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Literature for peptidase C14.002: CED-3 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: P Specificity, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2023
  1. Li,Y., Tian,L., Zhang,Y. and Shi,Y.
    Structural insights into CED-3 activation
    Life Sci Alliance6, PubMed  Europe PubMed DOI
    2. 2020
  2. Yarychkivska,O. and Shaham,S.
    Development or disease: caspases balance growth and immunity in C. elegans
    Dev Cell53, 259-260. PubMed  Europe PubMed DOI
    3. 2018
  3. Mishra,N., Wei,H. and Conradt,B.
    Caenorhabditis elegans ced-3 caspase is required for asymmetric divisions that generate cells programmed to die
    Genetics210, 983-998. PubMed  Europe PubMed DOI
    4. 2017
  4. Brantley,S.J., Cotten,S.W., Lamson,D.R., Smith,G.R., Liu,R. and Williams,K.P.
    Discovery of small molecule inhibitors for the C. elegans caspase CED-3 by high-throughput screening
    Biochem Biophys Res Commun491, 773-779. PubMed  Europe PubMed DOI  I
    5. 2016
  5. Chen,X., Wang,Y., Chen,Y.Z., Harry,B.L., Nakagawa,A., Lee,E.S., Guo,H. and Xue,D.
    Regulation of CED-3 caspase localization and activation by C. elegans nuclear-membrane protein NPP-14
    Nat Struct Mol Biol23, 958-964. PubMed  Europe PubMed DOI
  6. Conradt,B., Wu,Y.C. and Xue,D.
    Programmed cell death during Caenorhabditis elegans development
    Genetics203, 1533-1562. PubMed  Europe PubMed DOI
    7. 2015
  7. Meng,L., Mulcahy,B., Cook,S.J., Neubauer,M., Wan,A., Jin,Y. and Yan,D.
    The cell death pathway regulates synapse elimination through cleavage of gelsolin in Caenorhabditis elegans neurons
    Cell Rep11, 1737-1748. PubMed  Europe PubMed DOI
    8. 2014
  8. Aguirre-Chen,C. and Hammell,C.M.
    Cell death machinery makes life more robust
    elife3, e05816-e05816. PubMed  Europe PubMed DOI
  9. Ge,X., Zhao,X., Nakagawa,A., Gong,X., Skeen-Gaar,R.R., Shi,Y., Gong,H., Wang,X. and Xue,D.
    A novel mechanism underlies caspase-dependent conversion of the dicer ribonuclease into a deoxyribonuclease during apoptosis
    Cell Res24, 218-232. PubMed  Europe PubMed DOI
  10. Lee,E.S. and Xue,D.
    Caspase protocols in Caenorhabditis elegans
    Methods Mol Biol1133, 101-108. PubMed  Europe PubMed DOI
  11. Nakagawa,A., Sullivan,K.D. and Xue,D.
    Caspase-activated phosphoinositide binding by CNT-1 promotes apoptosis by inhibiting the AKT pathway
    Nat Struct Mol Biol21, 1082-1090. PubMed  Europe PubMed DOI
  12. Weaver,B.P., Zabinsky,R., Weaver,Y.M., Lee,E.S., Xue,D. and Han,M.
    CED-3 caspase acts with miRNAs to regulate non-apoptotic gene expression dynamics for robust development in C. elegans
    elife3, e04265-e04265. PubMed  Europe PubMed DOI
    13. 2013
  13. Huang,W., Jiang,T., Choi,W., Qi,S., Pang,Y., Hu,Q., Xu,Y., Gong,X., Jeffrey,P.D., Wang,J. and Shi,Y.
    Mechanistic insights into CED-4-mediated activation of CED-3
    Genes Dev27, 2039-2048. PubMed  Europe PubMed DOI
    14. 2012
  14. Pinan-Lucarre,B., Gabel,C.V., Reina,C.P., Hulme,S.E., Shevkoplyas,S.S., Slone,R.D., Xue,J., Qiao,Y., Weisberg,S., Roodhouse,K., Sun,L., Whitesides,G.M., Samuel,A. and Driscoll,M.
    The core apoptotic executioner proteins CED-3 and CED-4 promote initiation of neuronal regeneration in Caenorhabditis elegans
    PLoS Biol10, e1001331-e1001331. PubMed  Europe PubMed DOI
    15. 2010
  15. Nakagawa,A., Shi,Y., Kage-Nakadai,E., Mitani,S. and Xue,D.
    Caspase-dependent conversion of dicer ribonuclease into a death-promoting deoxyribonuclease
    Science328, 327-334. PubMed  Europe PubMed DOI  P
  16. Qi,S., Pang,Y., Hu,Q., Liu,Q., Li,H., Zhou,Y., He,T., Liang,Q., Liu,Y., Yuan,X., Luo,G., Li,H., Wang,J., Yan,N. and Shi,Y.
