11. Caba,C., Black,M., Liu,Y., DaDalt,A.A., Mallare,J., Fan,L., Harding,R.J., Wang,Y., Vacratsis,P.O., Huang,R., Zhuang,Z. and Tong,Y.
    Autoinhibition of ubiquitin-specific protease 8: insights into domain interactions and mechanisms of regulation
    J Biol Chem (2024) , 107727-107727. PubMed  Europe PubMed DOI
  12. Chang,X., Li,Z., Wang,M., Pei,K., Wang,J., Hu,J., Ding,K. and Chang,Y.
    USP8 suppresses porcine reproductive and respiratory syndrome virus replication by positively regulating MAVS mediated ƒ.ÿ-IFN signaling
    Vet Microbiol (2024) 298, 110286-110286. PubMed  Europe PubMed DOI  K
  13. Endo,A., Fukushima,T., Takahashi,C., Tsuchiya,H., Ohtake,F., Ono,S., Ly,T., Yoshida,Y., Tanaka,K., Saeki,Y. and Komada,M.
    USP8 prevents aberrant NF-kappaB and Nrf2 activation by counteracting ubiquitin signals from endosomes
    J Cell Biol (2024) 223 PubMed  Europe PubMed DOI  PMC  EPMC
  14. Endo,A., Komada,M. and Yoshida,Y.
    Ubiquitin-mediated endosomal stress: A novel organelle stress of early endosomes that initiates cellular signaling pathways: USP8 serves as a gatekeeper of ubiquitin-mediated endosomal stress to counteract the activation of cellular signaling pathways
    Bioessays (2024) , e2400127-e2400127. PubMed  Europe PubMed DOI
  15. Guo,J., Zheng,H. and Xiong,S.
    SENP6 restricts the IFN-I-induced signaling pathway and antiviral activity by deSUMOylating USP8
    Cell Mol Immunol (2024) 21, 892-904. PubMed  Europe PubMed DOI
  16. Ho,H.H. and Wing,S.S.
    alpha-Synuclein ubiquitination - functions in proteostasis and development of Lewy bodies
    Front Mol Neurosci (2024) 17, 1498459-1498459. PubMed  Europe PubMed DOI  PMC  EPMC  V
  17. Joshi,K., Mazumdar,V., Nandi,B.R. and Radhakrishnan,G.K.
    Brucella targets the host ubiquitin-specific protease, Usp8, through the effector protein, TcpB, for facilitating infection of macrophages
    Infect Immun (2024) 92, e0028923-e0028923. PubMed  Europe PubMed DOI  PMC  EPMC
  18. Kong,W., Feng,X., Yu,Z., Qi,X. and Zhao,Z.
    USP8-mediated PTK7 promotes PIK3CB-related pathway to accelerate the malignant progression of non-small cell lung cancer
    Thorac Cancer (2024) PubMed  Europe PubMed DOI  K
  19. Li,H., Sun,Y., Yao,Y., Ke,S., Zhang,N., Xiong,W., Shi,J., He,C., Xiao,X., Yu,H., Dai,P., Xiang,B., Xing,X., Xu,G., Song,W., Song,J. and Zhang,J.
    USP8-governed GPX4 homeostasis orchestrates ferroptosis and cancer immunotherapy
    Proc Natl Acad Sci U S A (2024) 121, e2315541121-e2315541121. PubMed  Europe PubMed DOI  PMC  EPMC
  20. Liu,L., Zhang,Y., Xu,D., Zhu,D., Zhou,Y., Chen,Z. and Huang,X.
    Overexpression of USP8 inhibits inflammation and ferroptosis in chronic obstructive pulmonary disease by regulating the OTUB1/SLC7A11 signaling pathway
    Allergol Immunopathol (Madr) (2024) 52, 60-67. PubMed  Europe PubMed DOI
  21. Long,G., Wang,D., Tang,J., Hu,K. and Zhou,L.
    USP8 promotes the tumorigenesis of intrahepatic cholangiocarcinoma via stabilizing OGT
    Cancer Cell Int (2024) 24, 238-238. PubMed  Europe PubMed DOI  PMC  EPMC
  22. Ma,T., Ge,X., Zhu,J., Song,C., Wang,P. and Cai,J.
    Dioscin Impedes Proliferation, Metastasis and Enhances Autophagy of Gastric Cancer Cells via Regulating the USP8/TGM2 Pathway
    Mol Biotechnol (2024) 66, 3700-3711. PubMed  Europe PubMed DOI  K
  23. Mathieu,J. and Huynh,J.R.
    Incomplete divisions between sister germline cells require Usp8 function
    C R Biol (2024) 347, 109-117. PubMed  Europe PubMed DOI
  24. Miao,H., Wang,L., Gong,F., Duan,L., Wang,L., Yao,Y., Feng,M., Deng,K., Wang,R., Xiao,Y., Ling,Q., Zhu,H. and Lu,L.
    A long-term prognosis study of human USP8-mutated ACTH-secreting pituitary neuroendocrine tumours
    Clin Endocrinol (Oxf) (2024) 101, 32-41. PubMed  Europe PubMed DOI
  25. Miao,Y., Du,Y., Wang,B., Liang,J., Liang,Y., Dang,S., Liu,J., Li,D., He,K. and Ding,M.
    Spatiotemporal recruitment of the ubiquitin-specific protease USP8 directs endosome maturation
    elife (2024) 13 PubMed  Europe PubMed DOI  PMC  EPMC
  26. Miranda,R.L., Guterres,A., de Azeredo Lima,C.H., Lamback,E. and Gadelha,M.R.
    Novel Drop-off PCR Assay for USP8 Hotspot Variant Detection in Corticotroph Tumors
    Endocr Pathol (2024) 35, 269-271. PubMed  Europe PubMed DOI
  27. Petukhova,N., Poluzerova,A., Bug,D., Nerubenko,E., Kostareva,A., Tsoy,U. and Dmitrieva,R.
    USP8 Mutations Associated with Cushing's Disease Alter Protein Structure Dynamics
    Int J Mol Sci (2024) 25 PubMed  Europe PubMed DOI  PMC  EPMC
  28. Sakamoto,M., Kurosawa,K., Tanoue,K., Iwama,K., Ishida,F., Watanabe,Y., Okamoto,N., Tsuchida,N., Uchiyama,Y., Koshimizu,E., Fujita,A., Misawa,K., Miyatake,S., Mizuguchi,T. and Matsumoto,N.
