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Literature for peptidase A01.075: plasmepsin-5 (Plasmodium sp.)

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, T Target, P Specificity, K Knockout, I Inhibitor, E Expression. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Hodder,A.N., Sleebs,B.E., Adams,G., Rezazadeh,S., Ngo,A., Jarman,K., Scally,S., Czabotar,P., Wang,H., McCauley,J.A., Olsen,D.B. and Cowman,A.F.
    Structure-activity analysis of imino-pyrimidinone-fused pyrrolidines aids the development of dual plasmepsin V and plasmepsin X inhibitors
    FEBS J (2025) PubMed  Europe PubMed DOI
  2. Prajapati,A.K., Kumar,Y. and Choudhary,S.
    Inhibiting catalytic activity of Plasmodium falciparum aspartate protease plasmepsin V: A biochemical approach to malaria intervention
    Biochimie (2025) 242, 42-58. PubMed  Europe PubMed DOI  I
    3. 2024
  3. Das,A., Rajkhowa,S., Sinha,S. and Zaki,M.E.A.
    Unveiling potential repurposed drug candidates for Plasmodium falciparum through in silico evaluation: A synergy of structure-based approaches, structure prediction, and molecular dynamics simulations
    Comput Biol Chem (2024) 110, 108048-108048. PubMed  Europe PubMed DOI  I
  4. Fierro,M.A., Muheljic,A., Sha,J., Wohlschlegel,J. and Beck,J.R.
    PEXEL is a proteolytic maturation site for both exported and non-exported Plasmodium proteins
    mSphere (2024) 9, e0039323-e0039323. PubMed  Europe PubMed DOI  PMC  EPMC
  5. Freville,A., Ressurreicao,M. and van Ooij,C.
    Identification of a non-exported Plasmepsin V substrate that functions in the parasitophorous vacuole of malaria parasites
    MBio (2024) 15, e0122323-e0122323. PubMed  Europe PubMed DOI  PMC  EPMC
  6. Gabriela,M., Barnes,C.B.G., Leong,D., Sleebs,B.E., Schneider,M.P., Littler,D.R., Crabb,B.S., de Koning-Ward,T.F. and Gilson,P.R.
    Sequence elements within the PEXEL motif and its downstream region modulate PTEX-dependent protein export in Plasmodium falciparum
    Traffic (2024) 25, e12922-e12922. PubMed  Europe PubMed DOI
    7. 2023
  7. Bobrovs,R., Drunka,L., Kanepe,I., Jirgensons,A., Caflisch,A., Salvalaglio,M. and Jaudzems,K.
    Exploring the Binding Pathway of Novel Nonpeptidomimetic Plasmepsin V Inhibitors
    J Chem Inf Model (2023) 63, 6890-6899. PubMed  Europe PubMed DOI
  8. Fierro,M.A., Muheljic,A., Sha,J., Wohlschlegel,J.A. and Beck,J.R.
    PEXEL is a proteolytic maturation site for both exported and non-exported Plasmodium proteins
    bioRxiv (2023) PubMed  Europe PubMed DOI  PMC  EPMC
  9. Hasan,M.M., Polino,A.J., Mukherjee,S., Vaupel,B. and Goldberg,D.E.
    The mature N-termini of Plasmodium effector proteins confer specificity of export
    MBio (2023) 14, e0121523-e0121523. PubMed  Europe PubMed DOI  PMC  EPMC
  10. Sulyman,A.O., Aje,O.O., Ajani,E.O., Abdulsalam,R.A., Balogun,F.O. and Sabiu,S.
    Bioprospection of Selected Plant Secondary Metabolites as Modulators of the Proteolytic Activity of Plasmodium falciparum Plasmepsin V
    Biomed Res Int (2023) 2023, 6229503-6229503. PubMed  Europe PubMed DOI  PMC  EPMC  I
    11. 2022
  11. Gabriela,M., Matthews,K.M., Boshoven,C., Kouskousis,B., Jonsdottir,T.K., Bullen,H.E., Modak,J., Steer,D.L., Sleebs,B.E., Crabb,B.S., Koning-Ward,T.F. and Gilson,P.R.
