Substrates for peptidase A02.005: bovine immunodeficiency virus retropepsin

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
gag polyprotein P19558 1-476 peptide-Tyr126+Pro-peptide P Lys Ser Ile Tyr Pro Ser Leu Thr Tobin et al., 1994
gag polyprotein P19558 1-476 peptide-Leu148+Pro-peptide P Thr Gln Ser Leu Pro Ala Ile Thr Tobin et al., 1994
gag polyprotein P19558 1-476 peptide-Phe367+Leu-peptide P Lys Met Gln Phe Leu Val Ala Ala Tobin et al., 1994
gag polyprotein P19558 1-476 peptide-Tyr392+Ala-peptide P Pro Glu Ala Tyr Ala Ser Gln Thr Tobin et al., 1994
gag polyprotein P19558 1-476 peptide-Phe458+His-peptide P Gln Asn Asn Phe His Gln Ser Asn Tobin et al., 1994
gag polyprotein P19558 1-476 peptide-Pro127+Ser-peptide P Ser Ile Tyr Pro Ser Leu Thr Gln Tobin et al., 1994
gag polyprotein P19558 1-476 peptide-Lys136+Lys-peptide P Thr Gln Asn Lys Lys Gln Thr Ser Tobin et al., 1994
gag polyprotein P19558 1-476 peptide-Leu368+Val-peptide P Met Gln Phe Leu Val Ala Ala Met Tobin et al., 1994
gag polyprotein P19558 1-476 peptide-Ala371+Met-peptide P Leu Val Ala Ala Met Lys Glu Met Tobin et al., 1994
gag polyprotein P19558 1-476 peptide-Asn462+Met-peptide P His Gln Ser Asn Met Ser Ser Val Tobin et al., 1994
gag polyprotein P19558 1-476 peptide-Met463+Ser-peptide P Gln Ser Asn Met Ser Ser Val Thr Tobin et al., 1994