Literature for peptidase A01.075: plasmepsin-5 (Plasmodium sp.)

(Topics flags: S Structure, T Target, P Specificity, K Knockout, I Inhibitor, E Expression. To select only the references relevant to a single topic, click the link above. See explanation.)

2025
1. Hodder,A.N., Sleebs,B.E., Adams,G., Rezazadeh,S., Ngo,A., Jarman,K., Scally,S., Czabotar,P., Wang,H., McCauley,J.A., Olsen,D.B. and Cowman,A.F.<br>Structure-activity analysis of imino-pyrimidinone-fused pyrrolidines aids the development of dual plasmepsin V and plasmepsin X inhibitors<br>FEBS J (2025) PubMed  Europe PubMed DOI
2. Prajapati,A.K., Kumar,Y. and Choudhary,S.<br>Inhibiting catalytic activity of Plasmodium falciparum aspartate protease plasmepsin V: A biochemical approach to malaria intervention<br>Biochimie (2025) 242, 42-58. PubMed  Europe PubMed DOI  I
2024
3. Das,A., Rajkhowa,S., Sinha,S. and Zaki,M.E.A.<br>Unveiling potential repurposed drug candidates for Plasmodium falciparum through in silico evaluation: A synergy of structure-based approaches, structure prediction, and molecular dynamics simulations<br>Comput Biol Chem (2024) 110, 108048-108048. PubMed  Europe PubMed DOI  I
4. Fierro,M.A., Muheljic,A., Sha,J., Wohlschlegel,J. and Beck,J.R.<br>PEXEL is a proteolytic maturation site for both exported and non-exported Plasmodium proteins<br>mSphere (2024) 9, e0039323-e0039323. PubMed  Europe PubMed DOI  PMC  EPMC
5. Freville,A., Ressurreicao,M. and van Ooij,C.<br>Identification of a non-exported Plasmepsin V substrate that functions in the parasitophorous vacuole of malaria parasites<br>MBio (2024) 15, e0122323-e0122323. PubMed  Europe PubMed DOI  PMC  EPMC
6. Gabriela,M., Barnes,C.B.G., Leong,D., Sleebs,B.E., Schneider,M.P., Littler,D.R., Crabb,B.S., de Koning-Ward,T.F. and Gilson,P.R.<br>Sequence elements within the PEXEL motif and its downstream region modulate PTEX-dependent protein export in Plasmodium falciparum<br>Traffic (2024) 25, e12922-e12922. PubMed  Europe PubMed DOI
2023
7. Bobrovs,R., Drunka,L., Kanepe,I., Jirgensons,A., Caflisch,A., Salvalaglio,M. and Jaudzems,K.<br>Exploring the Binding Pathway of Novel Nonpeptidomimetic Plasmepsin V Inhibitors<br>J Chem Inf Model (2023) 63, 6890-6899. PubMed  Europe PubMed DOI
8. Fierro,M.A., Muheljic,A., Sha,J., Wohlschlegel,J.A. and Beck,J.R.<br>PEXEL is a proteolytic maturation site for both exported and non-exported Plasmodium proteins<br>bioRxiv (2023) PubMed  Europe PubMed DOI  PMC  EPMC
9. Hasan,M.M., Polino,A.J., Mukherjee,S., Vaupel,B. and Goldberg,D.E.<br>The mature N-termini of Plasmodium effector proteins confer specificity of export<br>MBio (2023) 14, e0121523-e0121523. PubMed  Europe PubMed DOI  PMC  EPMC
10. Sulyman,A.O., Aje,O.O., Ajani,E.O., Abdulsalam,R.A., Balogun,F.O. and Sabiu,S.<br>Bioprospection of Selected Plant Secondary Metabolites as Modulators of the Proteolytic Activity of Plasmodium falciparum Plasmepsin V<br>Biomed Res Int (2023) 2023, 6229503-6229503. PubMed  Europe PubMed DOI  PMC  EPMC  I