    A revised mechanism for how Plasmodium falciparum recruits and exports proteins into its erythrocytic host cell
    PLoS Pathog (2022) 18, e1009977-e1009977. PubMed  Europe PubMed DOI  PMC  EPMC
  12. Ji,X., Wang,Z., Chen,Q., Li,J., Wang,H., Wang,Z. and Yang,L.
    In Silico and In Vitro Antimalarial Screening and Validation Targeting Plasmodium falciparum Plasmepsin V
    Molecules (2022) 27 PubMed  Europe PubMed DOI  PMC  EPMC
  13. Polino,A.J., Miller,J.J., Bhakat,S., Mukherjee,S., Bobba,S., Bowman,G.R. and Goldberg,D.E.
    The nepenthesin insert in the Plasmodium falciparum aspartic protease plasmepsin V is necessary for enzyme function
    J Biol Chem (2022) 298, 102355-102355. PubMed  Europe PubMed DOI  PMC  EPMC
    14. 2020
  14. Brancucci,N.M.B., Heussler,V.T. and Gruring,C.
    Targeting Plasmodium plasmepsin V: hitting two birds with one stone
    Trends Parasitol (2020) 36, 85-87. PubMed  Europe PubMed DOI
  15. Cheuka,P.M., Dziwornu,G., Okombo,J. and Chibale,K.
    Plasmepsin Inhibitors in Antimalarial Drug Discovery: Medicinal Chemistry and Target Validation (2000 to Present)
    J Med Chem (2020) 63, 4445-4467. PubMed  Europe PubMed DOI
  16. Nasamu,A.S., Polino,A.J., Istvan,E.S. and Goldberg,D.E.
    Malaria parasite plasmepsins: more than just plain old degradative pepsins
    J Biol Chem (2020) PubMed  Europe PubMed DOI
  17. Polino,A.J., Nasamu,A.S., Niles,J.C. and Goldberg,D.E.
    Assessment of biological role and insight into druggability of the Plasmodium falciparum protease plasmepsin V
    ACS Infect Dis (2020) 6, 738-746. PubMed  Europe PubMed DOI
    18. 2019
  18. Jennison,C., Lucantoni,L., O'Neill,M.T., McConville,R., Erickson,S.M., Cowman,A.F., Sleebs,B.E., Avery,V.M. and Boddey,J.A.
    Inhibition of plasmepsin V activity blocks Plasmodium falciparum gametocytogenesis and transmission to mosquitoes
    Cell Rep (2019) 29, 3796-3806. PubMed  Europe PubMed DOI
  19. Loymunkong,C., Sittikul,P., Songtawee,N., Wongpanya,R. and Boonyalai,N.
    Yield improvement and enzymatic dissection of Plasmodium falciparum plasmepsin V
    Mol Biochem Parasitol (2019) 231, 111188-111188. PubMed  Europe PubMed DOI  E
  20. Meissner,K.A., Kronenberger,T., Maltarollo,V.G., Trossini,G.H.G. and Wrenger,C.
    Targeting the Plasmodium falciparum plasmepsin V by ligand-based virtual screening
    Chem Biol Drug Des (2019) 93, 300-312. PubMed  Europe PubMed DOI  I
    21. 2018
  21. Boonyalai,N., Collins,C.R., Hackett,F., Withers-Martinez,C. and Blackman,M.J.
    Essentiality of Plasmodium falciparum plasmepsin V
    PLoS ONE (2018) 13, e0207621-e0207621. PubMed  Europe PubMed DOI  K
  22. Marapana,D.S., Dagley,L.F., Sandow,J.J., Nebl,T., Triglia,T., Pasternak,M., Dickerman,B.K., Crabb,B.S., Gilson,P.R., Webb,A.I., Boddey,J.A. and Cowman,A.F.
