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Literature for peptidase C14.002: CED-3 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: P Specificity, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Gopakumar,G., Aman,A., Rolland,S., Gartner,A. and Memar,N.
    Endogenous Expression and Subcellular Localization of Core Apoptosis Regulators Reveal Key Differences Between Embryonic and Germline Apoptosis in C. elegans
    Res Sq (2026) PubMed  Europe PubMed DOI  PMC  EPMC
  2. Shen,Y., Young,N.D., Song,J., Sleebs,B.E., Chang,B.C.H., Lee,E.F., Fairlie,W.D. and Gasser,R.B.
    Genome-wide reconstruction of the intrinsic apoptosis pathway in Haemonchus contortus
    BMC Genomics (2026) PubMed  Europe PubMed DOI
    3. 2023
  3. Li,Y., Tian,L., Zhang,Y. and Shi,Y.
    Structural insights into CED-3 activation
    Life Sci Alliance (2023) 6 PubMed  Europe PubMed DOI  PMC  EPMC
    4. 2020
  4. Yarychkivska,O. and Shaham,S.
    Development or disease: caspases balance growth and immunity in C. elegans
    Dev Cell (2020) 53, 259-260. PubMed  Europe PubMed DOI
    5. 2018
  5. Mishra,N., Wei,H. and Conradt,B.
    Caenorhabditis elegans ced-3 caspase is required for asymmetric divisions that generate cells programmed to die
    Genetics (2018) 210, 983-998. PubMed  Europe PubMed DOI
    6. 2017
  6. Brantley,S.J., Cotten,S.W., Lamson,D.R., Smith,G.R., Liu,R. and Williams,K.P.
    Discovery of small molecule inhibitors for the C. elegans caspase CED-3 by high-throughput screening
    Biochem Biophys Res Commun (2017) 491, 773-779. PubMed  Europe PubMed DOI  I
    7. 2016
  7. Chen,X., Wang,Y., Chen,Y.Z., Harry,B.L., Nakagawa,A., Lee,E.S., Guo,H. and Xue,D.
    Regulation of CED-3 caspase localization and activation by C. elegans nuclear-membrane protein NPP-14
    Nat Struct Mol Biol (2016) 23, 958-964. PubMed  Europe PubMed DOI
  8. Conradt,B., Wu,Y.C. and Xue,D.
    Programmed cell death during Caenorhabditis elegans development
    Genetics (2016) 203, 1533-1562. PubMed  Europe PubMed DOI  PMC  EPMC
    9. 2015
  9. Meng,L., Mulcahy,B., Cook,S.J., Neubauer,M., Wan,A., Jin,Y. and Yan,D.
    The cell death pathway regulates synapse elimination through cleavage of gelsolin in Caenorhabditis elegans neurons
    Cell Rep (2015) 11, 1737-1748. PubMed  Europe PubMed DOI
    10. 2014
  10. Aguirre-Chen,C. and Hammell,C.M.
    Cell death machinery makes life more robust
    elife (2014) 3, e05816-e05816. PubMed  Europe PubMed DOI
  11. Ge,X., Zhao,X., Nakagawa,A., Gong,X., Skeen-Gaar,R.R., Shi,Y., Gong,H., Wang,X. and Xue,D.
    A novel mechanism underlies caspase-dependent conversion of the dicer ribonuclease into a deoxyribonuclease during apoptosis
    Cell Res (2014) 24, 218-232. PubMed  Europe PubMed DOI
  12. Lee,E.S. and Xue,D.
    Caspase protocols in Caenorhabditis elegans
    Methods Mol Biol (2014) 1133, 101-108. PubMed  Europe PubMed DOI
  13. Nakagawa,A., Sullivan,K.D. and Xue,D.
    Caspase-activated phosphoinositide binding by CNT-1 promotes apoptosis by inhibiting the AKT pathway
    Nat Struct Mol Biol (2014) 21, 1082-1090. PubMed  Europe PubMed DOI
  14. Weaver,B.P., Zabinsky,R., Weaver,Y.M., Lee,E.S., Xue,D. and Han,M.
    CED-3 caspase acts with miRNAs to regulate non-apoptotic gene expression dynamics for robust development in C. elegans
    elife (2014) 3, e04265-e04265. PubMed  Europe PubMed DOI
    15. 2013
  15. Huang,W., Jiang,T., Choi,W., Qi,S., Pang,Y., Hu,Q., Xu,Y., Gong,X., Jeffrey,P.D., Wang,J. and Shi,Y.
    Mechanistic insights into CED-4-mediated activation of CED-3
    Genes Dev (2013) 27, 2039-2048. PubMed  Europe PubMed DOI
    16. 2012
  16. Pinan-Lucarre,B., Gabel,C.V., Reina,C.P., Hulme,S.E., Shevkoplyas,S.S., Slone,R.D., Xue,J., Qiao,Y., Weisberg,S., Roodhouse,K., Sun,L., Whitesides,G.M., Samuel,A. and Driscoll,M.