    A heterozygous germline deletion within USP8 causes severe neurodevelopmental delay with multiorgan abnormalities
    J Hum Genet (2024) 69, 85-90. PubMed  Europe PubMed DOI
  29. Tian,Y., Liu,K., Wu,D., Wu,L., Xu,Q., Wei,W., Li,Z., Du,Q. and Bian,J.
    The discovery of potent USP2/USP8 dual-target inhibitors for the treatment of breast cancer via structure guided optimization of ML364
    Eur J Med Chem (2024) 268, 116275-116275. PubMed  Europe PubMed DOI  I
  30. Wu,Y., Xian,D., Liu,Y., Huang,D., Liu,Q. and Yang,S.
    USP8-Dependent Family Tyrosine Kinase Promotes the Malignant Progression of Esophageal Squamous Cell Carcinoma by Upregulating Protein Tyrosine Kinase 2 Expression
    Thorac Cancer (2024) PubMed  Europe PubMed DOI
  31. Zhang,X., Han,L., Hou,J., Yang,H., Xu,H., Li,G., Shu,Q., Zhu,D., Zheng,Y. and Gao,C.
    Stress granule-localized USP8 potentiates cGAS-mediated type I interferonopathies through deubiquitination of DDX3X
    Cell Rep (2024) 43, 114248-114248. PubMed  Europe PubMed DOI
  32. Zhou,C.J., Zhang,C., Lu,L.F. and Li,S.
    Fish ubiquitin-specific protease 8 (USP8) inhibits IFN production through autophagy-lysosomal dependent degradation of IRF7
    Dev Comp Immunol (2024) 156, 105181-105181. PubMed  Europe PubMed DOI
    33. 2023
  33. Cui,J., Guo,Y., Yin,T., Gou,S., Xiong,J., Liang,X., Lu,C. and Peng,T.
    USP8 promotes gemcitabine resistance of pancreatic cancer via deubiquitinating and stabilizing Nrf2
    Biomed Pharmacother (2023) 166, 115359-115359. PubMed  Europe PubMed DOI
  34. Gao,W., Wang,L. and Li,Z.
    Ubiquitin-specific protease 8 regulates cognitive dysfunction of mice with sepsis-associated encephalopathy through SIRT1 deubiquitination
    Curr Neurovasc Res (2023) PubMed  Europe PubMed DOI  K
  35. Jiao,D., Chen,Y., Liu,X., Tang,X., Chen,J., Liu,Y., Jiang,C. and Chen,Q.
    Targeting MET endocytosis or degradation to overcome HGF-induced gefitinib resistance in EGFR-sensitive mutant lung adenocarcinoma
    Biochem Biophys Res Commun (2023) 682, 371-380. PubMed  Europe PubMed DOI
  36. Liu,N., Lin,M.M. and Wang,Y.
    The Emerging Roles of E3 Ligases and DUBs in Neurodegenerative Diseases
    Mol Neurobiol (2023) 60, 247-263. PubMed  Europe PubMed DOI  PMC  EPMC  V
  37. Mauri,S., Bernardo,G., Martinez,A., Favaro,M., Trevisan,M., Cobraiville,G., Fillet,M., Caicci,F., Whitworth,A.J. and Ziviani,E.
    USP8 Down-Regulation Promotes Parkin-Independent Mitophagy in the Drosophila Brain and in Human Neurons
    Cells (2023) 12 PubMed  Europe PubMed DOI  PMC  EPMC
  38. Rebollar-Vega,R.G., Zuarth-Vazquez,J.M. and Hernandez-Ramirez,L.C.
    Clinical Spectrum of USP8 Pathogenic Variants in Cushing's Disease
    Arch Med Res (2023) 54, 102899-102899. PubMed  Europe PubMed DOI
  39. Santelices,J., Ou,M., Maegawa,G.H.B., Hercik,K. and Edelmann,M.J.
    USP8 inhibition regulates autophagy flux and controls Salmonella infection
    Front Cell Infect Microbiol (2023) 13, 1070271-1070271. PubMed  Europe PubMed DOI  PMC  EPMC
  40. Tang,J., Long,G., Xiao,L. and Zhou,L.
    USP8 positively regulates hepatocellular carcinoma tumorigenesis and confers ferroptosis resistance through beta-catenin stabilization
    Cell Death Dis (2023) 14, 360-360. PubMed  Europe PubMed DOI  PMC  EPMC
  41. Wu,S., Lin,T. and Xu,Y.
    Polymorphic USP8 allele promotes Parkinson's disease by inducing the accumulation of alpha-synuclein through deubiquitination
    Cell Mol Life Sci (2023) 80, 363-363. PubMed  Europe PubMed DOI
  42. Zhang,L. and Liu,J.
    USP8 mitigates cognitive dysfunction of mice with sepsis-associated encephalopathy
    Psychogeriatrics (2023) 23, 713-724. PubMed  Europe PubMed DOI
  43. Zhang,S., Shi,Y. and Dong,P.
    USP8 targeted by Mir-874-3p promotes trophoblastic cell invasion by stabilizing the expression of ENaC on trophoblast membrane
    Hum Immunol (2023) 84, 618-630. PubMed  Europe PubMed DOI  K
  44. Zhang,W., Zheng,Z., Wang,K., Mao,W., Li,X., Wang,G., Zhang,Y., Huang,J., Zhang,N., Wu,P., Liu,J., Zhang,H., Che,J., Peng,B., Zheng,J., Li,W. and Yao,X.
    piRNA-1742 promotes renal cell carcinoma malignancy by regulating USP8 stability through binding to hnRNPU and thereby inhibiting MUC12 ubiquitination
    Exp Mol Med (2023) 55, 1258-1271. PubMed  Europe PubMed DOI  PMC  EPMC
    45. 2022
  45. Bi,W., Zhang,J., Zeng,Z., Zhou,R., Zhao,J., Yan,W., Wang,L., Li,X. and Zhu,L.
    Ubiquitinƒ_'specific protease 8 ameliorates lipopolysaccharideƒ_'induced spleen injury via suppression of NFƒ_'kappaB and MAPK signaling pathways
    Mol Med Rep (2022) 26 PubMed  Europe PubMed DOI  PMC  EPMC
  46. Colombo,D., Gatti,L., Sjostrand,L., Carenini,N., Costantino,M., Corna,E., Arrighetti,N., Zuccolo,M., De Cesare,M., Linder,S., D'Arcy,P. and Perego,P.
