Substrates for peptidase C14.002: CED-3 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
14-3-3-like protein 2	Q20655	1-248	peptide-Asp240+Ala-peptide	P		Asp	Asp	Thr	Asp	Ala	Asn	Glu	Thr	Taylor et al., 2007	26027
Ac-Asp-Glu-Val-Asp-AFC			Ac-Asp-Glu-Val-Asp+AFC	S		Asp	Glu	Val	Asp	AFC	-	-	-	Shaham, 1998
Caspase-related protein 2B	Q9TZP5	1-263	Peptide-Asp8+Gly-Peptide	P	NT	Asp	Ala	Ser	Asp	Gly	Lys	Lys	Ile	Shaham, 1998
CED-3 peptidase	P42573	1-503	peptide-Asp221+Ala-peptide	P		Asn	Phe	Val	Asp	Ala	Pro	Thr	Ile	Taylor et al., 2007	26030
CED-3 peptidase	P42573	1-503	peptide-Asp374+Gly-peptide	P		Asp	Ser	Val	Asp	Gly	Val	Pro	Ala	Taylor et al., 2007	26031
CED-3 peptidase	P42573	1-503	peptide-Asp388+Gly-peptide	P		Asp	Asn	Arg	Asp	Gly	Pro	Leu	Phe	Taylor et al., 2007	26032
crt-1 CalReTiculin family member (crt-1)	P27798	16-395	peptide-Asp182+Gly-peptide	P		Val	Lys	Ile	Asp	Gly	Glu	Ser	Ala	Taylor et al., 2007	26024
crt-1 CalReTiculin family member (crt-1)	P27798	16-395	peptide-Asp225+Ala-peptide	P		Asp	Ala	Glu	Asp	Ala	Lys	Pro	Glu	Taylor et al., 2007	26025
crt-1 CalReTiculin family member (crt-1)	P27798	16-395	peptide-Asp253+Gly-peptide	P		Asp	Glu	Met	Asp	Gly	Glu	Trp	Glu	Taylor et al., 2007	26026
Endoribonuclease dcr-1	P34529	1-1910	peptide-Asp1537+Gly-peptide	P		Ser	Thr	Thr	Asp	Gly	Ile	Glu	Thr	Nakagawa et al., 2010
sex-determining protein fem-1	P17221	1-656	peptide-Asp320+Gly-peptide	P		Glu	Leu	Leu	Asp	Gly	Asn	Ile	Glu	Chan et al., 2000	19264
tbb-2 tubulin, beta family member (tbb-2)	P52275	1-450	peptide-Asp404+Glu-peptide	P		Glu	Gly	Met	Asp	Glu	Met	Glu	Phe	Taylor et al., 2007	26021
tbb-2 tubulin, beta family member (tbb-2)	P52275	1-450	peptide-Asp417+Leu-peptide	P		Asn	Met	Asn	Asp	Leu	Ile	Ser	Glu	Taylor et al., 2007	26022
tbb-2 tubulin, beta family member (tbb-2)	P52275	1-450	peptide-Asp435+Gly-peptide	P		Asp	Asp	Val	Asp	Gly	Tyr	Ala	Glu	Taylor et al., 2007	26023