$VAR1 = undef;

Summary for peptidase A02.005: bovine immunodeficiency virus retropepsin

Names
MEROPS Name	bovine immunodeficiency virus retropepsin
Other names	retropepsin (bovine immunodeficiency virus)

Domain architecture

MEROPS Classification
Classification	Clan AA >> Subclan (none) >> Family A2 >> Subfamily A >> A02.005
Holotype	bovine immunodeficiency virus retropepsin, Uniprot accession P19560 (peptidase unit: 476-575), MERNUM MER0000960
History	Identifier created: MEROPS 3.02 (25 June 1998)

Activity
Catalytic type	Aspartic
NC-IUBMB	Not yet included in IUBMB recommendations.
Physiology	Processing of viral polyprotein.
Pharmaceutical relevance	Evaluated as a model of lentivirus disease.
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/q/-/--/s/-/t (based on 11 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	0	0	0	0	0	0	0	0
Pro	1	0	0	1	2	0	0	0
Ala	0	0	2	1	1	2	2	1
Val	0	1	0	0	1	1	1	1
Leu	1	0	0	2	1	1	1	0
Ile	0	1	1	0	0	0	1	0
Met	1	1	0	1	2	0	0	2
Phe	0	0	1	2	0	0	0	0
Tyr	0	0	1	2	0	0	0	0
Trp	0	0	0	0	0	0	0	0
Ser	1	2	2	0	2	4	2	1
Thr	2	0	0	0	0	0	2	4
Cys	0	0	0	0	0	0	0	0
Asn	0	1	3	1	0	0	0	1
Gln	2	4	1	0	0	2	1	1
Asp	0	0	0	0	0	0	0	0
Glu	0	1	0	0	0	0	1	0
Lys	2	0	0	1	1	1	0	0
Arg	0	0	0	0	0	0	0	0
His	1	0	0	0	1	0	0	0

Mouse genetics
Gene symbol	Position	Megabases	Ensembl	Entrez gene	MGI
	6:A1