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Literature for peptidase C14.002: CED-3 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: P Specificity, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Gopakumar,G., Aman,A., Rolland,S., Gartner,A. and Memar,N.<br>Endogenous Expression and Subcellular Localization of Core Apoptosis Regulators Reveal Key Differences Between Embryonic and Germline Apoptosis in C. elegans<br>Res Sq (2026) PubMed  Europe PubMed DOI  PMC  EPMC
  2. Shen,Y., Young,N.D., Song,J., Sleebs,B.E., Chang,B.C.H., Lee,E.F., Fairlie,W.D. and Gasser,R.B.<br>Genome-wide reconstruction of the intrinsic apoptosis pathway in Haemonchus contortus<br>BMC Genomics (2026) PubMed  Europe PubMed DOI
    3. 2023
  3. Li,Y., Tian,L., Zhang,Y. and Shi,Y.<br>Structural insights into CED-3 activation<br>Life Sci Alliance (2023) 6 PubMed  Europe PubMed DOI  PMC  EPMC
    4. 2020
  4. Yarychkivska,O. and Shaham,S.<br>Development or disease: caspases balance growth and immunity in C. elegans<br>Dev Cell (2020) 53, 259-260. PubMed  Europe PubMed DOI
    5. 2018
  5. Mishra,N., Wei,H. and Conradt,B.<br>Caenorhabditis elegans ced-3 caspase is required for asymmetric divisions that generate cells programmed to die<br>Genetics (2018) 210, 983-998. PubMed  Europe PubMed DOI
    6. 2017
  6. Brantley,S.J., Cotten,S.W., Lamson,D.R., Smith,G.R., Liu,R. and Williams,K.P.<br>Discovery of small molecule inhibitors for the C. elegans caspase CED-3 by high-throughput screening<br>Biochem Biophys Res Commun (2017) 491, 773-779. PubMed  Europe PubMed DOI  I
    7. 2016
  7. Chen,X., Wang,Y., Chen,Y.Z., Harry,B.L., Nakagawa,A., Lee,E.S., Guo,H. and Xue,D.<br>Regulation of CED-3 caspase localization and activation by C. elegans nuclear-membrane protein NPP-14<br>Nat Struct Mol Biol (2016) 23, 958-964. PubMed  Europe PubMed DOI
  8. Conradt,B., Wu,Y.C. and Xue,D.<br>Programmed cell death during Caenorhabditis elegans development<br>Genetics (2016) 203, 1533-1562. PubMed  Europe PubMed DOI  PMC  EPMC
    9. 2015
  9. Meng,L., Mulcahy,B., Cook,S.J., Neubauer,M., Wan,A., Jin,Y. and Yan,D.<br>The cell death pathway regulates synapse elimination through cleavage of gelsolin in Caenorhabditis elegans neurons<br>Cell Rep (2015) 11, 1737-1748. PubMed  Europe PubMed DOI
    10. 2014
  10. Aguirre-Chen,C. and Hammell,C.M.<br>Cell death machinery makes life more robust<br>elife (2014) 3, e05816-e05816. PubMed  Europe PubMed DOI
  11. Ge,X., Zhao,X., Nakagawa,A., Gong,X., Skeen-Gaar,R.R., Shi,Y., Gong,H., Wang,X. and Xue,D.<br>A novel mechanism underlies caspase-dependent conversion of the dicer ribonuclease into a deoxyribonuclease during apoptosis<br>Cell Res (2014) 24, 218-232. PubMed  Europe PubMed DOI
  12. Lee,E.S. and Xue,D.<br>Caspase protocols in Caenorhabditis elegans<br>Methods Mol Biol (2014) 1133, 101-108. PubMed  Europe PubMed DOI
  13. Nakagawa,A., Sullivan,K.D. and Xue,D.<br>Caspase-activated phosphoinositide binding by CNT-1 promotes apoptosis by inhibiting the AKT pathway<br>Nat Struct Mol Biol (2014) 21, 1082-1090. PubMed  Europe PubMed DOI
  14. Weaver,B.P., Zabinsky,R., Weaver,Y.M., Lee,E.S., Xue,D. and Han,M.<br>CED-3 caspase acts with miRNAs to regulate non-apoptotic gene expression dynamics for robust development in C. elegans<br>elife (2014) 3, e04265-e04265. PubMed  Europe PubMed DOI
    15. 2013
  15. Huang,W., Jiang,T., Choi,W., Qi,S., Pang,Y., Hu,Q., Xu,Y., Gong,X., Jeffrey,P.D., Wang,J. and Shi,Y.<br>Mechanistic insights into CED-4-mediated activation of CED-3<br>Genes Dev (2013) 27, 2039-2048. PubMed  Europe PubMed DOI
    16. 2012
  16. Pinan-Lucarre,B., Gabel,C.V., Reina,C.P., Hulme,S.E., Shevkoplyas,S.S., Slone,R.D., Xue,J., Qiao,Y., Weisberg,S., Roodhouse,K., Sun,L., Whitesides,G.M., Samuel,A. and Driscoll,M.<br>The core apoptotic executioner proteins CED-3 and CED-4 promote initiation of neuronal regeneration in Caenorhabditis elegans<br>PLoS Biol (2012) 10, e1001331-e1001331. PubMed  Europe PubMed DOI  PMC  EPMC
