Substrates for peptidase A02.010: mouse mammary tumor virus retropepsin

Summary Alignment Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
gag polyprotein P10258 2-353 peptide-Leu228+Pro-peptide P Glu Leu Ile Leu Pro Val Lys Arg 15993
gag polyprotein P10258 2-591 peptide-Phe194+Leu-peptide P Ser Lys Ala Phe Leu Ala Thr Asp 15991
mouse mammary tumor virus gag polyprotein-derived peptide P10258 265-278 Leu-Thr-Phe-Thr-Phe+Pro-Val-Val-Phe-Met-Arg-Arg P Thr Phe Thr Phe Pro Val Val Phe Menendez-Arias et al., 2004
Val-Ser-Gln-Asn-Leu-Pro-Ile-Val-Gln peptide-Leu5+Pro-peptide N AA Ser Gln Asn Leu Pro Ile Val Gln Eizert et al., 2008
Val-Ser-Gln-Asn-Met-Pro-Ile-Val-Gln peptide-Met5+Pro-peptide N AA Ser Gln Asn Met Pro Ile Val Gln Eizert et al., 2008
Val-Ser-Gln-Asn-Met-Pro-Ile-Val-Gln peptide-Met5+Pro-peptide N AA Ser Gln Asn Met Pro Ile Val Gln Eizert et al., 2008
Val-Ser-Gln-Asn-Phe-Pro-Ile-Val-Gln peptide-Phe5+Pro-peptide N AA Ser Gln Asn Phe Pro Ile Val Gln Eizert et al., 2008
Val-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln peptide-Tyr5+Pro-peptide N AA Ser Gln Asn Tyr Pro Ile Val Gln Eizert et al., 2008
Val-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln peptide-Tyr5+Pro-peptide N AA Ser Gln Asn Tyr Pro Ile Val Gln Eizert et al., 2008
Val-Ser-Leu-Asn-Tyr-Pro-Ile-Val-Gln peptide-Tyr5+Pro-peptide N AA Ser Leu Asn Tyr Pro Ile Val Gln Eizert et al., 2008
Val-Ser-Lys-Asn-Tyr-Pro-Ile-Val-Gln peptide-Tyr5+Pro-peptide N AA Ser Lys Asn Tyr Pro Ile Val Gln Eizert et al., 2008
Val-Ser-Phe-Asn-Tyr-Pro-Ile-Val-Gln peptide-Tyr5+Pro-peptide N AA Ser Phe Asn Tyr Pro Ile Val Gln Eizert et al., 2008
Val-Ser-Val-Asn-Tyr-Pro-Ile-Val-Gln peptide-Tyr5+Pro-peptide N AA Ser Val Asn Tyr Pro Ile Val Gln Eizert et al., 2008