    Caffeic acid phenethyl ester targets ubiquitin-specific protease 8 and synergizes with cisplatin in endometrioid ovarian carcinoma cells
    Biochem Pharmacol (2022) 197, 114900-114900. PubMed  Europe PubMed DOI  I
  47. Hatipoglu,E., Gunaldi,O., Erkan,B., Avcikurt,A., Mert,M. and Niyazoglu,M.
    Ubiquitin-specific Protease 8 Gene Expression in Sporadic Pituitary Adenomas
    Neuro Endocrinol Lett (2022) 43, 129-133. PubMed  Europe PubMed
  48. Islam,M.T., Chen,F.Z., Chen,H.C. and Wahid,A.
    Knockdown of USP8 inhibits prostate cancer cell growth, proliferation, and metastasis and promotes docetaxel's activity by suppressing the NF-kB signaling pathway
    Front Oncol (2022) 12, 923270-923270. PubMed  Europe PubMed DOI  PMC  EPMC  K
  49. Li,L., Liu,Y., Zhao,Y., Feng,R., Li,Y., Yu,X., Liu,Z. and Wang,L.
    Deubiquitinase USP8 increases ID1 stability and promotes esophageal squamous cell carcinoma tumorigenesis
    Cancer Lett (2022) 542, 215760-215760. PubMed  Europe PubMed DOI  K
  50. Liu,L., Huan,L., Zhang,Y., Wei,W., Chen,Z., Xu,D., Huang,X., Tan,Y. and Li,H.
    Ubiquitin-specific protease 8 inhibits lipopolysaccharide-triggered pyroptosis of human bronchial epithelial cells by regulating PI3K/AKT and NF-kappaB pathways
    Allergol Immunopathol (Madr) (2022) 50, 96-103. PubMed  Europe PubMed DOI
  51. Mathieu,J., Michel-Hissier,P., Boucherit,V. and Huynh,J.R.
    The deubiquitinase USP8 targets ESCRT-III to promote incomplete cell division
    Science (2022) 376, 818-823. PubMed  Europe PubMed DOI
  52. Sha,B., Sun,Y., Zhao,S., Li,M., Huang,W., Li,Z., Shi,J., Han,X., Li,P., Hu,T. and Chen,P.
    USP8 inhibitor-induced DNA damage activates cell cycle arrest, apoptosis, and autophagy in esophageal squamous cell carcinoma
    Cell Biol Toxicol (2022) PubMed  Europe PubMed DOI  I
  53. Shichi,H., Fukuoka,H., Kanzawa,M., Yamamoto,M., Yamamoto,N., Suzuki,M., Urai,S., Matsumoto,R., Kanie,K., Fujita,Y., Bando,H., Iguchi,G., Inoshita,N., Yamada,S., Takahashi,Y. and Ogawa,W.
    Responsiveness to DDAVP in Cushing's disease is associated with USP8 mutations through enhancing AVPR1B promoter activity
    Pituitary (2022) 25, 496-507. PubMed  Europe PubMed DOI
  54. Sun,Q., Zhang,J., Li,X., Yang,G., Cheng,S., Guo,D., Zhang,Q., Sun,F., Zhao,F., Yang,D., Wang,S., Wang,T., Liu,S., Zou,L., Zhang,Y. and Liu,H.
    The ubiquitin-specific protease 8 antagonizes melatonin-induced endocytic degradation of MT(1) receptor to promote lung adenocarcinoma growth
    J Adv Res (2022) 41, 1-12. PubMed  Europe PubMed DOI  PMC  EPMC  K  I
  55. Tan,L., Shan,H., Han,C., Zhang,Z., Shen,J., Zhang,X., Xiang,H., Lu,K., Qi,C., Li,Y., Zhuang,G., Chen,G. and Tan,L.
    Discovery of Potent OTUB1/USP8 Dual Inhibitors Targeting Proteostasis in Non-Small-Cell Lung Cancer
    J Med Chem (2022) 65, 13645-13659. PubMed  Europe PubMed DOI  K  I
  56. Xie,F., Zhou,X., Li,H., Su,P., Liu,S., Li,R., Zou,J., Wei,X., Pan,C., Zhang,Z., Zheng,M., Liu,Z., Meng,X., Ovaa,H., ten Dijke,P., Zhou,F. and Zhang,L.
    USP8 promotes cancer progression and extracellular vesicle-mediated CD8+ T cell exhaustion by deubiquitinating the TGF-beta receptor TbetaRII
    EMBO J (2022) 41, e108791-e108791. PubMed  Europe PubMed DOI  PMC  EPMC
  57. Xiong,W., Gao,X., Zhang,T., Jiang,B., Hu,M.M., Bu,X., Gao,Y., Zhang,L.Z., Xiao,B.L., He,C., Sun,Y., Li,H., Shi,J., Xiao,X., Xiang,B., Xie,C., Chen,G., Zhang,H., Wei,W., Freeman,G.J., Shu,H.B., Wang,H. and Zhang,J.
    USP8 inhibition reshapes an inflamed tumor microenvironment that potentiates the immunotherapy
    Nat Commun (2022) 13, 1700-1700. PubMed  Europe PubMed DOI  PMC  EPMC
  58. Zhao,Y., Peng,D., Liu,Y., Zhang,Q., Liu,B., Deng,Y., Ding,W., Zhou,Z. and Liu,Q.
    Usp8 promotes tumor cell migration through activating the JNK pathway
    Cell Death Dis (2022) 13, 286-286. PubMed  Europe PubMed DOI  PMC  EPMC  K
    59. 2021
  59. Duan,B., Wang,C., Liu,Z. and Yang,X.
    USP8 is a Novel Therapeutic Target in Melanoma Through Regulating Receptor Tyrosine Kinase Levels
    Cancer Manag Res (2021) 13, 4181-4189. PubMed  Europe PubMed DOI  PMC  EPMC  K
  60. Islam,M.T., Chen,F. and Chen,H.
    The oncogenic role of ubiquitin specific peptidase (USP8) and its signaling pathways targeting for cancer therapeutics
    Arch Biochem Biophys (2021) 701, 108811-108811. PubMed  Europe PubMed DOI  V
  61. Kim,M.J., Choi,B., Kim,J.Y., Min,Y., Kwon,D.H., Son,J., Lee,J.S., Lee,J.S., Chun,E. and Lee,K.Y.
    USP8 regulates liver cancer progression via the inhibition of TRAF6-mediated signal for NF-kappaB activation and autophagy induction by TLR4
    Transl Oncol (2021) 15, 101250-101250. PubMed  Europe PubMed DOI  PMC  EPMC
  62. Treppiedi,D., Di Muro,G., Marra,G., Barbieri,A.M., Mangili,F., Catalano,R., Serban,A., Ferrante,E., Locatelli,M., Lania,A.G., Arosio,M., Spada,A., Peverelli,E. and Mantovani,G.