2022
11. Gabriela,M., Matthews,K.M., Boshoven,C., Kouskousis,B., Jonsdottir,T.K., Bullen,H.E., Modak,J., Steer,D.L., Sleebs,B.E., Crabb,B.S., Koning-Ward,T.F. and Gilson,P.R.<br>A revised mechanism for how Plasmodium falciparum recruits and exports proteins into its erythrocytic host cell<br>PLoS Pathog (2022) 18, e1009977-e1009977. PubMed  Europe PubMed DOI  PMC  EPMC
12. Ji,X., Wang,Z., Chen,Q., Li,J., Wang,H., Wang,Z. and Yang,L.<br>In Silico and In Vitro Antimalarial Screening and Validation Targeting Plasmodium falciparum Plasmepsin V<br>Molecules (2022) 27 PubMed  Europe PubMed DOI  PMC  EPMC
13. Polino,A.J., Miller,J.J., Bhakat,S., Mukherjee,S., Bobba,S., Bowman,G.R. and Goldberg,D.E.<br>The nepenthesin insert in the Plasmodium falciparum aspartic protease plasmepsin V is necessary for enzyme function<br>J Biol Chem (2022) 298, 102355-102355. PubMed  Europe PubMed DOI  PMC  EPMC
2020
14. Brancucci,N.M.B., Heussler,V.T. and Gruring,C.<br>Targeting Plasmodium plasmepsin V: hitting two birds with one stone<br>Trends Parasitol (2020) 36, 85-87. PubMed  Europe PubMed DOI
15. Cheuka,P.M., Dziwornu,G., Okombo,J. and Chibale,K.<br>Plasmepsin Inhibitors in Antimalarial Drug Discovery: Medicinal Chemistry and Target Validation (2000 to Present)<br>J Med Chem (2020) 63, 4445-4467. PubMed  Europe PubMed DOI
16. Nasamu,A.S., Polino,A.J., Istvan,E.S. and Goldberg,D.E.<br>Malaria parasite plasmepsins: more than just plain old degradative pepsins<br>J Biol Chem (2020) PubMed  Europe PubMed DOI
17. Polino,A.J., Nasamu,A.S., Niles,J.C. and Goldberg,D.E.<br>Assessment of biological role and insight into druggability of the Plasmodium falciparum protease plasmepsin V<br>ACS Infect Dis (2020) 6, 738-746. PubMed  Europe PubMed DOI
2019
18. Jennison,C., Lucantoni,L., O'Neill,M.T., McConville,R., Erickson,S.M., Cowman,A.F., Sleebs,B.E., Avery,V.M. and Boddey,J.A.<br>Inhibition of plasmepsin V activity blocks Plasmodium falciparum gametocytogenesis and transmission to mosquitoes<br>Cell Rep (2019) 29, 3796-3806. PubMed  Europe PubMed DOI
19. Loymunkong,C., Sittikul,P., Songtawee,N., Wongpanya,R. and Boonyalai,N.<br>Yield improvement and enzymatic dissection of Plasmodium falciparum plasmepsin V<br>Mol Biochem Parasitol (2019) 231, 111188-111188. PubMed  Europe PubMed DOI  E
20. Meissner,K.A., Kronenberger,T., Maltarollo,V.G., Trossini,G.H.G. and Wrenger,C.<br>Targeting the Plasmodium falciparum plasmepsin V by ligand-based virtual screening<br>Chem Biol Drug Des (2019) 93, 300-312. PubMed  Europe PubMed DOI  I
2018
21. Boonyalai,N., Collins,C.R., Hackett,F., Withers-Martinez,C. and Blackman,M.J.<br>Essentiality of Plasmodium falciparum plasmepsin V<br>PLoS ONE (2018) 13, e0207621-e0207621. PubMed  Europe PubMed DOI  K
