Substrates for peptidase C13.005: glycosylphosphatidylinositol:protein transamidase
Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.
| Substrate | Uniprot | Residue range | Cleavage Site | Cleavage type | Evidence | P4 | P3 | P2 | P1 | P1' | P2' | P3' | P4' | Reference | CutDB | MERNUM |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1,3-beta-glucanosyltransferase GAS1 | P22146 | 23-559 | peptide-Asn528+Ala-peptide | P | NT | Ser | Lys | Lys | Asn | Ala | Ala | Thr | Asn | Popolo et al., 2008 | ||
| 1,3-beta-glucanosyltransferase GAS1 | P23151 | 23-559 | peptide-Asn528+Ala-peptide | P | NT | Ser | Lys | Lys | Asn | Ala | Ala | Thr | Asn | Popolo et al., 2008 | ||
| 5'-nucleotidase | P21589 | 27-574 | peptide-Ser549+Thr-peptide | P | NT | Ile | Lys | Phe | Ser | Thr | Gly | Ser | His | Misumi et al., 1990 | ||
| 5'-nucleotidase | P21588 | 29-576 | peptide-Ser551+Ala-peptide | P | NT | Ile | Lys | Phe | Ser | Ala | Ala | Ser | His | Ogata et al., 1990 | ||
| Acetylcholinesterase isoform T | P04058-2 | 22-596 | peptide-Arg564+Gln-peptide | P | NT | Glu | Ala | Glu | Arg | Gln | Trp | Lys | Thr | McPhee-Quigley et al., 1986 | ||
| Alkaline phosphatase, placental type | P05187 | 23-535 | peptide-Asp506+Ala-peptide | P | NT | Gly | Thr | Thr | Asp | Ala | Ala | His | Pro | Henthorn et al., 1986 | ||
| Alpha-agglutinin | P20840 | 20-650 | peptide-Gly627+Lys-peptide | N | NT | Thr | Tyr | Glu | Gly | Lys | Ala | Ser | Ile | |||
| Carbonic anhydrase 4 | P22748 | 19-312 | peptide-Ser284+Gly-peptide | P | NT | Val | Ile | Lys | Ser | Gly | Ala | Pro | Gly | Okuyama et al., 1995 | ||
| Carboxypeptidase M | P14384 | 18-443 | peptide-Ser423+Ala-peptide | P | NT | Pro | Asp | His | Ser | Ala | Ala | Thr | Lys | Tan et al., 2003 | ||
| CD59 glycoprotein | P13987 | 26-128 | peptide-Asn102+Gly-peptide | P | NT | Gln | Leu | Glu | Asn | Gly | Gly | Thr | Ser | Acosta et al., 2000 | ||
| cell-cell adhesion glycoprotein 64 | Q52085 | 20-320 | peptide-Ser298+Ser-peptide | P | NT | Asn | Val | Cys | Ser | Ser | Ala | Thr | Thr | Manabe et al., 1994 | ||
| Complement decay-accelerating factor | P08174 | 35-440 | peptide-Ser353+Gly-peptide | P | NT | Gly | Thr | Thr | Ser | Gly | Thr | Thr | Arg | Storry et al., 2003 | ||
| Complement decay-accelerating factor | P09679 | 35-440 | peptide-Ser353+Gly-peptide | P | NT | Gly | Thr | Thr | Ser | Gly | Thr | Thr | Arg | Storry et al., 2003 | ||
| Dipeptidase 1 | P16444 | 17-411 | peptide-Ser385+Gly-peptide | P | NT | Gly | Tyr | Ser | Ser | Gly | Ala | Ser | Ser | Sjoeblom et al., 2006 | ||
| Folate receptor alpha | P15328 | 25-257 | peptide-Ser234+Gly-peptide | P | NT | Ala | Ala | Met | Ser | Gly | Ala | Gly | Pro | Picariello et al., 2008 | ||
| Leishmanolysin | P08148 | 40-602 | peptide-Asn577+Thr-peptide | P | NT | Asp | Gly | Gly | Asn | Thr | Ala | Ala | Gly | McGwire & Chang, 1996 | ||
| Leishmanolysin | P15906 | 40-602 | peptide-Asn577+Thr-peptide | P | NT | Asp | Gly | Gly | Asn | Thr | Ala | Ala | Gly | McGwire & Chang, 1996 | ||
| Major prion protein | P04273 | 23-254 | peptide-Ile231+Ser-peptide | P | NT | Ile | Leu | Leu | Ile | Ser | Phe | Leu | Ile | Turk et al., 1988 | ||
| Procyclic form-specific polypeptide A-beta | P09791 | 28-129 | peptide-Gly107+Ala-peptide | P | NT | Pro | Glu | Pro | Gly | Ala | Ala | Thr | Leu | Clayton & Mowatt, 1989 |