    USP8 inhibitor RA-9 reduces ACTH release and cell growth in tumor corticotrophs
    Endocr Relat Cancer (2021) 28, 573-582. PubMed  Europe PubMed DOI  I
  63. Treppiedi,D., Barbieri,A.M., Di Muro,G., Marra,G., Mangili,F., Catalano,R., Esposito,E., Ferrante,E., Serban,A.L., Locatelli,M., Lania,A.G., Spada,A., Arosio,M., Peverelli,E. and Mantovani,G.
    Genetic Profiling of a Cohort of Italian Patients with ACTH-Secreting Pituitary Tumors and Characterization of a Novel USP8 Gene Variant
    Cancers (Basel) (2021) 13 PubMed  Europe PubMed DOI  PMC  EPMC
    64. 2020
  64. Chang,M., Yang,C., Bao,X. and Wang,R.
    Genetic and Epigenetic Causes of Pituitary Adenomas
    Front Endocrinol (Lausanne) (2020) 11, 596554-596554. PubMed  Europe PubMed DOI  PMC  EPMC  V
  65. Chen,M., Amado,N., Tan,J., Reis,A., Ge,M., Abreu,J.G. and He,X.
    TMEM79/MATTRIN defines a pathway for Frizzled regulation and is required for Xenopus embryogenesis
    elife (2020) 9 PubMed  Europe PubMed DOI  PMC  EPMC
  66. Martin-Rodriguez,C., Song,M., Anta,B., Gonzalez-Calvo,F.J., Deogracias,R., Jing,D., Lee,F.S. and Arevalo,J.C.
    TrkB deubiquitination by USP8 regulates receptor levels and BDNF-dependent neuronal differentiation
    J Cell Sci (2020) PubMed  Europe PubMed DOI  K
  67. Pasternak-Pietrzak,K., Faucz,F.R., Stratakis,C.A., Moszczynska,E., Roszkowski,M., Grajkowska,W., Pronicki,M. and Szalecki,M.
    Is there a common cause for pediatric Cushing's disease?
    Endokrynol Pol (2020) PubMed  Europe PubMed DOI
  68. Shin,S., Kim,K., Kim,H.R., Ylaya,K., Do,S.I., Hewitt,S.M., Park,H.S., Roe,J.S., Chung,J.Y. and Song,J.
    Deubiquitylation and stabilization of Notch1 intracellular domain by ubiquitin-specific protease 8 enhance tumorigenesis in breast cancer
    Cell Death Differ (2020) 27, 1341-1354. PubMed  Europe PubMed DOI
  69. Sun,J., Shen,D., Gao,Y., Zheng,Y., Zhao,L., Maa,M., Liu,H. and Chen,X.
    Down-Regulation of USP8 Suppresses HER-3 Positive Gastric Cancer Cells Proliferation
    Onco Targets Ther (2020) 13, 7973-7984. PubMed  Europe PubMed DOI  PMC  EPMC
  70. Sun,J., Shen,D., Zheng,Y., Ren,H., Liu,H., Chen,X. and Gao,Y.
    USP8 Inhibitor Suppresses HER-2 Positive Gastric Cancer Cell Proliferation and Metastasis via the PI3K/AKT Signaling Pathway
    Onco Targets Ther (2020) 13, 9941-9952. PubMed  Europe PubMed DOI  PMC  EPMC
  71. Vashistha,V., Bhardwaj,S., Yadav,B.K. and Yadav,A.K.
    Depleting deubiquitinating enzymes promotes apoptosis in glioma cell line via RNA binding proteins SF2/ASF1
    Biochem Biophys Rep (2020) 24, 100846-100846. PubMed  Europe PubMed DOI  PMC  EPMC  K  I
  72. Wang,Z., Guo,X., Gao,L., Deng,K., Lian,W., Bao,X., Feng,M., Duan,L., Zhu,H. and Xing,B.
    The Immune Profile of Pituitary Adenomas and a Novel Immune Classification for Predicting Immunotherapy Responsiveness
    J Clin Endocrinol Metab (2020) 105 PubMed  Europe PubMed DOI
  73. Zhang,W. and Qiu,W.
    OTUB1 Recruits Tumor Infiltrating Lymphocytes and Is a Prognostic Marker in Digestive Cancers
    Front Mol Biosci (2020) 7, 212-212. PubMed  Europe PubMed DOI  PMC  EPMC
    74. 2019
  74. Asari,Y., Kageyama,K., Sugiyama,A., Kogawa,H., Niioka,K. and Daimon,M.
    Lapatinib decreases the ACTH production and proliferation of corticotroph tumor cells
    Endocr J (2019) 66, 515-522. PubMed  Europe PubMed DOI  M
  75. Bland,T., Sahin,G.S., Zhu,M., Dillon,C., Impey,S., Appleyard,S.M. and Wayman,G.A.
    USP8 deubiquitinates the leptin receptor and is necessary for leptin-mediated synapse formation
    Endocrinology (2019) 160, 1982-1998. PubMed  Europe PubMed DOI
  76. Dufner,A. and Knobeloch,K.P.
    Ubiquitin-specific protease 8 (USP8/UBPy): a prototypic multidomain deubiquitinating enzyme with pleiotropic functions
    Biochem Soc Trans (2019) 47, 1867-1879. PubMed  Europe PubMed DOI
  77. Gu,H., Shi,X., Liu,C., Wang,C., Sui,N., Zhao,Y., Gong,J., Wang,F., Zhang,H., Li,W. and Zhao,T.
    USP8 maintains embryonic stem cell stemness via deubiquitination of EPG5
    Nat Commun (2019) 10, 1465-1465. PubMed  Europe PubMed DOI  PMC  EPMC
  78. Losa,M., Mortini,P., Pagnano,A., Detomas,M., Cassarino,M.F. and Pecori Giraldi,F.
    Clinical characteristics and surgical outcome in USP8-mutated human adrenocorticotropic hormone-secreting pituitary adenomas
    Endocrine (2019) 63, 240-246. PubMed  Europe PubMed DOI  M
  79. Sbiera,S., Kunz,M., Weigand,I., Deutschbein,T., Dandekar,T. and Fassnacht,M.
    The new genetic landscape of Cushing's disease: deubiquitinases in the spotlight
    Cancers (Basel) (2019) 11 PubMed  Europe PubMed DOI  M
  80. von Stockum,S., Sanchez-Martinez,A., Corra,S., Chakraborty,J., Marchesan,E., Locatello,L., Da Re,C., Cusumano,P., Caicci,F., Ferrari,V., Costa,R., Bubacco,L., Rasotto,M.B., Szabo,I., Whitworth,A.J., Scorrano,L. and Ziviani,E.