    Plasmepsin V cleaves malaria effector proteins in a distinct endoplasmic reticulum translocation interactome for export to the erythrocyte
    Nat Microbiol (2018) 3, 1010-1022. PubMed  Europe PubMed DOI
  23. Nguyen,W., Hodder,A.N., de Lezongard,R.B., Czabotar,P.E., Jarman,K.E., O'Neill,M.T., Thompson,J.K., Jousset Sabroux,H., Cowman,A.F., Boddey,J.A. and Sleebs,B.E.
    Enhanced antimalarial activity of plasmepsin V inhibitors by modification of the P2 position of PEXEL peptidomimetics
    Eur J Med Chem (2018) 154, 182-198. PubMed  Europe PubMed DOI  I
  24. Sittikul,P., Songtawee,N., Kongkathip,N. and Boonyalai,N.
    In vitro and in silico studies of naphthoquinones and peptidomimetics toward Plasmodium falciparum plasmepsin V
    Biochimie (2018) 152, 159-173. PubMed  Europe PubMed DOI  I
    25. 2017
  25. Pant,A., Pasupureddy,R., Pande,V., Seshadri,S., Dixit,R. and Pandey,K.C.
    Proteases in mosquito borne diseases: new avenues in drug development
    Curr Top Med Chem (2017) 17, 2221-2232. PubMed  Europe PubMed
    26. 2016
  26. Bedi,R.K., Patel,C., Mishra,V., Xiao,H., Yada,R.Y. and Bhaumik,P.
    Understanding the structural basis of substrate recognition by Plasmodium falciparum plasmepsin V to aid in the design of potent inhibitors
    Sci Rep (2016) 6, 31420-31420. PubMed  Europe PubMed DOI  I
  27. Boddey,J.A., O'Neill,M.T., Lopaticki,S., Carvalho,T.G., Hodder,A.N., Nebl,T., Wawra,S., Van West,P., Ebrahimzadeh,Z., Richard,D., Flemming,S., Spielmann,T., Przyborski,J., Babon,J.J. and Cowman,A.F.
    Export of malaria proteins requires co-translational processing of the PEXEL motif independent of phosphatidylinositol-3-phosphate binding
    Nat Commun (2016) 7, 10470-10470. PubMed  Europe PubMed DOI
  28. Gazdik,M., Jarman,K.E., O'Neill,M.T., Hodder,A.N., Lowes,K.N., Jousset Sabroux,H., Cowman,A.F., Boddey,J.A. and Sleebs,B.E.
    Exploration of the P3 region of PEXEL peptidomimetics leads to a potent inhibitor of the Plasmodium protease, plasmepsin V
    Bioorg Med Chem (2016) 24, 1993-2010. PubMed  Europe PubMed DOI  I
  29. L,M. and Soliman,M.E.
    The binding landscape of plasmepsin V and the implications for flap dynamics
    Mol Biosyst (2016) 12, 1457-1467. PubMed  Europe PubMed DOI  I
  30. Ponsuwanna,P., Kochakarn,T., Bunditvorapoom,D., Kumpornsin,K., Otto,T.D., Ridenour,C., Chotivanich,K., Wilairat,P., White,N.J., Miotto,O. and Chookajorn,T.
    Comparative genome-wide analysis and evolutionary history of haemoglobin-processing and haem detoxification enzymes in malarial parasites
    Malar J (2016) 15, 51-51. PubMed  Europe PubMed DOI  PMC  EPMC
    31. 2015
  31. Boonyalai,N., Sittikul,P. and Yuvaniyama,J.
    Plasmodium falciparum plasmepsin V (PfPMV): insights into recombinant expression, substrate specificity and active site structure
    Mol Biochem Parasitol (2015) 201, 5-15. PubMed  Europe PubMed DOI  E  P
  32. Gambini,L., Rizzi,L., Pedretti,A., Taglialatela-Scafati,O., Carucci,M., Pancotti,A., Galli,C., Read,M., Giurisato,E., Romeo,S. and Russo,I.
