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Literature for peptidase A01.075: plasmepsin-5 (Plasmodium sp.)

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, T Target, P Specificity, K Knockout, I Inhibitor, E Expression. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Hodder,A.N., Sleebs,B.E., Adams,G., Rezazadeh,S., Ngo,A., Jarman,K., Scally,S., Czabotar,P., Wang,H., McCauley,J.A., Olsen,D.B. and Cowman,A.F.
    Structure-activity analysis of imino-pyrimidinone-fused pyrrolidines aids the development of dual plasmepsin V and plasmepsin X inhibitors
    FEBS J PubMed  Europe PubMed DOI
    2. 2024
  2. Das,A., Rajkhowa,S., Sinha,S. and Zaki,M.E.A.
    Unveiling potential repurposed drug candidates for Plasmodium falciparum through in silico evaluation: A synergy of structure-based approaches, structure prediction, and molecular dynamics simulations
    Comput Biol Chem110, 108048-108048. PubMed  Europe PubMed DOI  I
  3. Fierro,M.A., Muheljic,A., Sha,J., Wohlschlegel,J. and Beck,J.R.
    PEXEL is a proteolytic maturation site for both exported and non-exported Plasmodium proteins
    mSphere9, e0039323-e0039323. PubMed  Europe PubMed DOI
  4. Freville,A., Ressurreicao,M. and van Ooij,C.
    Identification of a non-exported Plasmepsin V substrate that functions in the parasitophorous vacuole of malaria parasites
    MBio15, e0122323-e0122323. PubMed  Europe PubMed DOI
  5. Gabriela,M., Barnes,C.B.G., Leong,D., Sleebs,B.E., Schneider,M.P., Littler,D.R., Crabb,B.S., de Koning-Ward,T.F. and Gilson,P.R.
    Sequence elements within the PEXEL motif and its downstream region modulate PTEX-dependent protein export in Plasmodium falciparum
    Traffic25, e12922-e12922. PubMed  Europe PubMed DOI
    6. 2023
  6. Bobrovs,R., Drunka,L., Kanepe,I., Jirgensons,A., Caflisch,A., Salvalaglio,M. and Jaudzems,K.
    Exploring the Binding Pathway of Novel Nonpeptidomimetic Plasmepsin V Inhibitors
    J Chem Inf Model63, 6890-6899. PubMed  Europe PubMed DOI
  7. Fierro,M.A., Muheljic,A., Sha,J., Wohlschlegel,J.A. and Beck,J.R.
    PEXEL is a proteolytic maturation site for both exported and non-exported Plasmodium proteins
    bioRxiv PubMed  Europe PubMed DOI
  8. Hasan,M.M., Polino,A.J., Mukherjee,S., Vaupel,B. and Goldberg,D.E.
    The mature N-termini of Plasmodium effector proteins confer specificity of export
    MBio14, e0121523-e0121523. PubMed  Europe PubMed DOI
  9. Sulyman,A.O., Aje,O.O., Ajani,E.O., Abdulsalam,R.A., Balogun,F.O. and Sabiu,S.
    Bioprospection of Selected Plant Secondary Metabolites as Modulators of the Proteolytic Activity of Plasmodium falciparum Plasmepsin V
    Biomed Res Int2023, 6229503-6229503. PubMed  Europe PubMed DOI  I
    10. 2022
  10. Gabriela,M., Matthews,K.M., Boshoven,C., Kouskousis,B., Jonsdottir,T.K., Bullen,H.E., Modak,J., Steer,D.L., Sleebs,B.E., Crabb,B.S., Koning-Ward,T.F. and Gilson,P.R.
    A revised mechanism for how Plasmodium falciparum recruits and exports proteins into its erythrocytic host cell
    PLoS Pathog18, e1009977-e1009977. PubMed  Europe PubMed DOI
  11. Ji,X., Wang,Z., Chen,Q., Li,J., Wang,H., Wang,Z. and Yang,L.
    In Silico and In Vitro Antimalarial Screening and Validation Targeting Plasmodium falciparum Plasmepsin V
    Molecules27, PubMed  Europe PubMed DOI
  12. Polino,A.J., Miller,J.J., Bhakat,S., Mukherjee,S., Bobba,S., Bowman,G.R. and Goldberg,D.E.
    The nepenthesin insert in the Plasmodium falciparum aspartic protease plasmepsin V is necessary for enzyme function
