Substrates for peptidase A01.075: plasmepsin-5 (Plasmodium sp.)

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
Dabcyl-Arg-Tyr-Val-Arg-Ile-Leu-Ser-Glu-Thr-Glu-EDANS			Dabcyl-Arg-Tyr-Val-Arg-Ile-Leu+Ser-Glu-Thr-Glu-EDANS	S		Val	Arg	Ile	Leu	Ser	Glu	Thr	Glu	Russo et al., 2010
Dabcyl-Gly-Asn-Lys-Arg-Thr-Leu-Ala-Gln-Lys-Gln-Gly-EDANS			Lys-Arg-Thr-Leu+Ala-Gln-Lys-Gln	S		Lys	Arg	Thr	Leu	Ala	Gln	Lys	Gln	Boddey et al., 2013
Dabcyl-Leu-Asn-Lys-Arg-Leu-Leu-His-Glu-Thr-Gln-EDANS			Dabcyl-Leu-Asn-Lys-Arg-Leu-Leu+His-Glu-Thr-Gln-EDANS	S		Lys	Arg	Leu	Leu	His	Glu	Thr	Gln	Russo et al., 2010
knob-associated histidine-rich protein	P09346	41-62	peptide-Leu56+Ala-peptide	P	MU	Lys	Arg	Thr	Leu	Ala	Gln	Lys	Gln	Boddey et al., 2010
Rifin	Q8I2C7	28-47	Peptide-Leu38+Cys-Peptide	N	MS	Asn	Arg	Ser	Leu	Cys	Glu	Cys	Asp	Boddey et al., 2013
Ring-infected erythrocyte surface antigen	P13830	77-96	Peptide-Leu88+Tyr-Peptide	N	MS	Ser	Arg	Asn	Leu	Tyr	Gly	Glu	Thr	Boddey et al., 2013
Stevor	Q9U5L9	41-60	Peptide-Leu50+Ala-Peptide	N	MS	Ser	Arg	Leu	Leu	Ala	Gln	Thr	Gln	Boddey et al., 2013