22. Marapana,D.S., Dagley,L.F., Sandow,J.J., Nebl,T., Triglia,T., Pasternak,M., Dickerman,B.K., Crabb,B.S., Gilson,P.R., Webb,A.I., Boddey,J.A. and Cowman,A.F.<br>Plasmepsin V cleaves malaria effector proteins in a distinct endoplasmic reticulum translocation interactome for export to the erythrocyte<br>Nat Microbiol (2018) 3, 1010-1022. PubMed  Europe PubMed DOI
23. Nguyen,W., Hodder,A.N., de Lezongard,R.B., Czabotar,P.E., Jarman,K.E., O'Neill,M.T., Thompson,J.K., Jousset Sabroux,H., Cowman,A.F., Boddey,J.A. and Sleebs,B.E.<br>Enhanced antimalarial activity of plasmepsin V inhibitors by modification of the P2 position of PEXEL peptidomimetics<br>Eur J Med Chem (2018) 154, 182-198. PubMed  Europe PubMed DOI  I
24. Sittikul,P., Songtawee,N., Kongkathip,N. and Boonyalai,N.<br>In vitro and in silico studies of naphthoquinones and peptidomimetics toward Plasmodium falciparum plasmepsin V<br>Biochimie (2018) 152, 159-173. PubMed  Europe PubMed DOI  I
2017
25. Pant,A., Pasupureddy,R., Pande,V., Seshadri,S., Dixit,R. and Pandey,K.C.<br>Proteases in mosquito borne diseases: new avenues in drug development<br>Curr Top Med Chem (2017) 17, 2221-2232. PubMed  Europe PubMed
2016
26. Bedi,R.K., Patel,C., Mishra,V., Xiao,H., Yada,R.Y. and Bhaumik,P.<br>Understanding the structural basis of substrate recognition by Plasmodium falciparum plasmepsin V to aid in the design of potent inhibitors<br>Sci Rep (2016) 6, 31420-31420. PubMed  Europe PubMed DOI  I
27. Boddey,J.A., O'Neill,M.T., Lopaticki,S., Carvalho,T.G., Hodder,A.N., Nebl,T., Wawra,S., Van West,P., Ebrahimzadeh,Z., Richard,D., Flemming,S., Spielmann,T., Przyborski,J., Babon,J.J. and Cowman,A.F.<br>Export of malaria proteins requires co-translational processing of the PEXEL motif independent of phosphatidylinositol-3-phosphate binding<br>Nat Commun (2016) 7, 10470-10470. PubMed  Europe PubMed DOI
28. Gazdik,M., Jarman,K.E., O'Neill,M.T., Hodder,A.N., Lowes,K.N., Jousset Sabroux,H., Cowman,A.F., Boddey,J.A. and Sleebs,B.E.<br>Exploration of the P3 region of PEXEL peptidomimetics leads to a potent inhibitor of the Plasmodium protease, plasmepsin V<br>Bioorg Med Chem (2016) 24, 1993-2010. PubMed  Europe PubMed DOI  I
29. L,M. and Soliman,M.E.<br>The binding landscape of plasmepsin V and the implications for flap dynamics<br>Mol Biosyst (2016) 12, 1457-1467. PubMed  Europe PubMed DOI  I
30. Ponsuwanna,P., Kochakarn,T., Bunditvorapoom,D., Kumpornsin,K., Otto,T.D., Ridenour,C., Chotivanich,K., Wilairat,P., White,N.J., Miotto,O. and Chookajorn,T.<br>Comparative genome-wide analysis and evolutionary history of haemoglobin-processing and haem detoxification enzymes in malarial parasites<br>Malar J (2016) 15, 51-51. PubMed  Europe PubMed DOI  PMC  EPMC
2015
31. Boonyalai,N., Sittikul,P. and Yuvaniyama,J.<br>Plasmodium falciparum plasmepsin V (PfPMV): insights into recombinant expression, substrate specificity and active site structure<br>Mol Biochem Parasitol (2015) 201, 5-15. PubMed  Europe PubMed DOI  E  P