    Inhibition of the deubiquitinase USP8 corrects a Drosophila PINK1 model of mitochondria dysfunction
    Life Sci Alliance (2019) 2 PubMed  Europe PubMed DOI
  81. Weigand,I., Knobloch,L., Flitsch,J., Saeger,W., Monoranu,C.M., Hofner,K., Herterich,S., Rotermund,R., Ronchi,C.L., Buchfelder,M., Glatzel,M., Hagel,C., Fassnacht,M., Deutschbein,T. and Sbiera,S.
    Impact of USP8 gene mutations on protein deregulation in Cushing disease
    J Clin Endocrinol Metab (2019) 104, 2535-2546. PubMed  Europe PubMed DOI  M
    82. 2018
  82. Albani,A., Theodoropoulou,M. and Reincke,M.
    Genetics of Cushing's disease
    Clin Endocrinol (Oxf) (2018) 88, 3-12. PubMed  Europe PubMed DOI  M
  83. Albani,A., Perez-Rivas,L.G., Reincke,M. and Theodoropoulou,M.
    Pathogenesis of Cushing disease: an update on the genetics of corticotropinomas
    Endocr Pract (2018) 24, 907-914. PubMed  Europe PubMed DOI  M
  84. Ballmann,C., Thiel,A., Korah,H.E., Reis,A.C., Saeger,W., Stepanow,S., Kohrer,K., Reifenberger,G., Knobbe-Thomsen,C.B., Knappe,U.J. and Scholl,U.I.
    USP8 mutations in pituitary Cushing adenomas-targeted analysis by next-generation sequencing
    J Endocr Soc (2018) 2, 266-278. PubMed  Europe PubMed DOI  PMC  EPMC  M
  85. Crespo-Yanez,X., Aguilar-Gurrieri,C., Jacomin,A.C., Journet,A., Mortier,M., Taillebourg,E., Soleilhac,E., Weissenhorn,W. and Fauvarque,M.O.
    CHMP1B is a target of USP8/UBPY regulated by ubiquitin during endocytosis
    PLoS Genet (2018) 14, e1007456-e1007456. PubMed  Europe PubMed DOI
  86. Kasahara,K., Aoki,H., Kiyono,T., Wang,S., Kagiwada,H., Yuge,M., Tanaka,T., Nishimura,Y., Mizoguchi,A., Goshima,N. and Inagaki,M.
    EGF receptor kinase suppresses ciliogenesis through activation of USP8 deubiquitinase
    Nat Commun (2018) 9, 758-758. PubMed  Europe PubMed DOI  PMC  EPMC
  87. Kawaguchi,K., Endo,A., Fukushima,T., Madoka,Y., Tanaka,T. and Komada,M.
    Ubiquitin-specific protease 8 deubiquitinates Sec31A and decreases large COPII carriers and collagen IV secretion
    Biochem Biophys Res Commun (2018) 499, 635-641. PubMed  Europe PubMed DOI
  88. Kerrisk Campbell,M. and Sheng,M.
    USP8 deubiquitinates SHANK3 to control synapse density and SHANK3 activity-dependent protein levels
    J Neurosci (2018) 38, 5289-5301. PubMed  Europe PubMed DOI
  89. Perez-Rivas,L.G., Theodoropoulou,M., Puar,T.H., Fazel,J., Stieg,M.R., Ferrau,F., Assie,G., Gadelha,M.R., Deutschbein,T., Fragoso,M.C., Kusters,B., Saeger,W., Honegger,J., Buchfelder,M., Korbonits,M., Bertherat,J., Stalla,G.K., Hermus,A.R., Beuschlein,F. and Reincke,M.
    Somatic USP8 mutations are frequent events in corticotroph tumor progression causing Nelson's tumor
    Eur J Endocrinol (2018) 178, 57-63. PubMed  Europe PubMed DOI  M
  90. Sun,J., Hu,Q., Peng,H., Peng,C., Zhou,L., Lu,J. and Huang,C.
    The ubiquitin-specific protease USP8 deubiquitinates and stabilizes Cx43
    J Biol Chem (2018) 293, 8275-8284. PubMed  Europe PubMed DOI
  91. Zheng,Y., Liu,Q., Wu,Y., Ma,L., Zhang,Z., Liu,T., Jin,S., She,Y., Li,Y.P. and Cui,J.
    Zika virus elicits inflammation to evade antiviral response by cleaving cGAS via NS1-caspase-1 axis
    EMBO J (2018) 37, e99347-e99347. PubMed  Europe PubMed DOI
    92. 2017
  92. Daniel,E. and Newell-Price,J.
    Recent advances in understanding Cushing disease: resistance to glucocorticoid negative feedback and somatic USP8 mutations
    F1000Res (2017) 6, 613-613. PubMed  Europe PubMed DOI  PMC  EPMC  M
  93. Faucz,F.R., Tirosh,A., Tatsi,C., Berthon,A., Hernandez-Ramirez,L.C., Settas,N., Angelousi,A., Correa,R., Papadakis,G.Z., Chittiboina,P., Quezado,M., Pankratz,N., Lane,J., Dimopoulos,A., Mills,J.L., Lodish,M. and Stratakis,C.A.
    Somatic USP8 gene mutations are a common cause of pediatric Cushing disease
    J Clin Endocrinol Metab (2017) 102, 2836-2843. PubMed  Europe PubMed DOI  M
  94. Jeong,M., Lee,E.W., Seong,D., Seo,J., Kim,J.H., Grootjans,S., Kim,S.Y., Vandenabeele,P. and Song,J.
    USP8 suppresses death receptor-mediated apoptosis by enhancing FLIPL stability
    Oncogene (2017) 36, 458-470. PubMed  Europe PubMed DOI
  95. Perez-Rivas,L.G., Osswald,A., Knosel,T., Lucia,K., Schaaf,C., Hristov,M., Fazel,J., Kirchner,T., Beuschlein,F., Reincke,M. and Theodoropoulou,M.
    Expression and mutational status of USP8 in tumors causing ectopic ACTH secretion syndrome
    Endocr Relat Cancer (2017) 24, L73-L77. PubMed  Europe PubMed DOI  M
    96. 2016
  96. Hayashi,K., Inoshita,N., Kawaguchi,K., Ibrahim Ardisasmita,A., Suzuki,H., Fukuhara,N., Okada,M., Nishioka,H., Takeuchi,Y., Komada,M., Takeshita,A. and Yamada,S.