    The core apoptotic executioner proteins CED-3 and CED-4 promote initiation of neuronal regeneration in Caenorhabditis elegans
    PLoS Biol (2012) 10, e1001331-e1001331. PubMed  Europe PubMed DOI  PMC  EPMC
    17. 2010
  17. Nakagawa,A., Shi,Y., Kage-Nakadai,E., Mitani,S. and Xue,D.
    Caspase-dependent conversion of dicer ribonuclease into a death-promoting deoxyribonuclease
    Science (2010) 328, 327-334. PubMed  Europe PubMed DOI  P
  18. Qi,S., Pang,Y., Hu,Q., Liu,Q., Li,H., Zhou,Y., He,T., Liang,Q., Liu,Y., Yuan,X., Luo,G., Li,H., Wang,J., Yan,N. and Shi,Y.
    Crystal structure of the Caenorhabditis elegans apoptosome reveals an octameric assembly of CED-4
    Cell (2010) 141, 446-457. PubMed  Europe PubMed DOI
    19. 2008
  19. Geng,X., Shi,Y., Nakagawa,A., Yoshina,S., Mitani,S., Shi,Y. and Xue,D.
    Inhibition of CED-3 zymogen activation and apoptosis in Caenorhabditis elegans by caspase homolog CSP-3
    Nat Struct Mol Biol (2008) 15, 1094-1101. PubMed  Europe PubMed DOI  PMC  EPMC
    20. 2007
  20. Maurer,C.W., Chiorazzi,M. and Shaham,S.
    Timing of the onset of a developmental cell death is controlled by transcriptional induction of the C. elegans ced-3 caspase-encoding gene
    Development (2007) 134, 1357-1368. PubMed  Europe PubMed DOI
  21. Taylor,R.C., Brumatti,G., Ito,S., Hengartner,M.O., Derry,W.B. and Martin,S.J.
    Establishing a blueprint for CED-3-dependent killing through identification of multiple substrates for this protease
    J Biol Chem (2007) 282, 15011-15021. PubMed  Europe PubMed DOI
    22. 2005
  22. Conradt,B. and Xue,D.
    Programmed cell death
    WormBook (2005) 2005, 1-13. PubMed  Europe PubMed DOI  V
  23. [YEAR:6-10-2005]Yan,N., Chai,J., Lee,E.S., Gu,L., Liu,Q., He,J., Wu,J.W., Kokel,D., Li,H., Hao,Q., Xue,D. and Shi,Y.
    Structure of the CED-4-CED-9 complex provides insights into programmed cell death in Caenorhabditis elegans
    Nature (6-10-2005) 437, 831-837. PubMed  Europe PubMed DOI
    24. 2001
  24. [YEAR:16-2-2001]Azim,M.K., Grossmann,J.G. and Zaidi,Z.H.
    Homology modeling of nematode Caenorhabditis elegans CED3 protein-inhibitor complex
    Biochem Biophys Res Commun (16-2-2001) 281, 115-121. PubMed  Europe PubMed DOI  I
    25. 2000
  25. [YEAR:16-6-2000]Chan,S.L., Yee,K.S., Tan,K.M. and Yu,V.C.
    The Caenorhabditis elegans sex determination protein FEM-1 is a CED-3 substrate that associates with CED-4 and mediates apoptosis in mammalian cells
    J Biol Chem (16-6-2000) 275, 17925-17928. PubMed  Europe PubMed DOI
    26. 1998
  26. [YEAR:25-12-1998]Shaham,S.
    Identification of multiple Caenorhabditis elegans caspases and their potential roles in proteolytic cascades
    J Biol Chem (25-12-1998) 273, 35109-35117. PubMed  Europe PubMed DOI
    27. 1997
  27. Chinnaiyan,A.M., Chaudhary,D., O'Rourke,K., Koonin,E.V. and Dixit,V.M.
    Role of CED-4 in the activation of CED-3
    Nature (1997) 388, 728-729. PubMed  Europe PubMed DOI
  28. Irmler,M., Hofmann,K., Vaux,D. and Tschopp,J.
    Direct physical interaction between the Caenorhabditis elegans 'death proteins' CED-3 and CED-4
    FEBS Lett (1997) 406, 189-190. PubMed  Europe PubMed DOI
  29. Seshagiri,S. and Miller,L.K.
    Caenorhabditis elegans CED-4 stimulates CED-3 processing and CED-3-induced apoptosis
    Curr Biol (1997) 7, 455-460. PubMed  Europe PubMed
  30. [YEAR:18-7-1997]Thornberry,N.A., Rano,T.A., Peterson,E.P., Rasper,D.M., Timkey,T., Garcia-Calvo,M., Houtzager,V.M., Nordstrom,P.A., Roy,S., Vaillancourt,J.P., Chapman,K.T. and Nicholson,D.W.
    A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis
    J Biol Chem (18-7-1997) 272, 17907-17911. PubMed  Europe PubMed DOI  P
    31. 1996
  31. Hugunin,M., Quintal,L.J., Mankovich,J.A. and Ghayur,T.
    Protease activity of in vitro transcribed and translated Caenorhabditis elegans cell death gene (ced-3) product
    J Biol Chem (1996) 271, 3517-3522. PubMed  Europe PubMed DOI  I
    32. 1993
  32. [YEAR:19-11-1993]Yuan,J., Shaham,S., Ledoux,S., Ellis,H.M. and Horvitz,H.R.
    The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme
    Cell (19-11-1993) 75, 641-652. PubMed  Europe PubMed DOI

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