    Picomolar inhibition of plasmepsin V, an essential malaria protease, achieved exploiting the prime region
    PLoS ONE (2015) 10, e0142509-e0142509. PubMed  Europe PubMed DOI  PMC  EPMC  I
  33. Gazdik,M., O'Neill,M.T., Lopaticki,S., Lowes,K.N., Smith,B.J., Cowman,A.F., Boddey,J.A. and Sleebs,B.E.
    The effect of N-methylation on transition state mimetic inhibitors of the Plasmodium protease, plasmepsin V
    MedChemComm (2015) 6, 437-443. DOI  I
  34. Goldberg,D.E.
    Plasmepsin V shows its carnivorous side
    Nat Struct Mol Biol (2015) 22, 647-648. PubMed  Europe PubMed DOI  P  I
  35. Hodder,A.N., Sleebs,B.E., Czabotar,P.E., Gazdik,M., Xu,Y., O'Neill,M.T., Lopaticki,S., Nebl,T., Triglia,T., Smith,B.J., Lowes,K., Boddey,J.A. and Cowman,A.F.
    Structural basis for plasmepsin V inhibition that blocks export of malaria proteins to human erythrocytes
    Nat Struct Mol Biol (2015) 22, 590-596. PubMed  Europe PubMed DOI  S  I
  36. McGillewie,L. and Soliman,M.E.
    Flap flexibility amongst plasmepsins I, II, III, IV, and V: sequence, structural, and molecular dynamics analyses
    Proteins (2015) 83, 1693-1705. PubMed  Europe PubMed DOI
  37. Sappakhaw,K., Takasila,R., Sittikul,P., Wattana-Amorn,P., Assavalapsakul,W. and Boonyalai,N.
    Biochemical characterization of plasmepsin V from Plasmodium vivax Thailand isolates: substrate specificity and enzyme inhibition
    Mol Biochem Parasitol (2015) 204, 51-63. PubMed  Europe PubMed DOI  E
  38. Tarr,S.J. and Osborne,A.R.
    Experimental determination of the membrane topology of the Plasmodium protease plasmepsin V
    PLoS ONE (2015) 10, e0121786-e0121786. PubMed  Europe PubMed DOI
    39. 2014
  39. Sedwick,C.
    Plasmepsin V, a secret weapon against malaria
    PLoS Biol (2014) 12, e1001898-e1001898. PubMed  Europe PubMed DOI  PMC  EPMC  I
  40. Sleebs,B.E., Gazdik,M., O'Neill,M.T., Rajasekaran,P., Lopaticki,S., Lackovic,K., Lowes,K., Smith,B.J., Cowman,A.F. and Boddey,J.A.
    Transition state mimetics of the Plasmodium export element are potent inhibitors of plasmepsin V from P. falciparum and P. vivax
    J Med Chem (2014) 57, 7644-7662. PubMed  Europe PubMed DOI  T  I
  41. Sleebs,B.E., Lopaticki,S., Marapana,D.S., O'Neill,M.T., Rajasekaran,P., Gazdik,M., Gunther,S., Whitehead,L.W., Lowes,K.N., Barfod,L., Hviid,L., Shaw,P.J., Hodder,A.N., Smith,B.J., Cowman,A.F. and Boddey,J.A.