    The USP8 mutational status may predict drug susceptibility in corticotroph adenomas of Cushing's disease
    Eur J Endocrinol (2016) 174, 213-226. PubMed  Europe PubMed DOI  M
  97. Jacomin,A.C., Fauvarque,M.O. and Taillebourg,E.
    A functional endosomal pathway is necessary for lysosome biogenesis in Drosophila
    BMC Cell Biol (2016) 17, 36-36. PubMed  Europe PubMed DOI
  98. Jian,F.F., Li,Y.F., Chen,Y.F., Jiang,H., Chen,X., Zheng,L.L., Zhao,Y., Wang,W.Q., Ning,G., Bian,L.G. and Sun,Q.F.
    Inhibition of ubiquitin-specific peptidase 8 suppresses adrenocorticotropic hormone production and tumorous corticotroph cell growth in AtT20 cells
    Chin Med J (Engl) (2016) 129, 2102-2108. PubMed  Europe PubMed DOI  I
  99. Perez-Rivas,L.G. and Reincke,M.
    Genetics of Cushing's disease: an update
    J Endocrinol Invest (2016) 39, 29-35. PubMed  Europe PubMed DOI  M
  100. Smith,G.A., Fearnley,G.W., Abdul-Zani,I., Wheatcroft,S.B., Tomlinson,D.C., Harrison,M.A. and Ponnambalam,S.
    VEGFR2 trafficking, signaling and proteolysis is regulated by the ubiquitin isopeptidase USP8
    Traffic (2016) 17, 53-65. PubMed  Europe PubMed DOI
  101. Yeates,E.F. and Tesco,G.
    The endosome-associated deubiquitinating enzyme USP8 regulates BACE1 enzyme ubiquitination and degradation
    J Biol Chem (2016) 291, 15753-15766. PubMed  Europe PubMed DOI
    102. 2015
  102. Berruti,G. and Paiardi,C.
    USP8/UBPy-regulated sorting and the development of sperm acrosome: the recruitment of MET
    Reproduction (2015) 149, 633-644. PubMed  Europe PubMed DOI
  103. Ceriani,M., Amigoni,L., D'Aloia,A., Berruti,G. and Martegani,E.
    The deubiquitinating enzyme UBPy/USP8 interacts with TrkA and inhibits neuronal differentiation in PC12 cells
    Exp Cell Res (2015) 333, 49-59. PubMed  Europe PubMed DOI
  104. Dufner,A. and Knobeloch,K.P.
    USP8 - Another DUB in the T cell club
    Cell Cycle (2015) 14, 3775-3776. PubMed  Europe PubMed DOI
  105. Dufner,A., Kisser,A., Niendorf,S., Basters,A., Reissig,S., Schonle,A., Aichem,A., Kurz,T., Schlosser,A., Yablonski,D., Groettrup,M., Buch,T., Waisman,A., Schamel,W.W., Prinz,M. and Knobeloch,K.P.
    The ubiquitin-specific protease USP8 is critical for the development and homeostasis of T cells
    Nat Immunol (2015) 16, 950-960. PubMed  Europe PubMed DOI
  106. Huang,C., Shi,Y. and Zhao,Y.
    USP8 mutation in Cushing's disease
    Oncotarget (2015) 6, 18240-18241. PubMed  Europe PubMed DOI  M
  107. Jeong,C.H.
    Inhibition of ubiquitin-specific peptidase 8 suppresses growth of gefitinib-resistant non-small cell lung cancer cells by inducing apoptosis
    J Cancer Prev (2015) 20, 57-63. PubMed  Europe PubMed DOI  PMC  EPMC  I
  108. Kaiser,U.B.
    Cushing's disease: towards precision medicine
    Cell Res (2015) 25, 649-650. PubMed  Europe PubMed DOI  M
  109. Ma,Z.Y., Song,Z.J., Chen,J.H., Wang,Y.F., Li,S.Q., Zhou,L.F., Mao,Y., Li,Y.M., Hu,R.G., Zhang,Z.Y., Ye,H.Y., Shen,M., Shou,X.F., Li,Z.Q., Peng,H., Wang,Q.Z., Zhou,D.Z., Qin,X.L., Ji,J., Zheng,J., Chen,H., Wang,Y., Geng,D.Y., Tang,W.J., Fu,C.W., Shi,Z.F., Zhang,Y.C., Ye,Z., He,W.Q., Zhang,Q.L., Tang,Q.S., Xie,R., Shen,J.W., Wen,Z.J., Zhou,J., Wang,T., Huang,S., Qiu,H.J., Qiao,N.D., Zhang,Y., Pan,L., Bao,W.M., Liu,Y.C., Huang,C.X., Shi,Y.Y. and Zhao,Y.
    Recurrent gain-of-function USP8 mutations in Cushing's disease
    Cell Res (2015) 25, 306-317. PubMed  Europe PubMed DOI  M
  110. Perez-Rivas,L.G., Theodoropoulou,M., Ferrau,F., Nusser,C., Kawaguchi,K., Stratakis,C.A., Faucz,F.R., Wildemberg,L.E., Assie,G., Beschorner,R., Dimopoulou,C., Buchfelder,M., Popovic,V., Berr,C.M., Toth,M., Ardisasmita,A.I., Honegger,J., Bertherat,J., Gadelha,M.R., Beuschlein,F., Stalla,G., Komada,M., Korbonits,M. and Reincke,M.
    The gene of the ubiquitin-specific protease 8 is frequently mutated in adenomas causing Cushing's disease
    J Clin Endocrinol Metab (2015) 100, E997-E1004. PubMed  Europe PubMed DOI  M
  111. Reincke,M., Sbiera,S., Hayakawa,A., Theodoropoulou,M., Osswald,A., Beuschlein,F., Meitinger,T., Mizuno-Yamasaki,E., Kawaguchi,K., Saeki,Y., Tanaka,K., Wieland,T., Graf,E., Saeger,W., Ronchi,C.L., Allolio,B., Buchfelder,M., Strom,T.M., Fassnacht,M. and Komada,M.
    Mutations in the deubiquitinase gene USP8 cause Cushing's disease
    Nat Genet (2015) 47, 31-38. PubMed  Europe PubMed DOI  M
  112. Theodoropoulou,M., Reincke,M., Fassnacht,M. and Komada,M.
    Decoding the genetic basis of Cushing's disease: USP8 in the spotlight
    Eur J Endocrinol (2015) 173, M73-M83. PubMed  Europe PubMed DOI
  113. Zhu,L., Bi,W., Lu,D., Zhang,C., Shu,X., Wang,H., Qi,R., Shi,Q. and Lu,D.
    Regulation of ubiquitin-specific processing protease 8 suppresses neuroinflammation
    Mol Cell Neurosci (2015) 64C, 74-83. PubMed  Europe PubMed DOI
    114. 2014
  114. Durcan,T.M., Tang,M.Y., Perusse,J.R., Dashti,E.A., Aguileta,M.A., McLelland,G.L., Gros,P., Shaler,T.A., Faubert,D., Coulombe,B. and Fon,E.A.
