Substrates for peptidase C13.009: butelase 1

Summary Alignment Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
asparaginyl endopeptidase	A0A0P0QM28	1-497	peptide-Asp57+Glu-peptide	P	CS	Ala	Asp	Thr	Asp	Glu	Val	Gly	Thr	Serra et al., 2016
asparaginyl endopeptidase	A0A0P0QM28	1-497	peptide-Asn394+His-peptide	P	CS	Lys	His	Arg	Asn	His	Leu	Asp	Gly	Serra et al., 2016
cyclotide cliotide T1	G1CWH0	1-94	peptide-Asn29+His-peptide	P	MS	Cys	Tyr	Arg	Asn	His	Val	Ile	Ala	Serra et al., 2016
cyclotide cliotide T12	G1CWH8	1-123	peptide-Asp58+His-peptide	P	MS	Cys	Tyr	Arg	Asp	His	Val	Ile	Ala	Serra et al., 2016
cyclotide cliotide T17			peptide-Asn26+Lys-peptide	P		Ser	Cys	Lys	Asn	Lys	Val	Cys	Tyr	Serra et al., 2016
cyclotide cliotide T2	G1CWH1	1-132	peptide-Asn58+His-peptide	P	MS	Cys	Lys	Lys	Asn	His	Ile	Ile	Ala	Serra et al., 2016
cyclotide cliotide T3	G1CWH2	1-127	peptide-Asn53+His-peptide	P	MS	Cys	Met	Lys	Asn	His	Ile	Ile	Ala	Serra et al., 2016
cyclotide cliotide T4	G1CWH3	1-123	peptide-Asn58+His-peptide	P	MS	Cys	Tyr	Arg	Asn	His	Val	Ile	Ala	Serra et al., 2016
cyclotide cliotide T5	G1CWH4	1-94	peptide-Asn23+Lys-peptide	P	MS	Ser	Cys	Lys	Asn	Lys	Val	Cys	Tyr	Serra et al., 2016
cyclotide cliotide T7	G1CWH5	1-130	peptide-Asn56+His-peptide	P	MS	Cys	Tyr	Lys	Asn	His	Val	Ile	Ala	Serra et al., 2016
cyclotide cliotide T8	G1CWH6	1-122	peptide-Asn55+His-peptide	P	MS	Cys	Tyr	Asn	Asn	His	Val	Ile	Ala	Serra et al., 2016
cyclotide cliotide T9	G1CWH7	1-117	peptide-Asn55+His-peptide	P	MS	Cys	Tyr	Asn	Asn	His	Val	Ile	Ala	Serra et al., 2016