    J Biol Chem298, 102355-102355. PubMed  Europe PubMed DOI
    13. 2020
  13. Brancucci,N.M.B., Heussler,V.T. and Gruring,C.
    Targeting Plasmodium plasmepsin V: hitting two birds with one stone
    Trends Parasitol36, 85-87. PubMed  Europe PubMed DOI
  14. Cheuka,P.M., Dziwornu,G., Okombo,J. and Chibale,K.
    Plasmepsin Inhibitors in Antimalarial Drug Discovery: Medicinal Chemistry and Target Validation (2000 to Present)
    J Med Chem63, 4445-4467. PubMed  Europe PubMed DOI
  15. Nasamu,A.S., Polino,A.J., Istvan,E.S. and Goldberg,D.E.
    Malaria parasite plasmepsins: more than just plain old degradative pepsins
    J Biol Chem PubMed  Europe PubMed DOI
  16. Polino,A.J., Nasamu,A.S., Niles,J.C. and Goldberg,D.E.
    Assessment of biological role and insight into druggability of the Plasmodium falciparum protease plasmepsin V
    ACS Infect Dis6, 738-746. PubMed  Europe PubMed DOI
    17. 2019
  17. Jennison,C., Lucantoni,L., O'Neill,M.T., McConville,R., Erickson,S.M., Cowman,A.F., Sleebs,B.E., Avery,V.M. and Boddey,J.A.
    Inhibition of plasmepsin V activity blocks Plasmodium falciparum gametocytogenesis and transmission to mosquitoes
    Cell Rep29, 3796-3806. PubMed  Europe PubMed DOI
  18. Loymunkong,C., Sittikul,P., Songtawee,N., Wongpanya,R. and Boonyalai,N.
    Yield improvement and enzymatic dissection of Plasmodium falciparum plasmepsin V
    Mol Biochem Parasitol231, 111188-111188. PubMed  Europe PubMed DOI  E
  19. Meissner,K.A., Kronenberger,T., Maltarollo,V.G., Trossini,G.H.G. and Wrenger,C.
    Targeting the Plasmodium falciparum plasmepsin V by ligand-based virtual screening
    Chem Biol Drug Des93, 300-312. PubMed  Europe PubMed DOI  I
    20. 2018
  20. Boonyalai,N., Collins,C.R., Hackett,F., Withers-Martinez,C. and Blackman,M.J.
    Essentiality of Plasmodium falciparum plasmepsin V
    PLoS ONE13, e0207621-e0207621. PubMed  Europe PubMed DOI  K
  21. Marapana,D.S., Dagley,L.F., Sandow,J.J., Nebl,T., Triglia,T., Pasternak,M., Dickerman,B.K., Crabb,B.S., Gilson,P.R., Webb,A.I., Boddey,J.A. and Cowman,A.F.
    Plasmepsin V cleaves malaria effector proteins in a distinct endoplasmic reticulum translocation interactome for export to the erythrocyte
    Nat Microbiol3, 1010-1022. PubMed  Europe PubMed DOI
  22. Nguyen,W., Hodder,A.N., de Lezongard,R.B., Czabotar,P.E., Jarman,K.E., O'Neill,M.T., Thompson,J.K., Jousset Sabroux,H., Cowman,A.F., Boddey,J.A. and Sleebs,B.E.
    Enhanced antimalarial activity of plasmepsin V inhibitors by modification of the P2 position of PEXEL peptidomimetics
    Eur J Med Chem154, 182-198. PubMed  Europe PubMed DOI  I
  23. Sittikul,P., Songtawee,N., Kongkathip,N. and Boonyalai,N.
    In vitro and in silico studies of naphthoquinones and peptidomimetics toward Plasmodium falciparum plasmepsin V
    Biochimie152, 159-173. PubMed  Europe PubMed DOI  I
    24. 2017
  24. Pant,A., Pasupureddy,R., Pande,V., Seshadri,S., Dixit,R. and Pandey,K.C.
    Proteases in mosquito borne diseases: new avenues in drug development
    Curr Top Med Chem17, 2221-2232. PubMed  Europe PubMed
    25. 2016
  25. Bedi,R.K., Patel,C., Mishra,V., Xiao,H., Yada,R.Y. and Bhaumik,P.
    Understanding the structural basis of substrate recognition by Plasmodium falciparum plasmepsin V to aid in the design of potent inhibitors
    Sci Rep6, 31420-31420. PubMed  Europe PubMed DOI  I
  26. Boddey,J.A., O'Neill,M.T., Lopaticki,S., Carvalho,T.G., Hodder,A.N., Nebl,T., Wawra,S., Van West,P., Ebrahimzadeh,Z., Richard,D., Flemming,S., Spielmann,T., Przyborski,J., Babon,J.J. and Cowman,A.F.