    17. 2010
  17. Nakagawa,A., Shi,Y., Kage-Nakadai,E., Mitani,S. and Xue,D.<br>Caspase-dependent conversion of dicer ribonuclease into a death-promoting deoxyribonuclease<br>Science (2010) 328, 327-334. PubMed  Europe PubMed DOI  P
  18. Qi,S., Pang,Y., Hu,Q., Liu,Q., Li,H., Zhou,Y., He,T., Liang,Q., Liu,Y., Yuan,X., Luo,G., Li,H., Wang,J., Yan,N. and Shi,Y.<br>Crystal structure of the Caenorhabditis elegans apoptosome reveals an octameric assembly of CED-4<br>Cell (2010) 141, 446-457. PubMed  Europe PubMed DOI
    19. 2008
  19. Geng,X., Shi,Y., Nakagawa,A., Yoshina,S., Mitani,S., Shi,Y. and Xue,D.<br>Inhibition of CED-3 zymogen activation and apoptosis in Caenorhabditis elegans by caspase homolog CSP-3<br>Nat Struct Mol Biol (2008) 15, 1094-1101. PubMed  Europe PubMed DOI  PMC  EPMC
    20. 2007
  20. Maurer,C.W., Chiorazzi,M. and Shaham,S.<br>Timing of the onset of a developmental cell death is controlled by transcriptional induction of the C. elegans ced-3 caspase-encoding gene<br>Development (2007) 134, 1357-1368. PubMed  Europe PubMed DOI
  21. Taylor,R.C., Brumatti,G., Ito,S., Hengartner,M.O., Derry,W.B. and Martin,S.J.<br>Establishing a blueprint for CED-3-dependent killing through identification of multiple substrates for this protease<br>J Biol Chem (2007) 282, 15011-15021. PubMed  Europe PubMed DOI
    22. 2005
  22. Conradt,B. and Xue,D.<br>Programmed cell death<br>WormBook (2005) 2005, 1-13. PubMed  Europe PubMed DOI  V
  23. [YEAR:6-10-2005]Yan,N., Chai,J., Lee,E.S., Gu,L., Liu,Q., He,J., Wu,J.W., Kokel,D., Li,H., Hao,Q., Xue,D. and Shi,Y.<br>Structure of the CED-4-CED-9 complex provides insights into programmed cell death in Caenorhabditis elegans<br>Nature (6-10-2005) 437, 831-837. PubMed  Europe PubMed DOI
    24. 2001
  24. [YEAR:16-2-2001]Azim,M.K., Grossmann,J.G. and Zaidi,Z.H.<br>Homology modeling of nematode Caenorhabditis elegans CED3 protein-inhibitor complex<br>Biochem Biophys Res Commun (16-2-2001) 281, 115-121. PubMed  Europe PubMed DOI  I
    25. 2000
  25. [YEAR:16-6-2000]Chan,S.L., Yee,K.S., Tan,K.M. and Yu,V.C.<br>The Caenorhabditis elegans sex determination protein FEM-1 is a CED-3 substrate that associates with CED-4 and mediates apoptosis in mammalian cells<br>J Biol Chem (16-6-2000) 275, 17925-17928. PubMed  Europe PubMed DOI
    26. 1998
  26. [YEAR:25-12-1998]Shaham,S.<br>Identification of multiple Caenorhabditis elegans caspases and their potential roles in proteolytic cascades<br>J Biol Chem (25-12-1998) 273, 35109-35117. PubMed  Europe PubMed DOI
    27. 1997
  27. Chinnaiyan,A.M., Chaudhary,D., O'Rourke,K., Koonin,E.V. and Dixit,V.M.<br>Role of CED-4 in the activation of CED-3<br>Nature (1997) 388, 728-729. PubMed  Europe PubMed DOI
  28. Irmler,M., Hofmann,K., Vaux,D. and Tschopp,J.<br>Direct physical interaction between the Caenorhabditis elegans 'death proteins' CED-3 and CED-4<br>FEBS Lett (1997) 406, 189-190. PubMed  Europe PubMed DOI
  29. Seshagiri,S. and Miller,L.K.<br>Caenorhabditis elegans CED-4 stimulates CED-3 processing and CED-3-induced apoptosis<br>Curr Biol (1997) 7, 455-460. PubMed  Europe PubMed
  30. [YEAR:18-7-1997]Thornberry,N.A., Rano,T.A., Peterson,E.P., Rasper,D.M., Timkey,T., Garcia-Calvo,M., Houtzager,V.M., Nordstrom,P.A., Roy,S., Vaillancourt,J.P., Chapman,K.T. and Nicholson,D.W.<br>A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis<br>J Biol Chem (18-7-1997) 272, 17907-17911. PubMed  Europe PubMed DOI  P
    31. 1996
  31. Hugunin,M., Quintal,L.J., Mankovich,J.A. and Ghayur,T.<br>Protease activity of in vitro transcribed and translated Caenorhabditis elegans cell death gene (ced-3) product<br>J Biol Chem (1996) 271, 3517-3522. PubMed  Europe PubMed DOI  I
    32. 1993
  32. [YEAR:19-11-1993]Yuan,J., Shaham,S., Ledoux,S., Ellis,H.M. and Horvitz,H.R.<br>The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme<br>Cell (19-11-1993) 75, 641-652. PubMed  Europe PubMed DOI

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