32. Gambini,L., Rizzi,L., Pedretti,A., Taglialatela-Scafati,O., Carucci,M., Pancotti,A., Galli,C., Read,M., Giurisato,E., Romeo,S. and Russo,I.<br>Picomolar inhibition of plasmepsin V, an essential malaria protease, achieved exploiting the prime region<br>PLoS ONE (2015) 10, e0142509-e0142509. PubMed  Europe PubMed DOI  PMC  EPMC  I
33. Gazdik,M., O'Neill,M.T., Lopaticki,S., Lowes,K.N., Smith,B.J., Cowman,A.F., Boddey,J.A. and Sleebs,B.E.<br>The effect of N-methylation on transition state mimetic inhibitors of the Plasmodium protease, plasmepsin V<br>MedChemComm (2015) 6, 437-443. DOI  I
34. Goldberg,D.E.<br>Plasmepsin V shows its carnivorous side<br>Nat Struct Mol Biol (2015) 22, 647-648. PubMed  Europe PubMed DOI  P  I
35. Hodder,A.N., Sleebs,B.E., Czabotar,P.E., Gazdik,M., Xu,Y., O'Neill,M.T., Lopaticki,S., Nebl,T., Triglia,T., Smith,B.J., Lowes,K., Boddey,J.A. and Cowman,A.F.<br>Structural basis for plasmepsin V inhibition that blocks export of malaria proteins to human erythrocytes<br>Nat Struct Mol Biol (2015) 22, 590-596. PubMed  Europe PubMed DOI  S  I
36. McGillewie,L. and Soliman,M.E.<br>Flap flexibility amongst plasmepsins I, II, III, IV, and V: sequence, structural, and molecular dynamics analyses<br>Proteins (2015) 83, 1693-1705. PubMed  Europe PubMed DOI
37. Sappakhaw,K., Takasila,R., Sittikul,P., Wattana-Amorn,P., Assavalapsakul,W. and Boonyalai,N.<br>Biochemical characterization of plasmepsin V from Plasmodium vivax Thailand isolates: substrate specificity and enzyme inhibition<br>Mol Biochem Parasitol (2015) 204, 51-63. PubMed  Europe PubMed DOI  E
38. Tarr,S.J. and Osborne,A.R.<br>Experimental determination of the membrane topology of the Plasmodium protease plasmepsin V<br>PLoS ONE (2015) 10, e0121786-e0121786. PubMed  Europe PubMed DOI
2014
39. Sedwick,C.<br>Plasmepsin V, a secret weapon against malaria<br>PLoS Biol (2014) 12, e1001898-e1001898. PubMed  Europe PubMed DOI  PMC  EPMC  I
40. Sleebs,B.E., Gazdik,M., O'Neill,M.T., Rajasekaran,P., Lopaticki,S., Lackovic,K., Lowes,K., Smith,B.J., Cowman,A.F. and Boddey,J.A.<br>Transition state mimetics of the Plasmodium export element are potent inhibitors of plasmepsin V from P. falciparum and P. vivax<br>J Med Chem (2014) 57, 7644-7662. PubMed  Europe PubMed DOI  T  I
41. Sleebs,B.E., Lopaticki,S., Marapana,D.S., O'Neill,M.T., Rajasekaran,P., Gazdik,M., Gunther,S., Whitehead,L.W., Lowes,K.N., Barfod,L., Hviid,L., Shaw,P.J., Hodder,A.N., Smith,B.J., Cowman,A.F. and Boddey,J.A.<br>Inhibition of Plasmepsin V Activity Demonstrates Its Essential Role in Protein Export, PfEMP1 Display, and Survival of Malaria Parasites<br>PLoS Biol (2014) 12, e1001897-e1001897. PubMed  Europe PubMed DOI  PMC  EPMC  I
42. Xiao,H., Bryksa,B.C., Bhaumik,P., Gustchina,A., Kiso,Y., Yao,S.Q., Wlodawer,A. and Yada,R.Y.<br>The zymogen of plasmepsin V from Plasmodium falciparum is enzymatically active<br>Mol Biochem Parasitol (2014) 197, 56-63. PubMed  Europe PubMed DOI
