Substrates for peptidase C14.043: metacaspase Ld (Leishmania-type)

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
Ac-Val-Arg-Pro-Arg-NHMec			Ac-Val-Arg-Pro-Arg+NHMec	S		Val	Arg	Pro	Arg	AMC	-	-	-	El-Fadili et al., 2010
Ala-Phe-Lys-NHMec			Ala-Phe-Lys+NHMec	S		-	Ala	Phe	Lys	AMC	-	-	-	Lee et al., 2007
Boc-Gly-Arg-Arg-NHMec			Boc-Gly-Arg-Arg+NHMec	S		Boc	Gly	Arg	Arg	AMC	-	-	-	Lee et al., 2007
Boc-Gly-Arg-Arg-NHMec			Boc-Gly-Arg-Arg+NHMec	S		Boc	Gly	Arg	Arg	AMC	-	-	-	El-Fadili et al., 2010
Boc-Gly-Lys-Arg-NHMec			Boc-Gly-Lys-Arg+NHMec	S		Boc	Gly	Lys	Arg	AMC	-	-	-	Lee et al., 2007
Metacaspase	B6DU80	1-440	Peptide-Arg63+Ala-Peptide	N	CS	Gly	Arg	Val	Arg	Ala	Leu	Phe	Ile	Zalila et al., 2011
Metacaspase	B6DU80	1-440	Peptide-Arg298+Val-Peptide	N	CS	Lys	Lys	Gly	Arg	Val	Gln	Val	Pro	Zalila et al., 2011
Metacaspase	B6DU83	1-448	Peptide-Arg86+Leu-Peptide	N	CS	Asn	Asp	Val	Arg	Leu	Met	Leu	Gly	Zalila et al., 2011
Metacaspase	B6DU83	1-448	Peptide-Arg298+Val-Peptide	N	CS	Lys	Lys	Gly	Arg	Val	Gln	Val	Pro	Zalila et al., 2011
Metacaspase	B6DU82	1-435	Peptide-Arg86+Leu-Peptide	N	CS	Asn	Asp	Val	Arg	Leu	Met	Leu	Gly	Zalila et al., 2011
Metacaspase	B6DU82	1-435	Peptide-Arg298+Val-Peptide	N	CS	Lys	Lys	Gly	Arg	Val	Gln	Val	Pro	Zalila et al., 2011
Metacaspase	B6DU79	1-425	Peptide-Arg135+Pro-Peptide	N	CS	Gly	Asp	Val	Arg	Pro	Gly	Asp	Val	Zalila et al., 2011
Metacaspase	B6DU79	1-425	Peptide-Arg63+Ala-Peptide	N	CS	Gly	Arg	Val	Arg	Ala	Leu	Phe	Ile	Zalila et al., 2011
Metacaspase	B6DU79	1-425	Peptide-Arg75+Asn-Peptide	N	CS	Thr	Gly	Thr	Arg	Asn	Ala	Leu	Arg	Zalila et al., 2011
Metacaspase	B6DU79	1-425	Peptide-Arg79+Gly-Peptide	N	CS	Asn	Ala	Leu	Arg	Gly	Cys	Val	Asn	Zalila et al., 2011
Metacaspase	B6DU79	1-425	Peptide-Arg86+Ser-Peptide	N	CS	Asn	Asp	Val	Arg	Ser	Met	Leu	Gly	Zalila et al., 2011
Metacaspase	B6DU79	1-425	Peptide-Arg298+Thr-Peptide	N	CS	Lys	Lys	Gly	Arg	Thr	Gln	Ile	Pro	Zalila et al., 2011
Metacaspase	B6DU83	1-448	Peptide-Arg135+Pro-Peptide	N	CS	Gly	Asn	Leu	Arg	Pro	Gly	Asp	Val	Zalila et al., 2011
Metacaspase	B6DU82	1-435	Peptide-Arg135+Pro-Peptide	N	CS	Ser	Asn	Leu	Arg	Pro	Gly	Asp	Val	Zalila et al., 2011
Metacaspase	B6DU80	1-440	Peptide-Arg135+Pro-Peptide	N	CS	Gly	Asp	Val	Arg	Pro	Gly	Asp	Val	Zalila et al., 2011
Putative metacaspase	E9AEY0	1-435	Peptide-Arg63+Ala-Peptide	N	CS	Gly	Arg	Val	Arg	Ala	Leu	Phe	Ile	Zalila et al., 2011
Putative metacaspase	E9AEY0	1-435	Peptide-Arg298+Val-Peptide	N	CS	Lys	Lys	Gly	Arg	Val	Gln	Val	Pro	Zalila et al., 2011
Putative metacaspase	E9AEY0	1-435	Peptide-Arg75+Asn-Peptide	N	CS	Thr	Gly	Met	Arg	Asn	Ala	Leu	Arg	Zalila et al., 2011
Putative metacaspase	E9AEY0	1-435	Peptide-Arg79+Gly-Peptide	N	CS	Asn	Ala	Leu	Arg	Gly	Cys	Val	Asn	Zalila et al., 2011
Putative metacaspase	E9AEY0	1-435	Peptide-Arg135+Pro-Peptide	N	CS	Gly	Asp	Val	Arg	Pro	Gly	Asp	Val	Zalila et al., 2011
Z-Gly-Gly-Arg-NHMec			Z-Gly-Gly-Arg+NHMec	S		Z	Gly	Gly	Arg	AMC	-	-	-	El-Fadili et al., 2010
Z-Val-Arg-Pro-Arg-NHMec			Z-Val-Arg-Pro-Arg+NHMec	S		Val	Arg	Pro	Arg	AMC	-	-	-	Meslin et al., 2011