    Export of malaria proteins requires co-translational processing of the PEXEL motif independent of phosphatidylinositol-3-phosphate binding
    Nat Commun7, 10470-10470. PubMed  Europe PubMed DOI
  27. Gazdik,M., Jarman,K.E., O'Neill,M.T., Hodder,A.N., Lowes,K.N., Jousset Sabroux,H., Cowman,A.F., Boddey,J.A. and Sleebs,B.E.
    Exploration of the P3 region of PEXEL peptidomimetics leads to a potent inhibitor of the Plasmodium protease, plasmepsin V
    Bioorg Med Chem24, 1993-2010. PubMed  Europe PubMed DOI  I
  28. L,M. and Soliman,M.E.
    The binding landscape of plasmepsin V and the implications for flap dynamics
    Mol Biosyst12, 1457-1467. PubMed  Europe PubMed DOI  I
  29. Ponsuwanna,P., Kochakarn,T., Bunditvorapoom,D., Kumpornsin,K., Otto,T.D., Ridenour,C., Chotivanich,K., Wilairat,P., White,N.J., Miotto,O. and Chookajorn,T.
    Comparative genome-wide analysis and evolutionary history of haemoglobin-processing and haem detoxification enzymes in malarial parasites
    Malar J15, 51-51. PubMed  Europe PubMed DOI
    30. 2015
  30. Boonyalai,N., Sittikul,P. and Yuvaniyama,J.
    Plasmodium falciparum plasmepsin V (PfPMV): insights into recombinant expression, substrate specificity and active site structure
    Mol Biochem Parasitol201, 5-15. PubMed  Europe PubMed DOI  E  P
  31. Gambini,L., Rizzi,L., Pedretti,A., Taglialatela-Scafati,O., Carucci,M., Pancotti,A., Galli,C., Read,M., Giurisato,E., Romeo,S. and Russo,I.
    Picomolar inhibition of plasmepsin V, an essential malaria protease, achieved exploiting the prime region
    PLoS ONE10, e0142509-e0142509. PubMed  Europe PubMed DOI  I
  32. Gazdik,M., O'Neill,M.T., Lopaticki,S., Lowes,K.N., Smith,B.J., Cowman,A.F., Boddey,J.A. and Sleebs,B.E.
    The effect of N-methylation on transition state mimetic inhibitors of the Plasmodium protease, plasmepsin V
    MedChemComm6, 437-443. DOI  I
  33. Goldberg,D.E.
    Plasmepsin V shows its carnivorous side
    Nat Struct Mol Biol22, 647-648. PubMed  Europe PubMed DOI  P  I
  34. Hodder,A.N., Sleebs,B.E., Czabotar,P.E., Gazdik,M., Xu,Y., O'Neill,M.T., Lopaticki,S., Nebl,T., Triglia,T., Smith,B.J., Lowes,K., Boddey,J.A. and Cowman,A.F.
    Structural basis for plasmepsin V inhibition that blocks export of malaria proteins to human erythrocytes
    Nat Struct Mol Biol22, 590-596. PubMed  Europe PubMed DOI  S  I
  35. McGillewie,L. and Soliman,M.E.
    Flap flexibility amongst plasmepsins I, II, III, IV, and V: sequence, structural, and molecular dynamics analyses
    Proteins83, 1693-1705. PubMed  Europe PubMed DOI
  36. Sappakhaw,K., Takasila,R., Sittikul,P., Wattana-Amorn,P., Assavalapsakul,W. and Boonyalai,N.
    Biochemical characterization of plasmepsin V from Plasmodium vivax Thailand isolates: substrate specificity and enzyme inhibition
    Mol Biochem Parasitol204, 51-63. PubMed  Europe PubMed DOI  E
  37. Tarr,S.J. and Osborne,A.R.
    Experimental determination of the membrane topology of the Plasmodium protease plasmepsin V
    PLoS ONE10, e0121786-e0121786. PubMed  Europe PubMed DOI
    38. 2014
  38. Sedwick,C.
    Plasmepsin V, a secret weapon against malaria
    PLoS Biol12, e1001898-e1001898. PubMed  Europe PubMed DOI  I
  39. Sleebs,B.E., Gazdik,M., O'Neill,M.T., Rajasekaran,P., Lopaticki,S., Lackovic,K., Lowes,K., Smith,B.J., Cowman,A.F. and Boddey,J.A.
