Substrates for peptidase A02.013: bovine leukemia virus retropepsin

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
bovine leukemia virus Gag polyprotein CA/NC cleavage-related peptide P03344 103-112 Tyr-Asp-Pro-Pro-Ala-Ile-Leu+Pro-Ile-Ile P Pro Ala Ile Leu Pro Ile Ile - Menard & Guillemain, 2004
gag polyprotein P03344 2-392 peptide-Leu109+Pro-peptide P Pro Ala Ile Leu Pro Ile Ile Ser Menard & Guillemain, 2004 15999
gag polyprotein P03344 2-392 peptide-Leu77+Ala-peptide P NT Pro Leu Val Leu Ala Thr Leu Asn Katoh et al., 1991
gag polyprotein P03344 2-392 peptide-Leu84+Ser-peptide P NT Asn Glu Val Leu Ser Asn Glu Gly Katoh et al., 1991
polyprotein P10270 1-195 peptide-Leu43+Leu-peptide P Leu Glu Cys Leu Leu Ser Ile Pro Blaha et al., 1992 16001
polyprotein P10270 1-195 peptide-Gly169+Val-peptide P Pro Met Val Gly Val Leu Asp Ala Blaha et al., 1992 16000
protease P10270 1-195 peptide-Gly116+Pro-peptide P NT Trp Leu Gln Gly Pro Leu Thr Leu Pichov  et al., 1998
Val-Ser-Ala-Asn-Tyr-Pro-Ile-Val-Gln peptide-Tyr5+Pro-peptide N AA Ser Ala Asn Tyr Pro Ile Val Gln Eizert et al., 2008
Val-Ser-Gln-Asn-Ala-Pro-Ile-Val-Gln peptide-Ala5+Pro-peptide N AA Ser Gln Asn Ala Pro Ile Val Gln Eizert et al., 2008
Val-Ser-Gln-Asn-Leu-Pro-Ile-Val-Gln peptide-Leu5+Pro-peptide N AA Ser Gln Asn Leu Pro Ile Val Gln Eizert et al., 2008
Val-Ser-Gln-Asn-Met-Pro-Ile-Val-Gln peptide-Met5+Pro-peptide N AA Ser Gln Asn Met Pro Ile Val Gln Eizert et al., 2008
Val-Ser-Gln-Asn-Phe-Pro-Ile-Val-Gln peptide-Phe5+Pro-peptide N AA Ser Gln Asn Phe Pro Ile Val Gln Eizert et al., 2008
Val-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln peptide-Tyr5+Pro-peptide N AA Ser Gln Asn Tyr Pro Ile Val Gln Eizert et al., 2008
Val-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln peptide-Tyr5+Pro-peptide N AA Ser Gln Asn Tyr Pro Ile Val Gln Eizert et al., 2008
Val-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln peptide-Tyr5+Pro-peptide N AA Ser Gln Asn Tyr Pro Ile Val Gln Eizert et al., 2008
Val-Ser-Gly-Asn-Tyr-Pro-Ile-Val-Gln peptide-Tyr5+Pro-peptide N AA Ser Gly Asn Tyr Pro Ile Val Gln Eizert et al., 2008
Val-Ser-Leu-Asn-Tyr-Pro-Ile-Val-Gln peptide-Tyr5+Pro-peptide N AA Ser Leu Asn Tyr Pro Ile Val Gln Eizert et al., 2008
Val-Ser-Lys-Asn-Tyr-Pro-Ile-Val-Gln peptide-Tyr5+Pro-peptide N AA Ser Lys Asn Tyr Pro Ile Val Gln Eizert et al., 2008
Val-Ser-Phe-Asn-Tyr-Pro-Ile-Val-Gln peptide-Tyr5+Pro-peptide N AA Ser Phe Asn Tyr Pro Ile Val Gln Eizert et al., 2008
Val-Ser-Val-Asn-Tyr-Pro-Ile-Val-Gln peptide-Tyr5+Pro-peptide N AA Ser Val Asn Tyr Pro Ile Val Gln Eizert et al., 2008