Substrates for peptidase C01.149: TgCPL peptidase (Toxoplasma-type)

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
MIC2-associated protein	Q967S9	1-330	Peptide-Ser46+Thr-Peptide	P	NT	Ala	Gln	Leu	Ser	Thr	Phe	Leu	Glu	Parussini et al., 2010
MIC3 microneme protein	Q9GRG4	1-359	Peptide-Gln65+Ser-Peptide	P	CS	Ser	Ser	Val	Gln	Ser	Pro	Ser	Lys	Parussini et al., 2010
Micronemal protein 6	Q9XYH7	1-349	Peptide-Ser94+Glu-Peptide	P	CS	Val	Gln	Leu	Ser	Glu	Thr	Pro	Ala	Parussini et al., 2010
pro Cathepsin L	D1MNA5	1-421	Peptide-Leu197+Asn-Peptide	P	NT	Thr	Glu	Leu	Leu	Asn	Val	Leu	Pro	Parussini et al., 2010
pro Cathepsin L	D1MNA5	1-421	Peptide-Asn198+Val-Peptide	P	NT	Glu	Leu	Leu	Asn	Val	Leu	Pro	Ser	Parussini et al., 2010
Z-Leu-Arg-NHMec			Z-Leu-Arg+NHMec	S		-	Z	Leu	Arg	AMC	-	-	-	Huang et al., 2009
Z-Phe-Arg-NHMec			Z-Phe-Arg+NHMec	S		-	Z	Phe	Arg	AMC	-	-	-	Huang et al., 2009