    USP8 regulates mitophagy by removing K6-linked ubiquitin conjugates from parkin
    EMBO J (2014) 33, 2473-2491. PubMed  Europe PubMed DOI
  115. MacDonald,E., Urbe,S. and Clague,M.J.
    USP8 controls the trafficking and sorting of lysosomal enzymes
    Traffic (2014) 15, 879-888. PubMed  Europe PubMed DOI
  116. Paiardi,C., Pasini,M.E., Amadeo,A., Gioria,M. and Berruti,G.
    The ESCRT-deubiquitinating enzyme USP8 in the cervical spinal cord of wild-type and Vps54-recessive (wobbler) mutant mice
    Histochem Cell Biol (2014) 141, 57-73. PubMed  Europe PubMed DOI
  117. Troilo,A., Alexander,I., Muehl,S., Jaramillo,D., Knobeloch,K.P. and Krek,W.
    HIF1alpha deubiquitination by USP8 is essential for ciliogenesis in normoxia
    EMBO Rep (2014) 15, 77-85. PubMed  Europe PubMed DOI
    118. 2013
  118. Byun,S., Lee,S.Y., Lee,J., Jeong,C.H., Farrand,L., Lim,S., Reddy,K., Kim,J.Y., Lee,M.H., Lee,H.J., Bode,A.M., Won Lee,K. and Dong,Z.
    USP8 is a novel target for overcoming gefitinib resistance in lung cancer
    Clin Cancer Res (2013) 19, 3894-3904. PubMed  Europe PubMed DOI  I
  119. Meijer,I.M., Kerperien,J., Sotoca,A.M., van Zoelen,E.J. and van Leeuwen,J.E.
    The Usp8 deubiquitination enzyme is post-translationally modified by tyrosine and serine phosphorylation
    Cell Signal (2013) 25, 919-930. PubMed  Europe PubMed DOI
  120. Zhou,R., Tomkovicz,V.R., Butler,P.L., Ochoa,L.A., Peterson,Z.J. and Snyder,P.M.
    Ubiquitin-specific peptidase 8 (USP8) regulates endosomal trafficking of the epithelial Na+ channel
    J Biol Chem (2013) 288, 5389-5397. PubMed  Europe PubMed DOI  PMC  EPMC
    121. 2012
  121. Berruti,G. and Martegani,E.
    Ubiquitinspecific peptidase 8
    [ISSN:978-0-12-407743-0] (2012) 3, 2070-2075. DOI
  122. Issaenko,O.A. and Amerik,A.Y.
    Chalcone-based small-molecule inhibitors attenuate malignant phenotype via targeting deubiquitinating enzymes
    Cell Cycle (2012) 11, 1804-1817. PubMed  Europe PubMed DOI  I
  123. Xia,R., Jia,H., Fan,J., Liu,Y. and Jia,J.
    USP8 promotes Smoothened signaling by preventing its ubiquitination and changing its subcellular localization
    PLoS Biol (2012) 10, e1001238-e1001238. PubMed  Europe PubMed DOI  PMC  EPMC
    124. 2011
  124. Faesen,A.C., Luna-Vargas,M.P., Geurink,P.P., Clerici,M., Merkx,R., van Dijk,W.J., Hameed,D.S., El Oualid,F., Ovaa,H. and Sixma,T.K.
    The differential modulation of USP activity by internal regulatory domains, interactors and eight ubiquitin chain types
    Chem Biol (2011) 18, 1550-1561. PubMed  Europe PubMed DOI
  125. Meijer,I.M. and van Leeuwen,J.E.
    ERBB2 is a target for USP8-mediated deubiquitination
    Cell Signal (2011) 23, 458-467. PubMed  Europe PubMed DOI
  126. Wright,M.H., Berlin,I. and Nash,P.D.
    Regulation of endocytic sorting by ESCRT-DUB-mediated deubiquitination
    Cell Biochem Biophys (2011) 60, 39-46. PubMed  Europe PubMed DOI
    127. 2010
  127. Berlin,I., Higginbotham,K.M., Dise,R.S., Sierra,M.I. and Nash,P.D.
    The deubiquitinating enzyme USP8 promotes trafficking and degradation of the chemokine receptor 4 at the sorting endosome
    J Biol Chem (2010) 285, 37895-37908. PubMed  Europe PubMed DOI
  128. Berlin,I., Schwartz,H. and Nash,P.D.
    Regulation of epidermal growth factor receptor ubiquitination and trafficking by the USP8.STAM complex
    J Biol Chem (2010) 285, 34909-34921. PubMed  Europe PubMed DOI  PMC  EPMC
  129. Berruti,G., Ripolone,M. and Ceriani,M.
    USP8, a regulator of endosomal sorting, is involved in mouse acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules
    Biol Reprod (2010) 82, 930-939. PubMed  Europe PubMed DOI
  130. Cai,J., Crotty,T.M., Reichert,E., Carraway,K.L., III, Stafforini,D.M. and Topham,M.K.
    Diacylglycerol kinase delta and protein kinase C(alpha) modulate epidermal growth factor receptor abundance and degradation through ubiquitin-specific protease 8
    J Biol Chem (2010) 285, 6952-6959. PubMed  Europe PubMed DOI
  131. Chianese,R., Scarpa,D., Berruti,G., Cobellis,G., Pierantoni,R., Fasano,S. and Meccariello,R.
    Expression and localization of the deubiquitinating enzyme mUBPy in wobbler mouse testis during spermiogenesis
    Gen Comp Endocrinol (2010) 166, 289-295. PubMed  Europe PubMed DOI
  132. Colombo,M., Vallese,S., Peretto,I., Jacq,X., Rain,J.C., Colland,F. and Guedat,P.
    Synthesis and biological evaluation of 9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile analogues as potential inhibitors of deubiquitinating enzymes
    ChemMedChem (2010) 5, 552-558. PubMed  Europe PubMed DOI  I
  133. d'Amora,M., Angelini,C., Aluigi,M.G., Marcoli,M., Maura,G., Berruti,G. and Vallarino,M.