    Crystal structure of the Caenorhabditis elegans apoptosome reveals an octameric assembly of CED-4
    Cell141, 446-457. PubMed  Europe PubMed DOI
    17. 2008
  17. Geng,X., Shi,Y., Nakagawa,A., Yoshina,S., Mitani,S., Shi,Y. and Xue,D.
    Inhibition of CED-3 zymogen activation and apoptosis in Caenorhabditis elegans by caspase homolog CSP-3
    Nat Struct Mol Biol15, 1094-1101. PubMed  Europe PubMed DOI
    18. 2007
  18. Maurer,C.W., Chiorazzi,M. and Shaham,S.
    Timing of the onset of a developmental cell death is controlled by transcriptional induction of the C. elegans ced-3 caspase-encoding gene
    Development134, 1357-1368. PubMed  Europe PubMed DOI
  19. Taylor,R.C., Brumatti,G., Ito,S., Hengartner,M.O., Derry,W.B. and Martin,S.J.
    Establishing a blueprint for CED-3-dependent killing through identification of multiple substrates for this protease
    J Biol Chem282, 15011-15021. PubMed  Europe PubMed DOI
    20. 2005
  20. Conradt,B. and Xue,D.
    Programmed cell death
    WormBook2005, 1-13. PubMed  Europe PubMed DOI  V
  21. [YEAR:6-10-2005]Yan,N., Chai,J., Lee,E.S., Gu,L., Liu,Q., He,J., Wu,J.W., Kokel,D., Li,H., Hao,Q., Xue,D. and Shi,Y.
    Structure of the CED-4-CED-9 complex provides insights into programmed cell death in Caenorhabditis elegans
    Nature437, 831-837. PubMed  Europe PubMed DOI
    22. 2001
  22. [YEAR:16-2-2001]Azim,M.K., Grossmann,J.G. and Zaidi,Z.H.
    Homology modeling of nematode Caenorhabditis elegans CED3 protein-inhibitor complex
    Biochem Biophys Res Commun281, 115-121. PubMed  Europe PubMed DOI  I
    23. 2000
  23. [YEAR:16-6-2000]Chan,S.L., Yee,K.S., Tan,K.M. and Yu,V.C.
    The Caenorhabditis elegans sex determination protein FEM-1 is a CED-3 substrate that associates with CED-4 and mediates apoptosis in mammalian cells
    J Biol Chem275, 17925-17928. PubMed  Europe PubMed DOI
    24. 1998
  24. [YEAR:25-12-1998]Shaham,S.
    Identification of multiple Caenorhabditis elegans caspases and their potential roles in proteolytic cascades
    J Biol Chem273, 35109-35117. PubMed  Europe PubMed DOI
    25. 1997
  25. Chinnaiyan,A.M., Chaudhary,D., O'Rourke,K., Koonin,E.V. and Dixit,V.M.
    Role of CED-4 in the activation of CED-3
    Nature388, 728-729. PubMed  Europe PubMed DOI
  26. Irmler,M., Hofmann,K., Vaux,D. and Tschopp,J.
    Direct physical interaction between the Caenorhabditis elegans 'death proteins' CED-3 and CED-4
    FEBS Lett406, 189-190. PubMed  Europe PubMed DOI
  27. Seshagiri,S. and Miller,L.K.
    Caenorhabditis elegans CED-4 stimulates CED-3 processing and CED-3-induced apoptosis
    Curr Biol7, 455-460. PubMed  Europe PubMed
  28. [YEAR:18-7-1997]Thornberry,N.A., Rano,T.A., Peterson,E.P., Rasper,D.M., Timkey,T., Garcia-Calvo,M., Houtzager,V.M., Nordstrom,P.A., Roy,S., Vaillancourt,J.P., Chapman,K.T. and Nicholson,D.W.
    A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis
    J Biol Chem272, 17907-17911. PubMed  Europe PubMed DOI  P
    29. 1996
  29. Hugunin,M., Quintal,L.J., Mankovich,J.A. and Ghayur,T.
    Protease activity of in vitro transcribed and translated Caenorhabditis elegans cell death gene (ced-3) product
    J Biol Chem271, 3517-3522. PubMed  Europe PubMed DOI  I
    30. 1993
  30. [YEAR:19-11-1993]Yuan,J., Shaham,S., Ledoux,S., Ellis,H.M. and Horvitz,H.R.
    The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme
    Cell75, 641-652. PubMed  Europe PubMed DOI

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