2013
43. Rawat,M., Vijay,S., Gupta,Y., Tiwari,P.K. and Sharma,A.<br>Imperfect duplicate insertions type of mutations in plasmepsin V modulates binding properties of PEXEL motifs of export proteins in Indian Plasmodium vivax<br>PLoS ONE (2013) 8, e60077-e60077. PubMed  Europe PubMed DOI  PMC  EPMC
44. Tarr,S.J., Cryar,A., Thalassinos,K., Haldar,K. and Osborne,A.R.<br>The C-terminal portion of the cleaved HT motif is necessary and sufficient to mediate export of proteins from the malaria parasite into its host cell<br>Mol Microbiol (2013) 87, 835-850. PubMed  Europe PubMed DOI
2012
45. Bhattacharjee,S., Stahelin,R.V., Speicher,K.D., Speicher,D.W. and Haldar,K.<br>Endoplasmic reticulum PI(3)P lipid binding targets malaria proteins to the host cell<br>Cell (2012) 148, 201-212. PubMed  Europe PubMed DOI  PMC  EPMC
46. Meyers,M.J. and Goldberg,D.E.<br>Recent advances in plasmepsin medicinal chemistry and implications for future antimalarial drug discovery efforts<br>Curr Top Med Chem (2012) 12, 445-455. PubMed  Europe PubMed DOI  I
47. Russo,I. and Goldberg,D.E.<br>Plasmepsin V<br>[ISSN:978-0-12-407744-7] (2012) 3, 103-105. DOI
2011
48. Guruprasad,L., Tanneeru,K. and Guruprasad,K.<br>Structural rationale for the recognition of arginine at P3 in PEXEL motif containing proteins of Plasmodium falciparum by plasmepsin V<br>Protein Pept Lett (2011) 18, 634-641. PubMed  Europe PubMed  P
2010
49. Boddey,J.A., Hodder,A.N., Gunther,S., Gilson,P.R., Patsiouras,H., Kapp,E.A., Pearce,J.A., de Koning-Ward,T.F., Simpson,R.J., Crabb,B.S. and Cowman,A.F.<br>An aspartyl protease directs malaria effector proteins to the host cell<br>Nature (2010) 463, 627-631. PubMed  Europe PubMed DOI  PMC  EPMC  P
50. Haase,S. and de Koning-Ward,T.F.<br>New insights into protein export in malaria parasites<br>Cell Microbiol (2010) 12, 580-587. PubMed  Europe PubMed DOI
51. Russo,I., Babbitt,S., Muralidharan,V., Butler,T., Oksman,A. and Goldberg,D.E.<br>Plasmepsin V licenses Plasmodium proteins for export into the host erythrocyte<br>Nature (2010) 463, 632-636. PubMed  Europe PubMed DOI  P  T
2005
52. [YEAR:14-7-2005]Klemba,M. and Goldberg,D.E.<br>Characterization of plasmepsin V, a membrane-bound aspartic protease homolog in the endoplasmic reticulum of Plasmodium falciparum<br>Mol Biochem Parasitol (14-7-2005) 143, 183-191. PubMed  Europe PubMed DOI
2002
53. Nezami,A. and Freire,E.<br>The integration of genomic and structural information in the development of high affinity plasmepsin inhibitors<br>Int J Parasitol (2002) 32, 1669-1676. PubMed  Europe PubMed DOI  I
2001
54. Coombs,G.H., Goldberg,D.E., Klemba,M., Berry,C., Kay,J. and Mottram,J.C.<br>Aspartic proteases of Plasmodium falciparum and other parasitic protozoa as drug targets<br>Trends Parasitol (2001) 17, 532-537. PubMed  Europe PubMed DOI