Substrates for peptidase C14.035: metacaspase Yca1 (Saccharomyces cerevisiae-type)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Cleavage Site	Cleavage type	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
Bz-Arg-NHPhNO2	Bz-Arg+NHPhNO2	S	-	-	Bz	Arg	NAN	-	-	-	Ojha et al., 2010
Bz-Phe-Val-Arg-NHPhNO2	Bz-Phe-Val-Arg+NHPhNO2	S	Bz	Phe	Val	Arg	NAN	-	-	-	Ojha et al., 2010
Tos-Gly-Pro-Arg-NHPhNO2	Tos-Gly-Pro-Arg+NHPhNO2	S	Tos	Gly	Pro	Arg	NAN	-	-	-	Ojha et al., 2010
Tos-Gly-Pro-Lys-NHPhNO2	Tos-Gly-Pro-Lys+NHPhNO2	S	Tos	Gly	Pro	Lys	NAN	-	-	-	Ojha et al., 2010
Z-Ala-Arg-Arg-NHNap	Z-Ala-Arg-Arg+NHNap	S	Z	Ala	Arg	Arg	NAP	-	-	-	Watanabe & Lam, 2005
Z-Arg-Arg-NHNap	Z-Arg-Arg+NHNap	S	-	Z	Arg	Arg	NAP	-	-	-	Watanabe & Lam, 2005
Z-Arg-NHNap	Z-Arg+NHNap	S	-	-	Z	Arg	NAP	-	-	-	Watanabe & Lam, 2005
Z-Gly-Arg-Arg-NHNap	Z-Gly-Arg-Arg+NHNap	S	Z	Gly	Arg	Arg	NAP	-	-	-	Watanabe & Lam, 2005
Z-Gly-Gly-Arg-NHNap	Z-Gly-Gly-Arg+NHNap	S	Z	Gly	Gly	Arg	NAP	-	-	-	Watanabe & Lam, 2005
Z-Val-Leu-Lys-NHNap	Z-Val-Leu-Lys+NHNap	S	Z	Val	Leu	Lys	NAP	-	-	-	Watanabe & Lam, 2005
Z-Val-Lys-Lys-Arg-NHNap	Z-Val-Lys-Lys-Arg+NHNap	S	Val	Lys	Lys	Arg	NAP	-	-	-	Watanabe & Lam, 2005