    Expression pattern of mUBPy in the brain and sensory organs of mouse during embryonic development
    Brain Res (2010) 1355, 16-30. PubMed  Europe PubMed DOI
  134. Panner,A., Crane,C.A., Weng,C., Feletti,A., Fang,S., Parsa,A.T. and Pieper,R.O.
    Ubiquitin-specific protease 8 links the PTEN-Akt-AIP4 pathway to the control of FLIPS stability and TRAIL sensitivity in glioblastoma multiforme
    Cancer Res (2010) 70, 5046-5053. PubMed  Europe PubMed DOI
    135. 2008
  135. Bruzzone,F., Vallarino,M., Berruti,G. and Angelini,C.
    Expression of the deubiquitinating enzyme mUBPy in the mouse brain
    Brain Res (2008) 1195, 56-66. PubMed  Europe PubMed DOI
  136. Pohl,C. and Jentsch,S.
    Final stages of cytokinesis and midbody ring formation are controlled by BRUCE
    Cell (2008) 132, 832-845. PubMed  Europe PubMed DOI
    137. 2007
  137. Alwan,H.A. and van Leeuwen,J.E.
    UBPY-mediated epidermal growth factor receptor (EGFR) de-ubiquitination promotes EGFR degradation
    J Biol Chem (2007) 282, 1658-1669. PubMed  Europe PubMed DOI
  138. Cao,Z., Wu,X., Yen,L., Sweeney,C. and Carraway,K.L., III
    Neuregulin-induced ErbB3 downregulation is mediated by a protein stability cascade involving the E3 ubiquitin ligase Nrdp1
    Mol Cell Biol (2007) 27, 2180-2188. PubMed  Europe PubMed DOI  PMC  EPMC
  139. Mizuno,E., Kitamura,N. and Komada,M.
    14-3-3-dependent inhibition of the deubiquitinating activity of UBPY and its cancellation in the M phase
    Exp Cell Res (2007) 313, 3624-3634. PubMed  Europe PubMed DOI
  140. Niendorf,S., Oksche,A., Kisser,A., Lohler,J., Prinz,M., Schorle,H., Feller,S., Lewitzky,M., Horak,I. and Knobeloch,K.P.
    Essential role of ubiquitin-specific protease 8 for receptor tyrosine kinase stability and endocytic trafficking in vivo
    Mol Cell Biol (2007) 27, 5029-5039. PubMed  Europe PubMed DOI  PMC  EPMC  K
  141. Row,P.E., Liu,H., Hayes,S., Welchman,R., Charalabous,P., Hofmann,K., Clague,M.J., Sanderson,C.M. and Urbe,S.
    The MIT domain of UBPY constitutes a CHMP binding and endosomal localization signal required for efficient epidermal growth factor receptor degradation
    J Biol Chem (2007) 282, 30929-30937. PubMed  Europe PubMed DOI
    142. 2006
  142. Avvakumov,G.V., Walker,J.R., Xue,S., Finerty,P.J., Jr., Mackenzie,F., Newman,E.M. and Dhe-Paganon,S.
    Amino-terminal dimerization, NRDP1-rhodanese interaction, and inhibited catalytic domain conformation of the ubiquitin-specific protease 8 (USP8)
    J Biol Chem (2006) 281, 38061-38070. PubMed  Europe PubMed DOI  S
  143. Ballif,B.A., Cao,Z., Schwartz,D., Carraway,K.L., III and Gygi,S.P.
    Identification of 14-3-3epsilon substrates from embryonic murine brain
    J Proteome Res (2006) 5, 2372-2379. PubMed  Europe PubMed DOI
  144. Berruti,G. and Aivatiadou,E.
    MUBPy is a novel centrosome-associated protein and interacts with gamma-tubulin
    J Submicrosc Cytol Pathol (2006) 38, 77-83. PubMed  Europe PubMed
  145. Mizuno,E., Kobayashi,K., Yamamoto,A., Kitamura,N. and Komada,M.
    A deubiquitinating enzyme UBPY regulates the level of protein ubiquitination on endosomes
    Traffic (2006) 7, 1017-1031. PubMed  Europe PubMed DOI
  146. [YEAR:6-3-2006]Row,P.E., Prior,I.A., McCullough,J., Clague,M.J. and Urbe,S.
    The ubiquitin isopeptidase UBPY regulates endosomal ubiquitin dynamics and is essential for receptor down-regulation
    J Biol Chem (6-3-2006) 281, 12618-12624. PubMed  Europe PubMed DOI  K
  147. Urbe,S., McCullough,J., Row,P., Prior,I.A., Welchman,R. and Clague,M.J.
    Control of growth factor receptor dynamics by reversible ubiquitination
    Biochem Soc Trans (2006) 34, 754-756. PubMed  Europe PubMed DOI
    148. 2005
  148. [YEAR:1-9-2005]Berruti,G. and Martegani,E.
    The deubiquitinating enzyme mUBPy interacts with the sperm-specific molecular chaperone MSJ-1: the relation with the proteasome, acrosome, and centrosome in mouse male germ cells
    Biol Reprod (1-9-2005) 72, 14-21. PubMed  Europe PubMed DOI
  149. Mizuno,E., Iura,T., Mukai,A., Yoshimori,T., Kitamura,N. and Komada,M.
    Regulation of epidermal growth factor receptor down-regulation by UBPY-mediated deubiquitination at endosomes
    Mol Biol Cell (2005) 16, 5163-5174. PubMed  Europe PubMed DOI  PMC  EPMC
    150. 2004
  150. Wu,X., Yen,L., Irwin,L., Sweeney,C. and Carraway,K.L., III
    Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8
    Mol Cell Biol (2004) 24, 7748-7757. PubMed  Europe PubMed DOI  PMC  EPMC
    151. 2001
  151. Gnesutta,N., Ceriani,M., Innocenti,M., Mauri,I., Zippel,R., Sturani,E., Borgonovo,B., Berruti,G. and Martegani,E.
    Cloning and characterization of mouse UBPy, a deubiquitinating enzyme that interacts with the ras guanine nucleotide exchange factor CDC25(Mm)/Ras-GRF1
    J Biol Chem (2001) 276, 39448-39454. PubMed  Europe PubMed DOI
    152. 2000
  152. Kato,M., Miyazawa,K. and Kitamura,N.
    A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP
    J Biol Chem (2000) 275, 37481-37487. PubMed  Europe PubMed DOI
    153. 1998
  153. [YEAR:15-6-1998]Naviglio,S., Mattecucci,C., Matoskova,B., Nagase,T., Nomura,N., Di Fiore,P.P. and Draetta,G.F.
    UBPY: a growth-regulated human ubiquitin isopeptidase
    EMBO J (15-6-1998) 17, 3241-3250. PubMed  Europe PubMed DOI  PMC  EPMC
    154. 1997
  154. Baek,S.H., Woo,S.K., Lee,J.I., Yoo,Y.J., Cho,C.M., Kang,M.S., Tanaka,K. and Chung,C.H.
    New de-ubiquitinating enzyme, ubiquitin C-terminal hydrolase 8, in chick skeletal muscle
    Biochem J (1997) 325, 325-330. PubMed  Europe PubMed  PMC  EPMC  I

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