    Transition state mimetics of the Plasmodium export element are potent inhibitors of plasmepsin V from P. falciparum and P. vivax
    J Med Chem57, 7644-7662. PubMed  Europe PubMed DOI  T  I
  40. Sleebs,B.E., Lopaticki,S., Marapana,D.S., O'Neill,M.T., Rajasekaran,P., Gazdik,M., Gunther,S., Whitehead,L.W., Lowes,K.N., Barfod,L., Hviid,L., Shaw,P.J., Hodder,A.N., Smith,B.J., Cowman,A.F. and Boddey,J.A.
    Inhibition of Plasmepsin V Activity Demonstrates Its Essential Role in Protein Export, PfEMP1 Display, and Survival of Malaria Parasites
    PLoS Biol12, e1001897-e1001897. PubMed  Europe PubMed DOI  I
  41. Xiao,H., Bryksa,B.C., Bhaumik,P., Gustchina,A., Kiso,Y., Yao,S.Q., Wlodawer,A. and Yada,R.Y.
    The zymogen of plasmepsin V from Plasmodium falciparum is enzymatically active
    Mol Biochem Parasitol197, 56-63. PubMed  Europe PubMed DOI
    42. 2013
  42. Rawat,M., Vijay,S., Gupta,Y., Tiwari,P.K. and Sharma,A.
    Imperfect duplicate insertions type of mutations in plasmepsin V modulates binding properties of PEXEL motifs of export proteins in Indian Plasmodium vivax
    PLoS ONE8, e60077-e60077. PubMed  Europe PubMed DOI
  43. Tarr,S.J., Cryar,A., Thalassinos,K., Haldar,K. and Osborne,A.R.
    The C-terminal portion of the cleaved HT motif is necessary and sufficient to mediate export of proteins from the malaria parasite into its host cell
    Mol Microbiol87, 835-850. PubMed  Europe PubMed DOI
    44. 2012
  44. Bhattacharjee,S., Stahelin,R.V., Speicher,K.D., Speicher,D.W. and Haldar,K.
    Endoplasmic reticulum PI(3)P lipid binding targets malaria proteins to the host cell
    Cell148, 201-212. PubMed  Europe PubMed DOI
  45. Meyers,M.J. and Goldberg,D.E.
    Recent advances in plasmepsin medicinal chemistry and implications for future antimalarial drug discovery efforts
    Curr Top Med Chem12, 445-455. PubMed  Europe PubMed DOI  I
  46. Russo,I. and Goldberg,D.E.
    Plasmepsin V
    [ISSN:978-0-12-407744-7]3, 103-105. DOI
    47. 2011
  47. Guruprasad,L., Tanneeru,K. and Guruprasad,K.
    Structural rationale for the recognition of arginine at P3 in PEXEL motif containing proteins of Plasmodium falciparum by plasmepsin V
    Protein Pept Lett18, 634-641. PubMed  Europe PubMed  P
    48. 2010
  48. Boddey,J.A., Hodder,A.N., Gunther,S., Gilson,P.R., Patsiouras,H., Kapp,E.A., Pearce,J.A., de Koning-Ward,T.F., Simpson,R.J., Crabb,B.S. and Cowman,A.F.
    An aspartyl protease directs malaria effector proteins to the host cell
    Nature463, 627-631. PubMed  Europe PubMed DOI  P
  49. Haase,S. and de Koning-Ward,T.F.
    New insights into protein export in malaria parasites
    Cell Microbiol12, 580-587. PubMed  Europe PubMed DOI
  50. Russo,I., Babbitt,S., Muralidharan,V., Butler,T., Oksman,A. and Goldberg,D.E.
    Plasmepsin V licenses Plasmodium proteins for export into the host erythrocyte
    Nature463, 632-636. PubMed  Europe PubMed DOI  P  T
    51. 2005
  51. [YEAR:14-7-2005]Klemba,M. and Goldberg,D.E.
    Characterization of plasmepsin V, a membrane-bound aspartic protease homolog in the endoplasmic reticulum of Plasmodium falciparum
    Mol Biochem Parasitol143, 183-191. PubMed  Europe PubMed DOI
    52. 2002
  52. Nezami,A. and Freire,E.
    The integration of genomic and structural information in the development of high affinity plasmepsin inhibitors
    Int J Parasitol32, 1669-1676. PubMed  Europe PubMed DOI  I
    53. 2001
  53. Coombs,G.H., Goldberg,D.E., Klemba,M., Berry,C., Kay,J. and Mottram,J.C.
    Aspartic proteases of Plasmodium falciparum and other parasitic protozoa as drug targets
    Trends Parasitol17, 532-537. PubMed  Europe PubMed DOI

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