Substrates for peptidase C14.008: caspase-5

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
Ac-Trp-Glu-His-Asp-NHMec			Ac-Trp-Glu-His-Asp+NHMec	S		Trp	Glu	His	Asp	AMC	-	-	-	Garcia-Calvo et al., 1999
gasdermin-D	P57764	1-484	peptide-Asp275+Gly-peptide	P	MU	Phe	Leu	Thr	Asp	Gly	Val	Pro	Ala	Shi et al., 2015
Leu-Glu-His-Asp-NHMec			Leu-Glu-His-Asp+NHMec	S		Leu	Glu	His	Asp	AMC	-	-	-	Harvey et al., 2001
protein max	P61244	1-160	peptide-Glu10+Ser-peptide	P		Ile	Glu	Val	Glu	Ser	Asp	Glu	Glu	Krippner-Heidenreich et al., 2001	4008