Substrates for peptidase C12.008: ubiquitinyl hydrolase UCH-D

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
Ub-(alphaN)-Val	P62988	1-76	peptide-Gly76+(alphaN)-Val	S	Leu	Arg	Gly	Gly	Val	-	-	-	Layfield et al., 1999
Ub-(epsilonN)-Lys	P62988	1-76	peptide-Gly76+(epsilonN)-Lys	S	Leu	Arg	Gly	Gly	Lys	-	-	-	Layfield et al., 1999
UBICEP52	P0CG47	1-76	peptide-Gly76+Ile1-peptide	N	Leu	Arg	Gly	Gly	Ile	Ile	Glu	Pro	Layfield et al., 1999