$VAR1 = undef;

Summary for peptidase C13.005: glycosylphosphatidylinositol:protein transamidase

Names
MEROPS Name	glycosylphosphatidylinositol:protein transamidase
Other names	GPI8 g.p. (Saccharomyces cerevisiae)

Domain architecture

MEROPS Classification
Classification	Clan CD >> Subclan (none) >> Family C13 >> Subfamily (none) >> C13.005
Holotype	glycosylphosphatidylinositol:protein transamidase (Saccharomyces cerevisiae), Uniprot accession P49018 (peptidase unit: 34-299), MERNUM MER0002477
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Cysteine
NC-IUBMB	Not yet included in IUBMB recommendations.
Activity status	human: active (Meyer et al., 2000) mouse: putative
Physiology	GPI-anchor transamidase.
Knockout	A defect in glycosylphosphatidylinositol (GPI) transamidase activity in a human K562 cell mutant line renders them unable to display GPI-anchored surface proteins (Chen et al., 1996; Yu et al., 1997).
Pathways	KEGG	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
Other databases	WIKIPEDIA	http://en.wikipedia.org/wiki/PIGK
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/-/-/Sngagt/A/ts/- (based on 19 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	4	2	2	2	6	2	1	3
Pro	2	0	1	0	0	0	1	2
Ala	1	2	0	0	6	13	2	0
Val	1	1	0	0	0	0	0	0
Leu	0	2	1	0	0	0	1	1
Ile	3	1	0	1	0	0	0	2
Met	0	0	1	0	0	0	0	0
Phe	0	0	2	0	0	1	0	0
Tyr	0	2	0	0	0	0	0	0
Trp	0	0	0	0	0	1	0	0
Ser	2	0	1	9	2	0	4	2
Thr	1	3	3	0	3	2	8	2
Cys	0	0	1	0	0	0	0	0
Asn	1	0	0	5	0	0	0	2
Gln	1	0	0	0	1	0	0	0
Asp	2	1	0	1	0	0	0	0
Glu	1	1	3	0	0	0	0	0
Lys	0	4	3	0	1	0	1	1
Arg	0	0	0	1	0	0	0	2
His	0	0	1	0	0	0	1	2