    Inhibition of Plasmepsin V Activity Demonstrates Its Essential Role in Protein Export, PfEMP1 Display, and Survival of Malaria Parasites
    PLoS Biol (2014) 12, e1001897-e1001897. PubMed  Europe PubMed DOI  PMC  EPMC  I
  42. Xiao,H., Bryksa,B.C., Bhaumik,P., Gustchina,A., Kiso,Y., Yao,S.Q., Wlodawer,A. and Yada,R.Y.
    The zymogen of plasmepsin V from Plasmodium falciparum is enzymatically active
    Mol Biochem Parasitol (2014) 197, 56-63. PubMed  Europe PubMed DOI
    43. 2013
  43. Rawat,M., Vijay,S., Gupta,Y., Tiwari,P.K. and Sharma,A.
    Imperfect duplicate insertions type of mutations in plasmepsin V modulates binding properties of PEXEL motifs of export proteins in Indian Plasmodium vivax
    PLoS ONE (2013) 8, e60077-e60077. PubMed  Europe PubMed DOI  PMC  EPMC
  44. Tarr,S.J., Cryar,A., Thalassinos,K., Haldar,K. and Osborne,A.R.
    The C-terminal portion of the cleaved HT motif is necessary and sufficient to mediate export of proteins from the malaria parasite into its host cell
    Mol Microbiol (2013) 87, 835-850. PubMed  Europe PubMed DOI
    45. 2012
  45. Bhattacharjee,S., Stahelin,R.V., Speicher,K.D., Speicher,D.W. and Haldar,K.
    Endoplasmic reticulum PI(3)P lipid binding targets malaria proteins to the host cell
    Cell (2012) 148, 201-212. PubMed  Europe PubMed DOI  PMC  EPMC
  46. Meyers,M.J. and Goldberg,D.E.
    Recent advances in plasmepsin medicinal chemistry and implications for future antimalarial drug discovery efforts
    Curr Top Med Chem (2012) 12, 445-455. PubMed  Europe PubMed DOI  I
  47. Russo,I. and Goldberg,D.E.
    Plasmepsin V
    [ISSN:978-0-12-407744-7] (2012) 3, 103-105. DOI
    48. 2011
  48. Guruprasad,L., Tanneeru,K. and Guruprasad,K.
    Structural rationale for the recognition of arginine at P3 in PEXEL motif containing proteins of Plasmodium falciparum by plasmepsin V
    Protein Pept Lett (2011) 18, 634-641. PubMed  Europe PubMed  P
    49. 2010
  49. Boddey,J.A., Hodder,A.N., Gunther,S., Gilson,P.R., Patsiouras,H., Kapp,E.A., Pearce,J.A., de Koning-Ward,T.F., Simpson,R.J., Crabb,B.S. and Cowman,A.F.
    An aspartyl protease directs malaria effector proteins to the host cell
    Nature (2010) 463, 627-631. PubMed  Europe PubMed DOI  PMC  EPMC  P
  50. Haase,S. and de Koning-Ward,T.F.
    New insights into protein export in malaria parasites
    Cell Microbiol (2010) 12, 580-587. PubMed  Europe PubMed DOI
  51. Russo,I., Babbitt,S., Muralidharan,V., Butler,T., Oksman,A. and Goldberg,D.E.
    Plasmepsin V licenses Plasmodium proteins for export into the host erythrocyte
    Nature (2010) 463, 632-636. PubMed  Europe PubMed DOI  P  T
    52. 2005
  52. [YEAR:14-7-2005]Klemba,M. and Goldberg,D.E.
    Characterization of plasmepsin V, a membrane-bound aspartic protease homolog in the endoplasmic reticulum of Plasmodium falciparum
    Mol Biochem Parasitol (14-7-2005) 143, 183-191. PubMed  Europe PubMed DOI
    53. 2002
  53. Nezami,A. and Freire,E.
    The integration of genomic and structural information in the development of high affinity plasmepsin inhibitors
    Int J Parasitol (2002) 32, 1669-1676. PubMed  Europe PubMed DOI  I
    54. 2001
  54. Coombs,G.H., Goldberg,D.E., Klemba,M., Berry,C., Kay,J. and Mottram,J.C.
    Aspartic proteases of Plasmodium falciparum and other parasitic protozoa as drug targets
    Trends Parasitol (2001) 17, 532-537. PubMed  Europe PubMed DOI

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